Browsing by Author "Zinurova, E"

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A concise route to racemic anatoxin a from cycloocta-1,5-diene
(2006)
Ho, TL
;
Zinurova, E
;
應用化學系
;
Department of Applied Chemistry
The synthesis of racemic anatoxin a (1a) from cycloocta-1,5-diene via its 1:1 cycloadduct with N-chlorosulfonyl isocyanate is described. The N-unsubstituted beta-lactam 2b was converted to a beta-amino ester 3 which was then submitted to a Pd-catalyzed cyclization to afford the conjugated ester 4a. The N-tosyl derivative 4b was then elaborated into N-tosylanatoxin a (1b) via a Weinreb amide.