Browsing by Issue Date, starting with "2014-02-14"

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Room-temperature mid-infrared "M"-type GaAsSb/InGaAs quantum well lasers on InP substrate
(2014-02-14)
Chang, Chia-Hao
;
Li, Zong-Lin
;
Pan, Chien-Hung
;
Lu, Hong-Ting
;
Lee, Chien-Ping
We have demonstrated experimentally the InP-based "M"-type GaAsSb/InGaAs quantum-well (QW) laser lasing at 2.41 mu m at room temperature by optical pumping. The threshold power density per QW and extracted internal loss were about 234 W/cm(2) and 20.5 cm(-1), respectively. The temperature-dependent photoluminescence (PL) and lasing spectra revealed interesting characteristics for this type of lasers. Two distinct regions in the temperature dependent threshold behavior were observed and the transition temperature was found to coincide with the cross over point of the PL and lasing emission peaks. The current-voltage characteristic of "M"-type QW laser was superior to the inverse "W"-type one due to its thinner barrier for holes. Further improvement of the "M"-type QW structure could lead to a cost-effective mid-infrared light source. (C) 2014 AIP Publishing LLC.
Simultaneous 0.8, 1.0, and 1.3 mu m multispectral and common-path broadband source for optical coherence tomography
(2014-02-15)
Tsai, Meng-Tsan
;
Chan, Ming-Che
;
影像與生醫光電研究所
;
Institute of Imaging and Biomedical Photonics
Simultaneous multispectral generation in 0.8, 1.0, and 1.3 mu m wavelength ranges by efficient energy conversions of 1.0 mu m wavelength femtosecond pulses through a nonlinear fiber was reported. The output spectral range of this multispectral light source was composed of 0.6-0.9 mu m blue-shifted Cherenkov radiation (CR), 1.0 mu m residual pump, and 1.1-1.7 mu m red-shifted soliton self-frequency shift (SSFS) with more than 1 mW/nm power-spectral densities. Output characteristics of the multispectral light source were then quantitatively analyzed and the central wavelengths of CR and SSFS emissions can be further easily adjusted by changing the input power into wavelength conversion fiber. Example spectral-domain optical coherence tomography (OCT) images of an IR card and finger skin were also performed with the demonstrated source. Due to the advantages of its simplicity, easily operated, and wavelength tunability, the reported multispectral source could be widely applicable for various spectroscopic OCT applications. (C) 2014 Optical Society of America
High-yield water-based synthesis of truncated silver nanocubes
(2014-02-15)
Chang, Yun-Min
;
Lu, I-Te
;
Chen, Chih-Yuan
;
Hsieh, Yu-Chi
;
Wu, Pu-Wei
A high-yield water-based hydrothermal synthesis was developed using silver nitrate, ammonia, glucose, and cetyltrimethylammonium bromide (CTAB) as precursors to synthesize truncated silver nanocubes with uniform sizes and in large quantities. With a fixed CTAB concentration, truncated silver nanocubes with sizes of 49.3 +/- 4.1 nm were produced when the molar ratio of glucose/silver cation was maintained at 0.1. The sample exhibited (100), (110), and (111) planes on the facets, edges, and corners, respectively. In contrast, with a slightly larger glucose/silver cation ratio of 0.35, well-defined nanocubes with sizes of 70.9 +/- 3.8 nm sizes were observed with the (100) plane on six facets. When the ratio was further increased to 1.5, excess reduction of silver cations facilitated the simultaneous formation of nanoparticles with cubic, spherical, and irregular shapes. Consistent results were obtained from transmission electron microscopy, scanning electron microscopy, X-ray diffraction, and UV-visible absorption measurements. (C) 2013 Elsevier B. V. All rights reserved.
Synthesis, characterization and high temperature CO2 capture capacity of nanoscale Ca-based layered double hydroxides via reverse microemulsion
(2014-02-15)
Chang, Po-Hsueh
;
Chang, Yen-Po
;
Lai, Yen-Ho
;
Chen, San-Yuan
;
Yu, Ching-Tsung
In this study, we report a reverse microemulsion method to prepare stable homogeneous suspensions containing dispersed Ca-Al layered double hydroxide (LDH) nanoparticles. By changing the concentration, reaction time and temperature, the nano-particles with different structural morphology was developed from amorphous aggregation to platelet, regular hexagon and hydrangea-like hierarchical structure. The crystallization and growth of Ca-Al LDH nanoparticles were involved with a nucleation and growth process under nonaqueous polar solvent/surfactant system. After calcination at 700 degrees C, the calcined nano-sized Cal-Al LDH powders synthesized from the reverse microemulsion display remarkable CO2 capture behavior at 600 degrees C, which is strongly dependent on the reaction conditions (concentration, time and temperature). The calcined powder synthesized at 80 degrees C exhibits a faster rate of CO2 absorption and higher CO2 capture capacity of 44 wt% CO2 without apparent degradation under multiple cycles of carbonation-calcination. (C) 2013 Elsevier B. V. All rights reserved.
Development of a feasible assay for the detection of GAA mutations in patients with Pompe disease
(2014-02-15)
Er, Tze-Kiong
;
Chen, Chih-Chieh
;
Chien, Yin-Hsiu
;
Liang, Wen-Chen
;
Kan, Tzu-Min
Background: Pompe disease is an inherited autosomal recessive deficiency of acid alpha-glucosidase (GAA) and is due to pathogenic sequence variants in the corresponding GM gene. While the analysis of enzyme activity remains the diagnostic test of choice for individuals with Pompe disease, mutation analysis remains for establishing a definitive diagnosis. Methods: High resolution melting (HRM) analysis was performed to screen GM mutations. Genomic DNA was extracted from peripheral blood samples of the two patients with Pompe disease and 250 normal controls. Exons 2 through 20 of the GM gene were screened by the HEM analysis. The results were subsequently confirmed by direct sequencing. Results: This assay proved to be feasible in detecting seven known (c2T>C, c.1726G>A, c.1845G>A, c.1935C>A, c.1958C>A, c.2238G>C, and c2815_2816del) GM mutations. Each mutation could be readily and accurately identified in the difference plot curves. We estimated the carrier frequency of the most common mutation, c.1935G>A (p.D645E), in the Taiwanese population to be 02%. Conclusions: In clinical practice, we suggest that HEM analysis is assumed as a fast and reliable method for screening GM gene mutations especially the most common mutations which are responsible for Pompe disease among the Taiwanese populations. (C) 2013 Elsevier B.V. All rights reserved.
Ab Initio Chemical Kinetics for the Unimolecular Decomposition of Si2H5 Radical and Related Reverse Bimolecular Reactions
(2014-02-15)
Wu, Shang-Ying
;
Lee, Yun-Min
;
Wu, Jong-Shinn
;
Lin, Ming-Chang
;
機械工程學系
For plasma enhanced and catalytic chemical vapor deposition (PECVD and Cat-CVD) processes using small silanes as precursors, disilanyl radical (Si2H5) is a potential reactive intermediate involved in various chemical reactions. For modeling and optimization of homogeneous a-Si:H film growth on large-area substrates, we have investigated the kinetics and mechanisms for the thermal decomposition of Si2H5 producing smaller silicon hydrides including SiH, SiH2, SiH3, and Si2H4, and the related reverse reactions involving these species by using ab initio molecular-orbital calculations. The results show that the lowest energy path is the production of SiH+SiH4 that proceeds via a transition state with a barrier of 33.4 kcal/mol relative to Si2H5. Additionally, the dissociation energies for breaking the SiSi and HSiH2 bonds were predicted to be 53.4 and 61.4 kcal/mol, respectively. To validate the predicted enthalpies of reaction, we have evaluated the enthalpies of formation for SiH, SiH2, HSiSiH2, and Si2H4(C-2h) at 0 K by using the isodesmic reactions, such as (HSiSiH2)-H-2+(C2H6Si2H6)-C-1-Si-1+(HCCH2)-H-2 and (Si2H4)-Si-1(C-2h)+(C2H6)-C-1 (Si2H6)-Si-1+(C2H4)-C-1. The results of SiH (87.2 kcal/mol), SiH2 (64.9 kcal/mol), HSiSiH2 (98.0 kcal/mol), and Si2H4 (68.9 kcal/mol) agree reasonably well previous published data. Furthermore, the rate constants for the decomposition of Si2H5 and the related bimolecular reverse reactions have been predicted and tabulated for different T, P-conditions with variational Rice-Ramsperger-Kassel-Marcus (RRKM) theory by solving the master equation. The result indicates that the formation of SiH+SiH4 product pair is most favored in the decomposition as well as in the bimolecular reactions of SiH2+SiH3, HSiSiH2+H-2, and Si2H4(C-2h)+H under T, P-conditions typically used in PECVD and Cat-CVD. (c) 2013 Wiley Periodicals, Inc.
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2
(2014-02-15)
Wu, Ying
;
Gao, He
;
Li, Huaixing
;
Tabara, Yasuharu
;
Nakatochi, Masahiro
Blood levels of adiponectin, an adipocyte-secreted protein correlated with metabolic and cardiovascular risks, are highly heritable. Genome-wide association (GWA) studies for adiponectin levels have identified 14 loci harboring variants associated with blood levels of adiponectin. To identify novel adiponectin-associated loci, particularly those of importance in East Asians, we conducted a meta-analysis of GWA studies for adiponectin in 7827 individuals, followed by two stages of replications in 4298 and 5954 additional individuals. We identified a novel adiponectin-associated locus on chromosome 10 near WDR11-FGFR2 (P 3.0 10(14)) and provided suggestive evidence for a locus on chromosome 12 near OR8S1-LALBA (P 1.2 10(7)). Of the adiponectin-associated loci previously described, we confirmed the association at CDH13 (P 6.8 10(165)), ADIPOQ (P 1.8 10(22)), PEPD (P 3.6 10(12)), CMIP (P 2.1 10(10)), ZNF664 (P 2.3 10(7)) and GPR109A (P 7.4 10(6)). Conditional analysis at ADIPOQ revealed a second signal with suggestive evidence of association only after conditioning on the lead SNP (P-initial 0.020; P-conditional 7.0 10(7)). We further confirmed the independence of two pairs of closely located loci (2 Mb) on chromosome 16 at CMIP and CDH13, and on chromosome 12 at GPR109A and ZNF664. In addition, the newly identified signal near WDR11-FGFR2 exhibited evidence of association with triglycerides (P 3.3 10(4)), high density lipoprotein cholesterol (HDL-C, P 4.9 10(4)) and body mass index (BMI)-adjusted waisthip ratio (P 9.8 10(3)). These findings improve our knowledge of the genetic basis of adiponectin variation, demonstrate the shared allelic architecture for adiponectin with lipids and central obesity and motivate further studies of underlying mechanisms.
Weak turbulence plasma induced by two-scale homogenization
(2014-02-15)
Jiang, Jiann-Sheng
;
Lin, Chi-Kun
;
應用數學系
;
Department of Applied Mathematics
This paper is devoted to the homogenization of the quasilinear theory of the plasma turbulence described by the Vlasov-Poisson system. It is shown that the homogenization limit, in the sense of two-scale limit, of the distribution function satisfies the linear Vlasov-Poisson equations. Moreover, the limit distribution function can be decomposed into the mean and the fluctuation parts and the mean part (the equilibrium distribution function) is shown to be the solution of the nonlocal quasilinear velocity-space diffusion equation. We also investigate the Landau damping from the point of view of homogenization through the two-scale limit. Crown Copyright (C) 2013 Published by Elsevier Inc. All rights reserved.
Deformation mechanisms in ultrahigh-strength and high-ductility nanostructured FeMnAlC alloy
(2014-02-15)
Lin, Chih-Lung
;
Chao, Chuen-Guang
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Juang, Jenh-Yih
;
Yang, Jenn-Ming
;
Liu, Tzeng-Feng
The deformation mechanisms of a bulk nanostructured Fe-30Mn-9.5Al-2.0C (in wt.%) alloy were investigated. After aging at 450 degrees C for 9-12 h, the alloy exhibits an exceptional strength-ductility combination (e. g. yield strength similar to 1406 MPa with elongation similar to 32%). The aged alloy exhibits a novel microstructure with isolated austenite nano-channels bounded by an extremely high volume fraction of directional nano-sized (Fe,Mn)(3)AlC carbides (kappa'-carbides). The plastic deformation was found to be dominated by bursting dislocation nucleation within the isolated austenite nano-channels. (C) 2013 Elsevier B. V. All rights reserved.
Highly electrostatically-induced detection selectivity and sensitivity for a colloidal biosensor made of chitosan nanoparticle decorated with a few bare-surfaced gold nanorods
(2014-02-15)
Jean, Ren-Der
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Cheng, Wei-Da
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Hsiao, Meng-Hsuan
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Chou, Fu-Hsuan
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Bow, Jong-Shing
Metallic nanoparticles have been utilized as an analytical tool to detecting a wide variety of organic analytes. Among them, gold nanoparticles demonstrating outstanding surface plasmonic resonance property have been well recognized and received wide attention for plasmon-based sensing applications. However, in literature, gold-based nanosensor has to be integrated with specific "ligand" molecule in order to gain molecular recognition ability. However, "ligand" molecules, included proteins, peptides, nucleic acids, etc. are expensive and vulnerable to environmental change, in the meantime, anchoring procedure of the "ligand" molecules to gold surface may be cost-ineffective and endangered to the ligand's activity, making a final analytic probe less reliable and risk in production capability. Here, we develop a new approach by designing a colloid-type sensor using a few "bare" Au nanorods deposited on the surface of a colloidal chitosan carrier. By tuning the solution pH, the resulting colloidal nanoprobe is capable of detecting proteins, i.e., human serum albumin and lysozyme, with high specificity and sensitivity. This new approach allows a new type of the molecular probes to be well manipulated to monitor important biomolecules for medical detection, diagnosis, and bioengineering applications. (C) 2013 Elsevier B.V. All rights reserved.
半導體元件及其製作方法
(2014-02-16)
張俊彥
;
張哲榮
;
李悅榮
一種半導體元件的製作方法,包括以下步驟。提供基材,基材具有底座以及位於底座上的多個柱狀體。於各柱狀體的側壁上以及柱狀體間的底座上形成保護層。於柱狀體的頂面上成長第一型摻雜半導體材料,以形成多個第一型摻雜半導體結構。各第一型摻雜半導體結構具有底面以及連接底面的多個側壁面,且各側壁面相對底面傾斜。於第一型摻雜半導體結構的側壁面上形成多層發光層,其中各發光層包括一金屬元素,且此金屬元素於此些發光層中有3種以上的含量。於最上層之發光層上形成第二型摻雜半導體層。一種以上述方法製作而成的半導體元件亦被提出。
血紅素光學監測系統
(2014-02-16)
邱仲慶
;
王志中
;
林伯昰
;
郭進榮
一種血紅素光學監測系統，藉由光發射器和光接收器是彼此之間的距離差異可實現量測活體不同深度組織的含氧/缺氧血紅素。
House selection via the internet by considering homebuyers\' risk attitudes with S-shaped utility functions
(2014-02-16)
Ho, Hui-Ping
;
Chang, Ching-Ter
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Ku, Cheng-Yuan
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資訊管理與財務金融系註：原資管所+財金所
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Department of Information Management and Finance
The widespread use of the Internet has significantly changed the behavior of homebuyers. Using online real estate agents, homebuyers can rapidly find some modern houses that meet their needs; however, most current online housing systems provide limit features. In particular, existing systems fail to consider homebuyers\' housing goals and risk attitudes. To increase effectiveness, online real estate agents should provide an efficient matching mechanism, personalized service and house ranking with the aim of increasing both buyers\' satisfaction and deal rate. An efficient online real estate agent should provide an easy way for homebuyers to find (rank) a suitable house (alternatives) with consideration of their different housing philosophies and risk attitudes. In order to comprehend these ambiguous housing goals and risk attitudes, it is also indispensable to determine a satisfaction level for each fuzzy goal and constraint. In this study, we propose fuzzy goal programming with an S-shaped utility function as a decision aid to help homebuyers in choosing their preferred house via the Internet in an easy way. With the use of a decision aid, homebuyers can specify their housing goals and constraints with different priority levels and thresholds as a matching mechanism for a fuzzy search, while the matching mechanism can be translated into a standard query language for a regular relational database. Moreover, a laboratory experiment is conducted on a real case to demonstrate the effectiveness of the proposed approach. The results indicate that the proposed method provides better customer satisfaction than manual systems in housing selection service. (C) 2014 Elsevier B.V. All rights reserved.
發光二極體的封裝結構及其封裝方法
(2014-02-16)
王興宗
;
郭浩中
;
陳信助
;
陳國儒
本發明提供一種發光二極體的封裝結構,應用於一固態照明裝置中,且上述封裝結構至少包含一發光晶片、一封裝體、複數個襯墊與一光電轉換板材。其中,封裝體用以將發光晶片封裝於其中,且封裝體具有一出光面。複數個襯墊設置於出光面的週邊。光電轉換板材包含一基板與一螢光粉體層覆蓋於基板之一表面上,且光電轉換板材設置於該複數個襯墊上,使螢光粉體層以一間距面對封裝體之出光面。同時,一種發光二極體的封裝方法亦揭露於本發明中。
奈米球溶液塗佈方法與其應用
(2014-02-16)
孟心飛
;
冉曉雯
;
趙寅初
;
王凱瑞
;
徐永軒
本發明提供一種奈米球溶液塗佈方法與其應用。本發明之奈米球溶液塗佈方法是利用一刮刀將奈米球溶液刮塗於基材表面上，以在基材表面上塗佈附著數個奈米球，並使用一加熱的揮發性溶液(如醇類溶液)沖洗基材表面，使未附著於基材表面之奈米球懸浮於揮發性溶液上，最後利用刮刀刮除揮發性溶液及其中懸浮的奈米球，以簡化奈米球塗佈的製程步驟。本發明之方法也可應用於製作具有奈米孔洞之薄膜或垂直式有機電晶體，以利於量產並可用於大面積元件。
控制微游泳器轉向之方法
(2014-02-16)
陳慶耀
;
李彥宏
本發明係提供一種用以控制一微游泳器轉向之方法，其包括下述步驟：(A)提供一時變磁場，使設置於一流體中之該微游泳器擺動，其中，該微游泳器係於一具有固定磁場方向之串接磁場作用下，由M個第一磁性粒子及N個第二磁性粒子串接而成，且該時變磁場之磁場作用方向係與該串接磁場之磁場作用方向相互垂直，又M≧1且N≧1；以及(B)調整該時變磁場之頻率及強度中之至少一者，使該微游泳器轉向。
整合性儲存空間平台系統及方法
(2014-02-16)
曾建超
;
何承運
;
林家樑
;
吳捷
本發明提供一種整合性儲存空間平台系統及方法，其係包括至少一轉接模組，係分別連接至少一儲存空間，轉接模組進行與儲存空間相關之複數轉接設定；一存取介面，以供一使用者於存取介面上進行操作，透過儲存管理模組及轉接模組對儲存空間進行存取，並將存取結果呈現給使用者；以及一儲存管理模組，一端與轉接模組連接，另一端與存取介面連接，將儲存空間中之檔案資料進行處理；本發明藉由轉接模組之設定，讓使用者可與不同型態的儲存空間連接並存取。
製造有機電子元件的裝置及其方法
(2014-02-16)
孟心飛
;
林皓武
;
洪勝富
;
冉曉雯
;
張浩文
一種製造一有機電子元件的方法,包含下列步驟:提供一基板及一有機材料。以該有機材料塗佈於該基板上,並加熱該基板以形成一第一載子傳輸層。將含有一金屬離子之一材料摻雜於該有機材料中,並將其均勻地混合以形成一有機溶液。以及將該有機溶液塗佈在該第一載子傳輸層上,以形成一第二載子傳輸層。
交大e-News第157期
(2014-02-17)
Secretariat
;
國立交通大學秘書室
Toward Functional Screening of Cardioactive and Cardiotoxic Drugs with Zebrafish in Vivo Using Pseudodynamic Three-Dimensional Imaging
(2014-02-18)
Lin, Kuen-You
;
Chang, Wei-Tien
;
Lai, Yu-Cheng
;
Liau, Ian
;
應用化學系
Given the high mortality in patients with cardiovascular diseases and the life-threatening consequences of drugs with unforeseen adverse effects on hearts, a critical evaluation of the pharmacological response of cardiovascular function on model animals is important especially in the early stages of drug development. We report a proof-of-principle study to demonstrate the utility of zebrafish as an analytical platform to predict the cardiac response of new drugs or chemicals on human beings. With pseudodynamic 3D imaging, we derive individual parameters that are central to the cardiac function of zebrafish, including the ventricular stroke volume, ejection fraction, cardiac output, heart rate, diastolic filling function, and ventricular mass. We evaluate both inotropic and chronotropic responses of the heart of zebrafish treated with drugs that are commonly prescribed and possess varied known cardiac activities. We reveal deranged cardiac function of a zebrafish model of cardiomyopathy induced with a cardiotoxic drug. The cardiac function of zebrafish exhibits a pharmacological response similar to that of human beings. We compare also cardiac parameters obtained in this work with those derived with conventional 2D approximation and show that the latter tends to overestimate the cardiac parameters and produces results of greater variation. In view of the growing interest of using zebrafish in both fundamental and translational biomedical research, we envisage that our approach should benefit not only contemporary pharmaceutical development but also exploratory research such as gene, stem cell, or regenerative therapies targeting congenital or acquired heart diseases.