Browsing by Issue Date, starting with "2014-09-15"

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Structure and function of TatD exonuclease in DNA repair
(2014-09-15)
Chen, Yi-Chen
;
Li, Chia-Lung
;
Hsiao, Yu-Yuan
;
Duh, Yulander
;
Yuan, Hanna S.
TatD is an evolutionarily conserved protein with thousands of homologues in all kingdoms of life. It has been suggested that TatD participates in DNA fragmentation during apoptosis in eukaryotic cells. However, the cellular functions and biochemical properties of TatD in bacterial and non-apoptotic eukaryotic cells remain elusive. Here we show that Escherichia coli TatD is a Mg2+-dependent 3\'-5\' exonuclease that prefers to digest single-stranded DNA and RNA. TatD-knockout cells are less resistant to the DNA damaging agent hydrogen peroxide, and TatD can remove damaged deaminated nucleotides from a DNA chain, suggesting that it may play a role in the H2O2-induced DNA repair. The crystal structure of the apo-form TatD and TatD bound to a single-stranded three-nucleotide DNA was determined by X-ray diffraction methods at a resolution of 2.0 and 2.9 angstrom, respectively. TatD has a TIM-barrel fold and the single-stranded DNA is bound at the loop region on the top of the barrel. Mutational studies further identify important conserved metal ion-binding and catalytic residues in the TatD active site for DNA hydrolysis. We thus conclude that TatD is a new class of TIM-barrel 3\'-5\' exonuclease that not only degrades chromosomal DNA during apoptosis but also processes single-stranded DNA during DNA repair.
Expression of an expanded CGG-repeat RNA in a single pair of primary sensory neurons impairs olfactory adaptation in Caenorhabditis elegans
(2014-09-15)
Juang, Bi-Tzen
;
Ludwig, Anna L.
;
Benedetti, Kelli L.
;
Gu, Chen
;
Collins, Kimberly
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a severe neurodegenerative disorder that affects carriers of premutation CGG-repeat expansion alleles of the fragile X mental retardation 1 (FMR1) gene; current evidence supports a causal role of the expanded CGG repeat within the FMR1 mRNA in the pathogenesis of FXTAS. Though the mRNA has been observed to induce cellular toxicity in FXTAS, the mechanisms are unclear. One common neurophysiological characteristic of FXTAS patients is their inability to properly attenuate their response to an auditory stimulus upon receipt of a small pre-stimulus. Therefore, to gain genetic and cell biological insight into FXTAS, we examined the effect of expanded CGG repeats on the plasticity of the olfactory response of the genetically tractable nematode, Caenorhabditis elegans(C. elegans). While C. elegans is innately attracted to odors, this response can be downregulated if the odor is paired with starvation. We found that expressing expanded CGG repeats in olfactory neurons interfered with this plasticity without affecting either the innate odor-seeking response or the olfactory neuronal morphology. Interrogation of three RNA regulatory pathways indicated that the expanded CGG repeats act via the C. elegans microRNA (miRNA)-specific Argonaute ALG-2 to diminish olfactory plasticity. This observation suggests that the miRNA-Argonaute pathway may play a pathogenic role in subverting neuronal function in FXTAS.
Compositional grading in GaAsSb grown on GaAs substrates
(2014-09-15)
Lin, Y. M.
;
Chen, C. H.
;
Wu, J. S.
;
Lee, C. P.
;
電子工程學系及電子研究所
The composition profile and lattice strain of GaAsSb grown on GaAs substrates by molecular beam epitaxy have been investigated using the Rutherford backscattering spectrometry (RBS) and X-ray reciprocal space mapping. Through RBS, we found that the Sb content in the layer increases from the interface to the top surface. The X-ray reciprocal space mapping shows that the GaAsSb lattice also gradually relaxes as the layer becomes thicker. The behavior of composition grading and gradual lattice relaxation is quite different from those of III-V ternary compounds with two group Ill atoms. (C) 2014 Elsevier B.V. All rights reserved.
Dynamic magnetic interaction in La2/3Sr1/3MnO3/BiFeO3 heterostructure
(2014-09-15)
Guo, H. Y.
;
Lin, J. G.
;
Yang, Jan Chi
;
Chu, Y. H.
;
材料科學與工程學系
The La2/3Sr1/3MnO3/BiFeO3 (LSMO/BFO) heterostructure is studied as probed by temperature-dependent ferromagnetic resonance (FMR). Consistent with the structure analysis, two FMR modes are found for both a single LSMO layer and a LSMO/BFO bilayer grown on DyScO3, corresponding to the strained and relaxed phases of LSMO. The FMR linewidth intensity vs temperature curve shows two maxima at 200 K and 140 K in the strained phase of LSMO/BFO bilayer, which is related to the magnetic excitations in BFO. Our results demonstrate a dynamic spin interaction between LSMO and BFO, suggesting an effective route to manipulate the magnetic properties of oxide heterostructures. (C) 2014 AIP Publishing LLC.
Compositional grading in GaAsSb grown on GaAs substrates
(2014-09-15)
Lin, Y. M.
;
Chen, C. H.
;
Wu, J. S.
;
Lee, C. P.
;
電子工程學系及電子研究所
The composition profile and lattice strain of GaAsSb grown on GaAs substrates by molecular beam epitaxy have been investigated using the Rutherford backscattering spectrometry (RBS) and X-ray reciprocal space mapping. Through RBS, we found that the Sb content in the layer increases from the interface to the top surface. The X-ray reciprocal space mapping shows that the GaAsSb lattice also gradually relaxes as the layer becomes thicker. The behavior of composition grading and gradual lattice relaxation is quite different from those of III-V ternary compounds with two group Ill atoms. (C) 2014 Elsevier B.V. All rights reserved.
Circuit board with twinned CU circuit layer and method for manufacturing the same
(2014-09-16)
Chen Chih
;
Hsiao Hsiang-Yao
A circuit board with twinned Cu circuit layer and a method for manufacturing the same are disclosed, wherein the method comprises the following steps: (A) providing a substrate with a first circuit layer formed thereon, wherein the first circuit layer comprises a conductive pad; (B) forming a first dielectric layer on the surface of the substrate; (C) forming plural openings in the first dielectric layer, wherein each opening penetrates through the first dielectric layer and communicates with the conductive pad to expose the conductive pad; (D) forming a Cu seeding layer in the openings; (E) forming a nano-twinned Cu layer in the openings with an electroplating process; and (F) annealing the substrate to transfer the material of the Cu seeding layer into nano-twinned Cu, wherein the nano-twinned Cu layer and the transferred Cu seeding layer are formed into a second circuit layer.
工程變更之保持時間修復方法
(2014-09-16)
江蕙如
;
楊喻名
;
何松庭
近代電路設計中,往往需要考量可能面臨到的動態變異,因此,電路設計會考慮最糟的情況,並透過預留的時序保護帶來確保電路能夠正確的運作,但也因此降低的電路的效能。為了消除時序保護帶,習知技術使用可復原式電路。然而,可復原式電路將會面臨到更嚴峻的短路徑問題。本發明為了使得可復原式電路的錯誤偵測與修正能夠發揮作用,因此提供一工程變更之保持時間修復方法,以解決短路徑填補問題。異於習知技術的是本發明使用全域觀點來決定填補數値與位置。此外,本發明進一步提出粗質延遲填補與細質延遲填補方法,根據所決定的填補數値來加以實現。
奈米粒子藥物載體、藥物組合物及其製造方法
(2014-09-16)
陳三元
;
李偉銘
一種藥物組合物，包括奈米粒子、外殼及藥物，其中該奈米粒子具一外表面，該藥物與該外殼混合，並形成於該外表面上。
用於無線傳輸環境中的影像傳輸方法
(2014-09-16)
林烜立
;
吳東祐
;
余恭賢
;
黃經堯
一種跨層適應的方法,其可應用在家庭無線基地台,本發明在無線環境中傳輸可調式高畫質影像串流內容且同時維持服務質量。透過最小化影像失真之最適化架構,本發明可採用跨層之參數,包括影像率、封包長度及調變及編碼方式等。基於通道品質以及相關參數,本發明將參數選擇之問題公式化成最佳化問題並自動求解。
Digital-to-analog converter (DAC) circuit and weight error estimation/calibration method thereof
(2014-09-16)
Hong Hao-Chiao
;
Wang Yu-Shien
The present invention discloses a DAC circuit and a weight error estimation/calibration method thereof. In the method, an output switching circuit dynamically selects several conversion cells (at least containing know weight conversion cells (KWCC)) as a reference conversion cell group (RCCG) from all conversion cells, and dynamically selects at least one unknown weight conversion cell (UWCC) from all UWCCs. An ADC digitalizes the difference of the output of RCCG and the sum of the outputs of the UWCCs, and inputs the result to a digital controller. The digital controller controls the input of the RCCG according to the output of the ADC to make the output of the RCCG approximate the output of the UWCC. The digital controller uses the outputs of the ADC to work out the actual weights of the UWCCs and stores the actual weights in a calibration memory.
Engineering change order hold time fixing method
(2014-09-16)
Jiang Hiu-Ru
;
Yang Yu-Ming
;
Ho Sung-Ting
An ECO hold time fixing method fulfills a short path padding in a placed and routed design by a minimum capacitance insertion. In the method, a padding value determination step receives the placed and routed design and is based on a cell library, timing constraints, and a timing analysis report to determine padding values and locations required for each gate of the placed and routed design to output. A load/buffer allocation step is based on a spare cell information, a dummy metal information, and the padding values and locations to achieve the short path padding in the placed and routed design.
Method for extracting the feature of an abdominal breathing and a system using the same
(2014-09-16)
Hsiao Tzu-Chien
;
Hsu Ju-Hsin
A method for extracting the feature of an abdominal breathing is disclosed, capable of extracting the feature of an abdominal breathing, without the requirement of a standard model of an abdominal breathing and the execution of a learning process being executed prior to the method for extracting the feature of an abdominal breathing. By means of computing a plurality of intrinsic mode functions corresponding to the abdominal breathing signal received, an Euler angle function and an instantaneous frequency function of each of the plurality of intrinsic mode functions, and comparing the plurality of instantaneous frequency function with a pre-determined zero-point threshold region, the method for extracting the feature of an abdominal breathing defines one of the plurality of instantaneous frequency function as an abdominal breathing feature function, which contains the feature of the abdominal breathing. In this way, the feature of an abdominal breathing is extracted.
Method for inhibiting growth of intermetallic compounds
(2014-09-16)
Chen Chih
;
Tu King-Ning
;
Hsiao Hsiang-Yao
The present invention relates to a method for inhibiting growth of intermetallic compounds, comprising the steps of: (i) preparing a substrate element including a substrate on which at least one layer of metal pad is deposited, wherein at least one thin layer of solder is deposited onto the layer of metal pad, and then carry out reflowing process; and (ii) further depositing a bump of solder with an appropriate thickness on the substrate element, characterized in that a thin intermetallic compound is formed by the reaction of the thin solder layer and the metal in the metal pad after appropriate heat treatment of the thin solder layer. In the present invention, the formation of a thin intermetallic compound is able to slow the growth of the intermetallic compound and to prevent the transformation of the intermetallic compounds.
Flash memory
(2014-09-16)
Chin Albert
;
Tsai Chun-Yang
A MONOS Charge-Trapping flash (CTF), with record thinnest 3.6 nm ENT trapping layer, has a large 3.1 V 10-year extrapolated retention window at 125° C. and excellent 106 endurance at a fast 100 μs and ±16 V program/erase. This is achieved using As+-implanted higher κ trapping layer with deep 5.1 eV work-function of As. In contrast, the un-implanted device only has a small 10-year retention window of 1.9 V at 125° C. A MoN—[SiO2—LaAlO3]—[Ge—HfON]—[LaAlO3—SiO2]—Si CTF device is also provided with record-thinnest 2.5-nm Equivalent-Si3N4-Thickness (ENT) trapping layer, large 4.4 V initial memory window, 3.2 V 10-year extrapolated retention window at 125° C., and 3.6 V endurance window at 106 cycles, under very fast 100 μs and low ±16 V program/erase. These were achieved using Ge reaction with HfON trapping layer for better charge-trapping and retention.
Static memory and memory cell thereof
(2014-09-16)
Jou Shyh-Jye
;
Tu Ming-Hsien
;
Hu Yu-Hao
;
Chuang Ching-Te
;
Chiu Yi-Wei
A static memory and a static memory cell are provided. The static memory cell includes a first transistor, a second transistor, a third transistor, a fourth transistor, a fifth transistor, a sixth transistor, a first switch, a second switch, a third switch, a first pull-down switch, and a second pull-down switch. When a data writing operation is performed, the latching capability of the latch circuit constituted by the first to the sixth transistors is disabled by turning off the second transistor or the fifth transistor, so that the speed of the data writing operation is increased and the data writing performance is improved. The first switch and the second switch provide a path for reading or writing data, and the third switch is coupled to a bit line for receiving data from or transmitting data to the bit line.
Efficiency improvement of GaN-based ultraviolet light-emitting diodes with reactive plasma deposited AlN nucleation layer on patterned sapphire substrate
(2014-09-16)
Lee, Chia-Yu
;
Tzou, An-Jye
;
Lin, Bing-Cheng
;
Lan, Yu-Pin
;
Chiu, Ching-Hsueh
The flip chip ultraviolet light-emitting diodes (FC UV-LEDs) with a wavelength of 365 nm are developed with the ex situ reactive plasma deposited (RPD) AlN nucleation layer on patterned sapphire substrate (PSS) by an atmospheric pressure metal-organic chemical vapor deposition (AP MOCVD). The ex situ RPD AlN nucleation layer can significantly reduce dislocation density and thus improve the crystal quality of the GaN epitaxial layers. Utilizing high-resolution X-ray diffraction, the full width at half maximum of the rocking curve shows that the crystalline quality of the epitaxial layer with the (RPD) AlN nucleation layer is better than that with the low-temperature GaN (LT-GaN) nucleation layer. The threading dislocation density (TDD) is estimated by transmission electron microscopy (TEM), which shows the reduction from 6.8 x 10(7) cm(-2) to 2.6 x 10(7) cm(-2). Furthermore, the light output power (LOP) of the LEDs with the RPD AlN nucleation layer has been improved up to 30 % at a forward current of 350 mA compared to that of the LEDs grown on PSS with conventional LT-GaN nucleation layer.
WIRELESS INTRAOCULAR PRESSURE MONITORING DEVICE, AND DETECTING MODULE THEREOF
(2014-09-18)
Huang Tzuen-Hsi
;
Lin Ying-Chun
;
Su Wei-Shang
;
Cheng Huey-Wen
;
Huang Hong-Yi
A wireless intraocular pressure monitoring device includes reflecting and detecting modules. The reflecting module includes a soft contact lens having a curvature corresponding to that of a cornea while worn. A metal layer is embedded in and deformable with the soft contact lens. The detecting module includes two waveguides, an oscillator, and a converting unit. The oscillator is operable to generate oscillation signals having a frequency dependent on an equivalent impedance of the waveguides such that the equivalent impedance corresponds to intraocular pressure. The converting unit is operable for receiving and converting the oscillation signals into an output signal corresponding to the intraocular pressure.
METHOD FOR DISPLAYING A GRAPHIC INTERFACE WITH MESSAGE/NOTIFICATION, APPARATUS, AND NON-TRANSITORY COMPUTER-READABLE MEDIUM
(2014-09-18)
HSU TERNG-YIN
;
LAI WEI-CHI
Disclosure is related to a method for displaying a graphic interface with message/notification, an apparatus, and a computer-readable storage device. It is featured that a graphic interface is displayed on a screen of a mobile device for showing one or more messages/notifications in one limited area. This interface allows a user to preview the message before clicking the link. After that, the full content can be read while the link is opened. The method includes firstly parsing the received message/notification and retrieving the content, format, and the correlated software program. Based on numbers, formats and the correlated software programs of the messages, the content displayed onto a graphic interface is arranged. On the graphic interface, one or more preview content of the messages/notifications having profiles of specifying one or more software programs are provided for the user to click for viewing the full content.
TRANSMISSION OF VIDEO IN WIRELESS ENVIRONMENT
(2014-09-18)
LIN HSUAN-LI
;
WU TUNG-YU
;
YU KUNG-HSIEN
;
HUANG CHIN-YAO
A cross-layer adaptation scheme, which can be applied in a femto base station, is proposed for quality of service provisions for the scalable video streaming of high definition content in a wireless environment. Within the procedure of minimum video distortion optimization framework, the method can dynamically adopt the cross-layer parameters, which contain the video rate, payload length of a packet, the mode of modulation and coding scheme. Based on channel quality and related parameters, the proposed scheme formulates the problem of parameter selection into an optimization problem, which can be automatically solved.
Variability of stream flow discharge in response to self-similar random fields of temporal fluctuations in lateral inflow rate
(2014-09-19)
Chang, Ching-Min
;
Yeh, Hund-Der
;
環境工程研究所
;
Institute of Environmental Engineering
This article presents the use of stochastic methodology for quantitative analysis of variability in stream flow discharge in response to fluctuations in lateral inflow rate, where the lateral inflow rate is considered to be the difference between rainfall and infiltration rates. In this work, we focus on the case where the temporal correlation structure of the fluctuations in the lateral inflow rate can be characterized by the statistics of random fractals. A closed-form expression quantifying the stream flow variability is therefore developed to investigate the influence of the fractal dimension of lateral inflow process and the size of time domain. It is found that the stream flow discharge variability increases with the time domain size, while the fractal dimension of lateral inflow process plays a role in the smoothness of fluctuations in stream flow discharge around the mean. (C) 2014 Elsevier B.V. All rights reserved.