Browsing by Author "Wang, Cheng-Liang"

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Very small photoluminescent gold nanoparticles for multimodality biomedical imaging
(2013-05-01)
Lai, Sheng-Feng
;
Chien, Chia-Chi
;
Chen, Wen-Chang
;
Chen, Hsiang-Hsin
;
Chen, Yi-Yun
An original synthesis method based on X-ray irradiation produced gold nanoparticles (AuNPs) with two important properties for biomedical research: intense visible photoluminescence and very high accumulation in cancer cells. The nanoparticles, coated with MUA (11-mercaptoundecanoid acid), are very small (1.4 nm diameter); the above two properties are not present for even slightly larger sizes. The small MUA-AuNPs are non-cytotoxic (except for very high concentrations) and do not interfere with cancer cell proliferation. Multimodality imaging using visible light fluorescence and X-ray microscopy is demonstrated by tracing the nanoparticle-loaded tumor cells. (C) 2012 Elsevier Inc. All rights reserved.