Browsing by Author "Wang, Yu-Wei"

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Shared IgG Infection Signatures vs. Hemorrhage-Restricted IgA Clusters in Human Dengue: A Phenotype of Differential Class-Switch via TGF beta 1
(2017-12-04)
Huang, Chung-Hao
;
Chang, Ya-Hui
;
Lin, Chun-Yu
;
Wang, Wen-Hung
;
Kuan, Hui-Chung
Phenotypic manifestations of infectious diseases are closely related to individual immune responses. Methods to extract information from patients' own immune reactions would be of great use for both diagnosis and treatment. Dengue fever is one of the diseases that clinical aggravations could occur paradoxically after humoral immunity appears. This property makes dengue fever an excellent disease model to explore. A principal component analyses (PCAs)-based framework derived from a prior vaccination study was developed. The framework was verified by successful demonstrations of known IgG signatures from a Mexico Dengue data set. Afterward the pipeline was tested upon de novo IgG and IgA libraries of Dengue patients from southern Taiwan. We discovered four infection signatures within IgG repertoires, two of which were identical to previous reports. However, it was IgA but not IgG that could differentiate hemorrhagic from non-hemorrhagic patients. IgA repertoires were found more diversified among bleeders, from whom seven signature clusters were characterized. The expressions of transforming growth factor beta 1 (TGF beta 1) and accordingly mediated class-switch activity of IgA were distinct only among the PCA-segregated bleeding group. In sum, intercontinental sharing of IgG signatures in dengue fever was demonstrated via a unified working flow. Differential regulation of IgA class-switch with associated diversity expansion plus existences of hemorrhage-restricted clusters were shown. The ability of the framework to find common IgG signatures would implicate applications to infections even from unknown pathogens. The clusters within IgA repertoires could offer perspectives to other IgA-related bleeding disorders such as Henoch-Schonlein purpura or IgA nephropathy. Substantiated grounds for IgA-specific effector function via TGF beta 1-mediated class-switch would be a new factor to consider for infectious diseases.
Vibration Feedback Controlled by Intuitive Pressing in Virtual Reality
(2019-01-01)
Wang, Yu-Wei
;
Pan, Tse-Yu
;
Chang, Yung-Ju
;
Hu, Min-Chun
;
資訊工程學系
To provide more immersive experience in VR, highfidelity vibrotactile feedback is one of the most important task to make VR user can feel virtual objects. In this work, we propose a mobile-based vibrotactile feedback system called FingerVIP, which provides an intuitive and efficient way for VR application/game designers to input proper vibration configuration of each target vibrotactile feedback. Our system uses pressure sensors attached on fingers as the controllers to manipulate the vibration configuration, including amplitude, frequency, and time duration. We utilized the proposed FingerVIP to set three kinds of vibrotactile feedback in a VR sports game and validated that FingerVIP successfully helped game designers reduce the number of iteration and the time for configuring vibration.