Browsing by Issue Date, starting with "2014-10-23"

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YB-1 disrupts mismatch repair complex formation, interferes with MutS alpha recruitment on mismatch and inhibits mismatch repair through interacting with PCNA
(2014-10-23)
Chang, Y-W
;
Mai, R-T
;
Fang, W-H
;
Lin, C-C
;
Chiu, C-C
Y-box binding protein-1 (YB-1) is highly expressed in tumors and it participates in various cellular processes. Previous studies indicated that YB-1 binds to mispaired DNA and interacts with several mismatch repair (MMR)-related factors. However, its role in the MMR system remains undefined. Here, we found that YB-1 represses mutS homolog 6 (MSH6)-containing MMR complex formation and reduces MutS alpha mismatch binding activity by disrupting interactions among MMR-related factors. In an effort to elucidate how YB-1 exerts this inhibitory effect, we have identified two functional proliferating cell nuclear antigen (PCNA)interacting protein (PIP)-boxes that mediate YB-1/PCNA interaction and locate within the C-terminal region of YB-1. This interaction is critical for the regulatory role of YB-1 in repressing MutSa mismatch binding activity, disrupting MutS alpha/PCNA/G/T heteroduplex ternary complex formation and inhibiting in vitro MMR activity. The differential regulation of 3\' and 5\' nick-directed MMR activity by YB-1 was also observed. Moreover, YB-1 overexpression is associated with the alteration of microsatellite pattern and the enhancement of N-methyl-N\'-nitro-N-nitrosoguanidine (MNNG)-induced and spontaneous mutations. Furthermore, upregulation of other PIP-box-containing proteins, such as myeloid cell leukemia-1 (Mcl-1) and inhibitor of growth protein 1b (ING1b), has no impact on MMR complex formation and mutation accumulation, thus revealing the significant effect of YB-1 on regulating the MMR system. In conclusion, our study suggests that YB-1 functions as a PCNA-interacting factor to exert its regulatory role on the MMR process and involves in the induction of genome instability, which may partially account for the oncogenic potential of YB-1.
REAL-TIME SIGNAL PROCESSING SYSTEM AND METHOD BASED ON MULTI-CHANNEL INDEPENDENT COMPONENT ANALYSIS
(2014-10-23)
Fang Wai-Chi
;
Shih Wei-Yeh
;
Liao Jui-Chien
;
Huang Kuan-Ju
;
Chen Chiu-Kuo
A real-time signal processing system and method based on multi-channel independent component analysis (ICA). A one-pass recursive ICA processor uses a computation module to perform multi-channel ICA on a set of first data to generate a plurality of second data and third data. A noise removing module uses the computation module to identify noise in the second data and remove the identified noise to generate a plurality of fourth data. A reconstruction module uses the computation module to reconstruct the set of first data based on the fourth data and the third data to generate a plurality of fifth data. The one-pass recursive ICA processor, the noise removing module, the reconstruction module and the computation module are all implemented on a single chip, such that the one-pass recursive ICA processor, the noise removing module and the reconstruction module share the same computation module to save hardware resources.
Bacterial Communities in Semen from Men of Infertile Couples: Metagenomic Sequencing Reveals Relationships of Seminal Microbiota to Semen Quality
(2014-10-23)
Weng, Shun-Long
;
Chiu, Chih-Min
;
Lin, Feng-Mao
;
Huang, Wei-Chih
;
Liang, Chao
Some previous studies have identified bacteria in semen as being a potential factor in male infertility. However, only few types of bacteria were taken into consideration while using PCR-based or culturing methods. Here we present an analysis approach using next-generation sequencing technology and bioinformatics analysis to investigate the associations between bacterial communities and semen quality. Ninety-six semen samples collected were examined for bacterial communities, measuring seven clinical criteria for semen quality (semen volume, sperm concentration, motility, Kruger\'s strict morphology, antisperm antibody (IgA), Atypical, and leukocytes). Computer-assisted semen analysis (CASA) was also performed. Results showed that the most abundant genera among all samples were Lactobacillus (19.9%), Pseudomonas (9.85%), Prevotella (8.51%) and Gardnerella (4.21%). The proportion of Lactobacillus and Gardnerella was significantly higher in the normal samples, while that of Prevotella was significantly higher in the low quality samples. Unsupervised clustering analysis demonstrated that the seminal bacterial communities were clustered into three main groups: Lactobacillus, Pseudomonas, and Prevotella predominant group. Remarkably, most normal samples (80.6%) were clustered in Lactobacillus predominant group. The analysis results showed seminal bacteria community types were highly associated with semen health. Lactobacillus might not only be a potential probiotic for semen quality maintenance, but also might be helpful in countering the negative influence of Prevotella and Pseudomonas. In this study, we investigated whole seminal bacterial communities and provided the most comprehensive analysis of the association between bacterial community and semen quality. The study significantly contributes to the current understanding of the etiology of male fertility.
CARBON DIOXIDE ADSORBENT, THE MANUFACTURING METHOD THEREOF, AND THE USE METHOD THEREOF
(2014-10-23)
Chen San-Yuan
;
Su Fang-Yi
;
Chang Po-Hsueh
A method for manufacturing a carbon dioxide adsorbent is provided. The method comprises steps of providing a limestone having a first specific surface area, treating the limestone with acid solution to obtain a first substance having a second specific surface area larger than the first specific surface area, at the same time reacting the first substance with an anti-sintering agent to obtain a second substance, and calcining the second substance to obtain the carbon dioxide adsorbent containing calcium-based oxides.
丘昌泰　發掘客家新藍海
(2014-10-24)
吳雨潔
;
Department of Communication and Technology
;
傳播與科技學系
「你們其他族群到客家學院只有給客家學院加分，沒有減分，因為你客家人說自己的文化好，老實講，這個沒有什麼，自吹自擂，當別人都說你的文化好的時候，你當然就可以發展出來。」融合自身對於公共行政與管理的專長，曾經擔任中央大學客家學院院長、客家政治經濟研究所所長的丘昌泰，對於客家文化的延續總是有著創新的見解。
紙膠帶魅力　貼進臺灣
(2014-10-26)
張婷芳
;
李恬芳
;
Department of Communication and Technology
;
傳播與科技學系
日本mt和紙膠帶首度在海外舉辦展覽，地點選在臺北的原中山配銷處(URS 21)。
掀開面紗　揭示黑暗內幕
(2014-10-26)
郭穎慈
;
Department of Communication and Technology
;
傳播與科技學系
《黑暗邊緣》為土耳其作家哈根‧坤戴的小說作品，揭露土耳其社會中被藏在深處，從來不被人注意的邊陲地帶。
眼淚　模糊著眼看世界
(2014-10-26)
鄭青青
;
Department of Communication and Technology
;
傳播與科技學系
「其實我們也不想哭，只是真的忍不住。」這是一個愛哭鬼才會知道的秘密。
二手綠市集　公益新逛法
(2014-10-26)
洪詩宸
;
沈祖廷
;
Department of Communication and Technology
;
傳播與科技學系
新形式的二手市集，結合眾多社會面向，希望推廣環保及公益理念。
范范
(2014-10-26)
包金
;
Department of Communication and Technology
;
傳播與科技學系
你今天打噴嚏了嗎？
(2014-10-26)
黃美恩
;
Department of Communication and Technology
;
傳播與科技學系
過度趣味化的新聞媒體中的同志婚姻。
觀眾上台演　劇場中的論壇
(2014-10-26)
杜以翔
;
Department of Communication and Technology
;
傳播與科技學系
評論「論壇劇場」此種戲劇形式，與一般舞台劇的比較，以及論壇劇場本身的特色之處。
不只發夢　更要發達
(2014-10-26)
洪雯倩
;
Department of Communication and Technology
;
傳播與科技學系
當白日夢不再只是個幻想，實際付出於生活上時，一段充滿瘋狂的冒險旅程也就此展開。
浩室音樂　混音新樣貌
(2014-10-26)
黃詩涵
;
Department of Communication and Technology
;
傳播與科技學系
介紹韓國House Rulez三人電音團體的特別曲風與浩室音樂的發展。
總編輯的話
(2014-10-26)
劉敏慈
;
Department of Communication and Technology
;
傳播與科技學系
一九八期喀報是第五次出刊，共收到二十一份稿件。此次共有七種類目，分別為心情故事兩篇、書評七篇、影評五篇、樂評兩篇、即時兩則，人物及照片故事各一篇。
現實中的奇幻　角色扮演
(2014-10-26)
李怡安
;
Department of Communication and Technology
;
傳播與科技學系
《亞洲動漫創作展-Petit Fancy》盛大舉行，場內場外聚集了許多角色扮演玩家。
Perovskite Oxides as Resistive Switching Memories: A Review
(2014-10-26)
Panda, Debashis
;
Tseng, Tseung-Yuen
;
電子工程學系及電子研究所
;
Department of Electronics Engineering and Institute of Electronics
Numerous metal-insulator-metal systems demonstrate electrically induced resistive switching effects and have therefore been proposed as the basis for future nonvolatile memories. They combine the advantages of flash memories and dynamic random access memories while avoiding their drawbacks, such as operation speed, power consumption and device integration and scalable issues. The RRAM devices primarily operate at different resistance values to store the digital data and can keep the resistance state without any power supply. Recent advances in the understanding of the resistive switching mechanism are explained by a thermal or electrochemical redox reaction near the interface between the oxide and the top active metal electrode. Here we review the ongoing research and development activities on the perovskite based resistive switching memory devices. The possible switching mechanisms for the resistive switching are described. The effects of crystal structure, dopants, doping concentrations, annealing temperature, device structures and thickness of the active oxide layer on the resistive switching characteristics and consequently the memory performances are also discussed. From this insight, we take a brief look into different effect on the switching of the perovskite material systems.
魔術　追求頂尖的毀滅之路
(2014-10-26)
陳怡均
;
Department of Communication and Technology
;
傳播與科技學系
電影【頂尖對決】，以兩名魔術師賭上一切的世紀之爭，諭示出在過度的執著與狂熱中，所暗藏的致命危險。
正宗口味　日本拉麵職人
(2014-10-26)
賴奕安
;
Department of Communication and Technology
;
傳播與科技學系
什麼樣的理由，讓一個日本人來臺賣拉麵；又因為什麼樣的理由，讓他的拉麵有口皆碑。
愛的歌頌　最美的禮物
(2014-10-26)
余念竹
;
Department of Communication and Technology
;
傳播與科技學系
人生乃是由啜泣、擤鼻和微笑組成。