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Browsing by Issue Date, starting with "2017-11-03"

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    Nicotinic Acetylcholine Receptor Subtype Alpha-9 Mediates Triple-Negative Breast Cancers Based on a Spontaneous Pulmonary Metastasis Mouse Model
    (2017-11-03)
    Huang, Li-Chi
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    Lin, Ching-Ling
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    Qiu, Jia-Zheng
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    Lin, Chun-Yu
    ;
    Hsu, Kai-Wen
    Triple-negative breast cancer (TNBC) subtype is associated with poor prognosis and a high risk of recurrence-related death in women. Despite the aggressiveness of TNBCs, targeted TNBC therapy is not yet available in the clinic. To overcome this challenge, we generated highly metastatic TNBC cells (LM) derived from metastasized lung cells via a serial spontaneous pulmonary metastasis animal model to identify targetable molecules for attenuating the progression of TNBC metastasis. Gene analysis of primary tumor (P), first-round (1LM) and second-round (2LM) metastasized lung cells revealed that mesenchymal-related genes were significantly expressed in LM cells, especially in 2LM cells. Interestingly, alpha 9-nAChR gene expression was also dramatically induced in LM cells, confirming our previous finding that alpha 9-nAChR plays important roles in receptor-mediated carcinogenic signals in human breast cancer development. Using alpha 9-nAChR as a biomarker, we transfected 2LM cells with CRISPR/Cas9 lentivirus targeting the alpha 9-nAChR genomic region (2LM-alpha 9-nAChR-null), showing that mesenchymal markers and the migration and invasion abilities of 2LM cells were significantly attenuated in 2LM-alpha 9-nAChR-null cells both in vitro and in vivo. In addition, the high efficiency of editing the alpha 9-nAChR gene using a CRISPR/Cas9 lentivirus was demonstrated by gene sequencing, genomic indel frequency and protein expression analyses. Collectively, these results confirmed those of our previous study that advanced-stage breast tumors are associated with substantially higher levels of alpha 9-nAChR gene expression, indicating that alpha 9-nAChR expression is essential for mediating TNBC metastasis during cancer development and may potentially act as a biomarker for targeted therapy in clinical investigations.
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    僑生先修部　國際文化日
    (2017-11-05)
    姬正芳
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    Department of Communication and Technology
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    傳播與科技學系
    由台灣師範大學主辦「國際文化日」，在林口僑生先修部展現各國的美食與文化。
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    寵物年菜　自己煮最健康
    (2017-11-05)
    蔡璨竹
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    Department of Communication and Technology
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    傳播與科技學系
    用天然的食材，為毛寶貝製作健康、無負擔的年菜！
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    離岸風電　白海豚陷入危機
    (2017-11-05)
    巫尹文
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    Department of Communication and Technology
    ;
    傳播與科技學系
    近年來，隨著廢核議題持續延燒，各種再生能源被廣泛地討論。在風力發電方面，政府開始推行將風力發電機設置在海上的離岸風電，但預計開發的區域，就在僅剩下六十隻左右的白海豚棲地旁邊。
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    左營別處　最後的中華民國
    (2017-11-05)
    謝瀚陞
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    Department of Communication and Technology
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    傳播與科技學系
    走入眷村，猶如走入凍結的歷史時間裡。這裡的人們仍抱著同樣的信仰，在這座城市的角落中，義無反顧的支持著，但卻也同時也正與現實拉扯著。
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    初見世界的色彩　色盲眼鏡
    (2017-11-05)
    郭庭芸
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    Department of Communication and Technology
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    傳播與科技學系
    從造成色盲的原因出發，介紹色盲眼鏡這個產品是如何讓色盲者重新認識世界。
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    紅斑性狼瘡病因有解　治療契機
    (2017-11-05)
    朱珈漪
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    Department of Communication and Technology
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    傳播與科技學系
    中研院發現了導致自體免疫疾病的CLEC5A基因，未來可能就可以根治紅斑性狼瘡。
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    你今天「喪」了嗎？
    (2017-11-05)
    吳佩芸
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    Department of Communication and Technology
    ;
    傳播與科技學系
    流行於當代年輕人之間的「喪文化」，是否真如字面上看起來這麼悲觀？其背後的帶有什麼樣的意義呢？
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    監禁日記
    (2017-11-05)
    陳映瑜
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    Department of Communication and Technology
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    傳播與科技學系
    紀錄被監禁者的日常獨白。
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    迷妹手札　心目中最耀眼的他
    (2017-11-05)
    馮瑜庭
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    Department of Communication and Technology
    ;
    傳播與科技學系
    身為他的粉絲，我感到無比驕傲。
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    一秒充電有望　MXene鋰電池電極
    (2017-11-05)
    蔡翔宇
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    Department of Communication and Technology
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    傳播與科技學系
    等待充電的時間好痛苦，使用新型材料MXene製造的鋰電池電極，讓一秒充電變成現實。
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    桃花源，遂迷不復得路
    (2017-11-05)
    王毓楷
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    Department of Communication and Technology
    ;
    傳播與科技學系
    面對鬥爭時，該事件是否屬於政治議題，真的是我們該問的問題嗎？而我們每當看到新聞報導政治議題又應該大加撻伐嗎？
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    背包
    (2017-11-05)
    鄭頎
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    Department of Communication and Technology
    ;
    傳播與科技學系
    透過圖像詩　表達對家人的思念
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    生命中最珍貴的禮物
    (2017-11-05)
    簡嘉瑩
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    Department of Communication and Technology
    ;
    傳播與科技學系
    三種情感、三張畫、三首詩。
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    智能煞車器　騎士新保障
    (2017-11-05)
    鄭仰珉
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    Department of Communication and Technology
    ;
    傳播與科技學系
    淺談智能煞車器對於機車騎士安全保障的應用與原理，又將面臨到何種問題和挑戰。
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    當他們認真憂鬱時
    (2017-11-05)
    甘愷璇
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    Department of Communication and Technology
    ;
    傳播與科技學系
    別急著評斷，別急著定論，當他們認真憂鬱時，請你先聆聽。
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    動起來！過期牛奶
    (2017-11-05)
    嚴銘浩
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    Department of Communication and Technology
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    傳播與科技學系
    利用「高速攝影」把動態中的牛奶「凍結」在照片中。
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    重機上國道　到底「行」不行？
    (2017-11-05)
    林明慧
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    Department of Communication and Technology
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    傳播與科技學系
    大型重機團體已爭取道路平權多年，渴望能和汽車一樣擁有上國道的路權，然而社會大眾始終不支持，今年七月交通部決定實施為期一年的試駕觀察期，停滯多年的議題終於前進了一大步，而重機是否能上國道的爭議究竟為何？本文將帶您一同來了解。
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    簡單就好　自閉症創作者的綺想
    (2017-11-05)
    徐仟妤
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    顏維萱
    ;
    Department of Communication and Technology
    ;
    傳播與科技學系
    由多寶藝術學堂主辦的⟨簡單就好Just Fine!　多寶學堂生活好品展 ⟩，多位新銳設計師與自閉症創作者的跨界合作，在差異間創造不一樣美。
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    自欺的偽善者
    (2017-11-05)
    范晨星
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    Department of Communication and Technology
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    傳播與科技學系
    人與人的相處常常是很複雜的，什麼是善良？什麼是偽善？善良和偽善，或許也可能並存吧。