Browsing by Issue Date, starting with "2015-09-18"

Now showing 1 - 20 of 20998

Synthesis and inhibitory effects of novel pyrimido-pyrrolo-quinoxalinedione analogues targeting nucleoproteins of influenza A virus H1N1
(2015-09-18)
Lin, Meng-I.
;
Su, Bo-Han
;
Lee, Chia-Hsin
;
Wang, Suz-Ting
;
Wu, Wen-Chun
The influenza nucleoprotein (NP) is a single-strand RNA-binding protein and the core of the influenza ribonucleoprotein (RNP) particle that serves many critical functions for influenza replication. NP has been considered as a promising anti-influenza target. A new class of anti-influenza compounds, nudeozin and analogues were reported recently in several laboratories to inhibit the synthesis of influenza macromolecules and prevent the cytoplasmic trafficking of the influenza RNP. In this study, pyrimidopyrrolo-quinoxalinedione (PPQ) analogues as a new class of novel anti-influenza agents are reported. Compound PPQ-581 was identified as a potential anti-influenza lead with EC50 value of 1 mu M for preventing virus-induced cytopathic effects. PPQ produces similar anti-influenza effects as nucleozin does in influenza-infected cells. Treatment with PPQ at the beginning of H1N1 infection inhibited viral protein synthesis, while treatment at later times blocked the RNP nuclear export and the appearance of cytoplasmic RNP aggregation. PPQ resistant H1N1 (WSN) viruses were isolated and found to have a NPS377G mutation. Recombinant WSN carrying the S377G NP is resistant to PPQ in anti-influenza and RNA polymerase assays. The WSN virus with the NPS377G mutation also is devoid of the PPQ-mediated RNP nuclear retention and cytoplasmic aggregation. The NPS377G expressing WSN virus is not resistant to the reported NP inhibitors nucleozin. Similarly, the nucleozin resistant WSN viruses are not resistant to PPQ suggesting that PPQ targets a different site from the nucleozin-binding site. Our results also suggest that NP can be targeted through various binding sites to interrupt the crucial RNP trafficking, resulting in influenza replication inhibition. (C) 2015 Elsevier Masson SAS. All rights reserved.
用於檢測蛋白酶活性的奈米粒子螢光探針及其應用
(2015-09-21)
林志生
;
葉芳沅
;
曾一華
一種用於檢測蛋白酶活性的奈米粒子螢光探針，包含：一奈米粒子；複數個功能性短鏈，其中每一該功能性短鏈包含：一定位段，與該奈米粒子鍵結，以將該功能性短鏈固定於該奈米粒子上；一負電段，與該定位段鍵結，且包含至少一次負電段，其中該次負電段為帶負電之胺基酸或去氧核醣核酸；以及一受質段，與該負電段鍵結，其中該受質段係被該蛋白酶辨識之胺基酸序列；以及複數個螢光基團，與該受質段鍵結，其中該奈米粒子對該螢光基團具有螢光淬熄效應。
Experimentally-implemented genetic algorithm (Exp-GA): toward fully optimal photovoltaics
(2015-09-21)
Zhong, Yan Kai
;
Fu, Sze Ming
;
Ju, Nyan Ping
;
Chen, Po Yu
;
Lin, Albert
The geometry and dimension design is the most critical part for the success in nano-photonic devices. The choices of the geometrical parameters dramatically affect the device performance. Most of the time, simulation is conducted to locate the suitable geometry, but in many cases simulation can be ineffective. The most pronounced examples are large-area randomized patterns for solar cells, light emitting diode (LED), and thermophtovoltaics (TPV). The large random pattern is nearly impossible to calculate and optimize due to the extended CPU runtime and the memory limitation. Other scenarios that numerical simulations become ineffective include three-dimensional complex structures with anisotropic dielectric response. This leads to extended simulation time especially for the repeated runs during its geometry optimization. In this paper, we show that by incorporating genetic algorithm (GA) into real-world experiments, shortened trial-and-error time can be achieved. More importantly, this scheme can be used for many photonic design problems that are unsuitable for simulation-based optimizations. Moreover, the experimentally implemented genetic algorithm (Exp-GA) has the additional advantage that the resultant objective value is a real one rather than a theoretical one. This prevents the gaps between the modeling and the fabrication due to the process variation or inaccurate numerical models. Using TPV emitters as an example, 22% enhancement in the mean objective value is achieved. (C) 2015 Optical Society of America
估測逐次漸近類比數位轉換器中電容權重誤差之方法與其應用於校正該逐次漸進類比數位轉換器
(2015-09-21)
洪浩喬
;
謝宗殷
一種估測逐次漸近類比數位轉換器中電容權重誤差之方法，該逐次漸進類比數位轉換器包括一比較器、一電容組與一開關組，且該電容組包括一主電容陣列與一子電容陣列，該主電容陣列包括多個第一電容與一輔助電容，該子電容陣列包含一個由多個第二電容所構成之低權重電容陣列，該方法包括：(A)以一第一參考電壓對於該主電容陣列中之至少一電容進行預先充電；(B)以被充電的該至少一電容，重新分配電荷至該主電容陣列的所有該些第一電容、該輔助電容以及該子電容陣列的所有該些第二電容；以及(C)以該比較器之一輸出端的輸出作為位元循環訊號以控制該子電容陣列的該些第二電容，逐次使該主電容陣列之該些第一電容與該輔助電容的一電壓逼近於該第一參考電壓，以取得一電容權重值的數位估測值，並依據所得之該電容權重值的數位估測值計算出對應之該些第一電容與該輔助電容之一的一電容權重誤差估計值；其中在步驟(C)中之該電容權重值的數位估測值dcx由以下方程式表示：其中cMprc 代表該步驟(A)中連接至該第一參考電壓之該主電容陣列中的電容值總合，cMprc 代表該步驟(B)中連接至該第一參考電壓之該主電容陣列中的電容值總合，ccal 代表一衰減電容的電容值，cStotal 係為該子電容陣列中之該些第二電容的電容值總合，ccyc 代表該子電容陣列中經由該開關組連接至該第一參考電壓的該些第二電容的電容值總合，c0 代表該子電容陣列中之最小電容值，Wsub 代表該些子電容陣列的權重。
具有判斷方向性濾波器適用性功能之影像處理方法
(2015-09-21)
洪朝雄
;
杭學鳴
;
蔣迪豪
一種具有判斷方向性濾波器適用性功能之影像處理方法，用於一影像訊號之壓縮與編碼，該方法至少包含下列步驟：步驟(1)：將該影像訊號作二維富利葉轉換以取得該影像訊號於頻域的一能量頻譜；步驟(2)：修正所得到的該能量頻譜，消去該能量頻譜的小波峰；步驟(3)：在修正的該能量頻譜，找出用以判斷該頻域能量頻譜中每一個次頻帶波峰的界限值；步驟(4)：藉由比較該能量頻譜中每一個次頻帶波峰的界限值與波峰，以移動平均法計算每一個次頻帶的一質心座標的收斂位置；以及步驟(5)：藉由找到每一個次頻帶的該質心座標最後收斂的位置，判斷該能量頻譜中的每一個次頻帶是否需要使用一方向性濾波器作拆解。
Poly(3,4ethylenedioxythiophene): poly(styrenesulfonate)/GaAs hybrid solar cells with 13% power conversion efficiency using front- and back-surface field
(2015-09-21)
Lin, C. H.
;
Sun, K. W.
;
Liu, Q. M.
;
Shirai, H.
;
Lee, C. P.
Planar hybrid solar cells based on bulk GaAs wafers with a background doping density of 1016 cm(-3) and poly(3,4-ethylenedioxythiophene): poly(styrenesulfonate) (PEDOT:PSS) demonstrated an excellent power conversion efficiency of 8.99%. The efficiency of the cell was enhanced to 9.87% with a back-surface field feature using a molecular beam epitaxially grown n-type GaAs epi-layer. The efficiency and fill factor reach 11.86% and 0.8 when an additional p + GaAs epi-layer is deposited on the surface of the solar cells, which provides a front-surface field. The interface between the high-and low-doped regions in the polymer/GaAs and GaAs formed an electric field that introduced a barrier to minority carriers flow to the substrate and effectively reduced front surface carrier recombination, thereby enhancing light-generated free carrier collection efficiency and open-circuit voltage. Compared with the device without the front-and back-surface field, the fill factor and open-circuit voltage of the hybrid solar cell were improved from 0.76 to 0.8 and from 0.68 V to 0.77V, respectively. The highest efficiency reaches a record 13% when the Zonyl fluorosurfactant-treated PEDOT: PSS is used as a hole-transporting conducting layer for hybrid cells. (C) 2015 Optical Society of America
Large-area, uniform white light LED source on a flexible substrate
(2015-09-21)
Sher, Chin-Wei
;
Chen, Kuo-Ju
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Lin, Chien-Chung
;
Han, Hau-Vei
;
Lin, Huang-Yu
This study demonstrates the flexible white LED structure with high lumen efficiency and uniform optical performance for neutral white and warm white CCT. Flip-chip LEDs were attached on a polyimide substrate with copper strips as electrical and thermal conduction paths. Yellow phosphors are mixed with polydimenthysiloxane (PDMS) to provide mechanical support and flexibility. The light efficiency of this device can reach 120 lm/W and 85% of light output uniformity of the emission area can be achieved. Moreover, the optical simulation is employed to evaluate various designs of this flexible film in order to obtain uniform output. Both the pitch between the individual devices and the thickness of the phosphor film are calculated for optimization purpose. This flexible white LED with high lumen efficiency and good reliability is suitable for the large area fixture in the general lighting applications. (C) 2015 Optical Society of America
交大e-News第194期-張懋中校長與交大人共同邁向GREAT之交流圈
(2015-09-21)
國立交通大學秘書室
;
Secretariat
鎖相迴路
(2015-09-21)
陳巍仁
;
王艷婷
一種鎖相迴路，包括：一電壓控制振盪電路，用以產生一輸出時脈訊號；一降頻電路，電性連接該電壓控制振盪電路，用以接收該輸出時脈訊號與一輔助時脈訊號，並混波該輸出時脈訊號與該輔助時脈訊號，而藉以產生一回授時脈訊號；一相位頻率比較電路，電性連接該降頻電路，用以接收該回授時脈訊號與一參考時脈訊號，比較該回授時脈訊號與該參考時脈訊號的頻率及相位，並據以產生一調整訊號；以及一調整電路，電性連接該相位頻率比較電路與該電壓控制振盪電路，用以接收該調整訊號，並根據該調整訊號調整該電壓控制振盪電路所產生的該輸出時脈訊號的頻率；其中該降頻電路更包括：一接收訊號強度偵測器，用以偵測該回授時脈訊號的強度；以及一控制器，電性連接該接收訊號強度偵測器，當該回授時脈訊號的強度小於一預設門檻時，該控制器透過該調整電路以調降該輸出時脈訊號的頻率。
Stable gray soliton pinned by a defect in a microcavity-polariton condensate
(2015-09-21)
Chen, Ting-Wei
;
Hsieh, Wen-Feng
;
Cheng, Szu-Cheng
;
光電工程學系
;
光電工程研究所
We study the spatially localized dark state, called dark soliton, in a one-dimensional system of the non-resonantly pumped microcavity-polariton condensate (MPC). From the recent work by Xue and Matuszewski [Phys. Rev. Lett. 112, 216401 (2014)], we know that the dark soliton in the pure MPC system is unstable. But we find that a dark soliton pinned by a defect in the impure MPC becomes a gray soliton and can be stabilized by the presence of a defect. Moreover, the stable regime of the gray soliton is given in terms of the defect strength and pump parameter. (C) 2015 Optical Society of America
SESSION-AWARE NETWORK ADDRESS TRANSLATION TRAVERSAL METHOD
(2015-09-24)
TSENG CHIEN-CHAO
;
WANG MING-HUNG
;
LIN CHIA-LIANG
The session-aware NAT traversal method is used to establish network communication between two hosts, wherein a first and a second host are located behind a first and a second NAT router, respectively. First, these hosts conduct a standard NAT traversal to establish a session. Then, the second host sends a registration request message to the first NAT router for session registration. Upon receiving the registration request message, the first NAT router generates a session ID for this session and replies to the second host. As the second host moves to a private network behind a third NAT router, the second host only needs to send a new registration request message with the session ID to the first NAT router. The first NAT router observes a new mapped address of the second host and allows inbound traffic from the new mapped address without further NAT traversal.
TOUCH DISPLAY APPARATUS AND TOUCH SENSING METHOD
(2015-09-24)
WANG Guo-Zhen
;
CHANG Tian-Sheuan
;
CHUANG Jen-Hui
A touch display apparatus includes a display panel, a frame and a plurality of sensing modules. The frame is disposed around the display panel and a plurality of apertures is arranged on the frame. The sensing modules are disposed at different height levels respectively. Each sensing module generates sensing data. Each sensing module includes a plurality of sensing units. The sensing units are disposed along the frame respectively and sense light which passes through the apertures. A touch sensing method is also disclosed herein.
Automated on-line liquid-liquid extraction system for temporal mass spectrometric analysis of dynamic samples
(2015-09-24)
Hsieh, Kai-Ta
;
Liu, Pei-Han
;
Urban, Pawel L.
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應用化學系
;
應用化學系分子科學碩博班
Most real samples cannot directly be infused to mass spectrometers because they could contaminate delicate parts of ion source and guides, or cause ion suppression. Conventional sample preparation procedures limit temporal resolution of analysis. We have developed an automated liquid-liquid extraction system that enables unsupervised repetitive treatment of dynamic samples and instantaneous analysis by mass spectrometry (MS). It incorporates inexpensive open-source microcontroller boards (Arduino and Netduino) to guide the extraction and analysis process. Duration of every extraction cycle is 17 min. The system enables monitoring of dynamic processes over many hours. The extracts are automatically transferred to the ion source incorporating a Venturi pump. Operation of the device has been characterized (repeatability, RSD = 15%, n = 20; concentration range for ibuprofen, 0.053-2.000 mM; LOD for ibuprofen, similar to 0.005 mM; including extraction and detection). To exemplify its usefulness in real-world applications, we implemented this device in chemical profiling of pharmaceutical formulation dissolution process. Temporal dissolution profiles of commercial ibuprofen and acetaminophen tablets were recorded during 10 h. The extraction-MS datasets were fitted with exponential functions to characterize the rates of release of the main and auxiliary ingredients (e.g. ibuprofen, k = 0.43 +/- 0.01 h(-1)). The electronic control unit of this system interacts with the operator via touch screen, internet, voice, and short text messages sent to the mobile phone, which is helpful when launching long-term (e.g. overnight) measurements. Due to these interactive features, the platform brings the concept of the Internet-of-Things (IoT) to the chemistry laboratory environment. (C) 2015 Elsevier B.V. All rights reserved.
SENSING SYSTEM AND SENSOR CHIP THEREOF
(2015-09-24)
Lee Chen-Yi
;
Lai Kelvin Yi-Tse
;
Yang Yu-Tao
A sensing system includes a processing unit and sensor chip. The sensor chip includes a microelectrode array, a droplet space over the microelectrode array, and a plurality of control units coupled together in a daisy-chain configuration. Each of the control units is coupled to a respective one of the microelectrodes of the microelectrode array. The control units are controlled by the processing unit to drive movement of a droplet in the droplet space, and to inspect the droplet via the microelectrodes.
Shifting the waterlines of satellite images to the mean water shorelines considering wave runup, setup, and tidal variation
(2015-09-25)
Chang, Hsien-Kuo
;
Chen, Wei-Wei
;
Liou, Jin-Cheng
;
土木工程學系
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Department of Civil Engineering
Shoreline evolution is a simple and common method to illustrate beach erosion or accretion in coastal engineering. Extracted waterlines on different satellite images are sometimes used for shoreline evolution. However, time-varying waterlines for tidal variation and wave runup are different from the shoreline at the mean water level. Waterline evolution may bring about misunderstanding of beach erosion or accretion. In a former study, the one-line shift method was proposed to determine the waterlines on a satellite image and to shift the water-lines to shorelines while only considering the tidal variation. The upward shift extension of the waterline due to wave runup and wave setup is considered. Some acceptable equations of wave runup were examined to correct the waterlines on three satellite images in one month when the foreshore beach slopes were specified. The suggested equation for wave runup includes both wave conditions and an average beachface slope at two points located shoreward and seaward away from mean water level by an equal distance of 62.5 m. When on-site shore bathymetrical measurement is sometimes unavailable, a method of minimizing the difference between the initially guessed and estimated foreshore beach slopes by the one-line shift method is proposed. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Increased Risk of Chronic Kidney Disease in Rheumatoid Arthritis Associated with Cardiovascular Complications - A National Population-Based Cohort Study
(2015-09-25)
Chiu, Hsien-Yi
;
Huang, Hui-Ling
;
Li, Chien-Hsun
;
Chen, Hung-An
;
Yeh, Chia-Lun
Background and Objectives There have been few large population-based studies of the association between rheumatoid arthritis (RA) and chronic kidney disease (CKD) and glomerulonephritis. This nationwide cohort study investigated the risks of developing CKD and glomerulonephritis in patients with RA, and the associated risks for cardiovascular complications. Methods From the Taiwan National Health Insurance Research Database, we identified a study cohort of 12,579 patients with RA and randomly selected 37,737 subjects without RA as a control cohort. Each subject was individually followed for up for 5 years, and the risk of CKD was analyzed using Cox proportional hazards regression models. Results During the follow-up period, after adjusting for traditional cardiovascular risk factors RA was independently associated with a significantly increased risk of CKD (adjusted hazard ratio [aHR] 1.31; 95% confidence interval [CI] 1.23-1.40) and glomerulonephritis (aHR 1.55; 95% CI 1.37-1.76). Increased risk of CKD was also associated with the use of non-steroidal anti-inflammatory drugs, cyclosporine, glucocorticoids, mycophenolate mofetil, and cyclophosphamide. Patients with comorbidities had even greater increased risk of CKD. Moreover, RA patients with concurrent CKD had significantly higher likelihood of developing ischemic heart disease and stroke. Conclusions RA patients had higher risk of developing CKD and glomerulonephritis, independent of traditional cardiovascular risk factors. Their increased risk of CKD may be attributed to glomerulonephritis, chronic inflammation, comorbidities, and renal toxicity of antirheumatic drugs. Careful monitoring of renal function in RA patients and tight control of their comorbid diseases and cardiovascular risk factors are warranted.
台灣境內　打工換宿
(2015-09-27)
馮鈞鈺
;
Department of Communication and Technology
;
傳播與科技學系
近年來台灣興起一股打工換宿的熱潮，本島打工換宿較出國打工度假容易，讓生活體驗多一種選擇。
音樂季　魅力無窮
(2015-09-27)
孔婉寧
;
Department of Communication and Technology
;
傳播與科技學系
究竟是什麼魔力，讓人們願意放下繁忙的雜物與生活中無形的壓力，願意來到音樂季，體驗前所未有的心靈饗宴？
記憶層層交疊　生命吐真言　
(2015-09-27)
許馨仁
;
Department of Communication and Technology
;
傳播與科技學系
布芮特必須把自己十四歲時列出十個願望完成，透過信件，布芮特和已逝的母親對話。
黃湯故事　理想之外的人生
(2015-09-27)
蔡家寧
;
Department of Communication and Technology
;
傳播與科技學系
一個再尋常不過的小人物，在現實的壓力與理想的堅持的拔河中，他該如何取捨？抑或是他從來就沒有選擇？