Browsing by Issue Date, starting with "2017-06-16"

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有機發光元件及其製法
(2017-06-16)
孟心飛
;
冉曉雯
;
洪勝富
;
張宇帆
;
楊劭鈞
一種有機發光元件，包括：第一電極；平坦層，係形成於該第一電極上；電洞傳輸層，係形成於該平坦層上，使該平坦層夾置於該第一電極和該電洞傳輸層之間，其中，該電洞傳輸層包括具有芴衍生結構之聚合物；發光層，係形成於該電洞傳輸層上，使該電洞傳輸層夾置於該平坦層和該發光層之間，其中，該發光層包括雙主體材料及客發光體；以及第二電極，係形成於該發光層上，使該發光層夾置於該電洞傳輸層和第二電極之間，藉此提升有機發光元件的發光壽命。本發明復提供製造有機發光元件之方法。
具攝影機自動調派功能之3D影像監控系統及其監控方法
(2017-06-16)
黃嘉新
;
梁家銘
;
林奕廷
;
李冠毅
;
吳昆儒
一種3D影像監控系統，運用於監控端電腦並且包括監控目標物網點產生單元、覆蓋矩陣產生單元及權重矩陣產生單元。監控目標物網點產生單元對監控目標物進行切割以獲得複數表面視點；覆蓋矩陣產生單元根據複數攝影機的監控視野與複數表面視點產生覆蓋矩陣；權重矩陣產生單元依據依據覆蓋矩陣判斷各表面視點的被覆蓋機率，並據以產生權重矩陣。3D影像監控系統基於各個攝影機的不同監控視野與複數表面視點的覆蓋關係挑選適合的攝影機，並決定被挑選的攝影機要採用的監控視野。藉此，達到高效率、高覆蓋率、高影像清晰度的即時性攝影機調派工作。
用於無線區域網路中多接取點之合作傳輸系統及其方法
(2017-06-16)
伍紹勳
;
趙禧綠
;
曾俊凱
一種用於無線區域網路中多接取點之合作傳輸系統及其方法，係包括：複數個接取點、分群控制器以及至少一個叢集控制器。該複數個接取點係用於分別服務其服務範圍內之至少一使用者之設備，該分群控制器用於依據該複數個接取點之位置及該服務範圍以分群該複數個接取點，俾將該複數個接取點分群成複數個叢集，該至少一個叢集控制器用於控制其所管轄之叢集內所有接取點之間的合作式同步下行傳輸，且叢集之間在交集時，係採用干擾抑制機制，透過交換使用者通道資訊，以消除位於不同叢集交集區之使用者之設備所產生之干擾。本發明透過合作式通訊技術以及干擾抑制機制，將可避免無線區域網路中多個接取點之間因重疊基本服務區所產生之干擾。
畫素補償裝置、具有電流補償功能的顯示器
(2017-06-16)
戴亞翔
;
林玄用
;
張君毅
一種畫素補償裝置包含一個設定開關、一個畫素電路及一個補償電路。設定開關具有一接收一周期信號的第一端及一第二端，且受控制使該設定開關於導通與不導間切換，當導通時，該周期信號傳送到該第二端。畫素電路電連接該設定開關的第二端，當該設定開關導通時，該畫素電路接收來自該設定開關的該周期信號，且根據該周期信號產生一驅動電流。補償電路電連接該畫素電路與該設定開關的控制端，用來接收來自該畫素電路的該驅動電流，該補償電路判斷該驅動電流的大小是否符合一預設值，以決定是否將該設定開關切換成不導通，該預設值相關於一畫素亮度值。
Cascade Synthesis of Benzimidazole-Linked Pyrroles via Copper Catalyzed Oxidative Cyclization and Ketonization
(2017-06-16)
Ye, Tzuen-Yang
;
Selvaraju, Manikandan
;
Sun, Chung-Ming
;
應用化學系
;
Department of Applied Chemistry
A three-component cascade reaction of 2-aminobenzimidazole, aldehyde, and terminal alkyne has been explored for an efficient synthesis, of benzimidazole-linked tetrasubstituted pyrroles. The reaction sequence involves the formation Of propargylamine, insertion of 4 terminal alkyne, and a ring opening reaction, followed by, an intramolecular carboylative cyclization under aerobic conditions. It represents a novel, strategy to the construction of C=N, C=C, C=0 bonds and a new five-membered 2-ketopyrrole ring. In this process, the reaction conditions are crucial and an attempt to elucidate the novel reaction patway is well, supported by X=ray crystallography.
半導體裝置結構
(2017-06-16)
莊紹勳
;
謝易叡
;
趙堉斌
;
潘正聖
本揭露提供半導體裝置結構與其形成方法。半導體裝置結構包括源極結構於半導體基板中。半導體裝置結構亦包括通道層於半導體基板上。通道層的第一部份覆蓋部份源極結構。通道層的第二部份橫向地延伸出源極結構。半導體裝置結構更包括汲極結構於半導體基板上。汲極結構與源極結構具有不同的導電型態。汲極結構鄰接通道層的第二部份。
水溶性螢光胜肽材料
(2017-06-16)
林欣杰
;
許舒閔
一種水溶性螢光胜肽材料，具有式(I)之結構：在式(I)中，n為1以上之整數，R1係獨立選自氫或含氮取代基，R2係獨立選自氫或烷基，A1係由一個以上的胺基酸單體聚合而成，具有式(II)之結構：在式(II)中，m為1以上之整數，且A1中各該胺基酸單體的R3係獨立選自氫、烷基、芳香烷基、烷基硫代烷基、羥基芳香烷基、雜芳香烷基、羧基烷基、或胍基烷基，A2為-OR5或-N(R4)2，其中R4係獨立選自氫、烷基、芳香烷基、烷基硫代烷基、羥基芳香烷基、雜芳香烷基、羧基烷基、胍基烷基、單醣基、雙醣基、或寡醣基，R5為氫、烷基、芳香烷基、烷基硫代烷基、羥基芳香烷基、雜芳香烷基、羧基烷基、或胍基烷基。
MEASUREMENT OF SURFACE PROFILE AND SURFACE ROUGHNESS OF FIBRE-OPTIC INTERCONNECT BY FAST FOURIER TRANSFORM
(2017-06-17)
Lin, Chern S.
;
Yang, Shih W.
;
Lin, Hung L.
;
Li, Jhih W.
;
資訊工程學系
This study proposes a surface profile and roughness measurement system for a fibre-optic interconnect based on optical interferometry. On the principle of Fizeau interferometer, an interference fringe is formed on the fibre end-face of the fibre-optic interconnect, and the fringe pattern is analysed using the Fast Fourier transform method to reconstruct the surface profile. However, as the obtained surface profile contains some amount of tilt, a rule for estimating this tilt value is developed in this paper. The actual fibre end-face surface profile is obtained by subtracting the estimated tilt amount from the surface profile, as calculated by the Fast Fourier transform method, and the corresponding surface roughness can be determined. The proposed system is characterized by non-contact measurement, and the sample is not coated with a reflector during measurement. According to the experimental results, the difference between the roughness measurement result of an Atomic Force Microscope (AFM) and the measurement result of this system is less than 3 nm.
Inhibition effect of curcumin on UVB-induced secretion of pro-inflammatory cytokines from corneal limbus epithelial cells
(2017-06-18)
Chao, Shih-Chun
;
Hu, Dan-Ning
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Roberts, Joan
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Shen, Xilun
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Lee, Chia-Yi
AIM: To study the effects of curcumin on the secretion of interleukin (IL) -6 and IL-8 by corneal limbus epithelial cells. METHODS: Human corneal limbus epithelial cells were isolated and cultured from donor eyes and irradiated by UVB at different dosages with or without curcumin. MTT test was used for studying the effects of UVB and curcumin on the cell viability. The role of mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappa B) pathways on the UVB-induced secretion of IL-6 and IL-8 were tested by addition of their inhibitors to the culture with or without UVB-radiation. Levels of various signal pathways, IL-6 and IL-8 in the cells and in the conditioned culture medium were measured by ELISA analysis. RESULTS: UVB at 20 mJ/cm(2) or less and curcumin at 20 mu mol/L or less did not affect the cell viability of cultured limbus epithelial cells (P>0.05). UVB irradiation at 10 and 20 mJ/cm(2) induced a significant increase of secretion of IL-6 and IL-8 and upregulated NF-kappa B and phosphorylated MAPK pathways of cultured limbus epithelial cells (P<0.05). Various signal pathway inhibitors, including SP600125 (JNK inhibitor), SB203580 (p38 MAPK inhibitor) and BAY11-7082 (NF-kappa B inhibitor) significantly decreased the UVB-induced secretion of IL-6 and IL-8 secretion (P<0.05). Curcumin at 5-20 mu mol/L significantly inhibited UVB-induced secretion of IL-6 and IL-8 by limbus epithelial cells in a dose-dependent manner; while curcumin alone did not affect the secretion of IL-6 and IL-8. The upregulation of NF-kappa B and MAPK pathways induced by UVB treatment was significantly inhibited by curcumin, suggesting that NF-kappa B and MAPK pathways are involved in the inhibitory effect of curcumin on UVB-induced production of IL-6 and IL-8. CONCLUSION: Curcumin may be a promising agent to be explored for the prevention and treatment of pterygium.
Evolution of the Reactor Antineutrino Flux and Spectrum at Daya Bay
(2017-06-19)
An, F. P.
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Balantekin, A. B.
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Band, H. R.
;
Bishai, M.
;
Blyth, S.
The Daya Bay experiment has observed correlations between reactor core fuel evolution and changes in the reactor antineutrino flux and energy spectrum. Four antineutrino detectors in two experimental halls were used to identify 2.2 million inverse beta decays (IBDs) over 1230 days spanning multiple fuel cycles for each of six 2.9 GW(th) reactor cores at the Daya Bay and Ling Ao nuclear power plants. Using detector data spanning effective Pu-239 fission fractions F-239 from 0.25 to 0.35, Daya Bay measures an average IBD yield (sigma) over bar (f) of (5.90 +/- 0.13) x 10(-43) cm(2)/fission and a fuel-dependent variation in the IBD yield, d sigma(f)/dF(239), of (-1.86 +/- 0.18) x 10(-43) cm(2)/fission. This observation rejects the hypothesis of a constant antineutrino flux as a function of the Pu-239 fission fraction at 10 standard deviations. The variation in IBD yield is found to be energy dependent, rejecting the hypothesis of a constant antineutrino energy spectrum at 5.1 standard deviations. While measurements of the evolution in the IBD spectrum show general agreement with predictions from recent reactor models, the measured evolution in total IBD yield disagrees with recent predictions at 3.1 sigma. This discrepancy indicates that an overall deficit in the measured flux with respect to predictions does not result from equal fractional deficits from the primary fission isotopes U-235, Pu-239, U-238, and Pu-241. Based on measured IBD yield variations, yields of (6.17 +/- 0.17) and (4.27 +/- 0.26) x 10(-43) cm(2)/fission have been determined for the two dominant fission parent isotopes U-235 and Pu-239. A 7.8% discrepancy between the observed and predicted U-235 yields suggests that this isotope may be the primary contributor to the reactor antineutrino anomaly.
Schiff Base Proton Acceptor Assists Photoisomerization of Retinal Chromophores in Bacteriorhodopsin
(2017-06-20)
Hung, Chih-Chang
;
Chen, Xiao-Ru
;
Ko, Ying-Kuan
;
Kobayashi, Takayoshi
;
Yang, Chii-Shen
In this study, we investigated the ultrafast dynamics of bacteriorhodopsins (BRs) from Haloquadratum walsbyi (HwBR) and Haloarcula marismortui (HmBRI and HmBRII). First, the ultrafast dynamics were studied for three HwBR samples: wild-type, D93N mutation, and D104N mutation. The residues of the D93 and D104 mutants correspond to the control by the Schiff base proton acceptor and donor of the proton translocation subchannels. Measurements indicated that the negative charge from the Schiff base proton acceptor residue D93 interacts with the ultrafast and substantial change of the electrostatic potential associated with chromophore isomerization. By contrast, the Schiff base proton donor assists the restructuring of the chromophore cavity hydrogen-bond network during the thermalization of the vibrational hot state. Second, the ultrafast dynamics of the wild-types of HwBR, HmBRI, and HmBRII were compared. Measurements demonstrated that the hydrogen-bond network in the extracellular region in HwBR and HmBRII slows the photoisomerization of retinal chromophores, and the negatively charged helices on the cytoplasmic side of HwBR and HmBRII accelerate the thermalization of the vibrational hot state of retinal chromophores. The similarity of the correlation spectra of the wild-type HmBRI and D104N mutant of HwBR indicates that inactivation of the Schiff base proton donor induces a positive charge on the helices of the cytoplasmic side.
交大e-News第234期-美國輝達公司(NVIDIA)創辦人暨執行長黃仁勳獲頒交大名譽博士
(2017-06-20)
國立交通大學秘書室
;
Secretariat
High efficiency ternary organic solar cell with morphology-compatible polymers
(2017-06-21)
Mai, Jiangquan
;
Lu, Haipeng
;
Lau, Tsz-Ki
;
Peng, Shih-Hao
;
Hsu, Chain-Shu
Ternary organic solar cell is a promising strategy for improving the power conversion efficiency (PCE) of single-junction organic solar cells by broadening the light absorption spectrum with the incorporation of two electron donors and one acceptor or one donor and two acceptors. However, in many cases the optimized loading of the third component is so small that its contribution to the light absorption is limited. Following our previously proposed selection rule for the two polymers capable of comparable loadings, we report in this work a ternary system composed of two morphologically compatible polymers with distinct chemical structures that can achieve a high PCE of 9.0% with a mass ratio of 1:1. Besides the expected improvement in short circuit current due to the broadening of the absorption spectrum, the fill factor of the ternary device is improved significantly. We attribute it to the balanced electron and hole mobility and reduced recombination benefiting from the high morphology compatibility of the system.
Blending Homopolymers for Controlling the Morphology Transitions of Block Copolymer Nanorods Confined in Cylindrical Nanopores
(2017-06-21)
Cheng, Ming-Hsiang
;
Hsu, Yu-Chen
;
Chang, Chun-Wei
;
Ko, Hao-Wen
;
Chung, Pei-Yun
The microphase separation of block copolymers in confined geometries has been widely investigated over the last few decades. The controllability and versatility of the confinement-induced morphologies, however, are still difficult to be achieved because of the limited experimental parameters in the process of fabricating the confined nanostructures. In this work, we study the morphology transitions of lamellae forming polystyrene-block-polydimethylsiloxane (PS-b-PDMS) nanorods confined in the nanopores of anodic aluminum oxide (AAO) templates. The nanorods are formed by solvent-assisted template wetting, and the morphologies are compared to those in the bulk state. By blending PS-b-PDMS with homopolystyrene (hPS), the morphologies of the nanorods can be controlled because of the changes of the effective volume fractions. Special morphology transitions from concentric lamellar morphology, to multihelical morphology, and finally to spherical-like morphology are observed by increasing the weight ratios of hPS. hPS with different molecular weights is also applied to investigate the effect of hPS on the morphologies of the PS-b-PDMS/hPS blend nanostructures. The unusual morphologies are further confirmed by a selective removal process, which also generates nanochannels for possible refilling with functional materials.
Understanding the functional properties of bio-inorganic nanoflowers as biocatalysts by deciphering the metal-binding sites of enzymes
(2017-06-21)
Escobar, Sindy
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Velasco-Lozano, Susana
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Lu, Chih-Hao
;
Lin, Yu-Feng
;
Mesa, Monica
The biomineralisation of metal phosphates is a promising approach to develop more efficient nano-biocatalysts; however, the interactions between the protein and the inorganic mineral are poorly understood. Elucidating which protein regions most likely participate in the mineral formation will guide the fabrication of more efficient biocatalysts based on metal-phosphate nanoflowers. We have biomineralised the lipase from Thermomyces lanuginosus using three calcium, zinc and copper phosphates to fabricate different types of bio-inorganic nanoflowers. To better understand how the biomineralisation process affects the enzyme properties, we have computationally predicted the protein regions with a higher propensity for binding Ca2+, Cu2+ and Zn2+. These binding sites can be considered as presumable nucleation points where the biomineralisation process starts and explain why different metals can form bio-inorganic nanoflowers of the same enzyme with different functional properties. The formation of calcium, copper and zinc phosphates in the presence of this lipase gives rise to nanoflowers with different morphologies and different enzymatic properties such as activity, stability, hyperactivation and activity-pH profile; these functional differences are supported by structural studies based on fluorescence spectroscopy and can be explained by the different locations of the predicted nucleation sites for the different metals. Among the three metals used herein, the mineralisation of this lipase with zinc-phosphate enables the fabrication of bio-inorganic nanoflowers 34 times more stable than the soluble enzyme. These bio-inorganic nanoflowers were reused for 8 reaction cycles achieving 100% yield in the hydrolysis of p-nitrophenol butyrate but losing more than 50% of their initial activity after 6 operational cycles. Finally, this heterogeneous biocatalyst was more active and enantioselective than the soluble enzyme (ee = 79%(R)) towards the kinetic resolution of rac-1-phenylethyl acetate yielding the R enantiomer with ee = 84%.
METHOD OF PREPARING SELECTIVE CATALYTIC REDUCTION COMPOSITE CATALYST
(2017-06-22)
Hsun-Ling Bai
;
Liang-Yi Lin
;
Tsung-Yu Lee
;
You-Ren Zhang
A method of preparing selective catalytic reduction composite catalyst is provided. First, first metal compound support, second metal compound, third metal compound and water are mixed to formed a precursor solution. Then, dried mixture powder is formed from the precursor solution by a spray-drying process. Thereafter, a calcination process is performed on the dried mixture powder.
Effectively infinite optical path-length created using a simple cubic photonic crystal for extreme light trapping
(2017-06-23)
Frey, Brian J.
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Kuang, Ping
;
Hsieh, Mei-Li
;
Jiang, Jian-Hua
;
John, Sajeev
A 900 nm thick TiO2 simple cubic photonic crystal with lattice constant 450 nm was fabricated and used to experimentally validate a newly-discovered mechanism for extreme light-bending. Absorption enhancement was observed extending 1-2 orders of magnitude over that of a reference TiO2 film. Several enhancement peaks in the region from 600-950 nm were identified, which far exceed both the ergodic fundamental limit and the limit based on surface-gratings, with some peaks exceeding 100 times enhancement. These results are attributed to radically sharp refraction where the optical path length approaches infinity due to the Poynting vector lying nearly parallel to the photonic crystal interface. The observed phenomena follow directly from the simple cubic symmetry of the photonic crystal, and can be achieved by integrating the light-trapping architecture into the absorbing volume. These results are not dependent on the material used, and can be applied to any future light trapping applications such as phosphor-converted white light generation, water-splitting, or thin-film solar cells, where increased response in areas of weak absorption is desired.
A rapid and quantitative method to detect human circulating tumor cells in a preclinical animal model
(2017-06-23)
Tu, Shih-Hsin
;
Hsieh, Yi-Chen
;
Huang, Li-Chi
;
Lin, Chun-Yu
;
Hsu, Kai-Wen
Background: As cancer metastasis is the deadliest aspect of cancer, causing 90% of human deaths, evaluating the molecular mechanisms underlying this process is the major interest to those in the drug development field. Both therapeutic target identification and proof-of-concept experimentation in anti-cancer drug development require appropriate animal models, such as xenograft tumor transplantation in transgenic and knockout mice. In the progression of cancer metastasis, circulating tumor cells (CTCs) are the most critical factor in determining the prognosis of cancer patients. Several studies have demonstrated that measuring CTC-specific markers in a clinical setting (e.g., flow cytometry) can provide a current status of cancer development in patients. However, this useful technique has rarely been applied in the real-time monitoring of CTCs in preclinical animal models. Methods: In this study, we designed a rapid and reliable detection method by combining a bioluminescent in vivo imaging system (IVIS) and quantitative polymerase chain reaction (QPCR)-based analysis to measure CTCs in animal blood. Using the IVIS Spectrum CT System with 3D-imaging on orthotropic-developed breast-tumor-bearing mice. Results: In this manuscript, we established a quick and reliable method for measuring CTCs in a preclinical animal mode. The key to this technique is the use of specific human and mouse GUS primers on DNA/RNA of mouse peripheral blood under an absolute qPCR system. First, the high sensitivity of cancer cell detection on IVIS was presented by measuring the luciferase carried MDA-MB-231 cells from 5 to 5x10(11) cell numbers with great correlation (R-2 = 0.999). Next, the MDA-MB-231 cell numbers injected by tail vein and their IVIS radiance signals were strongly corrected with qPCR-calculated copy numbers (R-2 > 0.99). Furthermore, by applying an orthotropic implantation animal model, we successfully distinguished xenograft tumor-bearing mice and control mice with a significant difference (p < 0.001), whereas IVIS Spectrum-CT 3D-visualization showed that blood of mice with lung metastasis contained more than twice the CTC numbers than ordinary tumor-bearing mice. We demonstrated a positive correlation between lung metastasis status and CTC numbers in peripheral mouse blood. Conclusion: Collectively, the techniques developed for this study resulted in the integration of CTC assessments into preclinical models both in vivo and ex vivo, which will facilitate translational targeted therapy in clinical practice.
Effects of substrate and annealing on GaN films grown by plasma-assisted molecular beam epitaxy
(2017-06-25)
Yang, Zu-Po
;
Tsou, Tsung-Han
;
Lee, Chao-Yu
;
Kan, Ken-Yuan
;
Yu, Ing-Song
GaN films were deposited by plasma-assisted molecular beam epitaxy on different substrates, i.e. Si (111), Sapphire (0001) and 4H-SiC (0001) with 4 degrees of miscutting orientation. Due to the lattice mismatch between GaN films and substrates, the substrates profoundly affect the growth mechanism of GaN films on them during the epitaxy. The smooth and complete GaN films can be obtained on 4H-SiC substrates based on the analyses of reflection high energy electron diffraction, scanning electron microscopy and atomic force microscopy. Higher quality of GaN films on 4H-SiC was also confirmed by high resolution X-ray diffraction. Photoluminescence measurements show that the compress stress existed in GaN films grown on sapphire, but tensile stress was observed in the films grown on 4H-SiC and Si. Meanwhile, in-situ annealing treatment of post expitxy can remove Ga droplets on GaN films and decrease the surface roughness and defect density of GaN films; however, thermal decomposition on the surface of GaN films was observed in the characterizations of X-ray photoelectron spectroscopy. (C) 2016 Elsevier B.V. All rights reserved.
Performance of p-side-up thin-film AlGaInP light-emitting diodes with textured composite aluminum-doped zinc oxide transparent conductive layers
(2017-06-25)
Tseng, Ming-Chun
;
Wuu, Dong-Sing
;
Chen, Chi-Lu
;
Lee, Hsin-Ying
;
Lin, Yu-Chang
Composite transparent conductive layers (TCLs) were deposited on the GaP window layer of p-side-up thin-film AlGaInP light-emitting diodes (LEDs) in order to enhance their light-extraction efficiency. The composite TCLs were fabricated from aluminum-doped zinc oxide (AZO) layers grown through atomic-layer deposition and pulsed-laser deposition. The results showed that wet-etching of composite AZO thin films improved the light extraction efficiency of the corresponding LED devices. The droop efficiencies of LEDs with flat AZO thin films, composite AZO thin films, and optimum textured composite AZO thin films were 29%, 30%, and 22%, respectively. LEDs with textured composite AZO layers exhibited favorable optoelectronic performance. When the injection current was increased from 20 to 1000 mA, the emission wavelengths of LEDs with flat AZO thin films, composite AZO thin films, and optimum textured composite AZO thin films shifted by 3, 5, and 3 nm, respectively. The optimum textured composite AZO thin film can not only improve LED performance but also effectively substitute flat TCLs in AlGaInP LED applications. (C) 2016 Elsevier B.V. All rights reserved.