Browsing by Author "Wu, Tz-Yi"

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Palladium-catalyzed regioselective synthesis of 2(2 '-biphenyl)benzimidazoles through C-H activation
(2013-11-01)
Chen, Li-Hsun
;
Wu, Tz-Yi
;
Paike, Vijaykumar
;
Sun, Chung-Ming
;
應用化學系
An efficient palladium-catalyzed strategy through C-H bond activation for the synthesis of 2(2-biphenyl)-benzimidazoles is reported herein. The regioselective C-C bond formation proceeds in a sealed tube via oxidative C-H activation of ortho-directed 2-aryl-benzimidazole to couple with various iodobenzene analogs in high yields. This arylation exhibited high regioselectivity which is able to increase molecular diversity in difficult functionalized positions of parent molecules. This strategy provides a convenient and simple synthesis of biphenyl heterocyclic compounds with high regioselectivity.
Regioselective Synthesis of Pyranone-Fused Indazoles via Reductive Cyclization and Alkyne Insertion
(2018-03-01)
Wu, Tz-Yi
;
Dhole, Sandip
;
Selvaraju, Manikandan
;
Sun, Chung-Ming
;
應用化學系
A novel and efficient method for the one-pot synthesis of 2H-indazole from readily available building blocks is reported. The reaction of 2-nitrobenzylamines with zinc and ammonium formate underwent partial reduction to nitroso-benzylamine followed by an intramolecular cyclization to afford 2H-indazole via N-N bond formation. The carboxylic acid moiety of indazole was proceeded to regioselective alkyne insertion under ruthenium catalysis to form pyranone-fused indazoles. The regioselectivity is influenced by the weak coordination of indazole ring nitrogen to the metal center.