Browsing by Author "Hsiao, Chi-Sheng"

Now showing 1 - 10 of 10

Characterization and drug release behavior of chip-like amphiphilic chitosan-silica hybrid hydrogel for electrically modulated release of ethosuximide: an in vitro study
(2011)
Huang, Wei-Chen
;
Lee, Tai-Jung
;
Hsiao, Chi-Sheng
;
Chen, San-Yuan
;
Liu, Dean-Mo
The hydrogel response under environmental induction often decreases with time because of the mechanical weakness of polymeric hydrogels. Therefore, to reinforce the conventional hydrogels with improved responsiveness and service performance to an external stimulus, a hybrid hydrogel consisting of an amphiphilic chitosan and inorganic silica with a minimal concentration of organic cross-linker was made in order to ascertain the biocompatibility of resulting hydrogels and improve stimulus-induced responsiveness. The hybrid hydrogels generally illustrated a rapid drug (ethosuximide, ESM) release profile over a time period of less than 60 minutes. However, after assembling the hybrid hydrogels into a chip-like device, the sandwiched hybrid showed, under a number of applied DC voltages, a variety of release profiles from a burst-like to slow-elution pattern. A release mechanism was proposed and can be successfully explained as a result of combined effects of electrophoretic and electroosmotic operations. Kinetic analysis indicated that the ESM released from the chip-like device is essentially a shuttle between the swelling-controlled pattern and the diffusion-controlled mechanism, depending on the chemical compositions that were used to prepare the hybrid hydrogels under a given DC electrical field. The hybrid hydrogel chip-like device designed in this work has experimentally proved its technical potential as an electrically responsive drug delivery system to meet various biomedical demands.
Core/single-crystal-shell nanospheres for controlled drug release via a magnetically triggered rupturing mechanism
(2008-07-17)
Hu, Shang-Hsiu
;
Chen, San-Yuan
;
Liu, Dean-Mo
;
Hsiao, Chi-Sheng
;
材料科學與工程學系
Core/single-crystal-shell nanospheres are constructed from a poly-(N-vinyl2-pyrrolidone) (PVP)-modified silica core with an outer layer of single-crystal iron oxide shell. The nanospheres show outstanding release- and-zero-release characteristics via the addition and removal, respectively, of an external high-frequency magnetic field.
Multifunctional magnetically removable nanogated lids of Fe(3)O(4)-capped mesoporous silica nanoparticles for intracellular controlled release and MR imaging
(2011-01-01)
Chen, Po-Jung
;
Hu, Shang-Hsiu
;
Hsiao, Chi-Sheng
;
Chen, You-Yin
;
Liu, Dean-Mo
In this study, a novel nanocarrier (MSN@Fe(3)O(4)) is constructed using a facile technology by capping mesoporous silica nanoparticles (MSN) with monodispersed Fe(3)O(4) nanoparticles through chemical bonding. The chemical links provide adhesion, which permits the magnetic nanoparticles, as nano-caps, to efficiently cover the mesoporous pores on the mesoporous silica matrix and be tightly bonded with the matrix surface. Without magnetic stimulus, none or only a negligible amount of the drug can be released from the MSN@Fe(3)O(4). However, when subjected to an external controllable magnetic field, a quantity of nano-caps can be remotely and precisely removed, giving tunable release profiles for an anticancer drug, (S)-(+)-camptothecin (CPT), with various dosages depending upon the strength and time period of magnetic induction. The transverse relaxivity (r(2)) of the MSN@Fe(3)O(4) nanocarriers was measured to be about 121.57 s(-1)mM(-1) Fe, which is larger than that for the reported mesoporous silica nanoparticles decorated with magnetite nanocrystals. Therefore, MSN@Fe(3)O(4) nanocarriers could perform well as T(2)-type MR contrast enhancement agents for cell or molecular imaging. In addition, the MSN@Fe(3)O(4) nanocarriers also demonstrate fairly high cell uptake efficiency. Together with its versatile magnetic manipulation, this new type of MSN@Fe(3)O(4) nanosystem can be considered as a new class of multifunctional nanodevice, with combined tunable drug release and nanoimaging modalities for a variety of biomedical uses.
Multifunctional magnetically removable nanogated lids of Fe3O4-capped mesoporous silica nanoparticles for intracellular controlled release and MR imaging
(2011-01-01)
Chen, Po-Jung
;
Hu, Shang-Hsiu
;
Hsiao, Chi-Sheng
;
Chen, You-Yin
;
Liu, Dean-Mo
In this study, a novel nanocarrier (MSN@Fe3O4) is constructed using a facile technology by capping mesoporous silica nanoparticles (MSN) with monodispersed Fe3O4 nanoparticles through chemical bonding. The chemical links provide adhesion, which permits the magnetic nanoparticles, as nano-caps, to efficiently cover the mesoporous pores on the mesoporous silica matrix and be tightly bonded with the matrix surface. Without magnetic stimulus, none or only a negligible amount of the drug can be released from the MSN@Fe3O4. However, when subjected to an external controllable magnetic field, a quantity of nano-caps can be remotely and precisely removed, giving tunable release profiles for an anticancer drug, (S)-(+)-camptothecin (CPT), with various dosages depending upon the strength and time period of magnetic induction. The transverse relaxivity (r(2)) of the MSN@Fe3O4 nanocarriers was measured to be about 121.57 s(-1)mM(-1) Fe, which is larger than that for the reported mesoporous silica nanoparticles decorated with magnetite nanocrystals. Therefore, MSN@Fe3O4 nanocarriers could perform well as T-2-type MR contrast enhancement agents for cell or molecular imaging. In addition, the MSN@Fe3O4 nanocarriers also demonstrate fairly high cell uptake efficiency. Together with its versatile magnetic manipulation, this new type of MSN@Fe3O4 nanosystem can be considered as a new class of multifunctional nanodevice, with combined tunable drug release and nanoimaging modalities for a variety of biomedical uses.
Nano-hybrid carboxymethyl-hexanoyl chitosan modified with (3-aminopropyl)triethoxysilane for camptothecin delivery
(2012-06-20)
Hsiao, Meng-Hsuan
;
Tung, Tsan-Hua
;
Hsiao, Chi-Sheng
;
Liu, Dean-Mo
;
材料科學與工程學系
Silane-modified amphiphilic chitosan was synthesized by anchoring a silane coupling agent, (3-aminopropyl)triethoxysilane, to a novel amphiphilic carboxymethyl-hexanoyl chitosan (CHC). The chemical structure of this new organic-inorganic hybrid molecule was characterized by FTIR and C-13-, Si-29-nuclear magnetic resonance, while the structural evolution was examined using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and dynamic light scattering (DLS). Experimental results indicated a self-assembly behaviour of molecules into nanopartides with a stable polygonal geometry, consisting of ordered silane layers of 6 nm in thickness. The self-assembly property was found to be influenced by chemical composition and concentration of silane incorporated, while the size can be varied by the amount of anchored silane. It was also demonstrated that such vesicle exhibited excellent cytocompatibility and cellular internalization capability in ARPE-19 cell line, and presented well-controlled encapsulation and release profiles for (S)-(+)-camptothecin. These unique properties render it as a potential drug delivery nanosystem. (C) 2012 Elsevier Ltd. All rights reserved.
RETRACTION: Growth behavior and microstructure evolution of ZnO nanorods grown on Si in aqueous solution (Retraction of Vol 274, Pg 438, 2004)
(2018-12-15)
Liou, Sz-Chian
;
Hsiao, Chi-Sheng
;
Chen, San-Yuan
;
材料科學與工程學系
;
Department of Materials Science and Engineering
Structure and photoluminescence properties of strong blue-emitting alumina film developed from a liquid sol at low temperature
(2010-02-18)
Peng, Cheng-Hsiung
;
Hwang, Chyi-Ching
;
Hsiao, Chi-Sheng
;
材料科學與工程學系
;
Department of Materials Science and Engineering
Strong blue photoluminescence emission at 450 nm from alumina films prepared from an alumina precursor was observed. Photo luminescence measurements indicate that the peak intensity of the blue emission changes with the pH value of the peptizing solution, the annealing temperature and the atmosphere. The blue emission appears at a low temperature of 50 degrees C and reaches a maximum strength at 400 degrees C in an oxygen atmosphere and 600 degrees C in a nitrogen atmosphere. HRTEM images show that the alumina films are composed of nanoparticles with a diameter of <= 10 nm. it is believed that the observed strong photoluminescence is associated with inherent defect centers in the material, where these are related to the structure transition and transformation from the boehmite phase to the gamma-alumina phase and bond cleavage. (C) 2009 Elsevier B.V. All rights reserved.
Synthesis and luminescent properties of strong blue light-emitting Al2O3/ZnO nanocables
(2008)
Hsiao, Chi-Sheng
;
Kuo, Wan-Lin
;
Chen, San-Yuan
;
Shen, Ji-Lin
;
Lin, Chin-Ching
Photoelectronic characteristics are investigated in well-aligned aluminum-coated ZnO nanorods (Al2O3/ZnO nanocables) grown on Si substrates buffered with ZnO film at a low temperature. Photoluminescence measurement indicates that a strong blue emission peak at similar to 450 nm appears at 400 and 600 degrees C in O-2 and N-2 atmospheres, respectively. A 30x enhancement of the relative intensity ratio of blue emission (I-B) to ultraviolet emission (I-UV) has been observed for the Al2O3/ZnO nanocables. High-resolution transmission electron microscopy and X-ray photoelectron spectroscopy analyses reveal that the origin of the strong blue emission can be attributed to the structure transition and cleavage of the oxygen-hydrogen bond (OH) of the Al2O3/ZnO nanocable, which leads to the formation of singly ionized oxygen vacancies (Al-O-center dot). (C) 2008 The Electrochemical Society.
Synthesis and optical properties of white-light-emitting alumina/ZnO nanotubes
(2008-10-08)
Hsiao, Chi-Sheng
;
Chen, San-Yuan
;
Kuo, Wan-Lin
;
Lin, Chin-Ching
;
Cheng, Syh-Yuh
A simple chemical solution process was used to prepare alumina nanoparticle-coated ZnO nanotubes (ANZTs). Transmission electron microscope (TEM) images proved that the alumina nanoparticles were uniformly dispersed on the ZnO nanotubes. After thermal treatment at different temperatures under various atmospheres, photoluminescence (PL) measurements showed that the ANZTs emitted a variety of colors, including blue, green and white light. Gaussian curve fitting of the PL spectra revealed that the competition between the blue, blue-green, green and yellow band emissions and their relative emission intensities were strongly associated with various defects. Blue emission was attributed to large numbers of oxygen defects in alumina, while green and yellow emissions were related to oxygen and zinc defects in ZnO, respectively. Under specific conditions, white light, consisting of blue, blue-green, green and yellow band emissions, was obtained. Further TEM analysis indicated that the defect structure of ANZTs could be manipulated by the interface interaction between alumina and the ZnO nanotubes.
Synthesis and physical characteristics of AlOx-coated ZnO nanorod arrays grown in aqueous solution at low temperatures
(2008-02-01)
Hsiao, Chi-Sheng
;
Chen, San-Yuan
;
Cheng, Syh-Yuh
;
材料科學與工程學系
;
Department of Materials Science and Engineering
AlOx-ZnO core-shell nanorods arrays have been successfully synthesized by soaking the ZnO nanorods in the sol-gel solution of Al(NO3)(3) and NH4OH at room temperature. It was found that both crystal growth and morphology of the AlOx-ZnO core-shell nanorods are strongly influenced by the solution pH value. SEM image shows that the AlOx-ZnO core-shell nanorods can be perpendicularly grown on the ZnOf/Si substrate under the solution only with a pH value of 6-7. High-resolution TEM observation demonstrates that the structure of the AlOx layer is amorphous and the ZnO nanorod core remains single crystal. After annealed at 400 degrees C in N-2 atmosphere, a strong photoluminescence peak corresponding to blue emission (similar to 450 nm) was detected from the AlOx-ZnO core-shell nanorods that may result from the induced defects due to interaction between AlOx shell and ZnO nanorods. (C) 2007 Elsevier Ltd. All rights reserved.