Browsing by Issue Date, starting with "2016-12-25"

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體壇問題叢生　改革露曙光
(2016-12-25)
何家沂
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Department of Communication and Technology
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傳播與科技學系
闡述台灣目前的體育發展狀況、疑慮及近日送審一讀的《國民體育法》並期待未來的改革之路。
可移動機器人　運輸新選擇
(2016-12-25)
陳奕璇
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Department of Communication and Technology
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傳播與科技學系
介紹運輸機器人及其與社會現況之連結。
游喬茵　用攝影改變世界
(2016-12-25)
林孟盈
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Department of Communication and Technology
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傳播與科技學系
介紹擁有燦爛笑容的專職攝影師游喬茵，以及她與攝影的羈絆。
耶誕節前放光明　ERG衛星
(2016-12-25)
陳昶安
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Department of Communication and Technology
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傳播與科技學系
為探索宇宙間未知的高能輻射區，台日攜手共造的ERG衛星已於本周二晚間七點順利升空，點亮了太空學界伯利恆的夜晚。
總編輯的話
(2016-12-25)
凃易暄
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Department of Communication and Technology
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傳播與科技學系
本期喀報為第257期，以「無人機應用　競速賽新市場」為頭題，闡述無人機作為現今科技的一大新趨勢，不僅是新科技的應用，帶來的周邊產業商機更是無限。
綠幕下的危機　陸生限縮
(2016-12-25)
彭書耘
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Department of Communication and Technology
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傳播與科技學系
探討政黨輪替過後，陸生限縮的衝擊及其背後諸多原因，討論未來走向。
日夜交替　市場百態
(2016-12-25)
李瑞彥
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Department of Communication and Technology
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傳播與科技學系
在夜晚與清晨走訪蘆洲觀光夜市形象商圈，記錄它多變樣貌與生活其中的人們。
方信雄　引船入港的英雄
(2016-12-25)
曾婕茵
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Department of Communication and Technology
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傳播與科技學系
引水人方信雄，目前是基隆港的資深領港，從方信雄的人生故事，一探全臺95位引水人的辛酸血淚。
台灣街舞世界冠軍　黃柏青
(2016-12-25)
吳偉立
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Department of Communication and Technology
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傳播與科技學系
專訪正拿下街舞世界冠軍之團隊「Formosa Crew」的團長，黃柏青老師。
成長茁壯
(2016-12-25)
鄧涵文
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Department of Communication and Technology
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傳播與科技學系
以拍攝綠豆為創作手法，傳達唯有找到「家」的依靠，擁有全世界最堅強的後盾，才能無後顧之憂地闖蕩人生。
養一隻努努
(2016-12-25)
陳昱彣
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Department of Communication and Technology
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傳播與科技學系
作業、考試接踵而來的年末，就讓可愛的努努陪伴你的聖誕跨年週吧。
人性哲學　看見真實人生
(2016-12-25)
何肇耕
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Department of Communication and Technology
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傳播與科技學系
哲學探討的事物就在我們身邊，思考生命的一切聽起來非常抽象艱深，其實也可以很簡單。
無人機應用　競速賽新市場
(2016-12-25)
王廷瑄
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Department of Communication and Technology
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傳播與科技學系
本文針對「無人機競速賽」做應用分析與介紹，並探討台灣無人機產業未來發展與期待。
小檔案：發展以學校為核心之社區創新創業計畫
(國立交通大學客家文化學院, 2016-12-26)
簡嘉瑩
發展以學校為核心之社區創新創業計畫，其主持人為中山大學人力資源管理研究所教授同時也是創意與創新研發新中心主任陳以亨，以教育部「實驗創新」課程為出發點，為偏鄉教育納入更多創新及前瞻性規劃，並以地方大學協助偏鄉中小學模式，引進大學與社區力量協助偏鄉，擴展偏鄉學校功能。計畫的最終目的為整合在地教育及文化資源，讓學校成為偏鄉與社區創新創業之重要基地，活絡社區與在地經濟，並促進地方產業的攜手合作，吸引青年回流，同時帶動偏鄉教育。
即將活絡偏鄉：清水仰生股份有限公司大學和國小攜手合作再創偏鄉社區生機
(國立交通大學客家文化學院, 2016-12-26)
簡嘉瑩
清水國小位於新竹縣新埔鎮，該社區位於一個有濃厚客家特色的古樸偏鄉，因為地處偏鄉產業又以傳統一級農業為主，近年來有產業發展沒落與年輕人口外移的困境，而位於其社區內的清水國小，也因為就讀人數太少而曾面臨廢校危機，現今全校僅有53名學生。為了要活絡社區產業的與增加就業機會，同時讓年輕人口回流，便配合中山大學所寄出之「發展以學校為核心之創新創業計畫」與同樣在新竹之中華大學進行合作，兩校將站在輔導並協助清水社區產業發展的角色，協助社區和清水國小的活絡。其理念同時也希望能整合社區民眾力量，讓整個社區動起來，對於學校來說，也可以搭配課程，讓學生更認識社區，更能成為參與者。
雙連梨社會企業小小梨子，大大夢想
(國立交通大學客家文化學院, 2016-12-26)
簡嘉瑩
由中原大學企管系助理教授李明彥所帶領的中原企管系學生團隊，為了協助在苗栗偏鄉的雙連國小免於廢校危機，同時協助雙連社區的發展，共同成立了雙連梨社會企業，推廣當地的特產雙連梨。李明彥表示，他在親身探訪了雙連社區後發現，該地小農所種植的雙連梨，甜而多汁，因此萌生創立社會企業的構想。雙連梨社會企業(以下簡稱雙連梨)於2016年七月正式成立，短短五個月之內，已有500萬的營業額，運作行銷可謂十分成功。
Interleukin-18 deteriorates Fabry cardiomyopathy and contributes to the development of left ventricular hypertrophy in Fabry patients with GLA IVS4+919 G>A mutation
(2016-12-27)
Chien, Yueh
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Chien, Chian-Shiu
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Chiang, Huai-Chih
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Huang, Wei-Lin
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Chou, Shih-Jie
Rationale: A high incidence of GLA IVS4+919 G>A mutation in patients with Fabry disease of the later-onset cardiac phenotype, has been reported in Taiwan. However, suitable biomarkers or potential therapeutic surrogates for Fabry cardiomyopathy (FC) in such patients under enzyme replacement treatment (ERT) remain unknown. Objective: Using FC patients carrying IVS4+919 G>A mutation, we constructed an induced pluripotent stem cell (iPSC)-based disease model to investigate the pathogenetic biomarkers and potential therapeutic targets in ERT-treated FC. Results and methods: The iPSC-differentiated cardiomyocytes derived from FC-patients (FC-iPSC-CMs) carried IVS4+919 G>A mutation recapitulating FC characteristics, including low a-galactosidase A enzyme activity, cellular hypertrophy, and massive globotriaosylceramide accumulation. Microarray analysis revealed that interleukin-18 (IL-18), a pleiotropic cytokine involved in various myocardial diseases, was the most highly upregulated marker in FC-iPSC-CMs. Meanwhile, IL-18 levels were found to be significantly elevated in the culture media of FC-iPSC-CMs and patients\' sera. Notably, the serum IL-18 levels were highly paralleled with the progression of left ventricular hypertrophy in Fabry patients receiving ERT. Finally, using FC-iPSC-CMs as in vitro FC model, neutralization of IL-18 with specific antibodies combined with ERT synergistically reduced the secretion of IL-18 and the progression of cardiomyocyte hypertrophy in FC-iPSC-CMs. Conclusion: Our data demonstrated that cardiac IL-18 and circulating IL-18 are involved in the pathogenesis of FC and LVH. IL-18 may be a novel marker for evaluating ERT efficacy, and targeting IL-18 might be a potential adjunctive therapy combined with ERT for the treatment of advanced cardiomyopathy in FC patients with IVS4+919 G>A mutation.
Glucocorticoids may compromise the effect of gefitinib in non-small cell lung cancer
(2016-12-27)
Wang, Hsian-Yu
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Chang, Yu-Ling
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Cheng, Chun-Chun
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Chao, Min-Wu
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Lin, Su-I
The epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitors (TKIs) have shown remarkable benefits in non-small cell lung cancer (NSCLC) patients with drug-sensitive mutations in the EGFR gene. Responsive patients are usually continuously prescribed with TKIs until disease progression. Glucocorticoids (GCs) are potent homeostasis maintaining drugs and are frequently used in cancer patients to alleviate discomforts caused by anti-cancer therapies. Several previous studies reported that concomitant use of GCs may compromise the efficacy of chemo-therapeutics in patients with solid tumors. Little is known in the concomitant use of target therapy with GCs in treating NSCLC. In this study, we hypothesized that concomitant use of GCs in EGFR-TKI therapy may be detrimental and addressed this issue using cell cultures and xenograft studies followed by a retrospective population study based on data from the Taiwan national health insurance system. In cell cultures and xenograft studies, GCs were shown to unequally compromise the anti-cancer efficacy of TKIs in both PC9 and NCI-H1975 NSCLC cells models. In the retrospective population study, patients with similar disease status that were co-medicated with GCs had a significantly higher risk of disease progression.
Stepwise Structural Evolution of a DTS-F2BT Oligomer and Influence of Structural Disorder on Organic Field Effect Transistors and Organic Photovoltaic Performance
(2016-12-27)
Huang, Chi-Feng
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Huang, Sin-Hong
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Hsieh, Chou-Ting
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Chao, Yi-Hsiang
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Li, Chia-Hua
An A-D-A oligomer, DTS(F2BT)(2), was synthesized; its structural evolution was studied with DSC, POM, 2D-WAXD, and in-situ GI-XRD. The structural evolution of DTS(F2BT)(2) is stepwise and kinetically slow. Both rapid drying and the presence of PC71BM trapped DTS(F2BT)(2) in a less ordered nematic (N) phase. PDMS-assisted crystallization enabled a pristine DTS(F2BT)(2) thin film to attain a more ordered equilibrium phase, and enhanced the OFET mobility of DTS(F2BT)(2). In OPV devices, DIO additive drove the DTS(F2BT)(2) domains in the DTS(F2BT)(2):PC71BM blended film from the N phase toward the equilibrium phase, and resulted in enhanced OPV performances. These results reveal the slow ordering process of the A-D-A oligomer, and the importance of monitoring the degree of structural evolution of the active thin films in organic optoelectronics.
Fourier-transform microwave spectroscopy of dimethyl-substituted Criegee intermediate (CH3)(2)COO
(2016-12-28)
Nakajima, Masakazu
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Endo, Yasuki
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應用化學系
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Department of Applied Chemistry
Pure rotational transitions of the dimethyl-substituted Criegee intermediate (dimethyl carbonyl oxide, acetone oxide), (CH3)(2)COO, were observed in the discharge plasma of a C(CH3)(2)I-2/O-2 gas mixture by Fourier-transform microwave spectroscopy. The observed spectra show small splittings due to the internal rotations of the two methyl groups. Precise rotational constants of the molecule and the barrier heights of the methyl internal rotations were experimentally determined. Published by AIP Publishing.