Browsing by Author "Yu, Zih-Yu"

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A COMBINED PROCESS OF SILICON SHADOW MASKING AND INKJET PRINTING (SSMP) FOR MAKING GRAPHENE OXIDE AND REDUCED GRAPHENE OXIDE MICROSTRUCTURES FOR SELECTIVE CELL CULTURING APPLICATIONS
(2019-01-01)
Kang, Che-Hao
;
Fu, Yu-Min
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Kao, Chin-Chuan
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Yang, Jia-Wei
;
Tseng, Ming-Liang
This paper demonstrates a combined process of silicon shadow masking and inkjet printing (SSMP) to fabricate graphene oxide (GO) and reduced graphene oxide (rGO) line features with a width ranging from 20 to 70 mu m on varieties of substrates, such as PDMS, SiO2 , Kapton, etc. for selectively cell (RPE and PC-12 cells) culturing applications. The rGO with an electrical resistance of 33.48k Omega/ is characterized via a printed four point resistivity measurement structure. Owing to the characteristics of low chemical usage, low process temperature and complexity, and high fault tolerance of inkjet printers, the process technique has shown its potential for biomedical applications in terms of flexible cell culturing platform fabrication.
Graphene Oxide-Based Biosensors for Liquid Biopsies in Cancer Diagnosis
(2019-12-01)
Chen, Shiue-Luen
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Chen, Chong-You
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Hsieh, Jason Chia-Hsun
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Yu, Zih-Yu
;
Cheng, Sheng-Jen
Liquid biopsies use blood or urine as test samples, which are able to be continuously collected in a non-invasive manner. The analysis of cancer-related biomarkers such as circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), microRNA, and exosomes provides important information in early cancer diagnosis, tumor metastasis detection, and postoperative recurrence monitoring assist with clinical diagnosis. However, low concentrations of some tumor markers, such as CTCs, ctDNA, and microRNA, in the blood limit its applications in clinical detection and analysis. Nanomaterials based on graphene oxide have good physicochemical properties and are now widely used in biomedical detection technologies. These materials have properties including good hydrophilicity, mechanical flexibility, electrical conductivity, biocompatibility, and optical performance. Moreover, utilizing graphene oxide as a biosensor interface has effectively improved the sensitivity and specificity of biosensors for cancer detection. In this review, we discuss various cancer detection technologies regarding graphene oxide and discuss the prospects and challenges of this technology.
Graphene Oxide-Based Nanomaterials: An Insight into Retinal Prosthesis
(2020-04-01)
Yang, Jia-Wei
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Yu, Zih-Yu
;
Cheng, Sheng-Jen
;
Chung, Johnson H. Y.
;
Liu, Xiao
Retinal prosthesis has recently emerged as a treatment strategy for retinopathies, providing excellent assistance in the treatment of age-related macular degeneration (AMD) and retinitis pigmentosa. The potential application of graphene oxide (GO), a highly biocompatible nanomaterial with superior physicochemical properties, in the fabrication of electrodes for retinal prosthesis, is reviewed in this article. This review integrates insights from biological medicine and nanotechnology, with electronic and electrical engineering technological breakthroughs, and aims to highlight innovative objectives in developing biomedical applications of retinal prosthesis.