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Browsing by Issue Date, starting with "2008-10-22"

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    Celecoxib induces p53-PUMA pathway for apoptosis in human colorectal cancer cells
    (2008-10-22)
    Liu, Huei-Fang
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    Hsiao, Po-Wen
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    Chao, Jui-I
    ;
    生物科技學系
    ;
    Department of Biological Science and Technology
    Celecoxib, a clinical non-steroidal anti-inflammatory drug, displays anticarcinogenic and chemopreventive activities in human colorectal cancers, although the mechanisms of apoptosis by celecoxib are poorly understood. The existence of functional p53 but not securin in colorectal cancer cells was higher on the induction of cytotoxicity than the p53-mutational colorectal cancer cells following celecoxib treatment. The p53-wild type HCT116 cells were more susceptible to increase similar to 25% cell death than the p53-null HCT116 cells after treatment with 100 mu M celecoxib for 24 h.Transfection with a small interfering RNA of p53 reduced the celecoxib-induced cytotoxicity in the RKO (p53-wild type) colorectal cancer cells. Celecoxib (80-100 mu M for 24 h) significantly increased total p53 proteins and the phosphorylated p53 proteins at serine-15,-20,-46, and -392 in RKO cells. However, the phospho-p53 (serine-15, 20, and -392) proteins were presented on the nuclei of cells but the phospho-p53 (serine-46) protein was located on the cytoplasma of apoptotic cells following treatment with celecoxib. Interestingly, the p53 up-regulated modulator of apoptosis (PUMA) protein, which located on the mitochondria, was induced by celecoxib in the p53-functional colorectal cancer cells but not in the p53-mutational cells. Together, this study provides the first time that celecoxib induces the various phosphorylated sites of p53 and activates p53-PUMA pathway, which potentiates the apoptosis induction in human colorectal cancer cells. Crown Copyright (c) 2008 Published by Elsevier Ireland Ltd. All rights reserved.
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    OBJECT IMAGE DETECTION METHOD
    (2008-10-23)
    HAN, Chin-Chuan
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    Chen, Ying-Nong
    The present invention discloses an object image detection method, which uses a coarse-to-fine strategy to detect objects. The method of the present invention comprises steps: acquiring an image and pre-processing the image to achieve dimensional reduction and information fusion; using a trained filter to screen features; and sequentially using a coarse-level MLP verifier and a fine-level MLP verifier to perform a neural network image detection to determine whether the features of the image match the features of the image of a target object. The present invention simultaneously uses three mainstream image detection methods, including the statistic method, neural network method and adaboost method, to perform image detection. Therefore, the present invention has the advantages of the rapidity of the adaboost method and the accuracy of the neural network method at the same time.
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    Sequence generating method
    (2008-10-23)
    Chen, Ching Wei
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    Zheng, Yan Xiu
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    Su, Yu Ted
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    Li, Chi Fang
    This invention provides a sequence generating method, in which the method has steps of generating R sets of orthogonal sequence with each set of the orthogonal sequence including N elements, generating a low-autocorrelation sequence having N elements, and multiplying the N elements of the low-autocorrelation sequence by the N elements of each of R sets of the orthogonal sequence point-to-point. Therefore, a sequence generated by the method of the present invention has low-autocorrelation and low-crosscorrelation in transmission characteristics of a communication system.
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    春禾封箱 現實與理想的分飛
    (2008-10-26)
    陳怡秀
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    Department of Communication and Technology
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    傳播與科技學系
    國內知名劇團──春禾劇團於上周末以《梁山伯與祝英台》做為封箱作，正式告別台灣表演藝術界，團長郎祖筠嘆道，這是現實與理想的分飛。從春禾劇團八年半的辛苦卻仍舊無法抵擋現實考量，來闡述台灣表演藝術界的困境與展望。
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    Jacqueline du Pré－將生命注入琴聲
    (2008-10-26)
    郭大齊
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    Department of Communication and Technology
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    傳播與科技學系
    Jacqueline du Pré
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    《說走就走》 訴說父子相處之道
    (2008-10-26)
    梁素茵
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    Department of Communication and Technology
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    傳播與科技學系
    說走就走
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    不一樣的夏天
    (2008-10-26)
    陳碩峰
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    Department of Communication and Technology
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    傳播與科技學系
    2008年的暑假，一群熱血的排球隊員前往國境之南─墾丁進行移地訓練。 暑假對於普通的學生來說，是開心的，但對於我們來說，是極疲憊的。
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    總編輯的話
    (2008-10-26)
    趙祿平
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    Department of Communication and Technology
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    傳播與科技學系
    123
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    後青春ㄑㄧˊ的詩
    (2008-10-26)
    徐苾芬
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    Department of Communication and Technology
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    傳播與科技學系
    就是心情故事啊=ˇ= 終於可以好好休息一下了!我想來點創作!!
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    《無樂不作》范逸臣新的里程碑
    (2008-10-26)
    林潔
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    Department of Communication and Technology
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    傳播與科技學系
    樂評范逸臣2008精選輯
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    籃球與人生
    (2008-10-26)
    余建良
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    Department of Communication and Technology
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    傳播與科技學系
    籃球與人生
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    《20世紀少年》 彈奏反叛序曲
    (2008-10-26)
    楊睿愷
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    Department of Communication and Technology
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    傳播與科技學系
    正義永不凋零，反叛精神永存。當隱性的惡勢力來臨時，你的朋友或許是最後的敵人。
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    當歌手不會唱歌
    (2008-10-26)
    何宛芯
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    Department of Communication and Technology
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    傳播與科技學系
    唱歌好聽已不再是歌手們最在意的事。
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    部落格放廣告 點擊賺大錢？
    (2008-10-26)
    鄭秀芳
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    Department of Communication and Technology
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    傳播與科技學系
    為甚麼部落格會變成賺錢工具? 部落格廣告真的值得信賴嗎? 部落格未來趨勢?
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    傳播人 你「閱讀空氣」了嗎？
    (2008-10-26)
    羅佩雯
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    Department of Communication and Technology
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    傳播與科技學系
    天下雜誌十月分最熱門話題『閱讀空氣』－變動時代的求生新關鍵。 想從傳播產業去了解，不同大企業、商業利益為重的場域，探討傳播業者之間的『空氣成分』。 經由一連串的訪問，得知處在不同階段的傳播人，遭遇到的問題和身處環境的不同？
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    住所環境 你我做起
    (2008-10-26)
    林麗珊
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    Department of Communication and Technology
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    傳播與科技學系
    探討現在大學生的住宿環境。
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    詩學界的巨人─蔡中村
    (2008-10-26)
    吳佳玲
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    Department of Communication and Technology
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    傳播與科技學系
    採訪嘉義市詩學家蔡中村，先敘述他與詩的經歷，然後再介紹他特別之處，最後在側寫他對台灣詩學未來的看法。
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    《美由里之森》森林的守護者
    (2008-10-26)
    陳妙寧
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    Department of Communication and Technology
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    傳播與科技學系
    電影
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    音樂之下 曾經 愛是唯一
    (2008-10-26)
    黃惠琳
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    Department of Communication and Technology
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    傳播與科技學系
    無
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    行銷迪士尼　體驗式行銷
    (2008-10-26)
    洪效凡
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    Department of Communication and Technology
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    傳播與科技學系
    讓迪士尼行銷部經理－吳育達暢談迪士尼頻道的行銷方式