Browsing by Author "Yu, Ping-Chun"

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A CMOS-compatible optical biosensing system based on visible absorption spectroscopy
(2007)
Chang, Yu-Wei
;
Yu, Ping-Chun
;
Huang, Yang-Tung
;
Yang, Yuh-Shyong
;
電子工程學系及電子研究所
A CMOS-compatible optical biosensing system based on visible absorption spectroscopy is proposed. Within the compact prototype, the CMOS sensor consisting a P(+)/N(well) finger photodiode and a transimpedance amplifier (TIA) is implemented in a standard 0.35-mu m CMOS technology. The ABTS/H(2)O(2)/HRP method is adopted as the ground for medical diagnosis, Experimental results demonstrate that the minimum concentration successfully detected for H(2)O(2) is 1 mu M. The detection limit is one order of magnitude better than a traditional CMOS biosensor, and comparable to a commercial spectrophotometer.
A High-Sensitivity CMOS-Compatible Biosensing System Based on Absorption Photometry
(2009-01-01)
Chang, Yu-Wei
;
Yu, Ping-Chun
;
Huang, Yang-Tung
;
Yang, Yuh-Shyong
;
生物科技學系
An optical biosensing system based on a standard CMOS technology and absorption photometry is proposed. Within the compact prototype, a CMOS sensor consisting a P(+)/N(well) finger photodiode and a transimpedance amplifier was implemented in a standard 0.35-mu m CMOS technology. The ABTS/H(2)O(2)/HRP method was adopted to be coupled with various analytes of interest, such as glucose and histamine, which can serve as the basis for medical diagnosis. The experimental results demonstrate that the minimum concentrations successfully detected for H(2)O(2), glucose, and histamine are 1 mu M, 1 mu M, and 10 mu M, respectively. The detection limits are at least one order of magnitude better than those of reported CMOS biosensors, and are even comparable to those of a commercial spectrophotometer.