Browsing by Issue Date, starting with "2013-01-07"

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Prediction and Analysis of Antibody Amyloidogenesis from Sequences
(2013-01-07)
Liaw, Chyn
;
Tung, Chun-Wei
;
Ho, Shinn-Ying
;
生物科技學系
;
生物資訊及系統生物研究所
Antibody amyloidogenesis is the aggregation of soluble proteins into amyloid fibrils that is one of major causes of the failures of humanized antibodies. The prediction and prevention of antibody amyloidogenesis are helpful for restoring and enhancing therapeutic effects. Due to a large number of possible germlines, the existing method is not practical to predict sequences of novel germlines, which establishes individual models for each known germline. This study proposes a first automatic and across-germline prediction method (named AbAmyloid) capable of predicting antibody amyloidogenesis from sequences. Since the amyloidogenesis is determined by a whole sequence of an antibody rather than germline-dependent properties such as mutated residues, this study assess three types of germline-independent sequence features (amino acid composition, dipeptide composition and physicochemical properties). AbAmyloid using a Random Forests classifier with dipeptide composition performs well on a data set of 12 germlines. The within-and across-germline prediction accuracies are 83.10% and 83.33% using Jackknife tests, respectively, and the novel-germline prediction accuracy using a leave-one-germline-out test is 72.22%. A thorough analysis of sequence features is conducted to identify informative properties for further providing insights to antibody amyloidogenesis. Some identified informative physicochemical properties are amphiphilicity, hydrophobicity, reverse turn, helical structure, isoelectric point, net charge, mutability, coil, turn, linker, nuclear protein, etc. Additionally, the numbers of ubiquitylation sites in amyloidogenic and nonamyloidogenic antibodies are found to be significantly different. It reveals that antibodies less likely to be ubiquitylated tend to be amyloidogenic. The method AbAmyloid capable of automatically predicting antibody amyloidogenesis of novel germlines is implemented as a publicly available web server at http://iclab.life.nctu.edu.tw/abamyloid.
Synthesis and study of novel supramolecular nanocomposites containing aryl-imidazo-phenanthroline-based metallo-polymers (H-donors) and surface-modified ZnO nanoparticles (H-acceptors)
(2013-01-07)
Fang, Hsiao-Ping
;
Wu, Yen-Hsing
;
Lin, Hong-Cheu
;
材料科學與工程學系
;
Department of Materials Science and Engineering
Four novel metallo-polymers (P1-P4) containing aryl-imidazo-phenanthrolines (AIP) ligands (incorporated with phenyl and fused-thiophene cores) were synthesized and characterized. Interestingly, P1-P4 exhibited electrochromism during the oxidation processes of cyclic voltammogram studies. In addition, P1-P4 were blended with surface-modified pyridyl-ZnO nanoparticles (ZnOpy as proton acceptors) to form nanocomposites, where P3-P4 were functionalized with carboxylic acid pendants (as proton donors) on the polymer backbones to study for the H-bonded effects on surface-modified ZnOpy nanoparticles. In order to investigate the nanocomposites containing metallo-polymers P1-P4 and surface-modified ZnOpy nanoparticles, nanocomposites P1-P4/ZnOpy were characterized by UV-visible (UV) absorption spectra, Fourier transform infrared (FT-IR), photoluminescence (PL) spectra, time-resolved photoluminescence decays, X-ray diffraction (XRD) measurements, and transmission electron microscopy (TEM) analyses. In contrast to nanocomposites P1/ZnOpy and P2/ZnOpy, higher crystallinities with a distinct layered-structure of H-bonded nanocomposites P3/ZnOpy and P4/ZnOpy in XRD measurements were induced by the introduction of surface-modified ZnOpy nanoparticles to metallopolymers P3 and P4, correspondingly. Furthermore, due to the supramolecular interactions of surface-modified ZnOpy nanoparticles with metallo-polymers P3-P4, TEM images verified that ZnOpy nanoparticles were more homogeneously distributed in nanocomposites P3-P4/ZnOpy (with H-bonds) than those in P1-P2/ZnOpy (without H-bonds), respectively. (C) 2012 Elsevier Ltd. All rights reserved.
Investigation of an anomalous hump in gate current after negative-bias temperature-instability in HfO2/metal gate p-channel metal-oxide-semiconductor field-effect transistors
(2013-01-07)
Ho, Szu-Han
;
Chang, Ting-Chang
;
Wu, Chi-Wei
;
Lo, Wen-Hung
;
Chen, Ching-En
This Letter investigates a hump in gate current after negative-bias temperature-instability (NBTI) in HfO2/metal gate p-channel metal-oxide-semiconductor field-effect transistors. Measuring gate current at initial through body floating and source/drain floating shows that hole current flows from source/drain. The fitting of gate current (I-g)-gate voltage (V-g) characteristic curves demonstrates that the Frenkel-Poole mechanism dominates the conduction. Next, by fitting the gate current after NBTI, in the order of Frenkel-Poole then tunneling, the Frenkel-Poole mechanism can be confirmed. These phenomena can be attributed to hole trapping in high-k bulk and the electric field formula Ehigh-k epsilon(high-k) = Q+E-sio2 epsilon(sio2). (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4773479]
Optical controlled graphene-based nonvolatile ternary-logic transistor with azobenzene copolymer
(2013-01-07)
Lin, Chi-Yuan
;
Chang, Chen-Shiung
;
Lin, Jian Hung
;
Hsu, Chia-Chen
;
Chien, Forest Shih-Sen
We demonstrated optical-controlled graphene-based nonvolatile transistors incorporated with azobenzene copolymer. The transistor was gated by the quasi remnant polarization of azobenzene copolymer, which was built by photo-assisted poling and erased by photo-depoling at room temperature. By taking the nature of polymer electret of azobenzene copolymer, the graphene-based device can perform ternary logic, and the resistance change ratio of the written status "+/- 1" to the erased status "0" was -/+ 60%. The device can retain its statuses against an electric field as high as 0.2 MV/cm because the azobenzene molecules were frozen in copolymer at room temperature. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4773984]
Stochastic analysis of stream-groundwater interaction subject to temporally correlated recharge
(2013-01-07)
Chang, Ching-Min
;
Yeh, Hund-Der
;
環境工程研究所
;
Institute of Environmental Engineering
In this article, the coupled equations describing the transient groundwater flow and stream flow fluctuations are solved based on the Fourier-Stieltjes integral representation, where the lateral inflow term in the stream flow perturbation equation connects the process of groundwater flow to that of stream flow. The closed-form solutions describing the variability in groundwater flow specific discharge and stream flow discharge are developed to quantify the influence of the variability in temporally correlated recharge in an unconfined aquifer on the stream flow discharge. We found from the closed-form solutions that the temporal correlation scale and the variance of recharge fields influence the variability in groundwater flow specific discharge and the stream flow discharge positively. In addition, the hydraulic diffusivity coefficient takes the role of reducing the variability in stream flow discharge. (C) 2012 Elsevier B.V. All rights reserved.
交大e-News第133期
(2013-01-07)
Secretariat
;
國立交通大學秘書室
Large-area ultraviolet GaN-based photonic quasicrystal laser with high-efficiency green color emission of semipolar {10-11} In0.3Ga0.7N/GaN multiple quantum wells
(2013-01-07)
Chen, Cheng-Chang
;
Chiu, Ching-Hsueh
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Chang, Shih-Pang
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Shih, M. H.
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Kuo, Ming-Yen
In this study, a multi-color emission was observed from the large-area GaN-based photonic quasicrystal (PQC) nanopillar laser. The GaN PQC nanostructure was fabricated on an n-GaN layer by using nanoimprint lithographic technology. The regrown InGaN/GaN multiple quantum wells (MQWs) formed a nanopyramid structure on top of the PQC nanopillars. A lasing action was observed at ultraviolet wavelengths with a low threshold power density of 24 mJ/cm(2), and a green color emission from InGaN/GaN MQWs was also achieved simultaneously. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4775373]
Investigation of extra traps measured by charge pumping technique in high voltage zone in p-channel metal-oxide-semiconductor field-effect transistors with HfO2/metal gate stacks
(2013-01-07)
Ho, Szu-Han
;
Chang, Ting-Chang
;
Wang, Bin-Wei
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Lu, Ying-Shin
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Lo, Wen-Hung
This letter investigates extra traps measured by charge pumping technique in the high voltage zone in p-channel metal-oxide-semiconductor field-effect transistors with HfO2/metal gate stacks. N-V-high level characteristic curves with different duty ratios show that the hole discharge time (t(base level)) dominates the value of extra traps. By fitting ln (N (t(base level) = 1 mu s) -N (t(base level))) - Delta t(base level) at different temperatures and computing the equation t = tau(0) exp (alpha(h,SiO2)d(SiO2) + alpha(h,HfO2)d(HfO2,trap)), the results show that these extra traps measured by the charge pumping technique at high voltage zone can be attributed to high-k bulk shallow traps. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4773914]
Benzooxadiazole-based donor/acceptor copolymers imparting bulk-heterojunction solar cells with high open-circuit voltages
(2013-01-08)
Jiang, Jian-Ming
;
Yang, Po-An
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Lan, Shang-Che
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Yu, Chia-Ming
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Wei, Kung-Hwa
In this study we used Suzuki cross-coupling to synthesize three new donor/acceptor copolymers-PFTBO, PAF1130, and PCTBO-featuring soluble alkoxy-modified 2,1,3-benzooxadiazole (BO) moieties as acceptor units and electron-rich building blocks-dialkyl fluorene (F), alkylidene fluorene (AF), and carbazole (C), respectively-as donor units. These polymers, which we characterized using gel permeation chromatography, thermogravimetric analysis, NMR spectroscopy, UV-Vis absorption spectroscopy, and electrochemical cyclic voltammetry, exhibited good solubility, low-lying energy levels for their highest occupied molecular orbitals, excellent thermal stability, and air stability. Using these polymers, we fabricated bulk-heterojunction solar cell devices having the structure indium tin oxide/poly(3,4-ethylenedioxythiophene):polystyrenesulfonate/polymer:[6,6]-phenyl-C-61-butyric acid methyl ester (PC61BM) (1:1, w/w)/Ca/Al. Under AM 1.5G illumination (100 mW cm(-2)), the solar cell incorporating PFTBO exhibited a high value of V-OC of 1.04 V and that based on PCTBO provided a power conversion efficiency of 4.1% without the need for any post treatment. (C) 2012 Elsevier Ltd. All rights reserved.
Low-surface-free-energy polybenzoxazine/polyacrylonitrile fibers for biononfouling membrane
(2013-01-08)
Kao, Tzu-Hao
;
Chen, Jem-Kun
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Cheng, Chih-Chia
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Su, Ching-Juan
;
Chang, Feng-Chih
We blended poly(3-phenyl-3,4-dihydro-2H-1,3-benzoxazine) (PBA) into polyacrylonitrile (PAN) to generate low-surface-free-energy fibers without fluorine and silicon elements for electrospinning. Liquid-state BA at room temperature can be solidified in electrospinning process using PAN as a medium through their miscible behavior. Results indicate that the mixing below 50 wt% BA into PAN matrix for electrospinning has no significant dropping beads, indicated a miscible PAN/BA system. Above 70 wt% BA in PAN solution could not be solidified completely after electrospinning, revealed apparent beaded fibers. The PAN/PBA blend fibers, obtained after curing at 300 degrees C, generated a superhydrophobicity because of the low-surface-free-energy PBA. In addition, laser scanning confocal microscope (LSCM) measurements were included to determine the relative amount of antibody that adsorbed to these PAN/PBA fibers to examine the biofouling-resistant property. The results showed an obviously decreased protein adsorption with increasing PBA fraction. The correlations between PAN and PBA would provide insight into the designing and developing of low-surface-free-energy fibers without fluorine and silicon elements to improve biofouling-resistant property. (C) 2012 Elsevier Ltd. All rights reserved.
Crystal Structure and Molecular Packing Behavior of Poly(2,3-diphenyl-1,4-phenylenevinylene) Derivatives Containing Alkyl Side-Chains
(2013-01-08)
Ren, Xiang-Kui
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Wu, Yu-Chun
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Wang, Shao-Jie
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Jiang, Shi-Dong
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Zheng, Jun-Feng
Phase behavior and crystal structure of a series of poly(2,3-diphenyl-5-alkyl-p-phenylenevinylene) (denoted as DPn-PPV, where n represents the carbon number of the alkyl side-chain, n = 6, 8, 10, 12) were studied using differential scanning calorimetry, one- and two-dimensional (1D and 2D) wide-angle X-ray diffraction (WAXD), and selected area electron diffraction (SAED). The experimental results reveal that DPn-PPV exhibits one crystalline phase at low temperatures. On the basis of 2D WAXD and SAED patterns obtained from the oriented samples, the crystal structures are determined to be orthorhombic for DP6-PPV and monoclinic for DP8-PPV, DP10-PPV, and DP12-PPV. To account for the unusually large unit cell dimensions, we propose that the unit cell of DPn-PPV contains 4 chains (8 chemical repeat units). The complex crystal structure can be attributed to the longitudinal and transverse offsets between the neighboring chains, which shall be mainly due to the requirement of minimizing the steric hindrance caused by the attached pendent groups and maximizing the pi-pi interaction between the chains. The molecular packing scheme was simulated by using Cerius(2) software, of which the result agrees with the experimental data. The polarized UV-vis absorption and polarized solid-state photoluminescence (PL) property of these polymers was also investigated. The PL spectra indicated that the light emitted from the oriented film was preferentially polarized parallel to the shear direction, implying that DPn-PPV may potentially be useful in linearly polarized luminescence devices.
Dereverberation and noise reduction method for microphone array and apparatus using the same
(2013-01-08)
Bai Mingsian R.
;
Hur Ker-Nan
;
Liou Ying-Ting
A dereverberation and noise reduction method adapted for a microphone array and an apparatus using the same are proposed. The microphone array receives a plurality of audio signals from an audio source. The dereverberation and noise reduction method includes the following steps. The received audio signals are processed by a beamforming processing, and a first audio signal is generated. Besides, the received audio signals are processed by a suppression processing, and a suppression audio vector is generated. Further, suppression audio vector is processed by an adaptive filtering processing, and a second audio signal is generated. In addition, the second audio signal is subtracted from the first audio signal to acquire an audio output signal, where parameters of the adaptive filtering processing are adjusted according to a feedback of the audio output signal.
Drug-Carrying Contact Lens And Method For Fabricating The Same
(2013-01-09)
Liu, Dean-Mo
;
Liu, Pei-Ling
The present invention discloses a drug-carrying contact lens and a method for fabricating the same. The drug-carrying contact lens comprises a contact lens containing at least one amphiphatic hybrid nanocarrier carrying drug molecules. According to the heat or light sensitivity of the drug molecule, the present invention respectively fabricates an encapsulation-type drug-carrying contact lens and a drug-soaking type drug-carrying contact lens. The present invention uses a highly-biocompatible amphiphatic hybrid nanocarriers having superior drug encapsulation capability to wrap the drug molecules. Thereby, the drug molecules are uniformly distributed in the contact lens and can be gradually and locally released to the eye of the user wearing the contact lens. Therefore, the present invention can prevent or cure ocular diseases with the loss and side effects of the drug being reduced.
MAGNETICALLY-CONTROLLABLE NANOMETRIC POROUS DRUG CARRIER
(2013-01-10)
CHEN San-Yuan
;
CHEN Po-Jung
;
LIU Dean-Mo
;
HU Shang-Hsiu
The present invention discloses a magnetically-controllable nanometric porous drug carrier, wherein an organic or inorganic matrix is used to carry the drug, and wherein magnetic nanoparticles having magnetosensitivity are used to encapsulate the surface of the matrix and seal the drug inside the matrix. An external magnetic field is used to control the removal rate of the magnetic nanoparticles and control the behavior and rate of drug release.
DRUG-CARRYING CONTACT LENS AND METHOD FOR FABRICATING THE SAME
(2013-01-10)
Liu Dean-Mo
;
Liu Pei-Ling
The present invention discloses a drug-carrying contact lens and a method for fabricating the same. The drug-carrying contact lens comprises a contact lens containing at least one amphiphatic hybrid nanocarrier carrying drug molecules. According to the heat or light sensitivity of the drug molecule, the present invention respectively fabricates an encapsulation-type drug-carrying contact lens and a drug-soaking type drug-carrying contact lens. The present invention uses a highly-biocompatible amphiphatic hybrid nanocarriers having superior drug encapsulation capability to wrap the drug molecules. Thereby, the drug molecules are uniformly distributed in the contact lens and can be gradually and locally released to the eye of the user wearing the contact lens. Therefore, the present invention can prevent or cure ocular diseases with the loss and side effects of the drug being reduced.
Simple method to obtain accurate pretilt angles for thin twisted nematic liquid-crystal cells
(2013-01-10)
Wang, Sheng-Ya
;
Yang, Kei-Hsiung
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光電系統研究所
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影像與生醫光電研究所
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Institute of Photonic System
Modern thin-film-transistor-driven twisted nematic (TN) products on the market require thin cell gaps below the value to satisfy the condition of the Gooch-Tarry first minimum in transmission for fast response times and wide viewing angles. For the first time to our knowledge, we have developed a simple experimental method based on a new configuration of out-of-plane cell rotation and analyzed our data by extended Jones matrix method to obtain accurate pretilt angles for such thin TN cells where the well-accepted configuration of the out-of-plane cell rotation method analyzed by Birecki and Kahn [ The Physics and Chemistry of Liquid Crystal Devices (1980), p. 115] was insufficient to address. (C) 2013 Optical Society of America
TOP-GATE TRANSISTOR ARRAY SUBSTRATE
(2013-01-10)
CHENG Huang-Chung
;
HUANG Yu-Chih
;
YANG Po-Yu
;
CHIANG Shin-Chuan
;
LI Huai-An
A top-gate transistor array substrate includes a transparent substrate with a plane, an ion release layer, a pixel array, and a first insulating layer. The ion release layer is disposed on the transparent substrate and completely covers the plane. The pixel array is disposed on the ion release layer and includes a plurality of transistors and a plurality of pixel electrodes. Each of the transistors includes a source, a drain, a gate and a MOS (metal oxide semiconductor) layer. The drain, the source and the MOS layer are disposed on the ion release layer. The pixel electrodes are electrically connected to the drains respectively. The gate is disposed above the MOS layer. The first insulating layer is disposed between the MOS layers and the gates. The MOS layer contacts the ion release layer. The ion release layer can release a plurality of ions into the MOS layers.
SPECIMEN BOX FOR ELECTRON MICROSCOPE
(2013-01-10)
CHEN Chih
;
TU King-Ning
The present invention relates to a specimen box for an electron microscope, which comprises a first substrate, a second substrate, and a metal adhesion layer. The first substrate has a first surface, a second surface, a first concave, and one or more first through holes, wherein the first through hole penetrates through the first substrate. The second substrate has a third surface, a forth surface, and a second concave. Besides, the metal adhesion layer is disposed between the first substrate and the second substrate to form a space for a specimen placed therein. In addition, the specimen box of the present invention further comprises one or more plugs. When the plug is assembled into the first through hole to seal the specimen box, the in-situ observation can be accomplished by using an electron microscope.
SPECIMEN BOX FOR ELECTRON MICROSCOPE
(2013-01-10)
CHEN Chih
;
Tu King-Ning
The present invention relates to a specimen box for an electron microscope, comprising a first substrate, a second substrate, one or more photoelectric elements, and a metal adhesion layer. The first substrate has a first surface, a second surface, a first concave, and one or more first through holes, wherein the first through holes penetrate through the first substrate. The second substrate has a third surface, a forth surface, and a second concave. The photoelectric element is disposed between the first substrate and the second substrate. In addition, the metal adhesion layer is disposed between the first substrate and the second substrate to form a space for a specimen contained therein. Besides, the present specimen box further comprises one or more plugs. When the plugs are assembled into the first through holes to seal the specimen box, the in-situ observation can be accomplished by using the electron microscope.
PHOTO SENSOR AND METHOD OF FABRICATING THE SAME
(2013-01-10)
Chen Chih
;
Liu Chien-Min
;
Tseng Yuan-Chieh
A photo sensor and a method of fabricating the same are disclosed, the photo sensor of the present invention has ultra-high Schottky junction area per unit volume, and the photo sensor comprises: a first conductive layer; plural metallic nanowires, in which one end of each metallic nanowire connects with the first conductive layer and is covered with a semiconductive layer having a width of 1 nm to 20 nm; and a second conductive layer locating opposite to the first conductive layer, whereby the plural metallic nanowires locate between the first conductive layer and the second conductive layer, and the semiconductive layer contacts with the second conductive layer, wherein the photo sensor of the present invention is used to detect ultra violet (UV) light with a wavelength of 10 nm-400 nm.