標題: Enhancement of cell growth on honeycomb-structured polylactide surface using atmospheric-pressure plasma jet modification
作者: Cheng, Kuang-Yao
Chang, Chia-Hsing
Yang, Yi-Wei
Liao, Guo-Chun
Liu, Chih-Tung
Wu, Jong-Shinn
機械工程學系
Department of Mechanical Engineering
關鍵字: Atmospheric pressure plasma;Dielectric barrier discharge;Surface modification;Honeycomb structure;PLA;Cell proliferation
公開日期: 1-二月-2017
摘要: In this paper, we compare the cell growth results of NIH-3T3 and Neuro-2A cells over 72 h on flat and honeycomb structured PLA films without and with a two-step atmospheric-pressure nitrogen-based plasma jet treatment. We developed a fabrication system used for forming of a uniform honeycomb structure on PLA surface, which can produce two different pore sizes, 3-4 mu m and 7-8 mu m, of honeycomb pattern. We applied a previously developed nitrogen-based atmospheric-pressure dielectric barrier discharge (DBD) jet system to treat the PLA film without and with honeycomb structure. NIH-3T3 and a much smaller Neuro-2A cells were cultivated on the films under various surface conditions. The results show that the two-step plasma treatment in combination with a honeycomb structure can enhance cell growth on PLA film, should the cell size be not too smaller than the pore size of honeycomb structure, e.g., NIH-3T3. Otherwise, cell growth would be better on flat PLA film, e.g., Neuro-2A. (C) 2016 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.apsusc.2016.10.093
http://hdl.handle.net/11536/132731
ISSN: 0169-4332
DOI: 10.1016/j.apsusc.2016.10.093
期刊: APPLIED SURFACE SCIENCE
Volume: 394
起始頁: 534
結束頁: 542
顯示於類別:期刊論文