Browsing by Author "Wai, Yau-Yau"

Now showing 1 - 3 of 3

Decreased Functional Connectivity in Salience Network is Correlated with Dysfunctional Attitude in Late Life Depression
(2015-03-01)
Lin, Chemin
;
Huang, Chih-Mao
;
Wai, Yau-Yau
;
Liu, Ho-Ling
;
Lee, Tatia Mei-Chun
The neural correlates of perceived energy levels in older adults with late-life depression
(2019-10-01)
Lam, Charlene L. M.
;
Liu, Ho-Ling
;
Huang, Chih-Mao
;
Wai, Yau-Yau
;
Lee, Shwu-Hua
Late-life depression is common among older adults. Although white-matter abnormality is highly implicated, the extent to which the corticospinal tract is associated with the pathophysiology of late-life depression is unclear. The current study aims to investigate the white-matter structural integrity of the corticospinal tract and determine its cognitive and functional correlates in older adults with late-life depression. Twenty-eight older adults with clinical depression and 23 healthy age-matched older adults participated in the study. The white matter volume and the white matter hyperintensities (WMHs) of the corticospinal tract, as well as the global WMHs, were measured. Psychomotor processing speed, severity of depression, perceived levels of energy and physical functioning were measured to examine the relationships among the correlates in the depressed participants. The right corticospinal tract volume was significantly higher in depressed older adults relative to healthy controls. Moreover, the right corticospinal tract volume was significantly associated with the overall severity of depression and accounted for 17% of its variance. It further attenuated the relationship between the severity of depression and perceived levels of energy. Our findings suggested that higher volume in the right corticospinal tract is implicated in LLD and may relate to lower perceived levels of energy experienced by older adults with depression.
The relationships between brain structural changes and perceived loneliness in older adults suffering from late-life depression
(2018-04-01)
Sin, Emily L. L.
;
Liu, Ho-Ling
;
Lee, Shwu-Hua
;
Huang, Chih-Mao
;
Wai, Yau-Yau
ObjectiveLate-life depression is a significant health risk factor for older adults, part of which is perceived loneliness. In this voxel-based morphometry study, we examined the relationships between perceived loneliness and depression recurrence. MethodsFifty-two older adults were recruited, and they were split into 3 groups: single episode, multiple episodes, or normal control groups, according to their clinical histories. ResultsThis result suggests the level of functioning regarding the reward system may be negatively related to the number of depressive episodes. Taken together, the findings of this study offer important insight into the neural underpinnings of the course and chronicity of late-life depression.