標題: Label-free protein quantitation by dielectric spectroscopy of dual-frequency liquid crystal
作者: Lin, Ching-Min
Wu, Po-Chang
Lee, Mon-Juan
Lee, Wei
光電學院
College of Photonics
關鍵字: Dual-frequency liquid crystal;Dielectric spectroscopy;Protein;Bovine serum albumin;LC-based biosensor
公開日期: 1-三月-2019
摘要: A dual-frequency-liquid-crystal (DFLC)-based biosensor was developed and its frequency-dependent dielectric properties were exploited to detect and quantitate a protein standard, bovine serum albumin (BSA). By analyzing the dielectric spectra of DFLC in the presence of BSA at various concentrations, we found that the difference in dielectric permittivity between the high- and low-frequency regimes is correlated to BSA concentration, thereby permitting a DFLC-based protein quantitative method. The dielectric properties of DFLCs are fundamental in the design of liquid crystal displays and fast-switching devices. Results from this study demonstrate the extended potential of the frequency-revertible dielectric anisotropy of DFLC in biosensing and protein quantitation.
URI: http://dx.doi.org/10.1016/j.snb.2018.11.047
http://hdl.handle.net/11536/148686
ISSN: 0925-4005
DOI: 10.1016/j.snb.2018.11.047
期刊: SENSORS AND ACTUATORS B-CHEMICAL
Volume: 282
起始頁: 158
結束頁: 163
顯示於類別:期刊論文