標題: | Label-free protein quantitation by dielectric spectroscopy of dual-frequency liquid crystal |
作者: | Lin, Ching-Min Wu, Po-Chang Lee, Mon-Juan Lee, Wei 光電學院 College of Photonics |
關鍵字: | Dual-frequency liquid crystal;Dielectric spectroscopy;Protein;Bovine serum albumin;LC-based biosensor |
公開日期: | 1-三月-2019 |
摘要: | A dual-frequency-liquid-crystal (DFLC)-based biosensor was developed and its frequency-dependent dielectric properties were exploited to detect and quantitate a protein standard, bovine serum albumin (BSA). By analyzing the dielectric spectra of DFLC in the presence of BSA at various concentrations, we found that the difference in dielectric permittivity between the high- and low-frequency regimes is correlated to BSA concentration, thereby permitting a DFLC-based protein quantitative method. The dielectric properties of DFLCs are fundamental in the design of liquid crystal displays and fast-switching devices. Results from this study demonstrate the extended potential of the frequency-revertible dielectric anisotropy of DFLC in biosensing and protein quantitation. |
URI: | http://dx.doi.org/10.1016/j.snb.2018.11.047 http://hdl.handle.net/11536/148686 |
ISSN: | 0925-4005 |
DOI: | 10.1016/j.snb.2018.11.047 |
期刊: | SENSORS AND ACTUATORS B-CHEMICAL |
Volume: | 282 |
起始頁: | 158 |
結束頁: | 163 |
顯示於類別: | 期刊論文 |