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Browsing by Author "Wang, Ching Chi"

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    Sub-stoichiometric reductive etherification of carbohydrate substrates and one-pot protecting group manipulation
    (2020-04-28)
    Chen, Chiao Wen
    ;
    Wang, Ching Chi
    ;
    Li, Xin Ru
    ;
    Witek, Henryk
    ;
    Mong, Kwok-Kong Tony
    In this study, we report a new reductive etherification procedure for protection of carbohydrate substrates and its application for one-pot preparation of glycosyl building blocks. The reported procedure features the use of polymethylhydrosiloxane (PMHS) as a sub-stoichiometric reducing agent, which prevents the transilylation side reaction and improves the efficiency of the reductive etherification method. Application of the PMHS reductive etherification procedure for one-pot protecting group manipulation are described.