Browsing by Issue Date, starting with "2015-06-03"

Now showing 1 - 20 of 21549

Explore the Functional Connectivity between Brain Regions during a Chemistry Working Memory Task
(2015-06-03)
Chou, Wen-Chi
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Duann, Jeng-Ren
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She, Hsiao-Ching
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Huang, Li-Yu
;
Jung, Tzyy-Ping
Previous studies have rarely examined how temporal dynamic patterns, event-related coherence, and phase-locking are related to each other. This study assessed reaction-time-sorted spectral perturbation and event-related spectral perturbation in order to examine the temporal dynamic patterns in the frontal midline (F), central parietal (CP), and occipital (O) regions during a chemistry working memory task at theta, alpha, and beta frequencies. Furthermore, the functional connectivity between F-CP, CP-O, and F-O were assessed by component event-related coherence (ERCoh) and component phase-locking (PL) at different frequency bands. In addition, this study examined whether the temporal dynamic patterns are consistent with the functional connectivity patterns across different frequencies and time courses. Component ERCoh/PL measured the interactions between different independent components decomposed from the scalp EEG, mixtures of time courses of activities arising from different brain, and artifactual sources. The results indicate that the O and CP regions' temporal dynamic patterns are similar to each other. Furthermore, pronounced component ERCoh/PL patterns were found to exist between the O and CP regions across each stimulus and probe presentation, in both theta and alpha frequencies. The consistent theta component ERCoh/PL between the F and O regions was found at the first stimulus and after probe presentation. These findings demonstrate that temporal dynamic patterns at different regions are in accordance with the functional connectivity patterns. Such coordinated and robust EEG temporal dynamics and component ERCoh/PL patterns suggest that these brain regions' neurons work together both to induce similar event-related spectral perturbation and to synchronize or desynchronize simultaneously in order to swiftly accomplish a particular goal. The possible mechanisms for such distinct component phase-locking and coherence patterns were also further discussed.
Graphene Oxide Based Nanocarrier Combined with a pH-Sensitive Tracer: A Vehicle for Concurrent pH Sensing and pH-Responsive Oligonucleotide Delivery
(2015-06-03)
Hsieh, Chia-Jung
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Chen, Yu-Cheng
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Hsieh, Pei-Ying
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Liu, Shi-Rong
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Wu, Shu-Pao
We chemically tuned the oxidation status of graphene oxide (GO) and constructed a GO-based nanoplatform combined with a pH-sensitive fluorescence tracer that is designed for both pH sensing and pH-responsive drug delivery. A series of GOs oxidized to distinct degrees were examined to optimize the adsorption of the model drug, poly dT(30). We determined that highly oxidized GO was a superior drug-carrier candidate in vitro when compared to GOs oxidized to lesser degrees. In the cell experiment, the synthesized pH-sensitive rhodamine dye was first applied to monitor cellular pH; under acidic conditions, protonated rhodamine fluoresces at 588 mm (lambda(ex) = 561 nm). When the nanocarrier was introduced into cells, a rhodamine-triggered competition reaction occurred, and this led to the release of the oligonucleotides and the quenching of rhodamine fluorescence by GO. Our results indicate high drug loading (FAM-dT(30)/GO = 25/50 mu g/mL) and rapid cellular uptake (<0.5 h) of the nanocarrier which can potentially be used for targeted RNAi delivery to the acidic milieu of tumors.
Stable and Efficient Paclitaxel Nanoparticles for Targeted Glioblastoma Therapy
(2015-06-03)
Mu, Qingxin
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Jeon, Mike
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Hsiao, Meng-Hsuan
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Patton, Victoria K.
;
Wang, Kui
Development of efficient nanoparticles (NPs) for cancer therapy remains a challenge. NPs are required to have high stability, uniform size, sufficient drug loading, targeting capability, and ability to overcome drug resistance. In this study, the development of a NP formulation that can meet all these challenging requirements for targeted glioblastoma multiform (GBM) therapy is reported. This multifunctional NP is composed of a polyethylene glycol-coated magnetic iron oxide NP conjugated with cyclodextrin and chlorotoxin (CTX) and loaded with fluorescein and paclitaxel (PTX) (IONP-PTX-CTX-FL). The physicochemical properties of the IONP-PTX-CTX-FL are characterized by transmission electron microscope, dynamic light scattering, and high-performance liquid chromatography. The cellular uptake of NPs is studied using flow cytometry and confocal microscopy. Cell viability and apoptosis are assessed with the Alamar Blue viability assay and flow cytometry, respectively. The IONP-PTX-CTX-FL had a uniform size of approximate to 44 nm and high stability in cell culture medium. Importantly, the presence of CTX on NPs enhanced the uptake of the NPs by GBM cells and improved the efficacy of PTX in killing both GBM and GBM drug-resistant cells. The IONP-PTX-CTX-FL demonstrated its great potential for brain cancer therapy and may also be used to deliver PTX to treat other cancers.
Nonexistence of a Class of Distance-regular Graphs
(2015-06-03)
Huang, Yu-pei
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Pan, Yeh-jong
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Weng, Chih-wen
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應用數學系
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Department of Applied Mathematics
Let Gamma denote a distance-regular graph with diameter D >= 3 and intersection numbers a(1) = 0, a(2) not equal 0, and c(2) = 1. We show a connection between the d-bounded property and the nonexistence of parallelograms of any length up to d + 1. Assume further that Gamma is with classical parameters (D, b, alpha, beta), Pan and Weng (2009) showed that (b, alpha, beta) = (-2, 2, ((-2)(D+1) -1)/3). Under the assumption D >= 4, we exclude this class of graphs by an application of the above connection.
交大e-News第187期-交大研發第五代高階電子封裝技術低溫(150 oC)及低壓下之銅-銅直接接合
(2015-06-05)
國立交通大學秘書室
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Secretariat
Excellent enhancement of corrosion properties of Fe-9Al-30Mn-1.8C alloy in 3.5% NaCl and 10% HCl aqueous solutions using gas nitriding treatment
(2015-06-05)
Chen, Yung-Chang
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Lin, Chih-Lung
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Chao, Chuen-Guang
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Liu, Tzeng-Feng
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材料科學與工程學系
The as-quenched Fe-9.0Al-30Mn-1.8C (in wt.%) alloy gas nitrided at 550 degrees C for 4 h show excellent corrosion resistance investigated in 3.5% NaCl and 10% HCl solutions. Owing to the high corrosion resistance components, the gas-nitrided layer consists mainly of AlN with a slight amount of Fe3N and Fe4N identified by grazing incidence X-ray diffraction technique. Therefore, the pitting potential and corrosion potential of the nitrided sample are + 1860 mV and + 30 mV, respectively. Surprisingly, it is worthy to be pointed out that the nitrided and then tensile-tested alloy reveals very shallow in fracture depth and the excellent lattice coherence is shown between the nitrided layer and the substrate. Moreover, due to the extremely high nitrogen concentration (about 17-18 wt.%) at stretched surface, the corrosion resistance of present gas-nitrided and then tensile-tested alloy is superior to those optimally gas-nitrided or plasma-nitrided high-strength alloy steels, as well as martensitic stainless steels. The nitrided and then stretched alloy still retains a satisfactory corrosion resistance (E-pit = + 890 mV; E-corr = + 10 mV). Furthermore, only nanoscale-size pits were observed on the corroded surface after being immersed in 10% HCl for 24 h. (C) 2015 Elsevier B.V. All rights reserved.
第三勢力參政　選戰難預測
(2015-06-07)
賴坤猷
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Department of Communication and Technology
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傳播與科技學系
政治第三勢力的崛起，對於過往藍綠兩黨的政治有何影響？又有甚麼困難需面對？
低俗卻不膚淺　經典諷刺卡通
(2015-06-07)
許仲廷
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Department of Communication and Technology
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傳播與科技學系
《南方四賤客》以低俗、惡搞的包裝評論社會時事，是美國最受歡迎的卡通之一。
咖啡品牌營造　商業新價值
(2015-06-07)
顏晟宇
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Department of Communication and Technology
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傳播與科技學系
將科技業的商業模式改良，放入如咖啡的服務產業，為其建立更多的品牌價值和可能。
出境前　最後的送行人
(2015-06-07)
余念竹
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Department of Communication and Technology
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傳播與科技學系
「相遇時，學著愛；告別時，試著剛強。」
數位成果展　二社聯合展出
(2015-06-07)
許翔
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Department of Communication and Technology
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傳播與科技學系
喜歡電腦遊戲與3D動畫的朋友們，一定不能錯過這一次的展覽。
Integrated three-dimensional photonic nanostructures for achieving near-unity solar absorption and superhydrophobicity
(2015-06-07)
Kuang, Ping
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Hsieh, Mei-Li
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Lin, Shawn-Yu
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光電工程學系
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Department of Photonics
In this paper, we proposed and realized 3D photonic nanostructures consisting of ultra- thin graded index antireflective coatings (ARCs) and woodpile photonic crystals. The use of the integrated ARC and photonic crystal structure can achieve broadband, broad- angle near unity solar absorption. The amorphous silicon based photonic nanostructure experimentally shows an average absorption of similar to 95% for 400-620 nm over a wide angular acceptance of theta = 0 degrees - 60 degrees. Theoretical studies show that a Gallium Arsenide (GaAs) based structure can achieve an average absorption of > 95% for lambda = 400-870 nm. Furthermore, the use of the slanted SiO2 nanorod ARC surface layer by glancing angle deposition exhibits Cassie- Baxter state wetting, and superhydrophobic surface is obtained with highest water contact angle theta(CB) similar to 153 degrees. These properties are fundamentally important for achieving maximum solar absorption and surface self-cleaning in thin film solar cell applications. (C) 2015 AIP Publishing LLC.
獸醫創業　還原純粹鮮乳
(2015-06-07)
洪詩宸
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Department of Communication and Technology
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傳播與科技學系
大動物獸醫師龔建嘉有感於臺灣酪農處境艱難，因此在出診之餘，也致力於創業，期望能夠改變台灣的牛奶市場。
南鐵地下化　爭議延燒
(2015-06-07)
張凱翔
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Department of Communication and Technology
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傳播與科技學系
二○一五年五月，臺南市長賴清德在抗議聲中，通過鐵路地下化的都市計畫變更案，使南鐵議題，持續延燒。
女子棒球　巾幗不讓鬚眉
(2015-06-07)
郭穎慈
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Department of Communication and Technology
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傳播與科技學系
除了男子棒球之外，臺灣還有一群熱愛棒球的女孩，自發性地組成一支女子棒球隊。
愛美也愛動物　更添魅力
(2015-06-07)
洪雯倩
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Department of Communication and Technology
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傳播與科技學系
化妝品用動物作為試驗是相當慘忍的事情，因此臺灣努力推動讓動物遠離實驗。
Infrared spectrum of the simplest Criegee intermediate CH2OO at resolution 0.25 cm(-1) and new assignments of bands 2 nu(9) and nu(5)
(2015-06-07)
Huang, Yu-Hsuan
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Li, Jun
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Guo, Hua
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Lee, Yuan-Pern
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應用化學系
The simplest Criegee intermediate CH2OO is important in atmospheric chemistry. It has been detected in the reaction of CH2I + O-2 with various spectral methods, including infrared spectroscopy; infrared absorption of CH2OO was recorded at resolution 1.0 cm(-1) in our laboratory. We have improved our system and recorded the infrared spectrum of CH2OO at resolution 0.25 cm(-1) with rotational structures partially resolved. Observed vibrational wavenumbers and relative intensities are improved from those of the previous report and agree well with those predicted with quantum-mechanical calculations using the MULTIMODE method on an accurate potential energy surface. Observed rotational structures also agree with the simulated spectra according to theoretical predictions. In addition to derivation of critical vibrational and rotational parameters of the vibrationally excited states to confirm the assignments, the spectrum with improved resolution provides new assignments for bands 2 nu(9) at 1234.2 cm(-1) and nu(5) at 1213.3 cm(-1); some hot bands and combination bands are also tentatively assigned. (C) 2015 AIP Publishing LLC.
路跑干擾生活　研議收路權費
(2015-06-07)
許鴻財
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Department of Communication and Technology
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傳播與科技學系
路跑干擾民眾生活，政府如何取得平衡，全民運動是好事，但也不應該犧牲民眾權益。
總編輯的話
(2015-06-07)
陳亞柔
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Department of Communication and Technology
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傳播與科技學系
本期喀報為二一八期，共十三篇稿件，其中有五篇影像新聞、三篇廣播新聞、一篇動畫、一篇新聞圖表、三篇文字，題材相當多元。
茶香四溢　喝茶的學問
(2015-06-07)
杜以翔
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Department of Communication and Technology
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傳播與科技學系
飲茶一直是華人生活文化的一部分，本動畫帶您了解關於茶葉在製作、沖泡、飲茶上的許多學問。