Browsing by Issue Date, starting with "2016-05-03"

Now showing 1 - 20 of 17341

NF-kappa B-driven suppression of FOXO3a contributes to EGFR mutation-independent gefitinib resistance
(2016-05-03)
Chiu, Ching-Feng
;
Chang, Yi-Wen
;
Kuo, Kuang-Tai
;
Shen, Yu-Shiuan
;
Liu, Chien-Ying
Therapy with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs, such as gefitinib or erlotinib) significantly prolongs survival time for patients with tumors harboring an activated mutation on EGFR; however, up to 40% of lung cancer patients exhibit acquired resistance to EGFR-TKIs with an unknown mechanism. FOXO3a, a transcription factor of the forkhead family, triggers apoptosis, but the mechanistic details involved in EGFR-TKI resistance and cancer stemness remain largely unclear. Here, we observed that a high level of FOXO3a was correlated with EGFR mutation-independent EGFR-TKI sensitivity, the suppression of cancer stemness, and better progression-free survival in lung cancer patients. The suppression of FOXO3a obviously increased gefitinib resistance and enhanced the stem-like properties of lung cancer cells; consistent overexpression of FOXO3a in gefitinib-resistant lung cancer cells reduced these effects. Moreover, we identified that miR-155 targeted the 3\'UTR of FOXO3a and was transcriptionally regulated by NF-kappa B, leading to repressed FOXO3a expression and increased gefitinib resistance, as well as enhanced cancer stemness of lung cancer in vitro and in vivo. Our findings indicate that FOXO3a is a significant factor in EGFR mutation-independent gefitinib resistance and the stemness of lung cancer, and suggest that targeting the NF-kappa B/miR-155/FOXO3a pathway has potential therapeutic value in lung cancer with the acquisition of resistance to EGFR-TKIs.
Modular design and implementation of field-programmable-gate-array-based Gaussian noise generator
(2016-05-03)
Li, Yuan-Ping
;
Lee, Ta-Sung
;
Hwang, Jeng-Kuang
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電機工程學系
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Department of Electrical and Computer Engineering
The modular design of a Gaussian noise generator (GNG) based on field-programmable gate array (FPGA) technology was studied. A new range reduction architecture was included in a series of elementary function evaluation modules and was integrated into the GNG system. The approximation and quantisation errors for the square root module with a first polynomial approximation were high; therefore, we used the central limit theorem (CLT) to improve the noise quality. This resulted in an output rate of one sample per clock cycle. We subsequently applied Newton\'s method for the square root module, thus eliminating the need for the use of the CLT because applying the CLT resulted in an output rate of two samples per clock cycle (>200 million samples per second). Two statistical tests confirmed that our GNG is of high quality. Furthermore, the range reduction, which is used to solve a limited interval of the function approximation algorithms of the System Generator platform using Xilinx FPGAs, appeared to have a higher numerical accuracy, was operated at >350MHz, and can be suitably applied for any function evaluation.
A Decision Support System Based on a Genetic Algorithm for the Utilization of Leftovers
(2016-05-03)
Fu, Hsin-Pin
;
Ku, Cheng-Yuan
;
Chang, Tsung-Sheng
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資訊管理與財務金融系註：原資管所+財金所
;
Department of Information Management and Finance
There are usually some leftovers (usable pieces of raw material) and scraps (unusable pieces of raw material).generated after the completion of a manufacturing process. These leftovers consist of many different types, materials, styles and sizes so the use of such materials is difficult to manage, resulting in a significant material management problem for manufacturers. This study examines ways to use these leftovers and proposes the application of a genetic algorithm to handle the problem of matching usable leftovers to incoming orders. In order to verify the feasibility of the solution, a decision support system was implemented, based on a genetic algorithm. With lots of experimental results, we conclude this method is thus of considerable value to the managers of manufacturing factories.
Determination of Percent Crystallinity of Side-Chain Crystallized Alkylated-Dextran Derivatives with Raman Spectroscopy and Multivariate Curve Resolution
(2016-05-03)
Samuel, Ashok Zachariah
;
Zhou, Mengbo
;
Ando, Masahiro
;
Mueller, Robert
;
Liebert, Tim
We demonstrate a methodology to estimate the percent crystallinity of polymers directly with Raman spectroscopy and multivariate curve resolution (MCR) by alternating least-squares (ALS). In this methodology, the Raman spectrum of semicrystalline polymer is separated into two constituent components (crystalline and molten) and their corresponding concentrations. The percent crystallinity can be estimated as the change in area intensity of the molten spectral-component when polymer cools from a temperature above melting point to room temperature. The number of carbons in the crystalline lattice has also been estimated from the position of longitudinal acoustic (LA) Raman bands with the correlation established by Mizushima and Simanouti [Mizushima, S.; Simanouti, T. J. Am. Chem. Soc. 1949, 71, 1320]. The new method allows direct Raman estimation of absolute percent crystallinity of polymers. Until now, Raman spectroscopic estimation of percent crystallinity was possible only in conjunction with other techniques or by using internal standards.
Efficiently sphere-decodable physical layer transmission schemes for wireless storage networks
(2016-05-05)
Lu, Hsiao-feng (Francis)
;
Barreal, Amaro
;
Karpuk, David
;
Hollanti, Camilla
;
資訊工程學系
Three transmission schemes over a new type of multiple-access channel (MAC) model with inter-source communication links are proposed and investigated in this paper. This new channel model is well motivated by, e.g., wireless distributed storage networks, where communication to repair a lost node takes place from helper nodes to a repairing node over a wireless channel. Since in many wireless networks nodes can come and go in an arbitrary manner, there must be an inherent capability of inter-node communication between every pair of nodes. Assuming that communication is possible between every pair of helper nodes, the newly proposed schemes are based on various smart time-sharing and relaying strategies. In other words, certain helper nodes will be regarded as relays, thereby converting the conventional uncooperative multiple-access channel to a multiple-access relay channel (MARC). The diversity-multiplexing gain tradeoff (DMT) of the system together with efficient sphere-decodability and low structural complexity in terms of the number of antennas required at each end is used as the main design objectives. While the optimal DMT for the new channel model is fully open, it is shown that the proposed schemes outperform the DMT of the simple time-sharing protocol and, in some cases, even the optimal uncooperative MAC DMT. While using a wireless distributed storage network as a motivating example throughout the paper, the MAC transmission techniques proposed here are completely general and as such applicable to any MAC communication with inter-source communication links.
Efficiently sphere-decodable physical layer transmission schemes for wireless storage networks
(2016-05-05)
Lu, Hsiao-feng (Francis)
;
Barreal, Amaro
;
Karpuk, David
;
Hollanti, Camilla
;
電機工程學系
Three transmission schemes over a new type of multiple-access channel (MAC) model with inter-source communication links are proposed and investigated in this paper. This new channel model is well motivated by, e.g., wireless distributed storage networks, where communication to repair a lost node takes place from helper nodes to a repairing node over a wireless channel. Since in many wireless networks nodes can come and go in an arbitrary manner, there must be an inherent capability of inter-node communication between every pair of nodes. Assuming that communication is possible between every pair of helper nodes, the newly proposed schemes are based on various smart time-sharing and relaying strategies. In other words, certain helper nodes will be regarded as relays, thereby converting the conventional uncooperative multiple-access channel to a multiple-access relay channel (MARC). The diversity-multiplexing gain tradeoff (DMT) of the system together with efficient sphere-decodability and low structural complexity in terms of the number of antennas required at each end is used as the main design objectives. While the optimal DMT for the new channel model is fully open, it is shown that the proposed schemes outperform the DMT of the simple time-sharing protocol and, in some cases, even the optimal uncooperative MAC DMT. While using a wireless distributed storage network as a motivating example throughout the paper, the MAC transmission techniques proposed here are completely general and as such applicable to any MAC communication with inter-source communication links.
Quantum criticality of the two-channel pseudogap Anderson model: universal scaling in linear and non-linear conductance
(2016-05-05)
Wu, Tsan-Pei
;
Wang, Xiao-Qun
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Guo, Guang-Yu
;
Anders, Frithjof
;
Chung, Chung-Hou
The quantum criticality of the two-lead two-channel pseudogap Anderson impurity model is studied. Based on the non-crossing approximation (NCA) and numerical renormalization group (NRG) approaches, we calculate both the linear and nonlinear conductance of the model at finite temperatures with a voltage bias and a power-law vanishing conduction electron density of states, rho(c)(omega) alpha | omega-mu(F)|(r) (0 < r < 1) near the Fermi energy mu(F). At a fixed leadimpurity hybridization, a quantum phase transition from the two-channel Kondo (2CK) to the local moment (LM) phase is observed with increasing r from r = 0 to r = r(c) < 1. Surprisingly, in the 2CK phase, different power-law scalings from the well-known root T or root V form is found. Moreover, novel power-law scalings in conductances at the 2CK-LM quantum critical point are identified. Clear distinctions are found on the critical exponents between linear and non-linear conductance at criticality. The implications of these two distinct quantum critical properties for the non-equilibrium quantum criticality in general are discussed.
交大e-News第208期-以植物盆栽促進人類溝通頻率交大團隊奪高齡設計賽全球第三
(2016-05-05)
國立交通大學秘書室
;
Secretariat
Drag force of Anisotropic plasma at finite U(1) chemical potential
(2016-05-05)
Cheng, Long
;
Ge, Xian-Hui
;
Wu, Shang-Yu
;
電子物理學系
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Department of Electrophysics
We perform the calculation of the drag force acting on amassive quark moving through an anisotropic N = 4 SU(N) Super Yang-Mills plasma in the presence of a U(1) chemical potential. We present the numerical results for any value of the anisotropy and arbitrary direction of the quark velocity with respect to the direction of the anisotropy. We find the effect of the chemical potential or charge density will enhance the drag force for our charged solution.
Economic dispatch of chiller plant by improved ripple bee swarm optimization algorithm for saving energy
(2016-05-05)
Lo, Chi-Chun
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Tsai, Shang-Ho
;
Lin, Bor-Shyh
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影像與生醫光電研究所
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電控工程研究所
This paper presents an improved ripple bee swarm optimization (IRBSO) algorithm to solve the problem of the economic dispatch of chiller plants (EDCP). Using the characteristics of biological communities, different movement models are adopted to search within the feasible solution space. This paper uses nonlinear ripple weight factors and self-adaption repulsion factor to improve the BSO and proposes the influence of parameters on the IRBSO method to more effectively search the feasible space. For all bee swarms, the efficiency of searching movement in the solution space improves, and the capacity of information discovery and mining increases. This paper utilizes the test cases to verify the proposed IRBSO, including EDCP problems for a single day and a single week. Compared with other methods, the results of the proposed IRBSO exhibit higher accuracy and stability, making it suitable for the operation planning of multiple chiller systems. (C) 2016 Elsevier Ltd. All rights reserved.
Remarks on the weak formulation of the Navier-Stokes equations on the 2D hyperbolic space
(2016-05-06)
Chan, Chi Hin
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Czubak, Magdalena
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應用數學系
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Department of Applied Mathematics
The Leray-Hopf solutions to the Navier Stokes equation are known to be unique on R-2. In our previous work, we showed the breakdown of uniqueness in a hyperbolic setting. In this article, we show how to formulate the problem in order so the uniqueness can be restored. (C) 2015 Elsevier Masson SAS. All rights reserved.
Functional Connectivity During Phonemic and Semantic Verbal Fluency Test: A Multichannel Near Infrared Spectroscopy Study
(2016-05-06)
Huang, Chun-Jung
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Chou, Po-Han
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Wei, Hao-Lin
;
Sun, Chia-Wei
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光電工程學系
Verbal fluency tests (VFTs) are widely used frontal lobe neuropsychological tests. They have been frequently used in various functional brain mapping studies. There are two versions of VFTs based on the type of cue: the letter fluency task (LFT) and the category fluency task (CFT). However, the fundamental aspects of brain connectivity across the frontotemporal regions during the VFTs have not been elucidated. In this study, we hypothesized that differences in cortical functional connectivity over the left and right frontotemporal regions may be observed by means of multi-channel functional near-infrared spectroscopy (fNIRS) during the performance of LFT and CFT. Our results from fNIRS (ETG-4000) showed different patterns of brain functional connectivity during the two types of VFTs, which was consistent with the different cognitive requirements of each task. We demonstrate increased brain functional connectivity over the frontal and temporal regions during the LFT than during the CFT; these results are in line with previous brain activity studies using fNIRS to demonstrate higher frontal and temporal region activation during LFT and CFT, with more pronounced frontal activation by the LFT.
傢俱魔法師　理念付諸設計
(2016-05-08)
修瑞韓
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Department of Communication and Technology
;
傳播與科技學系
傢俱與道具佈置設計師李承峰堅持自我信念，賦予老舊傢俱新的生命及意義。
先知瑪莉　雨季的聲音
(2016-05-08)
趙廣絜
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Department of Communication and Technology
;
傳播與科技學系
以鏡頭紀錄先知瑪莉《梅雨季》巡迴臺北場。
藝術呈現與突破　蜷川實花
(2016-05-08)
蕭泳
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Department of Communication and Technology
;
傳播與科技學系
簡介蜷川實花的台北首展。
獸迷文化之介紹
(2016-05-08)
王鈞鋒
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Department of Communication and Technology
;
傳播與科技學系
以資訊圖表簡單介紹獸迷文化與理念。
斜坡上的歌手　達卡鬧
(2016-05-08)
林湘芸
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Department of Communication and Technology
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傳播與科技學系
原住民歌手達卡鬧，用音樂記錄原住民的一切。
沉默的王牌　王建民
(2016-05-08)
李宗諺
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Department of Communication and Technology
;
傳播與科技學系
王建民歷經成功、受傷、失意，一直以來默默地努力，沉默的王牌始終如一。
放膽追夢　以愛經營
(2016-05-08)
翁世樺
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Department of Communication and Technology
;
傳播與科技學系
吳佩君在南崁開了三間印尼小吃店，除了實踐自己的夢想外，她還希望帶給身邊的印尼朋友家鄉的溫暖。
廉價航空VS傳統航空
(2016-05-08)
鄭宇茹
;
Department of Communication and Technology
;
傳播與科技學系
比較廉價航空與傳統航空的差異。