標題: | Droplet Size-Aware and Error-Correcting Sample Preparation Using Micro-Electrode-Dot-Array Digital Microfluidic Biochips |
作者: | Li, Zipeng Lai, Kelvin Yi-Tse Chakrabarty, Krishnendu Ho, Tsung-Yi Lee, Chen-Yi 電子工程學系及電子研究所 Department of Electronics Engineering and Institute of Electronics |
關鍵字: | Digital mirofluidics;micro-electrode-dot-array;sample preparation;optimization algorithm;error recovery |
公開日期: | 1-十二月-2017 |
摘要: | Sample preparation in digital microfluidics refers to the generation of droplets with target concentrations for on-chip biochemical applications. In recent years, digital microfluidic biochips (DMFBs) have been adopted as a platform for sample preparation. However, there remain two major problems associated with sample preparation on a conventional DMFB. First, only a (1: 1) mixing/splitting model can be used, leading to an increase in the number of fluidic operations required for sample preparation. Second, only a limited number of sensors can be integrated on a conventional DMFB; as a result, the latency for error detection during sample preparation is significant. To overcome these drawbacks, we adopt a next generation DMFB platform, referred to as micro-electrode-dot-array (MEDA), for sample preparation. We propose the first sample-preparation method that exploits the MEDA-specific advantages of fine-grained control of droplet sizes and real-time droplet sensing. Experimental demonstration using a fabricated MEDA biochip and simulation results highlight the effectiveness of the proposed sample-preparation method. |
URI: | http://dx.doi.org/10.1109/TBCAS.2017.2742548 http://hdl.handle.net/11536/144328 |
ISSN: | 1932-4545 |
DOI: | 10.1109/TBCAS.2017.2742548 |
期刊: | IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS |
Volume: | 11 |
起始頁: | 1380 |
結束頁: | 1391 |
顯示於類別: | 期刊論文 |