Browsing by Issue Date, starting with "2010-02-18"

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Nanostructured thin-film formed by utilizing oblique-angle deposition and method of the same
(2010-02-18)
Chang, Chia-Hua
;
Yang, Chin-Sheng
;
Chiu, Ching-Hua
;
Yu, Pei-Chen
;
Kuo, Hao-Chung
The present invention discloses a transparent conductive nanostructured thin-film by oblique-angle deposition and method of the same. An electron beam system is utilized to evaporate the target source. Evaporation substrate is disposed on a plurality of adjustable sample stage. Multiple gas control valve and heat source is provided to control the gas flow and temperature within the process chamber. An annealing process is performed after the evaporation to improve the thin-film structure and optoelectronic properties.
Modulation of Donor-Acceptor Interface through Thermal Treatment for Efficient Bilayer Organic Solar Cells
(2010-02-18)
Kekuda, Dhananjaya
;
Huang, Jen-Hsien
;
Ho, Kuo-Chuan
;
Chu, Chih-Wei
;
光電工程學系
In this article, we demonstrate the effect of donor-acceptor (D-A) interface on the performance of bilayer organic solar cells. Solution processing was used to develop liquid crystal poly(9,9'-dioctylfluorene-co-bithiophene) (F8T2) polymer films and variable morphology of the films was achieved by varying the annealing temperature. The morphology of the annealed active layers signature a well-aligned nanodomain feature with an interdegitated structure at 200 degrees C. The devices with bilayer configuration, ITO/PEDOT:PSS/F8T2/C(70)/Al, have yielded a power conversion efficiency (PCE) of 3.4(+/- 0.2)% under 1 sun incident radiation. We attribute the high PCE to the increased D-A junction interface and balanced charge transport between electron/hole transport layers.
DIGITAL FAST-LOCKING FREQUENCY SYNTHESIZER
(2010-02-18)
CHEN, WEI-ZEN
;
YANG, SONG-YU
A digital PLL frequency synthesizer characterized by fast-locking and low-jitters is presented. The PLL comprises a phase detector, a controllable oscillator, a loop filter having an automatically-adjusted loop gain, a feedback phase integration circuit, and a reference phase integration circuit. Fast-locking is achieved by dynamically adjusting forward-path gain and integral-path gain according to the output of the phase detector and the output of the integral-path during phase tracking. A skew-compensated counter circuit is proposed, which incorporates an asynchronous counter, a data register and a sample phase generator and features high-speed and low-power operation.
Structure and photoluminescence properties of strong blue-emitting alumina film developed from a liquid sol at low temperature
(2010-02-18)
Peng, Cheng-Hsiung
;
Hwang, Chyi-Ching
;
Hsiao, Chi-Sheng
;
材料科學與工程學系
;
Department of Materials Science and Engineering
Strong blue photoluminescence emission at 450 nm from alumina films prepared from an alumina precursor was observed. Photo luminescence measurements indicate that the peak intensity of the blue emission changes with the pH value of the peptizing solution, the annealing temperature and the atmosphere. The blue emission appears at a low temperature of 50 degrees C and reaches a maximum strength at 400 degrees C in an oxygen atmosphere and 600 degrees C in a nitrogen atmosphere. HRTEM images show that the alumina films are composed of nanoparticles with a diameter of <= 10 nm. it is believed that the observed strong photoluminescence is associated with inherent defect centers in the material, where these are related to the structure transition and transformation from the boehmite phase to the gamma-alumina phase and bond cleavage. (C) 2009 Elsevier B.V. All rights reserved.
AUTOMATIC ULTRASONIC AND COMPUTER-VISION NAVIGATION DEVICE AND METHOD USING THE SAME
(2010-02-18)
WU, Chih-Jen
;
TSAI, Shung-Yung
;
TSAI, Wen-Hsiang
The present invention discloses an automatic ultrasonic and computer-vision navigation device and a method using the same. In the method of the present invention, the user guides an automatic navigation device to learn and plan a navigation path; next, the automatic navigation device navigates independently and uses ultrasonic signals and computer vision to detect the environment; then, the automatic navigation device compares the detected environment data with the navigation path to amend the physical movement track. The present invention enables ordinary persons to interact with the automatic navigation device without operating the computer. As the present invention adopts computer vision and ultrasonic signals to realize the functions thereof, the manufacturers can save the hardware cost.
感測裝置
(2010-02-21)
鄭璧瑩
;
黃健寶
本發明係提供一種感測裝置，係應用一半球形容器裝載液態介電質，利用半球形容器內兩對以上之電極端，以供液態介電質觸發電極來導通電路，而此容器外圍是以抗腐蝕材料包覆之；一緩衝頸縮口及一精度閥，設置於容器上，以避免該液態介電質與電極產生接觸，達成避免震動之干擾及調節液態介電質的液面高度改變感測裝置之靈敏度；以及一防漏感測裝置，係包覆半球形容器、液態介電質、緩衝頸縮口、精度閥，以防止該液態介電質洩漏，達成一個多方向可控制、偵測、調整傾斜功能之感測器。【創作特點】本發明之主要目的係提供一種感測裝置，係利用一容器來裝載液態介電質，再配合兩對以上之電極來達成具有可調整多向性水平的控制。本發明之另一目的係提供一種感測裝置，其係裝置一精度閥，而能改變感測裝置靈敏度之功能。本發明之再一目的係提供一種感測裝置，其係裝置一防漏感測裝置，作為防止液態介電質溢漏的第二防線。為達到上述之目的，本發明係提供一種感測裝置，係利用一半球形容器裝載液態介電質，而其外圍以抗腐蝕材料將容器包覆之，在容器內設有兩對電極端，以供液態介電質觸發來導通電路；在容器上設有一緩衝頸縮口及一精度閥，分別避免液態介電質與電極產生接觸達成防震之功能及調節液態介電質的液面高度，並另外使用一防漏感測裝置將半球形容器、液態介電質、緩衝頸縮口、精度閥包覆，以防止該液態介電質洩漏，作為第二層防線。底下藉由具體實施例配合所附的圖式詳加說明，當更容易瞭解本發明之目的、技術內容、特點及其所達成之功效。
High-excitation effect on photoluminescence of sol-gel ZnO nanopowder
(2010-02-22)
Chia, C. H.
;
Lai, Y. J.
;
Han, T. C.
;
Chiou, J. W.
;
Hu, Y. M.
We studied the power-dependent photoluminescence of ZnO nanopowder grown by sol-gel method at low temperature. At moderate optical pumping intensity, two nonlinear emission bands due to the radiative recombination of free biexciton and the inelastic exciton-exciton scattering were detected. We found that the threshold of the excitation density for the emergence of the nonlinear emission bands is low (< 18 W/cm(2)) in sol-gel ZnO nanopowders.
交大e-News第065期
(2010-02-22)
Secretariat
;
國立交通大學秘書室
Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity
(2010-02-23)
Shih, Shin-Ru
;
Chu, Tzu-Yun
;
Reddy, Gadarla Randheer
;
Tseng, Sung-Nain
;
Chen, Hsiun-Ling
Background: Influenza viruses are a major cause of morbidity and mortality around the world. More recently, a swine-origin influenza A (H1N1) virus that is spreading via human-to-human transmission has become a serious public concern. Although vaccination is the primary strategy for preventing infections, influenza antiviral drugs play an important role in a comprehensive approach to controlling illness and transmission. In addition, a search for influenza-inhibiting drugs is particularly important in the face of high rate of emergence of influenza strains resistant to several existing influenza antivirals. Methods: We searched for novel anti-influenza inhibitors using a cell-based neutralization (inhibition of virus-induced cytopathic effect) assay. After screening 20,800 randomly selected compounds from a library from ChemDiv, Inc., we found that BPR1P0034 has sub-micromolar antiviral activity. The compound was resynthesized in five steps by conventional chemical techniques. Lead optimization and a structure-activity analysis were used to improve potency. Time-of-addition assay was performed to target an event in the virus life cycle. Results: The 50% effective inhibitory concentration (IC(50)) of BPR1P0034 was 0.42 +/- 0.11 mu M, when measured with a plaque reduction assay. Viral protein and RNA synthesis of A/WSN/33 (H1N1) was inhibited by BPR1P0034 and the virus-induced cytopathic effects were thus significantly reduced. BPR1P0034 exhibited broad inhibition spectrum for influenza viruses but showed no antiviral effect for enteroviruses and echovirus 9. In a time-of-addition assay, in which the compound was added at different stages along the viral replication cycle (such as at adsorption or after adsorption), its antiviral activity was more efficient in cells treated with the test compound between 0 and 2 h, right after viral infection, implying that an early step of viral replication might be the target of the compound. These results suggest that BPR1P0034 targets the virus during viral uncoating or viral RNA importation into the nucleus. Conclusions: To the best of our knowledge, BPR1P0034 is the first pyrazole-based anti-influenza compound ever identified and characterized from high throughput screening to show potent (sub-mu M) antiviral activity. We conclude that BPR1P0034 has potential antiviral activity, which offers an opportunity for the development of a new anti-influenza virus agent.
Reconstructing genome trees of prokaryotes using overlapping genes
(2010-02-24)
Cheng, Chih-Hsien
;
Yang, Chung-Han
;
Chiu, Hsien-Tai
;
Lu, Chin Lung
;
生物科技學系
Background: Overlapping genes (OGs) are defined as adjacent genes whose coding sequences overlap partially or entirely. In fact, they are ubiquitous in microbial genomes and more conserved between species than nonoverlapping genes. Based on this property, we have previously implemented a web server, named OGtree, that allows the user to reconstruct genome trees of some prokaryotes according to their pairwise OG distances. By analogy to the analyses of gene content and gene order, the OG distance between two genomes we defined was based on a measure of combining OG content (i.e., the normalized number of shared orthologous OG pairs) and OG order (i.e., the normalized OG breakpoint distance) in their whole genomes. A shortcoming of using the concept of breakpoints to define the OG distance is its inability to analyze the OG distance of multi-chromosomal genomes. In addition, the amount of overlapping coding sequences between some distantly related prokaryotic genomes may be limited so that it is hard to find enough OGs to properly evaluate their pairwise OG distances. Results: In this study, we therefore define a new OG order distance that is based on more biologically accurate rearrangements (e. g., reversals, transpositions and translocations) rather than breakpoints and that is applicable to both uni-chromosomal and multi-chromosomal genomes. In addition, we expand the term "gene" to include both its coding sequence and regulatory regions so that two adjacent genes whose coding sequences or regulatory regions overlap with each other are considered as a pair of overlapping genes. This is because overlapping of regulatory regions of distinct genes suggests that the regulation of expression for these genes should be more or less interrelated. Based on these modifications, we have reimplemented our OGtree as a new web server, named OGtree2, and have also evaluated its accuracy of genome tree reconstruction on a testing dataset consisting of 21 Proteobacteria genomes. Our experimental results have finally shown that our current OGtree2 indeed outperforms its previous version OGtree, as well as another similar server, called BPhyOG, significantly in the quality of genome tree reconstruction, because the phylogenetic tree obtained by OGtree2 is greatly congruent with the reference tree that coincides with the taxonomy accepted by biologists for these Proteobacteria. Conclusions: In this study, we have introduced a new web server OGtree2 at http://bioalgorithm.life.nctu.edu.tw/ OGtree2.0/ that can serve as a useful tool for reconstructing more precise and robust genome trees of prokaryotes according to their overlapping genes.
Charge storage characteristics of high density Mo nanocrystal embedded in silicon oxide and silicon nitride
(2010-02-24)
Lin, Chao-Cheng
;
Chang, Ting-Chang
;
Tu, Chun-Hao
;
Chen, Shih-Ching
;
Hu, Chih-Wei
We investigated the formation and charge storage characteristics of Mo nanocrystals in silicon oxide and in silicon nitride by rapid thermal annealing of oxygen- and nitrogen-incorporated Mo and Si mixed layers. A high density of Mo nanocrystal (6 x 10(12) cm(-2)) was formed in the nitrogen-incorporated layer. Electrical analyses indicated that the memory window of the Mo nanocrystal embedded in the nitride is larger than that in the oxide. A reliability test showed that the Mo nanocrystal in the nitride has better reliability than the Mo nanocrystal in the oxide, which was explained by an electrical field simulation.
Reconstructing genome trees of prokaryotes using overlapping genes
(2010-02-24)
Cheng, Chih-Hsien
;
Yang, Chung-Han
;
Chiu, Hsien-Tai
;
Lu, Chin Lung
;
生物科技學系
Background: Overlapping genes (OGs) are defined as adjacent genes whose coding sequences overlap partially or entirely. In fact, they are ubiquitous in microbial genomes and more conserved between species than nonoverlapping genes. Based on this property, we have previously implemented a web server, named OGtree, that allows the user to reconstruct genome trees of some prokaryotes according to their pairwise OG distances. By analogy to the analyses of gene content and gene order, the OG distance between two genomes we defined was based on a measure of combining OG content (i.e., the normalized number of shared orthologous OG pairs) and OG order (i.e., the normalized OG breakpoint distance) in their whole genomes. A shortcoming of using the concept of breakpoints to define the OG distance is its inability to analyze the OG distance of multi-chromosomal genomes. In addition, the amount of overlapping coding sequences between some distantly related prokaryotic genomes may be limited so that it is hard to find enough OGs to properly evaluate their pairwise OG distances. Results: In this study, we therefore define a new OG order distance that is based on more biologically accurate rearrangements (e. g., reversals, transpositions and translocations) rather than breakpoints and that is applicable to both uni-chromosomal and multi-chromosomal genomes. In addition, we expand the term "gene" to include both its coding sequence and regulatory regions so that two adjacent genes whose coding sequences or regulatory regions overlap with each other are considered as a pair of overlapping genes. This is because overlapping of regulatory regions of distinct genes suggests that the regulation of expression for these genes should be more or less interrelated. Based on these modifications, we have reimplemented our OGtree as a new web server, named OGtree2, and have also evaluated its accuracy of genome tree reconstruction on a testing dataset consisting of 21 Proteobacteria genomes. Our experimental results have finally shown that our current OGtree2 indeed outperforms its previous version OGtree, as well as another similar server, called BPhyOG, significantly in the quality of genome tree reconstruction, because the phylogenetic tree obtained by OGtree2 is greatly congruent with the reference tree that coincides with the taxonomy accepted by biologists for these Proteobacteria. Conclusions: In this study, we have introduced a new web server OGtree2 at http://bioalgorithm.life.nctu.edu.tw/ OGtree2.0/ that can serve as a useful tool for reconstructing more precise and robust genome trees of prokaryotes according to their overlapping genes.
MATRIX DISPLAY INTERFACE FOR PRESENTATION SYSTEM
(2010-02-25)
Chen, Ming Jang
A matrix display interface for a presentation system includes a plurality of data units, a main switching element, a plurality of column switching elements, a plurality of row switching element, and a plurality of grid switching elements. The data units are arranged on a display interface and are written with presentation data in advance. The presentation system is operated on a computer. A user may click the switching elements to selectively display or conceal or highlight all the data units, a whole column of data units, a whole row of data units, or a single data unit. Thereby, a speaker of a presentation may selectively present the content of the presentation to draw the attention of the listeners, so that the speaker and the listeners may have positive interactions during the presentation.
Synthesis and Preclinical Evaluations of 2-(2-Fluorophenyl)-6,7-methylenedioxyquinolin-4-one Monosodium Phosphate (CHM-1-P-Na) as a Potent Antitumor Agent
(2010-02-25)
Chou, Li-Chen
;
Chen, Chien-Ting
;
Lee, Jang-Chang
;
Way, Tzong-Der
;
Huang, Chi-Hung
CHM-1 [2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one] (1) has a unique antitumor mechanism of action. However, because 1 has relatively low hydrophilicity, it was evaluated only via ip administration, which is not clinically acceptable. In this study, we synthesized the monosodium phosphate salt (CHM-1-P-Na, 4) of 1 as a hydrophilic prodrug. Compound 4 was rapidly converted into 1 following iv and po administration and also possessed excellent antitumor activity in a SKOV-3 xenograft nude mice model. Compound 4 also had clear-cut pharmacological effects oil enzymes related with tumor cells. Neither 4 not 1 significantly affected normal biological function in a safety pharmacology profiling study. Compound 1 caused apoptotic effects in breast carcinoma cells via accumulation of cyclin B1, and importantly, the endogenous levels of the mitotic spindle checkpoint proteins BubR1 directly correlated with cellular response to microtubule disruption. With excellent antitumor activity profiles, 4 is highly promising for development as all anticancer clinical trials candidate.
斜め堆積を用いて生成されたナノ構造薄膜およびその方法
(2010-02-25)
チア－フアチャン
;
チン－シェンヤン
;
チン－フア，チュ
;
ペイ－チェンユー
;
ハオ－チュンクオ
【課題】勾配型屈折率を備えた多孔質を含む単層構造をした透明導電性のナノ構造薄膜とその製造方法を提供する。【解決手段】電子ビームシステム１００を用いて、ターゲットソースが斜め堆積法により蒸着される。複数の調整可能な試料ステージ１０４上に蒸着基板１１４が配置される。プロセスチャンバー１０１内でガスの流量および温度を制御するため、熱源と複数のガス制御弁１０７および１０８が備えられる。蒸着後、薄膜構造と光電子特性を向上させるため、アニール工程が行われる。【選択図】図１ａ
MULTITASKING PROCESSOR AND TASK SWITCHING METHOD THEREOF
(2010-02-25)
Lin, Tay-Jyi
;
Huang, Pao-Jui
;
Liu, Chih-Wei
;
Chen, Shin-Kai
;
Wang, Bing-Shiun
A multitasking processor and a task switching method thereof are provided. The task switching method includes following steps. A first task is executed by the multitasking processor, wherein the first task contains a plurality of switching-point instructions. An interrupt event occurs. Accordingly, the multitasking processor temporarily stops executing the first task and starts to execute a second task. The multitasking processor executes a handling process of the interrupt event and sets a switching flag. After finishing the handling process of the interrupt event, the multitasking processor does not perform task switching but continues to execute the first task, and the multitasking processor only performs task switching to execute the second task when it reaches a switching-point instruction in the first task.
Anti-Influenza Drug Discovery: Structure-Activity Relationship and Mechanistic Insight into Novel Angelicin Derivatives
(2010-02-25)
Yeh, Jiann-Yih
;
Coumar, Mohane Selvaraj
;
Horng, Jim-Tong
;
Shiao, Hui-Yi
;
Kuo, Fu-Ming
By using a cell-based high throughput screening campaign,a novel angelicin derivative 6a was identified to inhibit influenza A (H1N1) virus induced Cytopathic effect in Madin-Darby canine kidney cell culture in low micromolar range. Detailed structure-activity relationship studies of 6a revealed that the angelicin scaffold is essential for activity in pharmacophore B, while meta-substituted phenyl/2-thiophene rings are optimal ill pharmacophore A and C. The optimized lead 4-methyl-9-phenyl-8-(thiophene-2-carbonyl)-furo[2,3-h]chromen-2-one (8g, IC(50) = 70 nM) showed 64-fold enhanced activity compared to the high throughput screening (HTS) hit 6a. Also, 8g was found effective in case of influenza A (H3N2) and influenza B virus strains similar to approved anti-influenza drug zanamivir (4). Preliminary mechanistic studies suggest that these compounds act as anti-influenza agents by inhibiting ribonucleoprotein (RNP) complex associated activity and have the potential to be developed further, Which Could form the basis for developing additional defense against influenza pandemics.
The cAMP Receptor-Like Protein CLP Is a Novel c-di-GMP Receptor Linking Cell-Cell Signaling to Virulence Gene Expression in Xanthomonas campestris
(2010-02-26)
Chin, Ko-Hsin
;
Lee, Yen-Chung
;
Tu, Zhi-Le
;
Chen, Chih-Hua
;
Tseng, Yi-Hsiung
Cyclic-di-GMP [bis-(3'-5')-cyclic diguanosine monophosphate] controls a wide range of functions in eubacteria, yet little is known about the underlying regulatory mechanisms. In the plant pathogen Xanthomonas campestris, expression of a subset of virulence genes is regulated by c-di-GMP and also by the CAP (catabolite activation protein)-like protein XcCLP, a global regulator in the CRP/FNR superfamily. Here, we report structural and functional insights into the interplay between XcCLP and c-di-GMP in regulation of gene expression. XcCLP bound target promoter DNA with submicromolar affinity in the absence of any ligand. This DNA-binding capability was abrogated by c-di-GMP, which bound to XcCLP with micromolar affinity. The crystal structure of XcCLP showed that the protein adopted an intrinsically active conformation for DNA binding. Alteration of residues of XcCLP implicated in c-di-GMP binding through modeling studies caused a substantial reduction in binding affinity for the nucleotide and rendered DNA binding by these variant proteins insensitive to inhibition by c-di-GMP. Together, these findings reveal the structural mechanism behind a novel class of c-di-GMP effector proteins in the CRP/FNR superfamily and indicate that XcCLP regulates bacterial virulence gene expression in a manner negatively controlled by the c-di-GMP concentrations. (C) 2009 Elsevier Ltd. All rights reserved.
The Fable of Intermittent Images: On Jacques Ranciere's Theses of Film Aesthetics
(國立陽明交通大學出版社, 2010-03-01)
孫松榮
當代法國思想家賈克•洪希耶以電影的「矛盾寓言」導引出「藝術的再現體制」與「藝術的美學體制」之間共構與間隔的雙重關係。作為延續「藝術思想體制」的電影，其位階的曖昧性在於接續與發展其他藝術範型所共有的古典型態與內容的同時，將差異於再現性與敘事性詩學的純粹感性影像，或更準確而言，將「間隔性影像」體現出來。如此一來，洪希耶將指涉殊異表達性與創置理念模式的電影美學定義，和浪漫主義以降實踐美學變革的藝術範型聯繫在一起。對哲學家而言，這除了是「藝術認同體制」的共同指涉外，更是表徵運動音像的獨特性。本文以為在哲學家的電影美學論述中，「間隔性影像」不僅是敘事詩學與純粹感性共構的微型影像事件，也是錯位於導演作者創作理念的人形物質，更是透過影像潛在變動性對非人性的歷史詩學進行「後設感性」的「寓言」見證。換言之，作為「電影美學力量」的「間隔性影像」即在內在交織、潛在差異與越界移位的電影歷史經驗和「藝術認同體制」中，一方面展現了啟發當代電影分析與理論研究的實質作用；另一方面則是表徵了一種形式共構與重新劃分的挪用能量及勾畫出殊異世界輪廓的方略，並進一步形構思想感性模式的藝術理念。
Electrostatic interactions of arbitrarily dispersed multicoated elliptic cylinders
(2010-03-01)
Kuo, Hsin-Yi
;
土木工程學系
;
Department of Civil Engineering
We propose a theoretical framework for evaluation of electrostatic potentials in an unbounded isotropic matrix containing a number of arbitrarily dispersed elliptic cylinders subjected to a remotely prescribed potential field. The inclusions could be homogeneous or confocally multicoated, and may have different sizes, aspect ratios and different conductivities. The approach is based on a multipole expansion formalism, together with a construction of consistency conditions and translation operators. This procedure generalizes the approach of the classic work of Rayleigh [1] for a periodic array of circular disks or spheres to an arbitrarily dispersion of elliptic cylinders. We combine the methods of complex potentials with a re-expansion formulae and the generalized Rayleigh's formualtion to obtain a complete solution of the many-inclusion problem. We show that the coefficients of field expansions can be written in the form of an infinite set of linear algebraic equations. Numerical results are presented for several configuarions. We further apply the obtained field solutions to determine the effective conductivity of the composite. (C) 2009 Elsevier Ltd. All rights reserved.