Browsing by Issue Date, starting with "2012-08-31"

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Inference of Biological Pathway from Gene Expression Profiles by Time Delay Boolean Networks
(2012-08-31)
Chueh, Tung-Hung
;
Lu, Henry Horng-Shing
;
統計學研究所
;
Institute of Statistics
One great challenge of genomic research is to efficiently and accurately identify complex gene regulatory networks. The development of high-throughput technologies provides numerous experimental data such as DNA sequences, protein sequence, and RNA expression profiles makes it possible to study interactions and regulations among genes or other substance in an organism. However, it is crucial to make inference of genetic regulatory networks from gene expression profiles and protein interaction data for systems biology. This study will develop a new approach to reconstruct time delay Boolean networks as a tool for exploring biological pathways. In the inference strategy, we will compare all pairs of input genes in those basic relationships by their corresponding p-scores for every output gene. Then, we will combine those consistent relationships to reveal the most probable relationship and reconstruct the genetic network. Specifically, we will prove that O(log n) state transition pairs are sufficient and necessary to reconstruct the time delay Boolean network of n nodes with high accuracy if the number of input genes to each gene is bounded. We also have implemented this method on simulated and empirical yeast gene expression data sets. The test results show that this proposed method is extensible for realistic networks.
マトリックス受動式有機発光ダイオード表示装置
(2012-08-31)
孟心飛
;
洪勝富
;
趙宇強
Dynamic regulation on energy landscape evolution of single-molecule protein by conformational fluctuation
(2012-08-31)
Lin, Chien Y.
;
Huang, Jung Y.
;
Lo, Leu-Wei
;
光電工程學系
;
Department of Photonics
We formalize a theory to help explore the effect of conformational fluctuation on the energy landscape evolution of single-molecule protein. Using this formalization, we investigate the photon emission from single photoactivated fluorescent protein. A bimodal regulation on the energy landscape evolution was discovered, and its origin was attributed to slow conformational fluctuations of the protein matrix.
陽明代表團參與2012世界模擬聯合國會議
(國立陽明大學, 2012-09)
陳昱穎
VIP DB - A viral protein domain usage and distribution database
(2012-09-01)
Chen, Ting-Wen
;
Gan, Richie Ruei-Chi
;
Wu, Timothy H.
;
Lin, Wen-Chang
;
Tang, Petrus
During the viral infection and replication processes, viral proteins are highly regulated and may interact with host proteins. However, the functions and interaction partners of many viral proteins have yet to be explored. Here, we compiled a Viral Protein domain DataBase (VIP DB) to associate viral proteins with putative functions and interaction partners. We systematically assign domains and infer the functions of proteins and their protein interaction partners from their domain annotations. A total of 2,322 unique domains that were identified from 2,404 viruses are used as a starting point to correlate GO classification, KEGG metabolic pathway annotation and domain-domain interactions. Of the unique domains, 42.7% have GO records, 39.6% have at least one domain-domain interaction record and 26.3% can also be found in either mammals or plants. This database provides a resource to help virologists identify potential roles for viral protein. All of the information is available at http://vipdb.cgu.edu.tw. (C) 2012 Elsevier Inc. All rights reserved.
A marcrolide glucosyltransferase promoting the synthesis of O-, S- and N-glucosidic compounds
(2012-09-01)
Li, Y. -K.
;
交大名義發表
;
National Chiao Tung University
"A marcrolide glucosyltransferase promoting the synthesis of O-, S- and N-glucosidic compounds"
(2012-09-01)
Li, Y. -K.
;
交大名義發表
;
National Chiao Tung University
Light-guide plate using periodical and single-sized microstructures to create a uniform backlight system
(2012-09-01)
Pan, Jui-Wen
;
Hu, Ya-Wen
;
光電系統研究所
;
生醫電子轉譯研究中心
;
Institute of Photonic System
Light-guide plates (LGPs) with aperiodic or size-varied microstructures are widely used in edge-lit light-source backlight systems for their high uniformity. In this Letter we designed a LGP with periodic and single-sized microstructures and analyzed the relationship between the holistic arrangement density of the microstructures and the uniformity. By controlling the holistic arrangement density of the microstructures, the uniformity could also be increased. (c) 2012 Optical Society of America
Improvement of a-Si1-xGex:H single-junction thin-film solar cell performance by bandgap profiling techniques
(2012-09-01)
Hsu, Hung-Jung
;
Hsu, Cheng-Hang
;
Tsai, Chuang-Chuang
;
資訊工程學系
;
Department of Computer Science
In this work, the effect of hydrogen dilution on the Ge content of the film and the effect of bandgap grading in the a-S1-xGex:H absorber near the p/i and the i/n interfaces on cell performance were discussed. The a-Si1-xGex:H single-junction solar cells were improved by employing both p/i grading and i/n grading. The i/n grading increased the V-OC and the FF while it also reduced the J(SC) as compared to the cell without grading. Presumably the potential gradient established by the i/n grading facilitates the hole transport hereby improved by the FF. On the contrary, the potential barrier established by the p/i grading seemed to limit the cell performance and constrain the p/i grading width below 20 nm due to the drop in FF and J(SC). Combining the effects of bandgap grading on the V-OC, J(SC) and FF, the suitable thicknesses of the p/i and the i/n grading were 20 nm and 45 nm, respectively. Finally, the grading structures accompanied with further optimization in doped layers were integrated to achieve a cell efficiency of 8.59%. (C) 2012 Elsevier B.V. All rights reserved.
Web-based undergraduate chemistry problem-solving: The interplay of task performance, domain knowledge and web-searching strategies
(2012-09-01)
She, Hsiao-Ching
;
Cheng, Meng-Tzu
;
Li, Ta-Wei
;
Wang, Chia-Yu
;
Chiu, Hsin-Tien
This study investigates the effect of Web-based Chemistry Problem-Solving, with the attributes of Web-searching and problem-solving scaffolds, on undergraduate students' problem-solving task performance. In addition, the nature and extent of Web-searching strategies students used and its correlation with task performance and domain knowledge also were examined. We recruited a total of 183 undergraduate students, all of whom are taking the freshman chemistry course, to participate in the study to solve three chemistry tasks across a semester. Mandated screen-capture software captured participants' on-screen Web-searching processes were recorded every five seconds. Results demonstrated that students' problem-solving performance was significantly improved from task 1 to 3, and students with more domain knowledge outperformed students with less domain knowledge. Students with higher problem-solving performance employed more existing knowledge and metacognitive Web-searching strategies; and students with lower problem-solving performance employed more cognitive Web-searching strategies. In addition, students' problem-solving performance was correlated with their domain knowledge, use of existing knowledge, and metacognitive Web-searching strategies. Moreover, students' use of existing knowledge was the major factor for predicting their problem-solving performance according to the regression model. (C) 2012 Elsevier Ltd. All rights reserved.
評介Helen Tilley’s ＂Africa as a Living Laboratory: Empire, Development, and the Problem of Scientific Knowledge, 1870-1950＂
(國立陽明交通大學出版社, 2012-09-01)
李尚仁
「與洪席耶面對面：洪席耶作品與思想座談會」紀錄
(國立陽明交通大學出版社, 2012-09-01)
楊成瀚
Easy-to-explain feature synthesis approach for recommending entertainment video
(2012-09-01)
Lee, Tsung-Ju
;
Tseng, Shian-Shyong
;
資訊工程學系
;
Department of Computer Science
The use of dimension reduction techniques has attracted considerable attention owing to information explosion. Without considering the underlying phenomena of interest, traditional dimension reduction approaches aim to search a feature set for optimizing performance. In recommending entertainment videos, beyond the successful recommendations, marketing strategy can be benefited from interpreting precise social context information accurately. Therefore, how to find an easy-to-explain feature set to achieve optimal prediction performance becomes an important issue. In this paper, we propose a three-phase feature synthesis approach to search heuristically optimal feature set within exponential easy-to-explain features. The first phase performs feature selection by screening low-informative features, the second phase shrinks the high-dependent feature subset, and the third phase enhances the dominated features. An implemented social recommendation system and the 11 months purchasing data from the largest commercial entertainment video Web shop in Taiwan are adopted to evaluate the effectiveness and efficiency of the proposed feature synthesis method in the experiments. The experimental results show that our approach can obtain the interpretable clustering results as well as improve the recommendation. (c) 2012 Elsevier B.V. All rights reserved.
Hydrodynamic limits of the nonlinear Klein-Gordon equation
(2012-09-01)
Lin, Chi-Kun
;
Wu, Kung-Chien
;
應用數學系
;
數學建模與科學計算所(含中心)
;
Department of Applied Mathematics
We perform the mathematical derivation of the compressible and incompressible Euler equations from the modulated nonlinear Klein-Gordon equation. Before the formation of singularities in the limit system, the nonrelativistic-semiclassical limit is shown to be the compressible Euler equations. If we further rescale the time variable, then in the semiclassical limit (the light speed kept fixed), the incompressible Euler equations are recovered. The proof involves the modulated energy introduced by Brenier (2000) [1]. (C) 2012 Elsevier Masson SAS. All rights reserved.
具有電晶體的半導體元件及其製法
(2012-09-01)
冉曉雯
;
蔡娟娟
;
孟心飛
;
蔡武衛
;
陳家新
一種具有電晶體的半導體元件，係包括：承載板；金屬氧化物半導體層，係設於該承載板上；介電層，係設於該金屬氧化物半導體層上，該介電層係構成微奈米級線寬的圖案，俾外露部分該金屬氧化物半導體層，該金屬氧化物半導體層之外露表面的載子濃度大於該金屬氧化物半導體層內部的載子濃度；圖案化遮罩層，係設於該介電層之頂面上；以及源極金屬層與汲極金屬層，係設於外露之該金屬氧化物半導體層上。本發明係於閘極區進行微奈米等級的圖形摻雜，因此大幅增進了有效載子遷移率，並提升電晶體的操作特性。本發明復提供一種具有電晶體的半導體元件之製法。
從公共化到產權化：都更城市淪亡記
(國立陽明交通大學出版社, 2012-09-01)
黃麗玲
每個人都在找他心裡的一頭鹿－蔡明亮訪談
(國立陽明交通大學出版社, 2012-09-01)
楊小濱
台北的身世．都更的身分：作為「營建經濟」的都市更新政策、私有權與公共之辯
(國立陽明交通大學出版社, 2012-09-01)
台灣都市更新受害者聯盟
「掠奪」資本城市中的都市保存
(國立陽明交通大學出版社, 2012-09-01)
康旻杰
Dynamic inventory rationing for systems with multiple demand classes and general demand processes
(2012-09-01)
Hung, Hui-Chih
;
Chew, Ek Peng
;
Lee, Loo Hay
;
Liu, Shudong
;
工業工程與管理學系
"We consider the dynamic rationing problem for inventory systems with multiple demand classes and general demand processes. We assume that backorders are allowed. Our aim is to find the threshold values for this dynamic rationing policy. For single period systems, dynamic critical level policy is developed and the detailed cost approximation subject to this policy is derived. For multiperiod systems, a dynamic rationing policy with periodic review is proposed. The numerical study shows that our dynamic critical level policies are close to being optimal for various parameter settings. (C) 2012 Elsevier B.V. All rights reserved."