Browsing by Issue Date, starting with "2012-01-31"

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Operating method and circuit for low density parity check (LDPC) decoder
(2012-01-31)
Liu Chih-Hao
;
Liao Yen-Chin
;
Lee Chen-Yi
;
Chang Hsie-Chia
;
Hsu Yarsun
An operating method and a circuit for low density parity check (LDPC) decoders, in which original bit nodes are incorporated into check nodes for simultaneous operation. The bit node messages are generated according to the difference between the newly generated check messages and the previous check node messages. The bit node messages can be updated immediately, and the decoder throughput can be improved. The required memory of LDPC decoders can be effectively reduced, and the decoding speed can also be enhanced.
BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML
(2012-01-31)
Lin, W-H
;
Jiaang, W-T
;
Chen, C-W
;
Yen, K-J
;
Hsieh, S-Y
BACKGROUND: Activating mutations of Fms-like tyrosine kinase 3 (FLT3) constitute a major driver in the pathogenesis of acute myeloid leukaemia (AML). Hence, pharmacological inhibitors of FLT3 are of therapeutic interest for AML. METHODS: The effects of inhibition of FLT3 activity by a novel potent FLT3 inhibitor, BPR1J-097, were investigated using in vitro and in vivo assays. RESULTS: The 50% inhibitory concentration (IC50) of BPR1J-097 required to inhibit FLT3 kinase activity ranged from 1 to 10 nM, and the 50% growth inhibition concentrations (GC(50)s) were 21 +/- 7 and 46 +/- 14 nM for MOLM-13 and MV4-11 cells, respectively. BPR1J-097 inhibited FLT3/signal transducer and activator of transcription 5 phosphorylation and triggered apoptosis in FLT3-driven AML cells. BPR1J-097 also showed favourable pharmacokinetic property and pronounced dose-dependent tumour growth inhibition and regression in FLT3-driven AML murine xenograft models. CONCLUSION: These results indicate that BPR1J-097 is a novel small molecule FLT-3 inhibitor with promising in vivo anti-tumour activities and suggest that BPR1J-097 may be further developed in preclinical and clinical studies as therapeutics in AML treatments. British Journal of Cancer (2012) 106, 475-481. doi: 10.1038/bjc.2011.564 www.bjcancer.com Published online 20 December 2011 (C) 2012 Cancer Research UK
pH-Sensitive Pegylated Cationic Lipid-DNA Complexes for Gene Delivery: Transfection Efficiency and Live Cell Imaging Studies
(2012-01-31)
Chan, Chia-Ling
;
Majzoub, Ramsey
;
Shirazi, Rahau S.
;
Liang, Keng-San
;
Ewert, Kai K.
Folding Thermodynamics of a Beta-Hairpin Peptide: A Theoretical Study
(2012-01-31)
Tsai, Min-Yeh
;
Yuan, Jian-Min
;
Teranishi, Yoshiaki
;
Lin, Sheng-Hsien
;
交大名義發表
High-Order Correlated Motion in Single-Molecule Human Adenylate Kinase 1
(2012-01-31)
Lin, Chien Y.
;
Huang, Jung Y.
;
Lo, Leu-Wei
;
光電工程學系
;
Department of Photonics
Effect of number of tube rows on the air-side performance of crimped spiral fin-and-tube heat exchanger with a multipass parallel and counter cross-flow configuration
(2012-01-31)
Pongsoi, Parinya
;
Pikulkajorn, Santi
;
Wang, Chi-Chuan
;
Wongwises, Somchai
;
機械工程學系
The air-side performance of crimped spiral fin and tube heat exchangers at high Reynolds number (3000-13,000) is investigated in this study. The test heat exchangers have a new type of multipass parallel and counter cross-flow water flow arrangement which is a combination of parallel cross-flow and counter cross-flow. The test samples are made from copper and aluminium with different number of tube rows (N-row = 2, 3, 4 and 5). The effects of number of tube rows and fin material on the heat transfer and friction characteristics are studied. The results show that no significant effect for either number of tube rows or fin materials on the heat transfer performance is found at high Reynolds number. In addition, the correlation of the air-side performances of this type of the heat exchangers at high Reynolds number is developed for industrial applications. (c) 2011 Elsevier Ltd. All rights reserved.
Rapid Detection and Quantification of Enterovirus 71 by Electrochemical Impedance Spectroscopy
(2012-01-31)
Li, Hsing-Yuan
;
Yang, Jyh-Yuan
;
Cheng, Tsia-Mu
;
Tseng, Shin-Hua
;
Chang, Chia-Ching
Transient oscillatory saturated flow boiling heat transfer and associated bubble characteristics of FC-72 over a small heated plate due to heat flux oscillation
(2012-01-31)
Wang, S. L.
;
Chen, C. A.
;
Lin, Y. L.
;
Lin, T. F.
;
機械工程學系
An experiment is carried out here to investigate the transient oscillatory boiling heat transfer and associated bubble characteristics of FC-72 flow over a small circular plate subject to a time varying heat flux with the plate flush mounted on the bottom of a horizontal rectangular channel. At the inlet the flow is maintained at saturated liquid state with zero vapor quality. The imposed heat flux oscillates periodically with time in the form of rectangular waves. In the experiment the FC-72 mass flux G varies from 300 to 400 kg/m(2)s, mean imposed heat flux (q) over bar ranges from 0 to 10 W/cm(2) and the amplitude of the heat flux oscillation Delta q is fixed at 10-50% of (q) over bar with the period of the heat flux oscillation varied from 10 to 30 s. The experimental results show that the time-averaging FC-72 oscillatory boiling heat transfer characteristics resemble that for stable flow boiling. However, the imposed heat flux oscillation causes significant temporal oscillations in the heated plate temperature, boiling heat transfer coefficient, bubble departure diameter and frequency, and active nucleation site density. These physical quantities oscillate at the same frequency as the heat flux oscillation and at a higher (q) over bar, a larger Delta q/(q) over bar, and a longer t(p) they exhibit stronger oscillations. Besides, a slight time lag in T-w oscillation is seen. Moreover, the size of departing bubbles, active nucleation site density and bubble departure frequency decrease as the heat flux is reduced to the low level of (q) over bar - Delta q. The opposite processes take place for the heat flux raised to the high level of (q) over bar + Delta q. Furthermore, at the mean imposed heat flux close to that for the ONB in the stable boiling we observe intermittent boiling in the flow. A regime map is provided to delineate the boundaries among single-phase liquid flow, intermittent boiling and persistent boiling. (C) 2011 Elsevier Ltd. All rights reserved.
Leaping iterative composition method of complicated graphic and storage medium having computer program executing the same
(2012-01-31)
Chen Ming-Jang
A leaping iterative composition method of a complicated graphic and a storage medium having a computer program executing the same are described. First, an initiator and generators are set. After several times of iterating, a transitional object is formed. Then, a leaping recursion is performed based on this transitional object. When performing the leaping recursion, a generator of each of the iterations is designed by a single pattern converted from a structural result of a previous iteration added with a base object. Since the result of each of the iterations keeps the original structure, the structure is used as the input initiator. The initiator of the first iteration can be a feature of different iteration objects. Since the input structure of iterations are the same, the advantage of reducing computing resources and avoid system overload are reachable.
Energy Landscape Evolution of Single-Molecule Protein Guided by Conformational Fluctuation
(2012-01-31)
Lin, Chien Y.
;
Huang, June Y.
;
Lo, Leu-Wei
;
光電工程學系
;
Department of Photonics
Effect of compressive stress on nickel-induced lateral crystallization of amorphous silicon thin films
(2012-01-31)
Huang, S. Y.
;
Lin, H. L.
;
Chao, C. G.
;
Liu, T. F.
;
材料科學與工程學系
The present study describes a method enabling the metal-induced lateral crystallization (MILC) of amorphous silicon (a-Si) films. Glass substrates coated with a-Si films were contacted with ground nickel sheets under compressive stresses ranging from 3.7 to 265.8 MPa at 550 degrees C for 1 h. Subsequently, the nickel sheet and stress were removed and the specimens were annealed at 550 degrees C for 1 to 4 h. The experimental results indicate that the extent of MILC decreased when the preliminary compressive stress was increased, while all specimens exhibited the same rate of lateral crystallization during annealing. The present study indicates that, by applying an appropriate compressive stress (similar to 4 MPa), an effective method to reduce the residual Ni content in polycrystalline silicon (poly-Si) can be obtained. (C) 2011 Published by Elsevier B.V.
Ultrathin limit and dead-layer effects in local polarization switching of BiFeO3
(2012-01-31)
Maksymovych, Peter
;
Huijben, Mark
;
Pan, Minghu
;
Jesse, Stephen
;
Balke, Nina
Using piezoresponse force microscopy in an ultrahigh vacuum, polarization switching has been detected and quantified in epitaxial BiFeO3 films from 200 to about 4 unit cells thick. Local remnant piezoresponse was utilized to probe both ferroelectric properties and effects of imperfect electrical contacts. It was found that the shape of electromechanical hysteresis loops is strongly influenced by an extrinsic dielectric gap, primarily through the suppressing effect of the depolarizing field on the spontaneous polarization in the ultrathin films. Furthermore, statistical analysis of the hysteresis loops has revealed lateral variation of the extrinsic dielectric gap with sub-10-nm resolution. Robust and reproducible ferroelectric properties of nanoscale BiFeO3 indicate its potential for nanoscale applications in information storage and spintronics.
Folding and Characterization of Intrinsically Disordered Protein Human Cyclin I (Ccni)
(2012-01-31)
Chu, Hsueh-Liang
;
Cheng, Tsai-Mu
;
Li, Hsing-Yuan
;
Chang, Chia-Ching
;
交大名義發表
pH-Sensitive Pegylated Cationic Lipid-DNA Complexes for Gene Delivery: Transfection Efficiency and Live Cell Imaging Studies
(2012-01-31)
Chan, Chia-Ling
;
Majzoub, Ramsey
;
Shirazi, Rahau S.
;
Liang, Keng-San
;
Ewert, Kai K.
Magnetic and Metal Binding Structural Analysis of Mn,Zn-Metallothionein-Green Fluorescence Fusion Protein
(2012-01-31)
Chen, Ting-Kai
;
Lin, Yin-Chih
;
Chen, Yu-Chen
;
Chen, Yen-Lin
;
Tseng, Wei-Lun
Functional Characterization of Glycine N-Methyltransferase and Its Interactive Protein DEPDC6/DEPTOR in Hepatocellular Carcinoma
(2012-02-01)
Yen, Chia-Hung
;
Lu, Yao-Cheng
;
Li, Chung-Hsien
;
Lee, Cheng-Ming
;
Chen, Chia-Yen
Glycine N-methyltransferase (GNMT) is a tumor suppressor for hepatocellular carcinoma (HCC). High rates of Gnmt knockout mice developed HCC. Epigenetic alteration and dysregulation of several pathways including wingless-type MMTV integration site (Wnt), mitogen-activated protein kinase (MAPK) and Janus kinase and signal transducer and activator of transcription (JAK-STAT) are associated with HCC development in Gnmt knockout mice. We hypothesized that GNMT may regulate signal transduction through interacting with other proteins directly. In this report, we identified a mammalian target of rapamycin (mTOR) inhibitor (DEP domain containing MTOR-interacting protein (DEPDC6/DEPTOR)) as a GNMT-binding protein by using yeast two-hybrid screening. Fluorescence resonance energy transfer assay demonstrated that the C-terminal half of GNMT interact with the PSD-95/DIg1/ZO-1 (PDZ) domain of DEPDC6/DEPTOR. Immunohistochemical staining showed that 27.5% (14/51) of HCC patients had higher expression levels of DEPDC6/DEPTOR in the tumorous tissues than in tumor-adjacent tissues, especially among HCC patients with hepatitis B viral infection (odds ratio 10.3, 95% confidence interval (CI) 1.05-11.3) or patients with poor prognosis (death hazard ratio 4.51, 95% CI 1.60-12.7). In terms of molecular mechanism, knockdown of DEPDC6/DEPTOR expression in HuH-7 cells caused S6K and 4E-BP activation, but suppressed Akt. Overexpression of DEPDC6/DEPTOR activated Akt and increased survival of HCC cells. Overexpression of GNMT caused activation of mTOR/raptor downstream signaling and delayed G2/M cell cycle progression, which altogether resulted in cellular senescence. Furthermore, GNMT reduced proliferation of HuH-7 cells and sensitized them to rapamycin treatment both in vitro and in vivo. In conclusion, GNMT regulates HOC growth in part through interacting with DEPDC6/DEPTOR and modulating mTOR/raptor signaling pathway. Both GNMT and DEPDC6/DEPTOR are potential targets for developing therapeutics for HCC. Online address: http://www.molmed.org doi: 10.2119/molmed.2011.00331
A New Negative Liquid Crystal Lens With Multiple Ring Electrodes in Unequal Widths
(2012-02-01)
Chao, P. C. -P.
;
Kao, Y. -Y.
;
Hsu, C. -J.
;
電機工程學系
;
Department of Electrical and Computer Engineering
This study is dedicated to the design of a new negative liquid crystal (LC) lens with multiple ring electrodes in unequal widths. The number and widths of the multiple ring electrodes are designed to offer online tunability on focusing length by predetermined individual electrode voltages. This aims to render a smooth refraction index distribution that mimics well a divergent lens based on the theory of a gradient refraction index (GRIN) lens. Finally, the proposed negative LC lens is fabricated with the capability of realizing different focus lengths in a relatively large aperture of 5 mm and a thickness of 0.7 mm. Experiments are conducted to verify expected light-diverging performance. The effective focus length (EFL) is measured based on interference patterns. It is shown that the proposed negative LC lens is able to realize light-divergent effects with an EFL as short as -357.9 mm.
A modal sensor integrated circular cylindrical wedge wave ultrasonic motor
(2012-02-01)
Yu, Tai-Ho
;
Yin, Ching-Chung
;
機械工程學系
;
Department of Mechanical Engineering
This study investigates a new circular cylindrical wedge wave ultrasonic motor (WW-USM) integrated with modal sensors. The presented motor is driven by continuous wedge waves of the fundamental modes with an integer circumferential number. In this design, the constructive interference of two equal-intensity standing waves actuated by two comb transducers generates a traveling wedge wave. Dual-phase electrodes were parallel to the axis placed on a piezoelectric (PZT) tube at a distance of 1/4 wavelength. Two orthogonal sinusoidal signals at the resonant frequency of designated flexural mode exerting on the electrodes have the WW-USM operate in bidirectional rotation. The base height of the stator was appropriately tuned to achieve an excellent modal separation from other vibration modes. A modal sensor on the border of the PZT tube was designed to detect the dynamic characteristics of the WW-USM and to improve the performance. The wedge wave motor has a flexible mechanical performance between the angular speed and output torque. Varying the contact position of the rotor on the inclined surface of the stator may exchange the angular speed for torque output. No further modification of the entire motor structure is needed. The prototype WW-USM driven by the flexural mode F(1, 4) under 1 N static preload was operated by an AC voltage of 400 V-pp at the frequency of 36.605 kHz. The maximum values of angular speed, output torque, and electromechanical transduction efficiency are 225 rpm, 15.736 mN m, and 16.22%, respectively. (C) 2011 Elsevier B.V. All rights reserved.
A new force-directed graph drawing method based on edge-edge repulsion
(2012-02-01)
Lin, Chun-Cheng
;
Yen, Hsu-Chun
;
工業工程與管理學系
;
Department of Industrial Engineering and Management
The conventional force-directed methods for drawing undirected graphs are based on either vertex-vertex repulsion or vertex-edge repulsion. In this paper, we propose a new force-directed method based on edge-edge repulsion to draw graphs, In our framework, edges are modelled as charged springs, and a final drawing can be generated by adjusting positions of vertices according to spring forces and the repulsive forces, derived from potential fields, among edges. Different from the previous methods, our new framework has the advantage of overcoming the problem of zero angular resolution, guaranteeing the absence of any overlapping of edges incident to the common vertex. Given graph layouts probably generated by previous algorithms as the inputs to our algorithm, experimental results reveal that our approach produces promising drawings not only preserving the original properties of a high degree of symmetry and uniform edge length, but also preventing zero angular resolution and usually having larger average angular resolution. However, it should be noted that exhibiting a higher degree of symmetry and larger average angular resolution does not come without a price, as the new approach might result in the increase in undesirable overlapping of vertices as some of our experimental results indicate. To ease the problem of node overlapping, we also consider a hybrid approach which takes into account both edge-edge and vertex-vertex repulsive forces in drawing a graph. (C) 2011 Elsevier Ltd. All rights reserved.
High rotation number effect on heat transfer in a trailing edge channel with tapered ribs
(2012-02-01)
Liu, Yao-Hsien
;
Huh, Michael
;
Han, Je-Chin
;
機械工程學系
;
Department of Mechanical Engineering
Detailed heat transfer measurements were conducted in a wedge-shaped channel with lateral flow ejection, which is commonly found in the trailing edge cooling cavities of the gas turbine blade. Tapered ribs were applied on the leading and trailing surfaces to enhance heat transfer. Rib spacing (P/e(max)) was 8 and the ratio of rib height to channel height (e/H) was 0.125. The inlet Reynolds number ranged from 10,000 to 40,000. At the highest rotational speed of 400 rpm, the inlet rotation number was 0.8. Effect of flow ejection on pressure drop, mass flow rate and heat transfer distribution were investigated. Results show that the configuration of this tapered rib enhances heat transfer on the ribbed surface but ejection still has pronounced effects on heat transfer distribution. The experimental data has been correlated with the high rotation number and high buoyancy parameter in ranges similar to industry applications. (C) 2011 Elsevier Inc. All rights reserved.