Browsing by Author "Wang, HI"

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Dielectric degradation of Cu/SiO2/Si structure during thermal annealing
(1996-03-01)
Chiou, JC
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Wang, HI
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Chen, MC
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電子工程學系及電子研究所
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Department of Electronics Engineering and Institute of Electronics
The impact of Cu on the dielectric SiO2 layer was studied using a Cu/SiO2/Si metal oxide semiconductor capacitor and rapid thermal annealing (RTA) treatment. With the RTA treatment, no chemical reaction was observed up to 900 degrees C; however, dielectric degradation occurred following RTA at 300 degrees C for 60 s and became worse with the increase of annealing temperature. The interface-trap density at the SiO2/Si interface also increased from 5 x 10(10) to 5 x 10(13) eV(-1) cm(-2) after 800 degrees C RTA treatment. The RTA anneal introduced a large number of positive Cu ions into the dielectric SiO2 layer. Under bias-temperature stress, Cu ions drift quickly in the SiO2 layer and may drift across the SiO2/Si interface and enter the Si substrate. With the use of 1200 Angstrom thick TiN and TiW barrier layers, respectively, the dielectric strength of the Cu/(barrier)/SiO2/Si structures was able to remain stable up to 500 and 600 degrees C.
PROGINS Alu sequence insertion is associated with hyperprolactinaemia but not leiomyoma susceptibility
(2005-04-01)
Hsieh, YY
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Chan, IP
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Wang, HI
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Chang, CC
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Huang, CW
Objective Leiomyoma and hyperprolactinaemia are both progesterone-dependent diseases. Hormone-related genes, such as the progesterone receptor (PGR), might be involved in their pathogenesis. Design and measurements Subjects were divided into three groups: (i) leiomyoma (n = 120); (ii) hyperprolactinaemia (n = 101); (iii) normal controls (n = 140). We investigated the Alu (306-bp DNA) insertion in intron G of the PGR gene in all individuals. PGR gene polymorphisms [T1 (wild-type); T2 (PROGINS, with Alu insertion)] were determined by PCR and electrophoresis. Genotype and allele frequencies of the PROGINS in each group were detected and compared. Results We observed no significant difference of the PGR*T1/T2 genotypes and allele frequencies between leiomyoma and other two groups. The proportions of T1 homozygote/heterozygote/T2 homozygote in each group were (i) 90/8.3/1.7%; (ii) 84.2/9.9/5.9%; (iii) 92.9/6.4/0.7%. In contrast, a higher percentage of T2-related genotype and allele were noted in hyperprolactinaemic women compared to other two groups. The proportions of T1/T2 alleles in each group were: (i) 94.2/5.8%; (ii) 89.1/10.9%; (iii) 96.1/3.9%. Conclusions The PROGIN*T2-related genotype and allele are related to a higher susceptibility to hyperprolactinaemia. The PROGINS polymorphism is not associated with leiomyoma development.