Browsing by Issue Date, starting with "2014-02-18"

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Toward Functional Screening of Cardioactive and Cardiotoxic Drugs with Zebrafish in Vivo Using Pseudodynamic Three-Dimensional Imaging
(2014-02-18)
Lin, Kuen-You
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Chang, Wei-Tien
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Lai, Yu-Cheng
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Liau, Ian
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應用化學系
Given the high mortality in patients with cardiovascular diseases and the life-threatening consequences of drugs with unforeseen adverse effects on hearts, a critical evaluation of the pharmacological response of cardiovascular function on model animals is important especially in the early stages of drug development. We report a proof-of-principle study to demonstrate the utility of zebrafish as an analytical platform to predict the cardiac response of new drugs or chemicals on human beings. With pseudodynamic 3D imaging, we derive individual parameters that are central to the cardiac function of zebrafish, including the ventricular stroke volume, ejection fraction, cardiac output, heart rate, diastolic filling function, and ventricular mass. We evaluate both inotropic and chronotropic responses of the heart of zebrafish treated with drugs that are commonly prescribed and possess varied known cardiac activities. We reveal deranged cardiac function of a zebrafish model of cardiomyopathy induced with a cardiotoxic drug. The cardiac function of zebrafish exhibits a pharmacological response similar to that of human beings. We compare also cardiac parameters obtained in this work with those derived with conventional 2D approximation and show that the latter tends to overestimate the cardiac parameters and produces results of greater variation. In view of the growing interest of using zebrafish in both fundamental and translational biomedical research, we envisage that our approach should benefit not only contemporary pharmaceutical development but also exploratory research such as gene, stem cell, or regenerative therapies targeting congenital or acquired heart diseases.
Contamination of Medical Charts: An Important Source of Potential Infection in Hospitals
(2014-02-18)
Chen, Kuo-Hu
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Chen, Li-Ru
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Wang, Ying-Kuan
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機械工程學系
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Department of Mechanical Engineering
Objective: This prospective study aims to identify and compare the incidence of bacterial contamination of hospital charts and the distribution of species responsible for chart contamination in different units of a tertiary hospital. Methods: All beds in medical, surgical, pediatric, and obstetric-gynecologic general wards (556) and those in corresponding special units (125) including medical, surgical, pediatric intensive care units (ICUs), the obstetric tocolytic unit and delivery room were surveyed for possible chart contamination. The outer surfaces of included charts were sampled by one experienced investigator with sterile cotton swabs rinsed with normal saline. Results: For general wards and special units, the overall sampling rates were 81.8% (455/556) and 85.6% (107/125) (p = 0.316); the incidence of chart contamination was 63.5% and 83.2%, respectively (p<0.001). Except for obstetric-gynecologic charts, the incidence was significantly higher in each and in all ICUs than in corresponding wards. Coagulase-negative staphylococci was the most common contaminant in general wards (40.0%) and special units (34.6%) (p>0.05). Special units had a significantly higher incidence of bacterial contamination due to Staphylococcus aureus (17.8%), Methicillin-resistant Staphylococcus aureus (9.3%), Streptococcus viridans (9.4%), Escherichia coli (11.2%), Klebsiella pneumoniae (7.5%), and Acinetobacter baumannii (7.5%). Logistic regression analysis revealed the incidence of chart contamination was 2- to 4-fold higher in special units than in general wards [odds ratios: 1.97-4.00]. Conclusions: Noting that most hospital charts are contaminated, our study confirms that a hospital chart is not only a medical record but also an important source of potential infection. The plastic cover of the medical chart can harbor potential pathogens, thus acting as a vector of bacteria. Additionally, chart contamination is more common in ICUs. These findings highlight the importance of effective hand-washing before and after handling medical charts. However, managers and clinical staff should pay more attention to the issue and may consider some interventions.
林保煙新瓦屋故事說給你聽
(2014-02-18)
Department of Communication and Technology
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傳播與科技學系
煦陽平鋪在略帶斑駁的水泥地，麻雀三兩成群地在客家花布拼貼成的燈籠上蹦跳，新瓦屋導覽員林保煙遠遠地從廣場走來，身上那件社區巡守隊的義工外套因為太陽的照射而閃著螢光，平穩的步伐、靦腆的表情，林保煙停下腳步，在他走過數萬遍的林家忠孝堂前，卸下一臉的疲憊說：「來，我們進來這裡。」　
Exploring steering effects using Bell tests
(2014-02-18)
Lo, Hsin-Pin
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Yabushita, Atsushi
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Hsu, Li-Yi
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電子物理學系
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Department of Electrophysics
We study the interconnection among steering, uncertainty, and quantum correlation. The practical steering criteria for bipartite quantum entanglement are proposed using the multiple applications of the Maassen-Uffink uncertainty relation. The results show that distant steering causes less uncertainty than that in any local-hidden-variable theories. The reduction of uncertainty in the quantum steering of entangled states leads to quantum correlation. The steering visibility for the mixed states is also discussed. The experimental results on the proposed steering criteria are reported.
看淡族群觀念　熱情擁抱賽夏人
(2014-02-18)
吳奕樺
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Department of Communication and Technology
;
傳播與科技學系
從南庄車站蜿蜒山路而上，密密麻麻的冷杉植物包圍著一個閃亮的民族。這是一個不同於南庄客家的另一個美麗文化。他們，在台灣文化默默綻放；他們，正敞開嗓子高聲歌唱；他們，墊腳尖跳著舞，心也跟著飛揚。左一個迴旋，右一個側彎，將賽夏文化展露無遺。
Integrated circuit device
(2014-02-18)
Chen Kuan-Neng
;
Lai Ming-Fang
;
Chen Hung-Ming
An integrated circuit device includes: a first chip including a first substrate and a main circuit formed on said first chip; a second chip stacked on the first substrate and including a second substrate that is independent from the first substrate, and a protective circuit for protecting the main circuit; and a conductive channel unit extending from the protective circuit and electrically connected to the main circuit.
彭淑蓉客家就在生活裡
(2014-02-18)
楊敦元
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Department of Communication and Technology
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傳播與科技學系
一談到要接受採訪時，身為上班族的彭淑蓉羞赧地說：「我什麼都不懂啦！沒有辦法像那些學者專家講出那麼冠冕堂皇的大道理，只能告訴你一些我自己怎麼在日常生活中實踐並散播客家精神的做法。」
Strong thermal fluctuations in cuprate superconductors in magnetic fields above T-c
(2014-02-18)
Jiang, Xujiang
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Li, Dingping
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Rosenstein, Baruch
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電子物理學系
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Department of Electrophysics
Recent measurements of fluctuation diamagnetism in high-temperature superconductors show distinct features above and below T-c, which can not be explained by simple Gaussian fluctuation theory. Self-consistent calculation of magnetization in layered high-temperature superconductors, based on the Ginzburg-Landau-Lawrence-Doniach model and including all Landau levels is presented. The results agree well with the experimental data in a wide region around T-c, including both the vortex liquid below T-c and the normal state above T-c. The Gaussian fluctuation theory significantly overestimates the diamagnetism for strong fluctuations. It is demonstrated that the intersection point of magnetization curves appears in the region where the lowest Landau level contribution dominates and magnetization just below T-c is nonmonotonic. Our calculation supports the phase disordering picture of fluctuations above T-c.
PROTEIN TRANSISTOR DEVICE
(2014-02-20)
HUANG Gue-Wha
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HUNG Meng-Yen
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CHEN Yu-Shiun
The present invention discloses a protein transistor device, wherein an antibody molecule (antibody-antigen) is bonded to at least two gold nanoparticles in a high reproducible self-assembly way to form molecular junctions, and wherein the two gold nanoparticles are respectively joined to a drain and a source. The protein transistor device can be controlled to regulate current via applying a bias to the gate. The conformational change of the protein molecule will cause the variation of the charge transport characteristics of the protein transistor device. The protein transistor device can be further controlled by different optical fields via conjugating a quantum dot to the molecular junctions. Therefore, the present invention has diversified applications.
METHOD FOR ADJUSTING A LAYOUT OF AN INTEGRATED CIRCUIT
(2014-02-20)
CHAO Mango C.-T.
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CHEN Kuo-An
;
CHANG Tsung-Wei
A method for adjusting a layout of an integrated circuit includes a first layer, a second layer, a target metal line, and a first non-target metal line. The integrated circuit is configured for a focused ion beam (FIB) detection to the target metal line. The method includes the steps of: disposing the first non-target metal line on the first layer; disposing the target metal line on the second layer; and adjusting one of the target metal line and the first non-target metal line such that the target metal line can be detected by the FIB detection.
OPTICAL DEVICE FOR CAMERA TESTING
(2014-02-20)
Pan Jui-Wen
An optical device is to be disposed between a test screen and a test camera that captures an image on the test screen through the optical device. The optical device includes first, second, third and fourth lenses arranged from a camera side to a screen side in the given order. The first lens has a shape factor ranging from −10 to 5, the second lens is a positive lens and has a shape factor ranging from −15 to 2, the third lens is a positive lens and has a shape factor ranging from −30 to 1, and the fourth lens is a positive lens and has a shape factor ranging from −30 to 1. A ratio of a focal length of the optical device to that of the test camera ranges from 1 to 80.
INTEGRATED STORAGE PLATFORM SYSTEM AND METHOD THEREOF
(2014-02-20)
TSENG Chien-Chao
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HO Cheng-Yun
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LIN Chia-Liang
;
WU Chieh
The present invention discloses an integrated storage platform system and a method thereof. The system comprises at least one adaption module respectively connecting with at least one storage space and each performing a plurality of adaption settings corresponding to one storage space; a storage administration module connecting with the adaption modules and processing the files of the storage spaces; and an access interface connecting the storage administration module, operated by a user to access the storage space through the storage administration module and the adaption module, and presenting access results to the user. The present invention establishes different adaption modules to enable the user to link to and access different types of storage spaces.
METHOD FOR FABRICATING ONE-DIMENSIONAL METALLIC NANOSTRUCTURES
(2014-02-20)
CHEN Yu-Liang
;
CHIEN Nai-Ying
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CHIU Hsin-Tien
;
LEE Chi-Young
A method for fabricating one-dimensional metallic nanostructures comprises steps: sputtering a conductive film on a flexible substrate to form a conductive substrate; placing the conductive substrate in an electrolytic solution, and undertaking electrochemical deposition to form one-dimensional metallic nanostructures corresponding to the conductive film on the conductive substrate. The method fabricates high-surface-area one-dimensional metallic nanostructures on a flexible substrate, exempted from the high price of the photolithographic method, the complicated process of the hard template method, the varied characteristic and non-uniform coating of the seed-mediated growth method.
水濕性可調薄膜及顯示裝置
(2014-02-21)
林怡欣
;
徐旭寬
一種水濕性可調薄膜，包括基板、聚合物層以及液晶層。基板具有交錯排列的第一電極圖案以及第二電極圖案。聚合物層配置於基板上並覆蓋第一電極圖案以及第二電極圖案。液晶層配置於聚合物層的表面上。配置於聚合物層的表面上並覆蓋液晶層的液滴與聚合物層之間的接觸角隨施加於第一電極圖案以及第二電極圖案的電壓改變而改變。另外，一種具有上述水濕性可調薄膜的顯示裝置亦被提出。
垂直式感測器
(2014-02-21)
冉曉雯
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孟心飛
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戴銘志
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趙宇強
一種垂直式感測器，係包括：基板；第一電極層，係形成於該基板上；感測層，係形成於該第一電極層上，且令該第一電極層夾置於該基板與感測層之間，其中，該感測層係選自對待測物質有反應的材料或具有對待測物質有反應之部位的材料；以及第二電極層，係形成於該感測層上，並令該感測層夾置於該第一電極層與第二電極層之間，且該第二電極層具有複數孔洞，以供該待測物質接觸該感測層。本發明之垂直式感測器提供即時、靈敏及快速之偵測性能。
光學成像系統
(2014-02-21)
鄭竹明
;
陳志隆
一種光學成像系統，包括一成像鏡頭及一空間光調變器。成像鏡頭具有一光闌位置。空間光調變器配置於成像鏡頭之光闌位置，以作為成像鏡頭的一孔徑光闌。空間光調變器適於調變空間光調變器的光傳遞率以使孔徑光闌的光強度振幅與相位改變。
錄製、還原與重播網路流量的方法
(2014-02-21)
林盈達
;
鄭宗寰
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賴源正
;
陳一瑋
一種錄製、還原與重播網路流量的方法係用以處理多個網路連線的多個網路封包。錄製、還原與重播網路流量的方法可包括錄製程序、還原程序或是選擇性重播程序。其中錄製程序包括：接收錄製參數(N,M,P)；完整錄製每一網路封包的檔頭以及酬載，並累計每一網路連線的酬載總值；當酬載總值之一超過N時，對與酬載總值對應的網路連線的連續P個網路封包錄製每一網路封包的檔頭，以及酬載的前M個位元組；以及當酬載總值之一超過N並對與酬載總值對應的網路連線連續錄製P個網路封包之後，對與酬載總值對應的網路連線錄製每一網路封包的檔頭。
Improvement of emission uniformity by using micro-cone patterned PDMS film
(2014-02-24)
Liu, Che-Yu
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Chen, Kuo-Ju
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Lin, Da-Wei
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Lee, Chia-Yu
;
Lin, Chien-Chung
Micro-patterned PDMS film was fabricated and combined with LED chip on board (COB) package to improve the emission uniformity of LED chip. The micro scale patterned sapphire substrate (PSS) was used as a mold to fabricate micro-cone patterned PDMS (MC-PDMS) film. A strong scattering effect from this MC-PDMS film can be verified by the high haze ratio and the Bi-directional Transmission effect. The angle dependent color temperature measurement system was used to measure the Delta CCT of COB with and without MC-PDMS. The measurement results indicate that the Delta CCT was reduced from 1025K to 428K. This improvement can effectively eliminate the yellow ring effect of LED chip. This technology can be thus considered as a cost-effective way for the next generation of light source packages. (C) 2014 Optical Society of America
Supercontinuum generation in highly nonlinear fibers using amplified noise-like optical pulses
(2014-02-24)
Lin, Shih-Shian
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Hwang, Sheng-Kwang
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Liu, Jia-Ming
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光電系統研究所
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Institute of Photonic System
Supercontinuum generation in a highly nonlinear fiber pumped by noise-like pulses from an erbium-doped fiber ring laser is investigated. To generate ultrabroad spectra, a fiber amplifier is used to boost the power launched into the highly nonlinear fiber. After amplification, not only the average power of the noise-like pulses is enhanced but the spectrum of the pulses is also broadened due to nonlinear effects in the fiber amplifier. This leads to a reduction of the peak duration in their autocorrelation trace, suggesting a similar extent of pulse compression; by contrast, the pedestal duration increases only slightly, suggesting that the noise-like characteristic is maintained. By controlling the pump power of the fiber amplifier, the compression ratio of the noise-like pulse duration can be adjusted. Due to the pulse compression, supercontinuum generation with a broader spectrum is therefore feasible at a given average power level of the noise-like pulses launched into the highly nonlinear fiber. As a result, supercontinuum generation with an optical spectrum spanning from 1208 to 2111 nm is achieved using a 1-m nonlinear fiber pumped by amplified noise-like pulses of 15.5 MHz repetition rate at an average power of 202 mW. (C) 2014 Optical Society of America
High spectral efficient W-band optical/wireless system employing Single-Sideband Single-Carrier Modulation
(2014-02-24)
Ho, Chun-Hung
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Lin, Chun-Ting
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Cheng, Yu-Hsuan
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Huang, Hou-Tzu
;
Wei, Chia-Chien
With broader available bandwidth, W-band wireless transmission has attracted a lot of interests for future Giga-bit communication. In this article, we experimentally demonstrate W-band radio-over-fiber (RoF) system employing single-sideband single-carrier (SSB-SC) modulation with lower peak-to-average-power ratio (PAPR) than orthogonal frequency division multiplex (OFDM). To overcome the inter-symbol interference (ISI) of the penalty from uneven frequency response and SSB-SC modulation, frequency domain equalizer (FDE) and decision feedback equalizer (DFE) are implemented. We discuss the maximum available bandwidth of different modulation formats between SSB-SC and OFDM signals at the BER below forward error correction (FEC) threshold (3.8 x 10(-3)). Up to 50-Gbps 32-QAM SSB-SC signals with spectral efficiency of 5 bit/s/Hz can be achieved. (C) 2014 Optical Society of America