Browsing by Issue Date, starting with "2016-11-08"

Now showing 1 - 20 of 16119

Lovastatin lowers the risk of breast cancer: a population-based study using logistic regression with a random effects model
(2016-11-08)
Murakami, Rimi
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Chen, Chiehfeng
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Lyu, Shu-Yu
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Lin, Ching-En
;
Tzeng, Pei-Chuan
Background: Laboratory studies have demonstrated statin-induced apoptosis of cancer cells, including breast cancer cells, and evidence is accumulating on the mechanism of statin-induced apoptosis. However, despite numerous epidemiological studies, no consensus has been reached regarding the relationship between statin use and breast cancer risk. Methods: This retrospective case-control study enrolled 4332 breast cancer patients and 21,660 age-matched controls registered in the National Health Insurance program of Taiwan, which covers approximately 99% of the population. The study cases were women for whom a diagnosis of breast cancer (ICD-9-CM code 174. X) had been recorded in LHID2005 between January 1, 2004 and December 31, 2010. A logistic regression model was adjusted for potential confounding factors, including the level of urbanization, and the Charlson Comorbidity Index was applied to assess potential comorbidities. We also considered possible bias caused by random urbanization, because nutrition and lifestyle factors are related to breast cancer incidence. Results: Our results showed that lovastatin was associated with a lower risk of breast cancer (adjusted OR 0.596; 95% CI 0.497-0.714; p < 0.001), and atorvastatin exhibited a protective tendency against breast cancer (adjusted OR 0.887; 95% CI 0.776-1.013; p < 0.077). Conclusions: Although no consensus has been established regarding the relationship between statin use and breast cancer risk, our study indicated that lovastatin is a potential chemopreventive agent against breast cancer. Further detailed research is warranted.
Two-Photon Photoexcited Photodynamic Therapy and Contrast Agent with Antimicrobial Graphene Quantum Dots
(2016-11-09)
Kuo, Wen-Shun
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Chang, Chia-Yuan
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Chen, Hua-Han
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Hsu, Chih-Li Lilian
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Wang, Jiu-Yao
A graphene quantum dot (GQD) used as the photosensitizer with high two-photon absorption in the near-infrared region, a large absolute cross section of two-photon excitation (TPE), strong two-photon luminescence, and impressive two-photon stability could be used for dual modality two-photon photodynamic therapy (PDT) and two-photon bioimaging with an ultrashot pulse laser (or defined as TPE). In this study, a GQD efficiently generated reactive oxygen species coupled with TPE, which highly increased the effective PDT ability of both Gram-positive and-negative bacteria, with ultralow energy and an extremely short photoexcitation time generated by TPE. Because of its two-photon properties, a GQD could serve,as a promising two photon contrast agent for observing specimens in depth in three-din-tensional biological environments while simultaneously proceeding with PDT action to eliminate bacteria, particularly in multidrug-resistant (MDR) strains. This procedure would provide an efficient alternative approach to easily cope with MDR bacteria.
Design and synthesis of 1,2,3-triazole-containing N-acyl zanamivir analogs as potent neuraminidase inhibitors
(2016-11-10)
Das, Anindya
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Adak, Avijit K.
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Ponnapalli, Kalyankumar
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Lin, Chien-Hung
;
Hsu, Kai-Cheng
The design of potent metabolically stable neuraminidase (NA) inhibitors represents an attractive approach for treating influenza virus infection. In this study, we describe the exploitation of the 150-cavity in the active site of group 1 NA for the design, synthesis, and in vitro evaluation of new triazole-containing N-acyl derivatives related to Zanamivir. Inhibition studies with influenza virus NAs of group 1 (H1N1) and group 2 (H3N2) revealed that several of them are good inhibitors, with IC50 values in the low nanomolar (2.3 nM-31 nM) range. Substituents that form stable van der Waals interaction with the 150-cavity residues play crucial roles in NA inhibition as demonstrated by the potency of 6a (H1N1 IC50 = 23 nM, and H3N2 IC50 = 2.9 nM). Docking studies indicated that the cyclohexane-substituted triazole ring extended toward the hydrophobic region in the active site of group 1 NA in open form. The high potency observed for inhibitor 6a may be attributable to the highly favorable hydrophobic interactions in this region. (C) 2016 Elsevier Masson SAS. All rights reserved.
The Lauricella functions and exactstring scattering amplitudes
(2016-11-10)
Lai, Sheng-Hong
;
Lee, Jen-Chi
;
Yang, Yi
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電子物理學系
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Department of Electrophysics
We discover that the 26D open bosonic string scattering amplitudes (SSA) of three tachyons and one arbitrary string state can be expressed in terms of the D-type Lauricella functions with associated SL(K + 3, C) symmetry. As a result, SSA and symmetries or relations among SSA of different string states at various limits calculated previously can be rederived. These include the linear relations first conjectured by Gross [1-5] and later corrected and proved in [6-12] in the hard scattering limit, the recurrence relations in the Regge scattering limit with associated SL(5,C) symmetry [24-26] and the extended recurrence relations in the nonrelativistic scattering limit with associated SL(4,C) symmetry [29] discovered recently. Finally, as an application, we calculate a new recurrence relation of SSA which is valid for all energies.
An adaptive Paris Metro Pricing scheme for mobile data networks
(2016-11-12)
Huang, Huai-Sheng
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Hu, Shu-Chiung
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Lee, Po-Han
;
Tseng, Yu-Chee
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資訊工程學系
Because static pricing models (such as flat-rate or tiered-rate models) cannot improve user utility for subscribers and ease network congestion for operators during peak time, Smart Data Pricing has become an important incentive for mobile data markets. Paris Metro Pricing (PMP), which is a static pricing mode inspired by the pricing model for the Paris metro system, uses differentiated prices to motivate users to choose different train classes. Before choosing a class, people will consider their expected quality of service versus the prices that they are willing to pay. Even though PMP cannot guarantee the actual quality of service during service time, a balance between users\' utilities and operators\' revenue is achieved. In this paper, we propose an adaptive PMP scheme, so-called APMP, which determines the dynamic access prices of different classes for the next 24h. The accessible prices should try to increase the revenue while operators can serve more subscribers. Our simulation results show that APMP can significantly improve total revenue and average revenue per user for the operator. Copyright (c) 2016 John Wiley & Sons, Ltd.
NETWORK FORENSICS AND SURVEILLANCE FOR EMERGING NETWORKS
(2016-11-12)
Lin, Xiaodong
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Choo, Kim-Kwang Raymond
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Lin, Ying-Dar
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Mueller, Peter
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交大名義發表
末代菸農
(2016-11-13)
曾婕茵
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Department of Communication and Technology
;
傳播與科技學系
時空背景為2017年元月的美濃，以第一人稱敘事，紀錄菸農們面臨收購政策即將畫下句點的無奈與憂愁。
孤獨寄生
(2016-11-13)
凃湘羚
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Department of Communication and Technology
;
傳播與科技學系
孤獨難逃，以舞台劇劇本方式呈現情緒的放血與刮痧。
文創生活　手手市集
(2016-11-13)
凃易暄
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Department of Communication and Technology
;
傳播與科技學系
文創是近幾年流行的詞，以文化創意為商機，凸顯個人價值。而市集的興起也提供文創工作者一個平台交流、增加自己的知名度。
與火共舞　吹出玻璃韻律
(2016-11-13)
范晨星
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Department of Communication and Technology
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傳播與科技學系
十月29日新竹市玻璃工藝博物館邀請玻璃藝術創作人黃瓊儀，至玻璃工坊表演窯爐吹製技法，展現藝術品製作過程的美。
總編輯的話
(2016-11-13)
陳奕璇
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Department of Communication and Technology
;
傳播與科技學系
本期為第251期，頭題「狂與直率　新行銷思維」搭上時事熱潮，結合國內外政治、電玩產業等例子分析現象。本期自由創作類文章表現優異，特殊創作類型值得讀者共賞。
十字路口的金屬惡魔
(2016-11-13)
李瑞彥
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Department of Communication and Technology
;
傳播與科技學系
一個關於小男孩遇見惡魔的故事。也是我面對內心的陰暗，試圖在金屬、後硬核及搖滾樂所造成腦內啡氾濫的腦海中找回自我的故事。
紀人豪　畫框外的繽紛人生
(2016-11-13)
陳昱彣
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Department of Communication and Technology
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傳播與科技學系
介紹壁畫家紀人豪的生命歷程，以及他的創作理念。
包種茶節　搶當一日政大人
(2016-11-13)
何書馨
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張芸瑄
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Department of Communication and Technology
;
傳播與科技學系
2016年11月5日由國立政治大學所舉辦的「包種茶節」吸引上千位高中生參加，各科系不僅發揮創意準備精彩導覽，還有快閃表演活動，現場熱鬧無比。
竹市動物園　80年風華
(2016-11-13)
黃佳俐
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卓業軒
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Department of Communication and Technology
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傳播與科技學系
新竹市立動物園慶祝80週年生日，舉辦「動物園都記得」回顧展，吸引眾多親子前來回顧動物園的過往。
同志遊行　走出性別多元
(2016-11-13)
劉以寧
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Department of Communication and Technology
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傳播與科技學系
2016同志大遊行於十月底舉行，當天估計有八萬多人走上街頭，遊行地點凱達格蘭大道上處處可見六色彩虹旗飛揚，引起許多民眾對於LGBTQIA族群的注意。
狂與直率　新行銷思維
(2016-11-13)
何肇耕
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Department of Communication and Technology
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傳播與科技學系
譁眾取寵的行銷策略，雖然爭議，但效果十足。
黃景輝　「搖」出新關係
(2016-11-13)
鄧涵文
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Department of Communication and Technology
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傳播與科技學系
飲料品牌創辦人黃景輝的創業夢，創造與家族、桃園的新關係。
堅持初衷　大衛蕭唱出自我
(2016-11-13)
沈慶柔
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Department of Communication and Technology
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傳播與科技學系
嘻哈新人，大衛．蕭，秉持著嘻哈最真實的文化，用新穎的唱風闖蕩星河。
全民司法　舞動改革
(2016-11-13)
林宥成
;
王羽廷
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Department of Communication and Technology
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傳播與科技學系
第11屆蔡瑞月國際舞蹈節，喚醒人民司法改革意識。