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Browsing by Author "Yeh, Wen-Pin"

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    Microwave-assisted traceless synthesis of hydantion-fused beta-carboline scaffold
    (2007-11-26)
    Yeh, Wen-Pin
    ;
    Chang, Wong-Jin
    ;
    Sun, Mei-Lian
    ;
    Sun, Chung-Ming
    ;
    應用化學系
    Multistep microwave-assisted reactions toward the synthesis of hydantoin-fused tricyclic tetrahydro-beta-carbolines on the soluble polymer support have been developed. Polymer-bound tryptophan with various aldehydes has been subjected to Pictet-Spengler reaction to obtain tricyclic beta-carboline conjugates. The terminal hydantoinyl moiety is constructed across polymer-bound beta-carbolines by the reaction with various isocyanates under microwave irradiation to form urea intermediate. Simultaneous intramolecular cyclization of urea followed by cleavage of the polymer support leads to a traceless synthesis of tetracyclic scaffolds in high yield and high purity. (c) 2007 Elsevier Ltd. All rights reserved.