Browsing by Author "Yen, Yu-Fang"

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Application of 2-Azido-2-deoxythioglycosides for beta-Glycoside Formation and Oligosaccharide Synthesis
(2012-05-01)
Mong, Kwok-Kong Tony
;
Yen, Yu-Fang
;
Hung, Wei-Cheng
;
Lai, Yen-Hsun
;
Chen, Jiun-Han
Most natural 2-acetamido-2-deoxyglycosides exist in a 1,2-trans-beta-glycosidic configuration. This study investigated the use of 2-azido-2-deoxythioglycosides for 1,2-trans-beta-glycosidic bond formation under low-concentration glycosylation conditions. Further application of the 2-azido-2-deoxythioglycosyl substrates for one-pot oligosaccharide synthesis was demonstrated in the synthesis of protected beta-(1?6)-N-acetylglucosamine trimer, core-6serine conjugate, and F1a serine conjugate.
Solvent Participation in a One-Pot Glycosylation Strategy (SPOG)
(2011-04-18)
Chao, Chin-Sheng
;
Yen, Yu-Fang
;
Hung, Wei-Cheng
;
Mong, Kwok-Kong Tony
;
應用化學系
Solvent participation in a one-pot glycosylation strategy (SPOG) was developed on the basis of the low concentration beta-selective glycosylation method. This strategy enables the production of a beta-glycosidic bond in a one-pot oligosaccharide synthesis without or with minimal use of any C-2 participating function.