Browsing by Author "Wang, Hui-Min"

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A +/- 6ms-Accuracy, 0.68mm(2) and 2.21 mu W QRS Detection ASIC
(2010)
Wang, Hui-Min
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Lai, You-Liang
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Hou, Mark C.
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Lin, Shih-Hsiang
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Yen, Brad S.
Healthcare issues arose from population aging. Meanwhile, electrocardiogram (ECG) is a powerful measurement tool. The first step of ECG is to detect QRS complexes. A state-of-the-art QRS detection algorithm was modified and implemented. By the dedicated architecture design, the novel ASIC is proposed with 2.21 mu W power consumption and 0.68mm(2) core area. It is the smallest QRS detection ASIC so far in the world. In addition, the positive prediction of the ASIC is 99.36% based on the MIT/BIH arrhythmia database certification.
A Computational Model of the Relationship Between Musical Rhythm and Heart Rhythm
(2009)
Wang, Hui-Min
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Lin, Shih-Hsiang
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Huang, Yu-Chieh
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Chen, I-Cheng
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Chou, Lei-Chun
Heart rate variability (HRV) is a measure of variation in the heart rate. Over the last 25 years, HRV analysis has became utilized more often as a non-invasive research and clinical tool for indirectly investigating both cardiac and autonomic nervous system (ANS) functions in health and disease. In our experiment, 22 healthy subjects and four testing rhythm patterns are studied. How the three musical-rhythmic characteristics of tempo, complexity and drum sample affect the performance of HRV is discussed and a computational model with four factors is proposed. This relationship can help us to improve our life and health by music.
A computerized system of nail-fold capillaroscopy for dry eye disease diagnosis
(2012-12-01)
Hou, Mark C.
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Huang, Sheng-Chieh
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Wang, Hui-Min
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Tseng, Cheng-Lung
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Lo, Lun-Chien
Nail-fold Capillaroscopy is a convenient and non-invasive tool to evaluate peripheral circulation. Rheumatic diseases such as Raynaud's disease and systemic sclerosis are investigated mostly by nail-fold capillaroscopy. However, it has not been used popularly due to the lack of golden standard in both measurement procedure and objective quantity analysis. This study proposes a computerized system of nail-fold capillaroscopy (CNC). CNC includes standard measurement procedures and three criterions of microcirculation which are capillary density, capillary width and blood flow velocity. CNC is applied to the images of 36 normal subjects and seven patients of dry eye disease (DED). We found density and width of afferent capillary were the better parameters to identify DED (p < 0.05). CNC could be a good auxiliary diagnostic tool for DED.
A New Image Blood Pressure Sensor Based on PPG, RRT, BPTT, and Harmonic Balancing
(2014-10-01)
Huang, Sheng-Chieh
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Hung, Pei-Hsuan
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Hong, Chung-Hung
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Wang, Hui-Min
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A new blood pressure (BP) sensor, also named sphygmomanometer, is developed in this paper for estimating BPs accurately from fingertips. The hardware of the sensor is a low-cost optical CMOS imaging device for detecting photoplethysmography (PPG) signals at fingertips. Therefore, the sensor neither needs to contact human skin nor pressurize it for accurate BP predictions. To calculate BPs based on captured PPG signals, the modified radial resonance theory is applied to develop a new BP transport theory (BPTT), and then composes a computation algorithm for implementing BPTT in a typical smart phone with limited computation load required. The algorithm is successfully implemented in a typical smart phone with minimum computation load and equipped with an efficient calibration process. An experiment is conducted to evaluate the performance of the designed BP-sensing techniques. The resulted data clearly show that the difference between the systolic BPs (SBPs) sensed by the propose sensor and a validated cumbersome instrument is 1.37 mmHg, while for diastolic BPs (DBPs) is -1.40 mmHg. The afore-reported accuracy is well below those required by the Association for the Advancement of Medical Instrumentation, which are +/- 5 and 8 mmHg, respectively, for SBPs and DBPs.
A Physiological Valence/Arousal Model from Musical Rhythm to Heart Rhythm
(2011)
Wang, Hui-Min
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Lee, Yaw-Chern
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Yen, Brad S.
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Wang, Chun-Yen
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Huang, Sheng-Chieh
This paper studies how the musical-rhythmic features affect the performance of heart rate variability (HRV). A physiological valence/arousal model of such a relationship is proposed. A systematic experiment was performed, subjecting human subjects to four different drum loops, in which was tried to define a set of rhythmic features (and 'factors') that could be correlated with the observed HRV readings. Twenty-two healthy subjects and these four testing rhythm patterns were studied in this paper. The results show that dedicated rhythm can be synthesized for relaxing and exciting, and such an understanding between music and autonomic nervous system can improve life and health
HRV Response of Vegetative State Patient with Music Therapy
(2011)
Lee, Yaw-Chern
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Lei, Chun-Yang
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Shih, Yi-Sen
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Zhang, Wen-Chih
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Wang, Hui-Min
This case study centered on the effects of Music Therapy (MT) on vegetative state (VS) patients for a continuous 41-day experiment with electrocardiogram (ECG) recorded. Mahler's Second Symphony was used for this MT. There are various elements in Mahler's second symphony, with string, wind, drum, and even voice; providing the subject a strong and dynamic stimulation. There are some significant changes after 14-day stimulation: both standard deviation of all normal RR intervals (SDNN) and root mean square successive differences (RMSSD) in heart rate variability of the subject increased, indicating the activity of the cardiovascular system was enhanced. Although there's only one subject in this experiment, the results are still encouraging.
Pheophytin a Inhibits Inflammation via Suppression of LPS-Induced Nitric Oxide Synthase-2, Prostaglandin E2, and Interleukin-1 beta of Macrophages
(2014-12-01)
Lin, Chun-Yu
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Lee, Chien-Hsing
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Chang, Yu-Wei
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Wang, Hui-Min
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Chen, Chung-Yi
Inflammation is a serious health issue worldwide that induces many diseases such as sepsis. There has been a vast search for potentially effective drugs to decrease mortality from sepsis. Pheophytin a is a chlorophyll-related compound derived from green tea. We found that pre-treatment with pheophytin a suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E2 (PGE2), and interleukin-1 beta in RAW 264.7 macrophages. NO synthase-2 (NOS2) and cyclooxygenase-2 (COX-2) expression levels were repressed by pre-treatment with pheophytin a at both the transcriptional and translational levels. Pheophytin a inhibited NOS2 promoter activity, but not its mRNA stability, through extracellular signal-regulated kinase (ERK1/2). This suppression was reversed by ERK1/2 inhibitor (U0126). Pheophytin a reduced signal transducers and activators of transcription 1 (STAT-1) activation, without an obvious influence on activator protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B). These results suggest that pheophytin a functions by down-regulating the transcriptional levels of inflammatory mediators and blocking the ERK and STAT-1 pathways.
The Relationship between Music Processing and Electrocardiogram (ECG) in Vegetative State (VS)
(2010)
Yen, Brad S.
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Wang, Hui-Min
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Hou, Mark C.
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Huang, Sheng-Chieh
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Chou, Lei-Chun
Previous literature has suggested that consciousness of patients in vegetative state (VS) may be enhanced via music listening; however, studies empirically documenting the link among music, vegetative state, and electrocardiogram (ECG) are scant. Therefore, the current article attempts to explore how music improves the VS patient's condition with the assessment of ECG recordings. The present work involved a follow-up of case report, consisting of forty-two 150-min sessions, whose duration is longer than other VS studies. The quantitative analysis of the data was conducted through C programming language, HRV Analysis, EXCEL and MATLAB package software in order to find a specific pattern of HRV. Results of the study showed a medium level of consistence between the two variables of music and ECG. To conclude, this publication may be of importance in presenting some specific pattern of the ECG diagram while letting VS patients listen to the music.
Twin-Peak Effect in Both Cardiac Response and Tempo of Popular Music
(2011)
Shih, Yi-Sen
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Zhang, Wen-Chih
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Lee, Yaw-Chern
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Lei, Chun-Yang
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Tseng, Cheng-Lung
How the musical tempo affects the performance of heart rate variability (HRV) was studied in this work. By understanding the relationship between the HRV response and the music tempo with decreasing tempo from 140 to 70 beats per minute (bpm) periodically in six successive weeks. There were two groups in the experiment, one was listening drum loop music 3 minutes in the middle of experiment and the other was just rest for 20 minutes. After the processed the information from the objects, the distribution of difference of HRV response between before and after listening various tempo drum loop was similar to the distribution of modern popular music in tempo. Both distributions have the twin peaks about 70-85 and 110-125 bpm.