Browsing by Author "Yang, Chih-Jen"
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Item type:Item, Decline in invasive pneumococcus diseases while combating the COVID-19 pandemic in Taiwan(1970-01-01) ;Tsai, Jong-Rung ;Yang, Chih-Jen ;Huang, Wei-Ling ;Chen, Yen-Hsu生物科技學系Item type:Item, EGFR Tyrosine Kinase Inhibitor-Associated Interstitial Lung Disease During the Coronavirus Disease 2019 Pandemic(2020-08-01) ;Chang, Hsu-Liang ;Chen, Yen-Hsu ;Taiwan, Hsin-Chu ;Yang, Chih-Jen生醫工程研究所Item type:Item, How to prevent outbreak of a hospital-affiliated dementia day-care facility in the pandemic COVID-19 infection in Taiwan(2020-06-01) ;Huang, Hsuan-Ti ;Chen, Tun-Chieh ;Liu, Tzu-Yin ;Chiu, Chun-FengHsieh, Wen-ChienItem type:Item, Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies(2013-09-01) ;Lin, Yuan-Feng ;Lai, Tsung-Ching ;Chang, Chih-Kang ;Chen, Chi-LongHuang, Ming-ShyanCaspase-3 downregulation (CASP3/DR) in tumors frequently confers resistance to cancer therapy and is significantly correlated with a poor prognosis in cancer patients. Because CASP3/DR cancer cells rely heavily on the activity of caspase-7 (CASP7) to initiate apoptosis, inhibition of activated CASP7 (p19/p12-CASP7) by X-linked inhibitor of apoptosis protein (XIAP) is a potential mechanism by which apoptosis is prevented in those cancer cells. Here, we identify the pocket surrounding the Cys(246) residue of p19/p12-CASP7 as a target for the development of a protein-protein interaction (PPI) inhibitor of the XIAP:p19/p12-CASP7 complex. Interrupting this PPI directly triggered CASP7-dependent apoptotic signaling that bypassed the activation of the apical caspases and selectively killed CASP3/DR malignancies in vitro and in vivo without adverse side effects in nontumor cells. Importantly, CASP3/DR combined with p19/p12-CASP7 accumulation correlated with the aggressive evolution of clinical malignancies and a poor prognosis in cancer patients. Moreover, targeting of this PPI effectively killed cancer cells with multidrug resistance due to microRNA let-7a-1-mediated CASP3/DR and resensitized cancer cells to chemotherapy-induced apoptosis. These findings not only provide an opportunity to treat CASP3/DR malignancies by targeting the XIAP:p19/p12-CASP7 complex, but also elucidate the molecular mechanism underlying CASP3/DR in cancers.Item type:Item, The preventive strategies of community hospital in the battle of fighting pandemic COVID-19 in Taiwan(2020-06-01) ;Yang, Chih-Jen ;Chen, Tun-Chieh ;Chen, Yen-Hsu ;生物科技學系Department of Biological Science and Technology