Browsing by Author "Yang, Ming-Chien"

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Core-shell magnetic nanoparticles of heparin conjugate as recycling anticoagulants
(2007-12-01)
Liu, Ting-Yu
;
Huang, Li-Ying
;
Hu, Shang-Hsiu
;
Yang, Ming-Chien
;
Chen, San-Yuan
Polyvinyl alcohol-shell magnetic nanoparticles (PVA-shell MNPs, PMNPs) were successfully prepared by in-situ co-precipitation process. Heparin (HEP) was then covalently conjugated on the PMNPs by using aminotrimethoxysilane (ATMS) and 4,4-diphenyl methane diisocyanate (HMDI) as molecular coupling agent (spacer). The morphology of the core-shell PMNPs was examined using transmission electron microscope (TEM), X-ray diffraction (XRD), and Raman spectrometry to demonstrate the core-shell structure, as well as X-ray photoelectron spectroscope (X-PS) to provide direct evidence that the heparin molecules were immobilized on the surface of the core-shell PMNPs. Anticoagulant activity was evaluated with several parameters including activated partial thrombin time (APTT), prothrombin time (PT), fibrinogen time (FT), and thrombin time (TT). The results show that longer spacer would give better anticoagulant activity since lower steric hindrance can induce higher heparin grafting density. It might be anticipated that PMNPs of heparin conjugate can be used as anticoagulants instead of traditional free heparin, owing to its recycling characteristics by magnetic fields.
Hamiltonian circuit and linear array embeddings in faulty k-ary n-cubes
(2007-04-01)
Yang, Ming-Chien
;
Tan, Jimmy J. M.
;
Hsu, Lih-Hsing
;
資訊工程學系
;
Department of Computer Science
In this paper, we investigate the fault-tolerant capabilities of the k-ary n-cubes for even integer k with respect to the hamiltonian and hamiltonian-connected properties. The k-ary n-cube is a bipartite graph if and only if k is an even integer. Let F be a faulty set with nodes and/or links, and let k >= 3 be an odd integer. When vertical bar F vertical bar <= 2n - 2, we show that there exists a hamiltonian cycle in a wounded k-ary n-cube. In addition, when vertical bar F vertical bar <= 2n - 3, we prove that, for two arbitrary nodes, there exists a hamiltonian path connecting these two nodes in a wounded k-ary n-cube. Since the k-ary n-cube is regular of degree 2n, the degrees of fault-tolerance 2n - 3 and 2n - 2 respectively, are optimal in the worst case. (c) 2005 Elsevier Inc. All rights reserved.
Highly fault-tolerant cycle embeddings of hypercubes
(2007-04-01)
Yang, Ming-Chien
;
Tan, Jimmy J. M.
;
Hsu, Lih-Hsing
;
資訊工程學系
;
Department of Computer Science
The hypercube Q(n) is one of the most popular networks. In this paper, we first prove that the n-dimensional hypercube is 2n - 5 conditional fault-bipancyclic. That is, an injured hypercube with up to 2n - 5 faulty links has a cycle of length l for every even 4 <= 1 <= 2(n) when each node of the hypercube is incident with at least two healthy links. In addition, if a certain node is incident with less than two healthy links, we show that an injured hypercube contains cycles of all even lengths except hamiltonian cycles with up to 2n - 3 faulty links. Furthermore, the above two results are optimal. In conclusion, we find cycles of all possible lengths in injured hypercubes with up to 2n - 5 faulty links under all possible fault distributions. (C) 2006 Elsevier B.V. All rights reserved.