Browsing by Author "Wang, Y. -K."

Now showing 1 - 4 of 4

Biochemical and physiochemical characterization of thermostable ditrect hemolysin from grimontia hollisae
(2010-06-01)
Wang, Y. -K.
;
Huang, S. -C.
;
Wu, Y. -F.
;
Wu, T. -K.
;
交大名義發表
Estrogen receptor alpha-351 XbaI*G and -397 PvuII*C-related genotypes and alleles are associated with higher susceptibilities of endometriosis and leiomyoma
(2007-02-01)
Hsieh, Y. -Y.
;
Wang, Y. -K.
;
Chang, C. -C.
;
Lin, C. -S.
;
生物科技學系
Endometriosis and leiomyoma are both common estrogen-related gynaecological diseases. We aimed to elucidate the association of estrogen receptor alpha (ER alpha)-351 A > G (XbaI) and -397 T > C (PvuII) gene polymorphisms with endometriosis and leiomyoma. Women were divided into three groups: (i) severe endometriosis (n = 112), (ii) leiomyoma (n = 106) and (iii) normal controls (n = 110). Genomic DNA was obtained from peripheral leukocytes. ER alpha-351 A/G XbaI and -397 T/C PvuII polymorphisms were assayed by the method of PCR and restriction fragment length polymorphism (RFLP). Genotypes and allelic frequencies in each group were compared. The genotype/allele frequencies of ER alpha-351 and -397 polymorphisms in endometriosis or leiomyoma groups were different from those of normal controls. ER alpha mutant-related genotypes/alleles (-351G and -397C) presented higher percentages in the endometriosis/leiomyoma population compared with normal controls. Proportions of ER alpha-351 AA/AG/GG genotypes and A/G alleles in each group were (i) 26.8/57.1/16.1 and 55.4/44.6%; (ii) 19.8/52.8/27.4 and 46.2/53.8% and (iii) 33.6/64.6/1.8 and 65.9/34.1%. Proportions of ER alpha-397 TT/TC/CC genotypes and T/C alleles in each group were (i) 24.1/60.7/15.2 and 54.5/45.5%; (ii) 23.6/70.8/5.6 and 59/41% and (iii) 54.5/40/5.5 and 74.5/25.5%. We concluded that ER alpha-351 XbaI*G- and -397 PvuII*C-related genotypes/alleles were correlated with higher susceptibilities of endometriosis or leiomyoma, which might be associated with related pathogeneses.
Multiple pleomorphic tetramers of pore-forming thermostable direct hemolysin from Grimontia hollisae in exerting hemolysis and membrane binding
(2015-07-01)
Wang, Y. -K.
;
Li, T. -H. T.
;
Wu, T. -K.
;
交大名義發表
;
National Chiao Tung University
Structural and functional characterization of aminoacylhistidine dipeptidase from Vibrio alginolyticus, a metallopeptidase with dinuclear metal center
(2008-06-01)
Kao, L. -W.
;
Chang, J. -Y.
;
Wang, Y. -K.
;
Wu, T. -K.
;
生物科技學系