Browsing by Issue Date, starting with "2015-10-06"

Now showing 1 - 20 of 20793

Double autophagy modulators reduce 2-deoxyglucose uptake in sarcoma patients
(2015-10-06)
Chi, Mau-Shin
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Lee, Cheng-Yen
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Huang, Su-Chen
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Yang, Kai-Lin
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Ko, Hui-Ling
Rationale: According to the metabolic symbiosis model, cancer stromal fibroblasts could be hijacked by surrounding cancer cells into a state of autophagy with aerobic glycolysis to help provide recycled nutrients. The purpose of this study was to investigate whether combined treatment with the autophagy inhibitor: hydroxychloroquine (HCQ) and the autophagy inducer: sirolimus (rapamycin, Rapa) would reduce glucose utilization in sarcoma patients. Methods: Ten sarcoma patients who failed first-line treatment were enrolled in this study. They were treated with 1 mg of Rapa and 200 mg of HCQ twice daily for two weeks. The standardized uptake values (SUV) from pretreatment and posttreatment [F-18]-fluorodeoxyglucose positron emission tomography (FDG PET) scans were reviewed, and changes from the baseline SUVmax were evaluated. Results: Based on FDG PET response criteria, six patients had a partial response; three had stable disease, and one had progressive disease. Nevertheless, none of them showed a reduction in tumor volume. The mean SUVmax reduction in the 34 lesions evaluated was -19.6% (95% CI = -30.1% to -9.1%), while the mean volume change was +16.4% (95% CI = +5.8% to + 27%). Only grade 1 toxicities were observed. Elevated serum levels of lactate dehydrogenase were detected after treatment in most metabolic responders. Conclusions: The results of reduced SUVmax without tumor volume reduction after two weeks of Rapa and HCQ treatment may indicate that non-proliferative glycolysis occurred mainly in the cancer associated fibroblast compartment, and decreased glycolytic activity was evident from Rapa + HCQ double autophagy modulator treatment.
Triple-layer dissection of the lung adenocarcinoma transcriptome - regulation at the gene, transcript, and exon levels
(2015-10-06)
Hsu, Min-Kung
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Wu, I-Ching
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Cheng, Ching-Chia
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Su, Jen-Liang
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Hsieh, Chang-Huain
Lung adenocarcinoma is one of the most deadly human diseases. However, the molecular mechanisms underlying this disease, particularly RNA splicing, have remained underexplored. Here, we report a triple-level (gene-, transcript-, and exon-level) analysis of lung adenocarcinoma transcriptomes from 77 paired tumor and normal tissues, as well as an analysis pipeline to overcome genetic variability for accurate differentiation between tumor and normal tissues. We report three major results. First, more than 5,000 differentially expressed transcripts/exonic regions occur repeatedly in lung adenocarcinoma patients. These transcripts/exonic regions are enriched in nicotine metabolism and ribosomal functions in addition to the pathways enriched for differentially expressed genes (cell cycle, extracellular matrix receptor interaction, and axon guidance). Second, classification models based on rationally selected transcripts or exonic regions can reach accuracies of 0.93 to 1.00 in differentiating tumor from normal tissues. Of the 28 selected exonic regions, 26 regions correspond to alternative exons located in such regulators as tumor suppressor (GDF10), signal receptor (LYVE1), vascular-specific regulator (RASIP1), ubiquitination mediator (RNF5), and transcriptional repressor (TRIM27). Third, classification systems based on 13 to 14 differentially expressed genes yield accuracies near 100%. Genes selected by both detection methods include C16orf59, DAP3, ETV4, GABARAPL1, PPAR, RADIL, RSPO1, SERTM1, SRPK1, ST6GALNAC6, and TNXB. Our findings imply a multilayered lung adenocarcinoma regulome in which transcript-/exon-level regulation may be dissociated from gene-level regulation. Our described method may be used to identify potentially important genes/transcripts/exonic regions for the tumorigenesis of lung adenocarcinoma and to construct accurate tumor vs. normal classification systems for this disease.
Nitrite selective anion receptor based on 1-methyl-1H-perimidine
(2015-10-07)
Pandian, Thiravidamani Senthil
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Srinivasadesikan, Venkatesan
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Lin, M. C.
;
Kang, Jongmin
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應用化學系
A new anion receptor 1, which utilizes only C-H hydrogen bonding have been designed and synthesized. This receptor utilizes both aromatic C-H (two perimidine C2-H, anthracene 9-H) and aliphatic C-H (two perimidine 1-methyl C-H, two benzylic C-H) as hydrogen bonding moieties. The receptor 1 is found to have considerable binding affinity for weakly basic anions even in polar solvent such as DMSO. In addition, receptor 1 is selective for nitrite. The experimental data from UV-vis, fluorescence and H-1 NMR titration are consistent with theoretical studies. The order of the interaction of the C-H groups of perimidine containing receptor with NO2- anion is found to be perimidine (C-H)>methylene (C-H)>methyl (C-H)>anthracene (C-H). 0 2015 Elsevier Ltd. All rights reserved.
Enhanced mixing via alternating injection in radial Hele-Shaw flows
(2015-10-07)
Chen, Ching-Yao
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Huang, Yi-Cheng
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Huang, Yu-Sheng
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Miranda, Jose A.
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機械工程學系
Mixing at low Reynolds numbers, especially in the framework of confined flows occurring in Hele-Shaw cells, porous media, and microfluidic devices, has attracted considerable attention lately. Under such circumstances, enhanced mixing is limited due to the lack of turbulence, and absence of sizable inertial effects. Recent studies, performed in rectangular Hele-Shaw cells, have demonstrated that the combined action of viscous fluid fingering and alternating injection can dramatically improve mixing efficiency. In this work, we revisit this important fluid mechanical problem, and analyze it in the context of radial Hele-Shaw flows. The development of radial fingering instabilities under alternating injection conditions is investigated by intensive numerical simulations. We focus on the impact of the relevant physical parameters of the problem (Peclet number Pe, viscosity contrast A, and injection time interval Delta t) on fluid mixing performance.
METHOD FOR MANUFACTURING PLATINUM NANOPARTICLE SOLUTION AND SELF-ASSEMBLED PLATINUM COUNTER ELECTRODE THEREOF
(2015-10-08)
DIAU Eric Wei-Guang
;
TSAI Chia-Hung
;
LI Lu-Lin
;
WU Hsin-Hui
The present invention provides a method for manufacturing platinum nanoparticle solution and a self-assembled platinum counter electrode thereof. The present invention adopts a polyol reduction method and controls the reduction reaction periods under various pH conditions. After the platinum nanoparticle dispersion solution of uniformly distributed platinum nanoparticles having small sizes is produced, the self-assembled platinum nanoparticles are adsorbed on a functionalized surface of a conductive substrate by dip coating at the normal temperature. Therefore, the structure of a platinum nanoparticle monolayer is formed, to obtain the self-assembled platinum counter electrode with a homogeneous single layer on the surface. This process is much simpler without adding any stabilizers or surfactants, without involving any subsequent heat treatments, and it consumes less amount of the platinum material. By employing the present invention for commercialization, the cost of mass production for the dye-sensitized solar cell application is thus reduced.
HETEROCYCLIC COMPOUNDS AND THE SYNTHESIS METHOD THEREOF
(2015-10-08)
Cheng Yen-Ju
;
Cheng Sheng-Wen
;
Chiou De-Yang
A synthesis method of a heterocyclic compound is disclosed. The synthesis method includes steps of: carrying out a McMurry coupling reaction on a first compound having a carbonyl group to form a second compound, wherein the second compound includes an alkyl group which is symmetrical to a symmetrical center, and carrying out a 6π-cyclization on the second compound to form a third compound.
Light Emitting Diode Device
(2015-10-08)
CHU Hung-Shen
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LIN Da-Wei
;
KUO Hao-Chung
A light emitting diode device comprises the transparent conductive layer is formed on the conductive substrate, the p-type semiconductor layer is formed on the transparent conductive layer, the active layer is formed on the p-type semiconductor layer, and the n-type semiconductor layer is formed on the active layer, the buffer layer is formed on the n-type semiconductor layer, and a metal electrode is formed on a rough and uneven surface of the buffer layer, in which the electrical property of the n-type semiconductor layer is opposites to that of the p-type semiconductor layer. The reflective effect within the light emitting diode device can be increased. In addition, by reducing the thickness of the undoped GaN layer, the absorption of ultraviolet light inside the components of the light emitting diode device can be reduced.
Light Emitting Diode Device Having Super Lattice Structure and a Nano-Structure Layer
(2015-10-08)
LEE Chia-Yu
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LIN Da-Wei
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TZOU An-Jye
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KUO Hao-Chung
A light emitting diode device is provided, which comprises a silicon-based substrate, a buffer layer, a super lattice structure layer, a nano-structure layer, a first semiconductor layer, a light emitting layer, and a second semiconductor layer. The buffer layer is formed on the silicon-based substrate, the super lattice structure layer is formed on the buffer layer, the nano-structure layer is formed on the super lattice structure layer, a first semiconductor layer is formed on the nano-structure layer, and the light emitting layer is formed between the first semiconductor layer and the second semiconductor layer. The super lattice layer and the nano-structure can release the stress within the light emitting diode device, and reduce the epitaxy defect, so that the internal quantum effect and the external quantum effect can be increased.
SEMICONDUCTOR DEVICE AND FORMATION THEREOF
(2015-10-08)
Chien Chao-Hsin
;
Chung Cheng-Ting
;
Chen Che-Wei
A semiconductor device and methods of formation are provided. The semiconductor device includes a first metal alloy over a first active region of a fin and a second metal alloy over a second active region of the fin. A conductive layer is over a channel region of the fin. A semiconductive layer is over the conductive layer. The conductive layer over the channel region suppresses current leakage and the semiconductive layer over the conductive layer reduces electro flux from a source to a drain, as compared to a channel region that does not have such a conductive layer or a semiconductive layer over a conductive layer. The semiconductor device having the first metal alloy as at least one of the source or drain requires a lower activation temperature than a semiconductor device that does not have a metal alloy as a source or a drain.
人生高年級　生命正發光
(2015-10-11)
梅瑞庭
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Department of Communication and Technology
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傳播與科技學系
一位年輕的職場女強人，和一位重返職場的老先生，從相知到相惜，成為彼此身命中的貴人。
衝突鑽石　染血的浪漫
(2015-10-11)
許心如
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Department of Communication and Technology
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傳播與科技學系
象徵真愛恆久不變的鑽石，卻是非洲礦工無限輪迴的夢魘，被貿易商層層剝削後留下的是貧窮與血淚。
高中制服日　回不去的從前
(2015-10-11)
李宗諺
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Department of Communication and Technology
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傳播與科技學系
小時候希望能夠快快長大，長大後才發覺還是以前美好，高中制服日能讓人們短暫回憶過去、重溫高中時代。
從美術到科學的勇敢跨越
(2015-10-11)
陳緯僑
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Department of Communication and Technology
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傳播與科技學系
學習美術20年的曾映舜，為了夢想，勇敢克服了種種困境與挑戰，終於成為了一位科學研究員。
文化傳承　柿餅風華再現　
(2015-10-11)
胡浣莊
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林謙耘
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Department of Communication and Technology
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傳播與科技學系
為期兩天的柿餅節於新竹縣新埔鎮登場，吸引民眾攜家帶眷前往共襄盛舉。
廣視角鏡片
(2015-10-11)
王志中
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許銘仁
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柳景豑
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洪祥傑
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潘瑞文
一種廣視角鏡片，適於配置在一使用者的一眼前，該廣視角鏡片包括：一鏡片，具有一第一面、一第二面、一第三面以及一第四面，該第二面與該第一面相對，該第三面及該第四面分別連接該第一面與該第二面，該第二面位於該第一面與該使用者的該眼之間，其中該第一面的寬度大於該第二面的寬度；以及一反射層，設置在該第三面上，其中該第三面與該第一面的距離在遠離該第四面的方向上逐漸變小。
NBA球星　來臺飆球技
(2015-10-11)
趙廣絜
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Department of Communication and Technology
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傳播與科技學系
NBA球星昌西・畢拉普斯（Chauncey Billups）與肯楊・馬丁（Kenyon Martin）來臺，與本土球員同場競技。
總編輯的話
(2015-10-11)
許人文
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Department of Communication and Technology
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傳播與科技學系
本期為二二二期，共三十一篇稿件，其中以評論類文章及文化現象居多。本期側欄廣告以交通大學傳科系一〇五級媒體實習展「媒關係」為題，介紹實習展系列活動，令人十分期待。
挑戰極限　勇敢向前衝
(2015-10-11)
王鈞鋒
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Department of Communication and Technology
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傳播與科技學系
關於挑戰，每個人都不一樣，也有不一樣的行動與風格，那屬於你的挑戰又是甚麼？
顯示觸控面板的複合驅動電路
(2015-10-11)
周凱茹
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康鎮璽
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陳品充
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陳仁龍
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吳哲耀
一種顯示觸控面板的複合驅動電路，其用於驅動顯示觸控面板的一共用電極，該複合驅動電路包含：一訊號產生電路，輸出一顯示訊號及一驅動時脈；一掃描控制電路，輸出一掃描訊號、一第一起始訊號及一第二起始訊號，該掃描訊號掃描該顯示觸控面板的複數畫素；及一顯示觸控電路，耦接該掃描控制電路、該訊號產生電路及該共用電極，並依據該第一起始訊號輸出該顯示訊號至該共用電極，或依據該第二起始訊號及該驅動時脈輸出一驅動訊號至該共用電極。
東京飯店　德國音樂奇蹟
(2015-10-11)
何佳頴
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Department of Communication and Technology
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傳播與科技學系
德國搖滾天團Tokio Hotel十五歲出道便迅速竄紅，在事業巔峰之時又急流勇退，沉潛五年後的他們以全新面貌復出。