Browsing by Author "Lu, Yi-Wen"

Now showing 1 - 5 of 5

A DIGITAL MICROFLUIDIC PROCESSOR FOR BIOMEDICAL APPLICATIONS
(2013)
Lai, Kelvin Yi-Tse
;
Yang, Yu-Tao
;
Wang, Gary
;
Lu, Yi-Wen
;
Lee, Chen-Yi
A digital microfluidic processor for biomedical detection is presented. This processor integrates the functions of droplet actuation, droplet position/shape/volume detection and capacitive measurement window to demonstrate a novel prototype for personalize medicine. In this proposed system, the location map of microdroplets and reaction behaviors are visible on 2-dimentional (2D) graphical user-interface due to capacitive sensing technology and hence automatic signal processing is achievable. Fabricated in standard 0.35um 2P4M CMOS process, this test chip integrates 900 microelectrodes with measurement window in 3.2mm(2). Measurement results show that operation of microdroplet moving is under 1KHz and digital signal extractions of position detection and statistical analysis are under 1MHz respectively.
A Field-Programmable Lab-on-a-Chip with Built-in Self-Test Circuit and Low-Power Sensor-Fusion Solution in 0.35 mu m Standard CMOS Process
(2015)
Lai, Kelvin Yi-Tse
;
Shiu, Ming-Feng
;
Lu, Yi-Wen
;
Ho, Yingchieh
;
Kao, Yu-Chi
This paper presents a field programmable lab-on-a-chip (FPLOC) with microfluidics actuation, droplet location/category readback, built-in-self-test (BIST), and bioassays detection. This FPLOC is composed of 1,800 MEDA microelectrodes and integrates a set of microfluidic operations to perform droplet moving/cutting/mixing. Besides, capacitive sensing circuits are considered for system automation, droplets classification, malfunctioning microelectrodes and surface flatness testing, and biomedical detection. Implemented in 0.35 mu m standard CMOS process in 7.4mm(2), the FPLOC demonstrates microfluidic operations under 25V at 1KHz, 1.3fF resolution for droplet location/category/chip BIST maps readback at 1MHz, and 0.34fF sensitivity of capacitive measurement window for biomedical detection at 1KHz.
Field-programmable lab-on-a-chip based on microelectrode dot array architecture
(2014-09-01)
Wang, Gary
;
Teng, Daniel
;
Lai, Yi-Tse
;
Lu, Yi-Wen
;
Ho, Yingchieh
The fundamentals of electrowetting-on-dielectric (EWOD) digital microfluidics are very strong: advantageous capability in the manipulation of fluids, small test volumes, precise dynamic control and detection, and microscale systems. These advantages are very important for future biochip developments, but the development of EWOD microfluidics has been hindered by the absence of: integrated detector technology, standard commercial components, on-chip sample preparation, standard manufacturing technology and end-to-end system integration. A field-programmable lab-on-a-chip (FPLOC) system based on microelectrode dot array (MEDA) architecture is presented in this research. The MEDA architecture proposes a standard EWOD microfluidic component called 'microelectrode cell', which can be dynamically configured into microfluidic components to perform microfluidic operations of the biochip. A proof-of-concept prototype FPLOC, containing a 30 x 30 MEDA, was developed by using generic integrated circuits computer aided design tools, and it was manufactured with standard low-voltage complementary metal-oxide-semiconductor technology, which allows smooth on-chip integration of microfluidics and microelectronics. By integrating 900 droplet detection circuits into microelectrode cells, the FPLOC has achieved large-scale integration of microfluidics and microelectronics. Compared to the full-custom and bottom-up design methods, the FPLOC provides hierarchical top-down design approach, field-programmability and dynamic manipulations of droplets for advanced microfluidic operations.
Field-programmable lab-on-a-chip based on microelectrode dot array architecture
(2014-09-01)
Wang, Gary
;
Teng, Daniel
;
Lai, Yi-Tse
;
Lu, Yi-Wen
;
Ho, Yingchieh
The fundamentals of electrowetting-on-dielectric (EWOD) digital microfluidics are very strong: advantageous capability in the manipulation of fluids, small test volumes, precise dynamic control and detection, and microscale systems. These advantages are very important for future biochip developments, but the development of EWOD microfluidics has been hindered by the absence of: integrated detector technology, standard commercial components, on-chip sample preparation, standard manufacturing technology and end-to-end system integration. A field-programmable lab-on-a-chip (FPLOC) system based on microelectrode dot array (MEDA) architecture is presented in this research. The MEDA architecture proposes a standard EWOD microfluidic component called \'microelectrode cell\', which can be dynamically configured into microfluidic components to perform microfluidic operations of the biochip. A proof-of-concept prototype FPLOC, containing a 30 x 30 MEDA, was developed by using generic integrated circuits computer aided design tools, and it was manufactured with standard low-voltage complementary metal-oxide-semiconductor technology, which allows smooth on-chip integration of microfluidics and microelectronics. By integrating 900 droplet detection circuits into microelectrode cells, the FPLOC has achieved large-scale integration of microfluidics and microelectronics. Compared to the full-custom and bottom-up design methods, the FPLOC provides hierarchical top-down design approach, field-programmability and dynamic manipulations of droplets for advanced microfluidic operations.
Reconfigurable liquid-core/liquid-cladding optical waveguides with dielectrophoresis-driven virtual microchannels on an electromicrofluidic platform
(2016)
Fan, Shih-Kang
;
Lee, Hsuan-Ping
;
Chien, Chia-Chi
;
Lu, Yi-Wen
;
Chiu, Yi
An electrically reconfigurable liquid-core/liquid-cladding (L-2) optical waveguide with core liquid gamma-butyrolactone (GBL, n(core) = 1.4341, epsilon(core) = 39) and silicone oil (n(cladding) = 1.401, epsilon(cladding) = 2.5) as cladding liquid is accomplished using dielectrophoresis (DEP) that attracts and deforms the core liquid with the greater permittivity to occupy the region of strong electric field provided by Teflon-coated ITO electrodes between parallel glass plates. Instead of continuously flowing core and cladding liquids along a physical microchannel, the DEP-formed L-2 optical waveguide guides light in a stationary virtual microchannel that requires liquids of limited volume without constant supply and creates stable liquid/liquid interfaces for efficient light guidance in a simply fabricated microfluidic device. We designed and examined (1) stationary and (2) moving L-2 optical waveguides on the parallel-plate electromicrofluidic platform. In the stationary L-shaped waveguide, light was guided in a GBL virtual microchannel core for a total of 27.85 mm via a 90 degrees bend (radius 5 mm) before exiting from the light outlet of cross-sectional area 100 mu m x 100 mu m. For the stationary spiral waveguide, light was guided in a GBL core containing Rhodamine 6G (R6G, 1 mM) and through a series of 90 degrees bends with decreasing radii from 5 mm to 2.5 mm. With the stationary straight waveguide, the propagation loss was measured to be 2.09 dB cm(-1) in GBL with R6G (0.01 mM). The moving L-shaped waveguide was implemented on a versatile electromicrofluidic platform on which electrowetting and DEP were employed to generate a precise GBL droplet and form a waveguide core. On sequentially applying appropriate voltage to one of three parallel L-shaped driving electrodes, the GBL waveguide core was shifted; the guided light was switched at a speed of up to 0.929 mm s(-1) (switching period 70 ms, switching rate 14.3 Hz) when an adequate electric signal (173.1 V-RMS, 100 kHz) was applied.