Browsing by Issue Date, starting with "2011-10-21"

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Desymmetrization of 2,4,5,6-Tetra-O-benzyl-D-myo-inositol for the Synthesis of Mycothiol
(2011-10-21)
Chung, Chuan-Chung
;
Zulueta, Medel Manuel L.
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Padiyar, Laxmansingh T.
;
Hung, Shang-Cheng
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應用化學系
An efficient chemical synthesis of mycothiol Involving the regioselective ketopinyl desymmetrization of 2,4,5,6-tetrabenzylated D-myo-inositol as the key step Is described. Together with a highly alpha-stereoselective D-glucosaminylation, the whole procedure was accomplished in eight steps with an overall yield of 40%.
Compact dual-passband microstrip bandpass filters with larger design flexibility and multi-spurious suppression
(2011-10-21)
Chang, L-M.
;
Jiang, M.
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電子工程學系及電子研究所
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Department of Electronics Engineering and Institute of Electronics
Compact folded stepped impedance resonators (SIRs) with a novel asymmetric structure are used to design dual-passband filters with multi-spurious suppression. A complete design procedure enhancing both overall design flexibility and suppressing spurious responses is detailed. The new asymmetric SIR structure can effectively increase the degree of freedom (DOF) in the dual-passband bandwidth design. Extra DOF is simultaneously incorporated so that transmission zeros of the coupling stages may be adjusted to suppress unwanted spurious responses. Owing to circuit symmetry and a short coupling length, the circuit can be easily folded and the size is decreased by 62% compared with the previous work. The measured results agree well with the simulation and show that the attenuation level of the upper stopband is greater than 30 dB up to more than 20 GHz (8.16f(0)).
A specific and ratiometric chemosensor for Hg2+ based on triazole coupled ortho-methoxyphenylazocalix[4]arene
(2011-10-21)
Wang, Nae-Jen
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Sun, Chung-Ming
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Chung, Wen-Sheng
;
應用化學系
;
Department of Applied Chemistry
Calix[4]arene 3, which contains two distal triazole groups on the lower rim and two distal o-methoxyphenylazo groups on the upper rim, was synthesized and found to be a specific and ratiometric sensor for Hg2+ in a polar protic solvent. A series of o-methoxyphenylazo derivatives (3, 4, 5, 7, and 9) were synthesized, which proved that the lower-rim triazoles and the hydroxyl azophenol(s) were the major ligands for metal ion binding. Though analogues 4 and 10 showed some sensitivity for Hg2+, compound 3 was the only ratiometric chemosensor for Hg2+ among the series of azocalix[4]arenes synthesized in this work. The formation of 3. Hg2+ complex was supported by UV/vis and NMR titration studies and Mass spectrometry. Based on the symmetrical features of NMR spectra of 3 center dot Hg2+, the complex is believed to be symmetrical with respect to the calix[4]arene cavity. Furthermore, the complex was determined to be 1:1 binding stoichiometry by Job's plot, and the association constant was determined to be 4.02 x 10(3) M-1 using Benesi-Hildebrand plot. (C) 2011 Elsevier Ltd. All rights reserved.
Thieno[3,2-b]pyrrolo Donor Fused with Benzothiadiazolo, Benzoselenadiazolo and Quinoxalino Acceptors: Synthesis, Characterization, and Molecular Properties
(2011-10-21)
Cheng, Yen-Ju
;
Chen, Chiu-Hsiang
;
Ho, Yu-Ju
;
Chang, Shu-Wei
;
Witek, Henryk A.
Nitrogen-bridged donor acceptor multifused dithienopyrrolobenzothladiazole (DTPBT) and dibenzothiadiazolopyrrolothlophene (DBTPT) were successfully synthesized by intramolecular Cadogan annulation. The electron-deficient benzothiadiazole unit In DTPBT can be converted to benzoselenadiazole and quinoxaline moieties through reduction/cyclization to generate dithienopyrrolobenzoselenadiazole (DTPBSe) and dithienopyrroloquinoxaline (DTPQX), respectively. The nitrogen atoms function as the bridges for covalent planarization to induce intermolecular interaction and intramolecular charge transfer.
A specific and ratiometric chemosensor for Hg(2+) based on triazole coupled ortho-methoxyphenylazocalix[4]arene
(2011-10-21)
Wang, Nae-Jen
;
Sun, Chung-Ming
;
Chung, Wen-Sheng
;
應用化學系
;
Department of Applied Chemistry
Calix[4]arene 3, which contains two distal triazole groups on the lower rim and two distal o-methoxyphenylazo groups on the upper rim, was synthesized and found to be a specific and ratiometric sensor for Hg(2+) in a polar protic solvent. A series of o-methoxyphenylazo derivatives (3, 4, 5, 7, and 9) were synthesized, which proved that the lower-rim triazoles and the hydroxyl azophenol(s) were the major ligands for metal ion binding. Though analogues 4 and 10 showed some sensitivity for Hg(2+), compound 3 was the only ratiometric chemosensor for Hg(2+) among the series of azocalix[4]arenes synthesized in this work. The formation of 3. Hg(2+) complex was supported by UV/vis and NMR titration studies and Mass spectrometry. Based on the symmetrical features of NMR spectra of 3 center dot Hg(2+), the complex is believed to be symmetrical with respect to the calix[4]arene cavity. Furthermore, the complex was determined to be 1:1 binding stoichiometry by Job's plot, and the association constant was determined to be 4.02 x 10(3) M(-1) using Benesi-Hildebrand plot. (C) 2011 Elsevier Ltd. All rights reserved.
Computational analysis of a novel mutation in ETFDH gene highlights its long-range effects on the FAD-binding motif
(2011-10-21)
Er, Tze-Kiong
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Chen, Chih-Chieh
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Liu, Yen-Yi
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Chang, Hui-Chiu
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Chien, Yin-Hsiu
Background: Multiple acyl-coenzyme A dehydrogenase deficiency (MADD) is an autosomal recessive disease caused by the defects in the mitochondrial electron transfer system and the metabolism of fatty acids. Recently, mutations in electron transfer flavoprotein dehydrogenase (ETFDH) gene, encoding electron transfer flavoprotein: ubiquinone oxidoreductase (ETF:QO) have been reported to be the major causes of riboflavin-responsive MADD. To date, no studies have been performed to explore the functional impact of these mutations or their mechanism of disrupting enzyme activity. Results: High resolution melting (HRM) analysis and sequencing of the entire ETFDH gene revealed a novel mutation (p.Phe128Ser) and the hotspot mutation (p.Ala84Thr) from a patient with MADD. According to the predicted 3D structure of ETF: QO, the two mutations are located within the flavin adenine dinucleotide (FAD) binding domain; however, the two residues do not have direct interactions with the FAD ligand. Using molecular dynamics (MD) simulations and normal mode analysis (NMA), we found that the p. Ala84Thr and p.Phe128Ser mutations are most likely to alter the protein structure near the FAD binding site as well as disrupt the stability of the FAD binding required for the activation of ETF: QO. Intriguingly, NMA revealed that several reported disease-causing mutations in the ETF: QO protein show highly correlated motions with the FAD-binding site. Conclusions: Based on the present findings, we conclude that the changes made to the amino acids in ETF: QO are likely to influence the FAD-binding stability.
靜電放電防護裝置以及積體電路
(2011-10-21)
柯明道
;
顏承正
;
陳東暘
一種積體電路，包括一核心電路以及一靜電放電防護裝置。核心電路耦接於一第一電源線及一第二電源線之間。靜電放電防護裝置包括，一放電元件、一第一偵測電路以及一第二偵測電路。當放電元件被致能時，則在一第一及第二電源線之間提供一放電路徑，當放電元件被禁能時，則停止提供放電路徑。第一偵測電路耦接於第一及第二電源線之間。當第一電源線發生一靜電放電事件時，則第一偵測電路致能放電元件。當第一電源線未發生靜電放電事件時，則第二偵測電路禁能放電元件。
時光的採集者　叮咚
(2011-10-23)
陳燕珩
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Department of Communication and Technology
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傳播與科技學系
在數位相機盛行、許多人爭相學習攝影技術的現在，叮咚（李建廷）選擇用底片相機紀錄生活中的片刻。攝影之路十年走來，不刻意專研艱深的攝影理論，也沒有專業複雜的攝影器材輔助，他憑著對底片膠卷的熱愛，與按下快門的勇氣，用照片傳達出簡單而深刻的生活態度。
人生的歌
(2011-10-23)
楊雅涵
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Department of Communication and Technology
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傳播與科技學系
人的一生有許多旋律，但在眾多音符中，總有幾個主要符號，他們扮演重要的角色，在生命中來回出現，牽動情緒。
曾御欽　無懼的錄像青春
(2011-10-23)
陳琦
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Department of Communication and Technology
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傳播與科技學系
我的腦子是一片森林，裡面住著很多的怪獸，怪獸碰在一起時，會交往甚至交配生產，小怪獸們會一起去搭場景慶祝，那些場景就是我作品的畫面。
「哥哥姐姐」真偉大
(2011-10-23)
陳奕儒
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Department of Communication and Technology
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傳播與科技學系
最近在網路上有一個奇怪的趨勢，那就是出現了一堆「哥哥姐姐」。無論是身懷絕技的素人，還是社會上的奇人軼事，只要被網友PO上網路，很快地就被冠上什麼哥什麼姐。
迷你購物狂　為之發狂
(2011-10-23)
李安媞
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Department of Communication and Technology
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傳播與科技學系
麗貝卡原以為可以把女兒打扮得漂漂亮亮以引起其他媽媽的讚嘆，殊不知米妮是個難以控制的小女孩。她看到什麼就想擁有，似乎跟她媽媽很像，難道購物慾是會遺傳的？
米粉貢丸節丸味粉時尚
(2011-10-23)
戴子嘉
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Department of Communication and Technology
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傳播與科技學系
2011新竹市米粉摃丸節已經舉辦到了第九屆，參加的店家越來越踴躍，而且摃丸和米粉業者也一直隨著新的飲食習慣不斷推陳出新，以「百年丸味粉時尚」為題，結合時下最受歡迎的APP來推廣新竹的傳統美食──米粉與貢丸。
人與人　那些我們將懂的
(2011-10-23)
胡乃文
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Department of Communication and Technology
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傳播與科技學系
不奢求在所有人面前表現完美，只希望在對的人面前有對的樣子。要珍惜那種無與倫比的默契，還有你隨時的樣子。
你是乙男還是蟻女
(2011-10-23)
嚴芷茵
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Department of Communication and Technology
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傳播與科技學系
如果對日本文化有深厚興趣，但看日劇又看不懂一堆日本專有名詞的話，卻又苦無門路，《乙男蟻女》絕對可以帶領你進入你所不太瞭解的日本，這本書就是另類的詞典。
走過青春的六弦時光
(2011-10-23)
蘇冠心
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Department of Communication and Technology
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傳播與科技學系
日子像風吹過曬衣繩上的白Ｔ恤，一眨眼就這樣啪搭搭過去了。高中畢業後，偶爾我還是會想起這些歌，那些彈吉他的時光像散場電影讓人流連忘返，而只為了那首歌存在於當時時空的我們已然逝去。
琴音猶存　指腹下的溫度　
(2011-10-23)
顏伊婷
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Department of Communication and Technology
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傳播與科技學系
「為什麼姊姊就可以學鋼琴？不公平啦！我不管，我也要學鋼琴！」從小體內就有著一股不服輸的傲氣。直到現在回想起來，便忍不住對當時誇下海口的自己會心一笑。
大師經典重現　流浪者之歌
(2011-10-23)
王升含
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Department of Communication and Technology
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傳播與科技學系
隨著古典音樂最後一位大師馬勒（Gustav Mahler）逝世一百週年，加拿大籍的次女高音 Julie Boulianne 今年秋天發行了她在 ATMA 唱片錄製的首張專輯〈流浪者之歌〉（Lieder eines fahrenden Gesellen）。
眼裡藏不住的秘密
(2011-10-23)
林彥伶
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Department of Communication and Technology
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傳播與科技學系
眼神真的會說話嗎？如何穿透眼神深入人的內心？《謎樣的雙眼》以一樁殘忍的強暴殺人案件與一段埋藏二十五年刻骨銘心的愛情，拼湊出過去與現實交錯的故事。
奧妙人聲　挑逗你的耳
(2011-10-23)
劉玉蘋
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Department of Communication and Technology
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傳播與科技學系
知名德國人聲樂團Tonalrausch，今年再度來台參加國際賽並進行巡迴演出，其音樂會曲風多變，高潮迭起，為台灣藝術界注入一筆新氣象。