Browsing by Issue Date, starting with "2010-10-04"

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Formation of iridium nanocrystals with highly thermal stability for the applications of nonvolatile memory device with excellent trapping ability
(2010-10-04)
Wang, Terry Tai-Jui
;
Chu, Chang-Lung
;
Hsieh, Ing-Jar
;
Tseng, Wen-Shou
;
材料科學與工程學系
This paper presents the formation of iridium nanocrystals (Ir-NCs) embedded in SiO(2) matrix and it can be used for potential applications of nonvolatile memory devices. The NC formation is investigated by varying Ir film thickness; and the thermal agglomeration is also studied by applying various annealing temperatures and process time. The results of systematic characterization including capacitance-voltage, transmission electron microscopy, and x-ray photoelectron spectroscopy show that the high work-function (5.27 eV) metallic-NCs have a highly thermal stability (up to 900 degrees C) and the resulted Al/SiO(2)/Ir-NCs/SiO(2)/Si/Al stack can have a good retention ability and significant hysteresis window of 17.4 V. (C) 2010 American Institute of Physics. [doi:10.1063/1.3498049]
Formation of iridium nanocrystals with highly thermal stability for the applications of nonvolatile memory device with excellent trapping ability
(2010-10-04)
Wang, Terry Tai-Jui
;
Chu, Chang-Lung
;
Hsieh, Ing-Jar
;
Tseng, Wen-Shou
;
材料科學與工程學系
This paper presents the formation of iridium nanocrystals (Ir-NCs) embedded in SiO(2) matrix and it can be used for potential applications of nonvolatile memory devices. The NC formation is investigated by varying Ir film thickness; and the thermal agglomeration is also studied by applying various annealing temperatures and process time. The results of systematic characterization including capacitance-voltage, transmission electron microscopy, and x-ray photoelectron spectroscopy show that the high work-function (5.27 eV) metallic-NCs have a highly thermal stability (up to 900 degrees C) and the resulted Al/SiO(2)/Ir-NCs/SiO(2)/Si/Al stack can have a good retention ability and significant hysteresis window of 17.4 V. (C) 2010 American Institute of Physics. [doi:10.1063/1.3498049]
Structural Basis for the Improved Potency of Peroxisome Proliferator-Activated Receptor (PPAR) Agonists
(2010-10-04)
Peng, Yi-Hui
;
Coumar, Mohane Selvaraj
;
Leou, Jiun-Shyang
;
Wu, Jian-Sung
;
Shiao, Hui-Yi
The need to develop safer and more effective antidiabetic drugs is essential owing to the growth worldwide of the diabetic population. Targeting the PPAR receptor is one strategy for the treatment of diabetes; the PPAR agonists rosiglitazone and pioglitazone are already on the market. Here we report the identification of a potent PPAR agonist, 15, whose PPAR gamma activation was more than 20 times better than that of rosiglitazone. Compound 15 was designed to incorporate an indole head with a carboxylic acid group, and 4-phenylbenzophenone tail to achieve a PPAR gamma EC(50) of 10 nm. Compound 15 showed the most potent PPAR gamma agonist activity among the compounds we investigated. To gain molecular insight into the improved potency of 15, a structural biology study and binding energy calculations were carried out. Superimposition of the X-ray structures of 15 and agonist 10 revealed that, even though they have the same indole head part, they adopt different conformations. The head part of 15 showed stronger interactions toward PPAR gamma; this could be due to the presence of the novel tail part 4-phenylbenzophenone, which could enhance the binding efficiency of 15 to PPAR gamma.
Structural Basis for the Improved Potency of Peroxisome Proliferator-Activated Receptor (PPAR) Agonists
(2010-10-04)
Peng, Yi-Hui
;
Coumar, Mohane Selvaraj
;
Leou, Jiun-Shyang
;
Wu, Jian-Sung
;
Shiao, Hui-Yi
The need to develop safer and more effective antidiabetic drugs is essential owing to the growth worldwide of the diabetic population. Targeting the PPAR receptor is one strategy for the treatment of diabetes; the PPAR agonists rosiglitazone and pioglitazone are already on the market. Here we report the identification of a potent PPAR agonist, 15, whose PPAR gamma activation was more than 20 times better than that of rosiglitazone. Compound 15 was designed to incorporate an indole head with a carboxylic acid group, and 4-phenylbenzophenone tail to achieve a PPAR gamma EC(50) of 10 nm. Compound 15 showed the most potent PPAR gamma agonist activity among the compounds we investigated. To gain molecular insight into the improved potency of 15, a structural biology study and binding energy calculations were carried out. Superimposition of the X-ray structures of 15 and agonist 10 revealed that, even though they have the same indole head part, they adopt different conformations. The head part of 15 showed stronger interactions toward PPAR gamma; this could be due to the presence of the novel tail part 4-phenylbenzophenone, which could enhance the binding efficiency of 15 to PPAR gamma.
交大e-News第080期
(2010-10-05)
Secretariat
;
國立交通大學秘書室
White-emitting phosphors and lighting apparatus using the same
(2010-10-05)
Chen
;
Teng-Ming
;
Chang
;
Chun-Kuei
A phosphor has a general formula of (M1-m-nCemEun)3Al2O5X2, wherein M is at least one selected from the group consisting of Ca, Sr and Ba; and X is at least one selected from the group consisting of Cl and Br, while 0
Effect of impurity scattering on the linear and nonlinear conductances of quasi-one-dimensional disordered quantum wires by asymmetrically lateral confinement
(2010-10-06)
Liu, K. M.
;
Juang, C. H.
;
Umansky, V.
;
Hsu, S. Y.
;
電子物理學系
We have studied the linear conductance and source-drain bias spectroscopies of clean and disordered quantum wires (QWs) against thermal cycling and lateral shifting, which change the impurity configuration. Conductance quantization and the zero bias anomaly (ZBA) are robust in clean QWs. In contrast, disordered QWs show complexities in the ways of conductance resonance, peak splitting and trace crossing in source-drain bias spectroscopies. The experimental results and theoretical predictions are in congruence. Moreover, the resonant state arising from the impurities results in either a single peak or double-splitting peaks in the spectroscopies from the detailed impurity configurations. The resonant splitting peaks are found to influence the ZBA, indicating that a clean QW is crucial for investigating the intrinsic characteristics of the ZBA of QWs.
Effect of impurity scattering on the linear and nonlinear conductances of quasi-one-dimensional disordered quantum wires by asymmetrically lateral confinement
(2010-10-06)
Liu, K. M.
;
Juang, C. H.
;
Umansky, V.
;
Hsu, S. Y.
;
電子物理學系
We have studied the linear conductance and source-drain bias spectroscopies of clean and disordered quantum wires (QWs) against thermal cycling and lateral shifting, which change the impurity configuration. Conductance quantization and the zero bias anomaly (ZBA) are robust in clean QWs. In contrast, disordered QWs show complexities in the ways of conductance resonance, peak splitting and trace crossing in source-drain bias spectroscopies. The experimental results and theoretical predictions are in congruence. Moreover, the resonant state arising from the impurities results in either a single peak or double-splitting peaks in the spectroscopies from the detailed impurity configurations. The resonant splitting peaks are found to influence the ZBA, indicating that a clean QW is crucial for investigating the intrinsic characteristics of the ZBA of QWs.
有恨無悔的愛情：《羅密歐與茱麗葉》
(2010-10-06)
彭鏡禧
;
開放教育推動中心
;
Open Education Office
課程首頁本課程是由交通大學新文藝復興閱讀計畫提供。 96 年 8 月當各大學紛紛摩拳擦掌準備迎接新生的同時，交通大學校長吳重雨則因為一則來自於七月份泰晤士報，有關於英國首相布朗公布其夏日讀書清單的新聞中，看到了他對知識的尊重。在這同時，吳重雨校長也思考著，要如何為學生準備追求知識的環境和激發他們對知識的尊重與喜愛。台積電張忠謀董事長曾陳述他 18 歲進入哈佛那一年，博覽文史哲理工經典群籍，至此奠定了他求知的基礎，並借海明威名言，將其改為「哈佛這一年為人生可帶走的盛宴。」吳重雨校長以張董事長的學習為借鏡，認為學生固然能藉由自我閱讀的方式學習到豐沛的知識，但透過名人、大師親臨現場地介紹經典書籍，更能加深學子們對於書籍的認識與興趣，這也是「新文藝復興閱讀計劃」 ( 以下簡稱 : 「經典名著選讀」 ) 活動展開籌劃的緣由。於是，吳重雨校長便積極敦請「交大通識教育委員會」，接手籌備本計劃的相關活動，而該中心也成為實際施行本計畫的策動、開課以及認證單位。至此，期許交大學子藉由閱讀、聽講來提昇人文素養、開拓視野的「新文藝復興閱讀計劃」，就此展開。
Site-Selective Reaction of Cl plus Propene in Solid para-Hydrogen: Formation of 2-Chloropropyl Radicals
(2010-10-07)
Amicangelo, Jay C.
;
Lee, Yuan-Pern
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應用化學系
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應用化學系分子科學碩博班
;
Department of Applied Chemistry
The reaction of chlorine atoms with propene in a solid para-hydrogen matrix has been studied using infrared spectroscopy. For the Cl atom addition, reaction, we find that the only observed isomer of the chloropropyl radical is the 2-chloropropyl and not the 1-chloropropyl radical, indicating that the addition of the Cl atom to the carbon-carbon double bond of propene occurs primarily at the central carbon atom. This is in sharp contrast to the generally accepted mechanism in organic chemistry and in gas-phase reactions in which the addition to the terminal carbon atom is greatly favored. This unique selectivity is possibly due to steric effects in solid para-hydrogen, in which the complex of Cl(2) and propene are positioned so that the reacting Cl atom is closer to the central versus the terminal carbon atom of propene. One might be able to make use of this unique property to perform selective chemistry.
METHOD FOR GROWING GROUP III-V NITRIDE FILM AND STRUCTURE THEREOF
(2010-10-07)
LEE, Wei I
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Huang, Hsin Hsiung
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Chen, Kuei Ming
;
Yeh, Yen Hsien
A method for growing a Group III-V nitride film and a structure thereof are presented. The method is carried out by hydride vapor phase epitaxy (HVPE). The method includes the steps of, inter alia, slowly epitaxially growing a temperature ramping nitride layer on a substrate by rising a first growth temperature of 900-950° C. to a second growth temperature of 1000-1050° C. at a temperature-rising rate of 0.5-10° C./min. The lattice quality of the temperature ramping nitride layer is slowly transformed with the layer height, so that a stress induced by lattice mismatch between a sapphire substrate and a gallium nitride (GaN) layer is relieved.
PIXEL DRIVING STRUCTURE OF DISPLAYING THREE COLORS OF PARTICLE DISPLAY AND ITS DISPLAYING COLORS METHOD
(2010-10-07)
Fan, Shih-Kang
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Chiu, Cheng-Pu
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Hsu, Ching-Hsiang
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Mo, Chi-Neng
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Chiang, Mei-Tsao
A pixel driving structure of a particle display displaying three colors and a method for displaying colors thereof are provided. The pixel driving structure includes a first substrate; a first electrode layer disposed on a surface of the first substrate; a second substrate dispoed opposite to the first substrate; a second electrode layer on the second substrate; a particle solution disposed between the first electrode layer and the second electrode layer and having a first color solution, a plurality of second color positive particles, and a plurality of third color negative particles; and an alternating/direct power supply connecting with the first and second electrode layers. A method for displaying color includes steps of applying an alternating voltage to display a first color; applying a first direct voltage to display a third color; and applying a second direct voltage to display a second color.
独立温度制御付き成形構造とその成形方法
(2010-10-07)
陳仁浩
;
劉安誠
【課題】本発明は、離型工程中、熱溶融材料の熱応力を解消できる独立温度制御付き成形構造を提供する。【解決手段】本発明は、成形過程の冷却、離型の際に、熱溶融材料が収縮する性質に関し、独立温度制御を備えた成形構造において、金型の表面に埋め込まれた電熱線を設けた成形構造である。金型の表面温度を調節することにより、熱溶融材料と金型の間に生じる熱応力を解消し、バランスをとることができ、離型工程中に熱溶融材料を保持力によるダメージから守る。【選択図】図２
Crystal Structures of Bacillus cereus NCTU2 Chitinase Complexes with Chitooligomers Reveal Novel Substrate Binding for Catalysis A CHITINASE WITHOUT CHITIN BINDING AND INSERTION DOMAINS
(2010-10-08)
Hsieh, Yin-Cheng
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Wu, Yue-Jin
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Chiang, Tzu-Ying
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Kuo, Chueh-Yuan
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Shrestha, Keshab Lal
Chitinases hydrolyze chitin, an insoluble linear polymer of N-acetyl-D-glucosamine (NAG)(n), into nutrient sources. Bacillus cereus NCTU2 chitinase (ChiNCTU2) predominantly produces chitobioses and belongs to glycoside hydrolase family 18. The crystal structure of wild-type ChiNCTU2 comprises only a catalytic domain, unlike other chitinases that are equipped with additional chitin binding and insertion domains to bind substrates into the active site. Lacking chitin binding and chitin insertion domains, ChiNCTU2 utilizes two dynamic loops (Gly-67-Thr-69 and Ile-106-Val-112) to interact with (NAG)(n), generating novel substrate binding and distortion for catalysis. Gln-109 is crucial for direct binding with substrates, leading to conformational changes of two loops with a maximum shift of similar to 4.6 angstrom along the binding cleft. The structures of E145Q, E145Q/Y227F, and E145G/Y227F mutants complexed with (NAG)(n) reveal (NAG)(2), (NAG)(2), and (NAG)(4) in the active site, respectively, implying various stages of reaction: before hydrolysis, E145G/Y227F with (NAG)(4); in an intermediate state, E145Q/Y227F with a boat-form NAG at the -1 subsite, -1-(NAG); after hydrolysis, E145Q with a chair form -1-(NAG). Several residues were confirmed to play catalytic roles: Glu-145 in cleavage of the glycosidic bond between -1-(NAG) and -1-(NAG); Tyr-227 in the conformational change of -1-(NAG); Asp-143 and Gln-225 in stabilizing the conformation of -1-(NAG). Additionally, Glu-190 acts in the process of product release, and Tyr-193 coordinates with water for catalysis. Residues Asp-143, E145Q, Glu190, and Tyr-193 exhibit multiple conformations for functions. The inhibitors zinc ions and cyclo-(L-His-L-Pro) are located at various positions and confirm the catalytic-site topology. Together with kinetics analyses of related mutants, the structures of ChiNCTU2 and its mutant complexes with (NAG)(n) provide new insights into its substrate binding and the mechanistic action.
Crystal Structures of Bacillus cereus NCTU2 Chitinase Complexes with Chitooligomers Reveal Novel Substrate Binding for Catalysis A CHITINASE WITHOUT CHITIN BINDING AND INSERTION DOMAINS
(2010-10-08)
Hsieh, Yin-Cheng
;
Wu, Yue-Jin
;
Chiang, Tzu-Ying
;
Kuo, Chueh-Yuan
;
Shrestha, Keshab Lal
Chitinases hydrolyze chitin, an insoluble linear polymer of N-acetyl-D-glucosamine (NAG)(n), into nutrient sources. Bacillus cereus NCTU2 chitinase (ChiNCTU2) predominantly produces chitobioses and belongs to glycoside hydrolase family 18. The crystal structure of wild-type ChiNCTU2 comprises only a catalytic domain, unlike other chitinases that are equipped with additional chitin binding and insertion domains to bind substrates into the active site. Lacking chitin binding and chitin insertion domains, ChiNCTU2 utilizes two dynamic loops (Gly-67-Thr-69 and Ile-106-Val-112) to interact with (NAG)(n), generating novel substrate binding and distortion for catalysis. Gln-109 is crucial for direct binding with substrates, leading to conformational changes of two loops with a maximum shift of similar to 4.6 angstrom along the binding cleft. The structures of E145Q, E145Q/Y227F, and E145G/Y227F mutants complexed with (NAG)(n) reveal (NAG)(2), (NAG)(2), and (NAG)(4) in the active site, respectively, implying various stages of reaction: before hydrolysis, E145G/Y227F with (NAG)(4); in an intermediate state, E145Q/Y227F with a boat-form NAG at the -1 subsite, -1-(NAG); after hydrolysis, E145Q with a chair form -1-(NAG). Several residues were confirmed to play catalytic roles: Glu-145 in cleavage of the glycosidic bond between -1-(NAG) and -1-(NAG); Tyr-227 in the conformational change of -1-(NAG); Asp-143 and Gln-225 in stabilizing the conformation of -1-(NAG). Additionally, Glu-190 acts in the process of product release, and Tyr-193 coordinates with water for catalysis. Residues Asp-143, E145Q, Glu190, and Tyr-193 exhibit multiple conformations for functions. The inhibitors zinc ions and cyclo-(L-His-L-Pro) are located at various positions and confirm the catalytic-site topology. Together with kinetics analyses of related mutants, the structures of ChiNCTU2 and its mutant complexes with (NAG)(n) provide new insights into its substrate binding and the mechanistic action.
用「試穿」認識世川
(2010-10-10)
蔡妙鈴
;
Department of Communication and Technology
;
傳播與科技學系
喜歡可以試穿是一種生活態度--勇於嘗試更多彩、更多樣的生活態度。 2010的夏天，來自台東的陳世川提著擺滿彩色T-shirt的旅行箱，在各個城市的誠品書店親力親為地宣傳他的首張個人專輯《喜歡可以試穿》，真誠地吟唱著他對音樂以及生活的熱愛。
被中國政府扭轉的人生
(2010-10-10)
張瑜庭
;
Department of Communication and Technology
;
傳播與科技學系
來自德國的交換學生 David Demes，帶著簡單的行李與他的故事來到台灣。一個看似平凡的大學生，究竟藏了什麼樣的祕密呢？
藝術屬於誰？
(2010-10-10)
劉芮菁
;
Department of Communication and Technology
;
傳播與科技學系
藝術是人類熱愛美學的證明，也是文化內部的高度成就。在古代，藝術屬於上層階級的生活內涵，只有吃得飽、穿得暖的人才有機會踏上追求美學的道路。而在民主化、大眾化的現代社會裡，各種各樣的音樂、繪畫、文學藝術也走進一般民眾的生活，豐富了次文化現象。然而，在大眾當道的社會下，通往藝術的道路仍有所限制，無形中，經濟能力似乎部分決定了接觸它的人們。
To wait or not to wait ？
(2010-10-10)
劉怡潔
;
Department of Communication and Technology
;
傳播與科技學系
想要在一天之內環遊世界，並不像想像中那麼困難。2010上海世博會，在今年五月熱鬧展開，吸引兩百多個國家與組織參展，每個國家使出渾身解數，想讓全世界的人認識他們，向全球展現自己的國力。但是，來自世界各地的遊客們，想要在人潮洶湧的世博園區內殺出一條血路，一窺心目中想參觀的場館可不是那麼容易，頂著四十度的高溫、看著前方永無止盡的排隊人龍，雖然心中想放棄的念頭不斷興起，遊客們卻仍發揮出野草一般的韌性，等待著……。
傳統藝陣創新風格
(2010-10-10)
王雅涵
;
Department of Communication and Technology
;
傳播與科技學系
台灣寺廟密度高，平均每鄉鎮擁有32座寺廟，這主要是歸因於早期移民以寺廟、宗廟為中心聚集，宗教和家族、地方緊密集合。因此，由迎神賽會所衍生出的種種廟會文化，久而久之也成為地方間比拚的重點。台灣話裡有一句「輸人不輸陣，輸陣就歹看面」，點出酬神活動的藝陣，在過去是等同於鄉里間重大的藝文交流活動。如今藝陣逐漸改良，並自成一門精緻的民俗藝術。