Browsing by Author "Wu, Hung-Yi"

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A fuzzy MCDM approach for evaluating banking performance based on Balanced Scorecard
(2009-08-01)
Wu, Hung-Yi
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Tzeng, Gwo-Hshiung
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Chen, Yi-Hsuan
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科技管理研究所
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Institute of Management of Technology
The paper proposed a Fuzzy Multiple Criteria Decision Making (FMCDM) approach for banking performance evaluation. Drawing on the four perspectives of a Balanced Scorecard (BSC), this research first summarized the evaluation indexes synthesized from the literature relating to banking performance. Then, for screening these indexes, 23 indexes fit for banking performance evaluation were selected through expert questionnaires. Furthermore, the relative weights of the chosen evaluation indexes were Calculated by Fuzzy Analytic Hierarchy Process (FAHP). And the three MCDM analytical tools of SAW, TOPSIS, and VIKOR were respectively adopted to rank the banking performance and improve the gaps with three banks as an empirical example. The analysis results highlight the critical aspects of evaluation criteria as well as the gaps to improve banking performance for achieving aspired/desired level. It shows that the proposed FMCDM evaluation model of banking performance using the BSC framework can be a useful and effective assessment tool. (C) 2009 Elsevier Ltd. All rights reserved.
A rapid and selective method for monitoring the growth of coliforms in milk using the combination of amperometric sensor and reducing of methylene blue
(2009-09-07)
Lee, Yuan-Geuy
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Wu, Hung-Yi
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Hsu, Chuan-Liang
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Liang, Hong-Jen
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Yuan, Chiun-Jye
A novel method for monitoring the growth of coliforms in milk was developed based on measuring the current change in an amperometric sensor. The sensor consists of a circuit with a homemade potentiostat and a pair of electrodes. The electrode was immersed in milk samples containing methylene blue with various concentrations of bacterial inoculums. The microbial metabolism led to the reduction of methylene blue resulting in a change of current. The time required to identify readily detectable change (detection time, DT) provided an approximate measurement of the amount of microorganisms in the initial inoculums. The sensor system used in this study has the selectivity towards coliform bacteria such as Escherichia coli and Enterobacter aerogenes. The calibration curve of DT against concentration of coliform showed a linear correlation coefficient (R(2) = 0.9192) over the range of 10(2)-10(8) CFU/mL. The sensor was able to detect the coliform bacteria at initial concentrations of 10(5) CFU/mL within 6 h, making it suitable for use in real-time monitoring of bacterial growth. This system has potential application in the detection of coliform concentration in milk at dairy farms when a proper selective media is designed. (C) 2009 Elsevier B.V. All rights reserved.
Innovation capital indicator assessment of Taiwanese Universities: A hybrid fuzzy model application
(2010-03-01)
Wu, Hung-Yi
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Chen, Jui-Kuei
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Chen, I-Shuo
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經營管理研究所
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Institute of Business and Management
Intellectual capital today has become an essential concept for assessing firm value Universities in Taiwan that are emphasizing knowledge more in order to gain a competitive advantage, as is the case with most organizations, are adopting intellectual capital to measure school performance as well The objective of (his Study is to analyze the intellectual capital of universities based on indicators of innovation capital After reviewing related literature and conducting in-depth interviews with experts in the field, the Study extracts critical relevant dimensions and indicators of Innovation capital that fit the characteristics of universities and then categorizes the main types of universities in Taiwan. The proposed analysis method is in accordance with the Fuzzy Analytic Hierarchy Process (FAHP) and with ViseKriterijumska Optimizacija I Kompromisno Resenje (VIKOR) methods. FAHP is used in determining the weights of the innovation capital indicators by educational experts: then, the rankings of the types Of universities are determined by VIKOR, based on the result of the weights of indicators. (C) 2009 Elsevier Ltd. All rights reserved.
Mammalian Ste20-like protein kinase 3 induces a caspase-independent apoptotic pathway
(2010-01-01)
Lin, Chia-Ying
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Wu, Hung-Yi
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Wang, Pei-Ling
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Yuan, Chiun-Jye
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生物科技學系
In this study, it was shown that the mammalian sterile 20-like serine/threonine protein kinase 3 (Mst3) plays an essential role in the staurosporine-induced apoptosis of HeLa cells. The staurosporine-induced apoptosis was reduced by around 65% by the selective knockdown of Mst3 in stable clones, HeLa(siMst3). Although caspases were shown to be involved in the Mst3-mediated apoptosis, only 15-20% of staurosporine-induced apoptosis was suppressed by the caspase inhibitor, z-DEVD-fmk. Accordingly, Mst3 was proposed to trigger a caspase-independent apoptotic pathway in response to staurosporine. Interestingly, staurosporine greatly induced the mitochondrial membrane potential transition in HeLa cells, but had no effect in Hela(siMst3). The role of Mst3 in controlling the mitochondrial integrity was therefore proposed, presumably through the regulation of Bax. Furthermore, it was shown that staurosporine promoted the nuclear translocation of apoptosis-inducing factor and endonuclease G in HeLa cells. The nuclease activity associated with endonuclease G was also enhanced in response to staurosporine. However, both staurosporine-induced nuclear translocation of apoptosis-inducing factor and endonuclease G and the nuclease activity associated with endonuclease G were markedly reduced in Hela(siMst3). These results suggest that Mst3 may respond to staurosporine to trigger the caspase-independent apoptotic pathway by regulating the nuclear translocation of apoptosis-inducing factor and endonuclease G, and the nuclease activity associated with endonuclease G. (C) 2009 Elsevier Ltd. All rights reserved.
Mammalian Ste20-like protein kinase 3 mediates trophoblast apoptosis in spontaneous delivery
(2008-02-01)
Wu, Hung-Yi
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Lin, Chia-Ying
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Lin, Tze-Yi
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Chen, Tai-Chang
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Yuan, Chiun-Jye
The placenta is essential in transferring gases and nutrients from the mother to the developing fetus. Trophoblast apoptosis may cause labor or other pregnancy-related disorders. This study demonstrated the essential role of Mst3, a human Ste20-like protein kinase, in the oxidative stress-induced apoptosis of trophoblasts of term placenta in normal spontaneous delivery. Oxidative stress, but not hormones released during labor such as prostaglandin E-1, oxytocin or angiotensin II, induces the expression of Mst3 and apoptosis of human term placenta after elective Cesarean section without labor pain. The role of Mst3 in oxidative stress-induced apoptosis was further demonstrated in the 3A-sub-E, a human trophoblast cell line. The H2O2-induced apoptosis of 3A-sub-E cells was largely suppressed by overexpressed Mst3(KR), the kinase-dead mutant or by selective knockdown of endogenous Mst3. Further studies showed that Jun N-terminal kinase (JNK) may participate in the signaling pathway of H2O2-induced apoptosis by mediating the level of Mst3. Subsequently, caspase 3 and other downstream apoptotic components may be activated by Mst3 and trigger the apoptotic process in human trophoblasts.
Mammalian Ste20-like protein kinase 3 plays a role in hypoxia-induced apoptosis of trophoblast cell line 3A-sub-E
(2011-05-01)
Wu, Hung-Yi
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Lin, Chia-Ying
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Chen, Tai-Chang
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Pan, Shien-Tung
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Yuan, Chiun-Jye
Mammalian Ste20-like protein kinase 3 (Mst3) is a key player in inducing apoptosis in a variety of cell types and has recently been shown to participate in the signaling pathway of hypoxia-induced apoptosis of human trophoblast cell line 3A-sub-E (3A). It is believed that oxidative stress may occur during hypoxia and induce the expression of Mst3 in 3A cells via the activation of c-Jun N-terminal protein kinase 1 (JNK1). This hypothesis was demonstrated by the suppressive effect of DL-alpha-lipoic acid, a reactive oxygen species scavenger, in hypoxia-induced responses of 3A cells such as Mst3 expression, nitrotyrosine formation. JNK1 activation and apoptosis. Similar results were also observed in trophoblasts of human placental explants in both immunohistochemical studies and immunoblot analyses. These suggested that the activation of Mst3 might trigger the apoptotic process in trophoblasts by activating caspase 3 and possibly other apoptotic pathways. The role of nitric oxide synthase (NOS) and NADPH oxidase (NOX) in hypoxia-induced Mst3 up-regulation was also demonstrated by the inhibitory effect of N(G)-nitro-L-arginine and apocynin, which inhibits NOS and NOX, respectively. Oxidative stress was postulated to be induced by NOS and NOX in 3A cells during hypoxia. In conclusion, hypoxia induces oxidative stress in human trophoblasts by activating NOS and NOX. Subsequently, Mst3 is up-regulated and plays an important role in hypoxia-induced apoptosis of human trophoblasts. (C) 2011 Elsevier Ltd. All rights reserved.
Mst3 Plays an Important Role in Hypoxia-induced placental Apoptosis in Preeclampsia
(2009-04-01)
Yuan, Chiun-Jye
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Wu, Hung-Yi
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Lin, Chia-Ying
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生物科技學系
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Department of Biological Science and Technology
Mst3 plays an important role in the hypoxia-induced apoptosis of human trophoblasts
(2010-04-01)
Wu, Hung-Yi
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Lin, Chia-Ying
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Pan, Shien-Tung
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Yuan, Chiun-Jye
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交大名義發表
Role of Mst3 in oxidative phosphorylation
(2010-04-01)
Lin, Chia-Ying
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Wu, Hung-Yi
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Yuan, Chiun-Jye
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交大名義發表
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National Chiao Tung University
Ways to promote valuable innovation: intellectual capital assessment for higher education system
(2012-08-01)
Wu, Hung-Yi
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Chen, Jui-Kuei
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Chen, I-Shuo
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經營管理研究所
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Institute of Business and Management
The importance of intellectual capital (IC) has been emphasized during recent year. Such a trend puts higher education systems under great pressure for two main reasons: first, IC has been shown to be a key driver of innovation; second, the higher education system assumes the unique function of fostering innovation. Knowing how best to improve IC is considered the most significant factor of success in enhancing innovation. However, the higher education system of today has difficulty in measuring IC precisely to improve its innovation performance. This study is to conquer such a problem by establishing critical criteria for IC assessment. Based on the findings, the higher education system is encouraged to successfully evaluate its IC performance and then find ways to improve this performance to achieve better innovation.