Browsing by Author "Lin, Yu-Wei"

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A 2.4-Gsample/s DVFS FFT processor for MIMO OFDM communication systems
(2008-05-01)
Chen, Yuan
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Lin, Yu-Wei
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Tsao, Yu-Chi
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Lee, Chen-Yi
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電子工程學系及電子研究所
This paper presents a new dynamic voltage and frequency scaling (DVFS) FFT processor for MIMO OFDM applications. By the proposed multimode multipath-delay-feedback (MMDF) architecture, our FFT processor can process 1-8-stream 256-point FFTs or a high-speed 256-point FFT in two processing domains at minimum clock frequency for DVFS operations. A parallelized radix-2(4) FFT algorithm is also employed to save the power consumption and hardware cost of complex multipliers. Furthermore, a novel open-loop voltage detection and scaling (OLVDS) mechanism is proposed for fast and robust voltage management. With these schemes, the proposed FFT processor can operate at adequate voltage/frequency under different configurations to support the power-aware feature. A test chip of the proposed FITT processor has been fabricated using UMC 90 nm single-poly nine-metal CMOS process with a core area of 1.88 x 1.88 mm(2). The SQNR performance of this FFT chip is over 35.8 dB for QPSK/16-QAM modulation. Power dissipation of 2.4 Gsample/s 256-point FFT computations is about 119.7 mW at 0.85 V. Depending on the operation mode, power can be saved by 18%-43% with voltage scaling in TT corner.
A MRMDF FFT processor for MIMO OFDM applications
(2005)
Lin, Yu-Wei
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Liao, Wan-Chun
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Lee, Chen-Yi
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電子工程學系及電子研究所
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Department of Electronics Engineering and Institute of Electronics
In this paper, the proposed pipelined FFT processor, which is based on MRMDF structure, can deal with the simultaneous multiple input sequences more efficiently for MIMO OFDM applications. Furthermore, the hardware costs of memory and complex multipliers in our method can be saved by means of delay feedback and data scheduling approaches. The higher-radix FFT algorithm is also realized in our processor to reduce the number of complex multiplications. A test chip for 802.11n system has been designed using 0.13 mu m 1P8M CMOS process with core area of 2142 x 660 mu m(2). Power dissipation is 5.2mW when 128 points FFT with four data streams are calculated.
An indexed-scaling pipelined FFT processor for OFDM-based WPAN applications
(2008-02-01)
Chen, Yuan
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Tsao, Yu-Chi
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Lin, Yu-Wei
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Lin, Chin-Hung
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Lee, Chen-Yi
In this brief, a high-throughput and low-complexity fast Fourier transform (FFT) processor for wideband orthogonal frequency division multiplexing communication systems is presented. A new indexed-scaling method is proposed to reduce both the critical-path delay and hardware cost by employing shorter wordlength. Together with the mixed-radix multipath delay feedback structure, the proposed FFT processor can achieve very high throughput with low hardware cost. From analysis, it is shown that the proposed indexed-scaling method can save at least 11% memory utilizations compared to other state-of-the-art scaling algorithms. Also,,a-test chip of a 1.2 Gsample/s 2048-point FFT processor has been designed using UMC 90-nm 1P9M process with a core area of 0.97 mm(2). The signal-to-quantization-noise ratio (SQNR) performance of this test chip is over 32.7 dB to support 16-QAM modulation and the power consumption is about 117 mW at 300 MHz. Compared to the fixed-point FFT processors, about 26% area and 28% power can be saved under the same throughput and SQNR specifications.
Co-delivery of paclitaxel and cetuximab by nanodiamond enhances mitotic catastrophe and tumor inhibition
(2017-08-29)
Lin, Yu-Wei
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Raj, Emmanuel Naveen
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Liao, Wei-Siang
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Lin, Johnson
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Liu, Kuang-Kai
The poor intracellular uptake and non-specific binding of anticancer drugs into cancer cells are the bottlenecks in cancer therapy. Nanocarrier platforms provide the opportunities to improve the drug efficacy. Here we show a carbon-based nanomaterial nanodiamond (ND) that carried paclitaxel (PTX), a microtubule inhibitor, and cetuximab (Cet), a specific monoclonal antibody against epidermal growth factor receptor (EGFR), inducing mitotic catastrophe and tumor inhibition in human colorectal cancer (CRC). ND-PTX blocked the mitotic progression, chromosomal separation, and induced apoptosis in the CRC cells; however, NDs did not induce these effects. Conjugation of ND-PTX with Cet (ND-PTX-Cet) was specifically binding to the EGFR-positive CRC cells and enhanced the mitotic catastrophe and apoptosis induction. Besides, ND-PTX-Cet markedly decreased tumor size in the xenograft EGFR-expressed human CRC tumors of nude mice. Moreover, ND-PTX-Cet induced the mitotic marker protein phospho-histone 3 (Ser10) and apoptotic protein active-caspase 3 for mitotic catastrophe and apoptosis. Taken together, this study demonstrated that the co-delivery of PTX and Cet by ND enhanced the effects of mitotic catastrophe and apoptosis in vitro and in vivo, which may be applied in the human CRC therapy.
Delivery of paclitaxel and cetuximab by nanodiamond enhances mitotic catastrophe and tumor inhibition in colorectal cancer
(2016-04-01)
Lin, Yu-Wei
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Liao, Wei-Siang
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Lin, Johnson
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Liu, Kuang-Kai
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Cheng, Hsiao-Chun
Delivery of paclitaxel and cetuximab by nanodiamond enhances mitotic catastrophe and tumor inhibition in colorectal cancer
(2016-04-01)
Lin, Yu-Wei
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Liao, Wei-Siang
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Lin, Johnson
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Liu, Kuang-Kai
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Cheng, Hsiao-Chun
Design of an FFT/IFFT processor for MIMO OFDM systems
(2007-04-01)
Lin, Yu-Wei
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Lee, Chen-Yi
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電子工程學系及電子研究所
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Department of Electronics Engineering and Institute of Electronics
In this paper, we present a novel 128/64 point fast Fourier transform (FFT)/ inverse FFT (IFFT) processor for the applications in a multiple-input multiple-output orthogonal frequency-division multiplexing based IEEE 802.11n wireless local area network baseband processor. The unfolding mixed-radix multipath delay feedback FFT architecture is proposed to efficiently deal with multiple data sequences. The proposed processor not only supports the operation of FFT/IFFT in 128 points and 64 points but can also provide different throughput rates for 1-4 simultaneous data sequences to meet IEEE 802.11n requirements. Furthermore, less hardware complexity is needed in our design compared with traditional four-parallel approach. The proposed FFT/IFFT processor is designed in a 0.13-mu m single-poly and eight-metal CMOS process. The core area is 660 x 2142 mu m(2), including an FFT/IFFT processor and a test module. At the operation clock rate of 40 MHz, our proposed processor can calculate 128-point FFT with four independent data sequences within 3.2 mu s meeting IEEE 802.11n standard requirements.
Fast fourier transform processor, dynamic scaling method and fast Fourier transform with radix-8 algorithm
(2005-12-29)
Lee, Chen-Yi
;
Lin, Yu-Wei
The present invention provides a fast Fourier transform processor, dynamic scaling method and fast Fourier transform with radix-8 algorithm. It reduces quantization errors generated from the operation by using a matrix prefetch buffer-based fast Fourier transform processor. Operation sizes of the matrix prefetch buffer as block sizes the invention adjust the signals against overflow by the status of signals in each block. It can shunt time of complex multiplication operation systematically and reduce operation complexity in butterfly units by utilizing algorithms of 3-step radix-8 fast Fourier transform and re-scheduling. Moreover, the present invention provides a fast Fourier transform processor for realizing the methods and algorithms mentioned above.
High-throughput pipelined FFT processor
(2006-12-14)
Lee, Chen-Yi
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Lin, Yu-Wei
The invention proposes a pipelined FFT processor for UWB system, comprising a first module for implementing radix-2 FFT algorithm; a second module is to realize radix-8 FFT algorithm; a third module is to realize radix-8 FFT algorithm; a plurality of conjugate blocks; a division block; and a plurality of multiplexers. The proposed pipelined FFT architecture called Mixed-Radix Multi-Path Delay Feedback (MRMDF) can provide higher throughput rate by using the multi-data-path scheme. The high-radix FFT algorithm is also realized in our processor to reduce the number of complex multiplications.
One-pot formation of fluorescent gamma-lactams having an alpha-phosphorus ylide moiety through three-component alpha(delta ')-Michael reactions of phosphines with an enyne and N-tosyl aldimines
(2014-01-07)
Lin, Yu-Wei
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Deng, Jie-Cheng
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Hsieh, You-Zung
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Chuang, Shih-Ching
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應用化學系
We demonstrate a straightforward synthesis of gamma-lactams possessing an a-phosphorus Aide moiety from assembly of phosphines, N-tosyl aldimines and an enyne through an initial alpha(delta')-attack of phosphines to an enyne in up to 79% yield. The investigated multicomponent reaction tolerates a variety of triaryl-phosphines and electron-poor aldimines to give gamma-lactams in one pot. One of the lactams, with the tri(p-tol)phosphine and 4-cyanophenyl moiety, exhibits fluorescence emission at 447 nm with a quantum yield of 0.11.
Open-Cage Fullerenes as n-Type Materials in Organic Photovoltaics: Relevance of Frontier Energy Levels, Carrier Mobility and Morphology of Different Sizable Open-Cage Fullerenes with Power Conversion Efficiency in Devices
(2011-10-01)
Chen, Chih-Ping
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Lin, Yu-Wei
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Horng, Jia-Cherng
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Chuang, Shih-Ching
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應用化學系
Targeting EGFR of triple-negative breast cancer enhances the therapeutic efficacy of paclitaxel- and cetuximab-conjugated nanodiamond nanocomposite
(2019-03-01)
Liao, Wei-Siang
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Ho, Yu
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Lin, Yu-Wei
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Raj, Emmanuel Naveen
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Liu, Kuang-Kai
Breast cancer is the most common malignancy and a leading cause of cancer-related mortality among women worldwide. Triple-negative breast cancer (TNBC) is characterized by the lack of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2). However, epidermal growth factor receptor (EGFR) is highly expressed in most of the TNBCs, which may provide a potential target for EGFR targeting therapy. Nanodiamond (ND) is a carbon-based nanomaterial with several advantages, including fluorescence emission, biocompatibility, and drug delivery applications. In this study, we designed a nanocomposite by using ND conjugated with paclitaxel (PTX) and cetuximab (Cet) for targeting therapy on the EGFR-positive TNBC cells. ND-PTX inhibited cell viability and induced mitotic catastrophe in various human breast cancer cell lines (MDA-MB-231, MCF-7, and BT474); in contrast, ND alone did not induce cell death. ND-PTX inhibited the xenografted human breast tumors in nude mice. We further investigated ND-PTX-Cet drug efficacy on the TNBC of MDA-MB-231 breast cancer cells. ND-PTX-Cet could specifically bind to EGFR and enhanced the anticancer effects including drug uptake levels, mitotic catastrophe, and apoptosis in the EGFR-expressed MDA-MB-231 cells but not in the EGFR-negative MCF-7 cells. In addition, ND-PTX-Cet increased the protein levels of active caspase-3 and phospho-histone H3 (Ser10). Furthermore, ND-PTX-Cet showed more effective on the reduction of TNBC tumor volume by comparison with ND-PTX. Taken together, these results demonstrated that ND-PTX-Cet nanocomposite enhanced mitotic catastrophe and apoptosis by targeting EGFR of TNBC cells, which can provide a feasible strategy for TNBC therapy. Statement of significance Current TNBC treatment is ineffective against the survival rate of TNBC patients. Therefore, the development of new treatment strategies for TNBC patients is urgently needed. Here, we have designed a nanocomposite by targeting on the EGFR of TNBC to enhance therapeutic efficacy by ND-conjugated PTX and Cet (ND-PTX-Cet). Interestingly, we found that the co-delivery of Cet and PTX by ND enhanced the apoptosis, mitotic catastrophe and tumor inhibition in the EGFR-expressed TNBC in vitro and in vivo. Consequently, this nanocomposite ND-PTX-Cet can be applied for targeting EGFR of human TNBC therapy. (C) 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Tracking of epidermal growth factor receptor in cancer cells using nanodiamond
(2017-04-01)
Lin, Yu-Wei
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交大名義發表
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National Chiao Tung University
Ubiquitin-coated nanodiamonds bind to autophagy receptors for entry into the selective autophagy pathway
(2017-01-01)
Liu, Kuang-Kai
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Qiu, Wei-Ru
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Raj, Emmanuel Naveen
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Liu, Huei-Fang
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Huang, Hou-Syun
Selective macroautophagy/autophagy plays a pivotal role in the processing of foreign pathogens and cellular components to maintain homeostasis in human cells. To date, numerous studies have demonstrated the uptake of nanoparticles by cells, but their intracellular processing through selective autophagy remains unclear. Here we show that carbon-based nanodiamonds (NDs) coated with ubiquitin (Ub) bind to autophagy receptors (SQSTM1 [sequestosome 1], OPTN [optineurin], and CALCOCO2/NDP52 [calcium binding and coiled-coil domain 2]) and are then linked to MAP1LC3/LC3 (microtubule-associated protein 1 light chain 3) for entry into the selective autophagy pathway. NDs are ultimately delivered to lysosomes. Ectopically expressed SQSTM1-green fluorescence protein (GFP) could bind to the Ub-coated NDs. By contrast, the Ub-associated domain mutant of SQSTM1 (UBA)-GFP did not bind to the Ub-coated NDs. Chloroquine, an autophagy inhibitor, prevented the ND-containing autophagosomes from fusing with lysosomes. Furthermore, autophagy receptors OPTN and CALCOCO2/NDP52, involved in the processing of bacteria, were found to be involved in the selective autophagy of NDs. However, ND particles located in the lysosomes of cells did not induce mitotic blockage, senescence, or cell death. Single ND clusters in the lysosomes of cells were observed in the xenografted human lung tumors of nude mice. This study demonstrated for the first time that Ub-coated nanoparticles bind to autophagy receptors for entry into the selective autophagy pathway, facilitating their delivery to lysosomes.
YY Ubiquitin-coated nanodiamonds bind to autophagy receptors for entry into the selective autophagy pathway
(2017)
Liu, Kuang-Kai
;
Qiu, Wei-Ru
;
Raj, Emmanuel Naveen
;
Liu, Huei-Fang
;
Huang, Hou-Syun
Selective macroautophagy/autophagy plays a pivotal role in the processing of foreign pathogens and cellular components to maintain homeostasis in human cells. To date, numerous studies have demonstrated the uptake of nanoparticles by cells, but their intracellular processing through selective autophagy remains unclear. Here we show that carbon-based nanodiamonds (NDs) coated with ubiquitin (Ub) bind to autophagy receptors (SQSTM1 [sequestosome 1], OPTN [optineurin], and CALCOCO2/NDP52 [calcium binding and coiled-coil domain 2]) and are then linked to MAP1LC3/LC3 (microtubule-associated protein 1 light chain 3) for entry into the selective autophagy pathway. NDs are ultimately delivered to lysosomes. Ectopically expressed SQSTM1-green fluorescence protein (GFP) could bind to the Ub-coated NDs. By contrast, the Ub-associated domain mutant of SQSTM1 (UBA)-GFP did not bind to the Ub-coated NDs. Chloroquine, an autophagy inhibitor, prevented the ND-containing autophagosomes from fusing with lysosomes. Furthermore, autophagy receptors OPTN and CALCOCO2/NDP52, involved in the processing of bacteria, were found to be involved in the selective autophagy of NDs. However, ND particles located in the lysosomes of cells did not induce mitotic blockage, senescence, or cell death. Single ND clusters in the lysosomes of cells were observed in the xenografted human lung tumors of nude mice. This study demonstrated for the first time that Ub-coated nanoparticles bind to autophagy receptors for entry into the selective autophagy pathway, facilitating their delivery to lysosomes.
YY Ubiquitin-coated nanodiamonds bind to autophagy receptors for entry into the selective autophagy pathway
(2017)
Liu, Kuang-Kai
;
Qiu, Wei-Ru
;
Raj, Emmanuel Naveen
;
Liu, Huei-Fang
;
Huang, Hou-Syun
Selective macroautophagy/autophagy plays a pivotal role in the processing of foreign pathogens and cellular components to maintain homeostasis in human cells. To date, numerous studies have demonstrated the uptake of nanoparticles by cells, but their intracellular processing through selective autophagy remains unclear. Here we show that carbon-based nanodiamonds (NDs) coated with ubiquitin (Ub) bind to autophagy receptors (SQSTM1 [sequestosome 1], OPTN [optineurin], and CALCOCO2/NDP52 [calcium binding and coiled-coil domain 2]) and are then linked to MAP1LC3/LC3 (microtubule-associated protein 1 light chain 3) for entry into the selective autophagy pathway. NDs are ultimately delivered to lysosomes. Ectopically expressed SQSTM1-green fluorescence protein (GFP) could bind to the Ub-coated NDs. By contrast, the Ub-associated domain mutant of SQSTM1 (UBA)-GFP did not bind to the Ub-coated NDs. Chloroquine, an autophagy inhibitor, prevented the ND-containing autophagosomes from fusing with lysosomes. Furthermore, autophagy receptors OPTN and CALCOCO2/NDP52, involved in the processing of bacteria, were found to be involved in the selective autophagy of NDs. However, ND particles located in the lysosomes of cells did not induce mitotic blockage, senescence, or cell death. Single ND clusters in the lysosomes of cells were observed in the xenografted human lung tumors of nude mice. This study demonstrated for the first time that Ub-coated nanoparticles bind to autophagy receptors for entry into the selective autophagy pathway, facilitating their delivery to lysosomes.