Browsing by Issue Date, starting with "2018-05-02"

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Constrained Adherable Area of Nanotopographic Surfaces Promotes Cell Migration through the Regulation of Focal Adhesion via Focal Adhesion Kinase/Racl Activation
(2018-05-02)
Lim, Jiwon
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Choi, Andrew
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Kim, Hyung Woo
;
Yoon, Hyungjun
;
Park, Sang Min
Cell migration is crucial in physiological and pathological processes such as embryonic development and wound healing; such migration is strongly guided by the surrounding nanostructured extracellular matrix Previous studies have extensively studied the cell migration on anisotropic nanotopographic surfaces; however, only a few studies have reported cell migration on isotropic nanotopographic surfaces. We herein, for the first time, propose a novel concept of adherable area on cell migration using isotropic nanopore surfaces with sufficient nanopore depth by adopting a high aspect ratio. As the pore size of the nanopore surface was controlled to 200, 300, and 400 nm in a fixed center-to-center distance of 480 nm, it produced 86, 68, and 36% of adherable area, respectively, on the fabricated surface. A meticulous investigation of the cell migration in response to changes in the constrained adherable area of the nanotopographic surface showed 1.4-, 1.5-, and 1.6-fold increase in migration speeds and a 1.4-, 2-, and 2.5-fold decrease in the number of focal adhesions as the adherable area was decreased to 86, 68, and 36%, respectively. Furthermore, a strong activation of FAK/Racl signaling was observed to be involved in the promoted cell migration. These results suggest that the reduced adherable area promotes cell migration through decreasing the FA formation, which in turn upregulates FAK/Racl activation. The findings in this study can be utilized to control the cell migration behaviors, which is a powerful tool in the research fields involving cell migration such as promoting wound healing and tissue repair.
Glucosamine-Based Supramolecular Nanotubes for Human Mesenchymal Cell Therapy
(2018-05-02)
Talloj, Satish Kumar
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Cheng, Bill
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Weng, Jen-Po
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Lin, Hsin-Chieh
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材料科學與工程學系
Herein, we demonstrate an example of glucosamine-based supramolecular hydrogels that can be used for human mesenchymal cell therapy. We designed and synthesized a series of amino acid derivatives based on a strategy of capping D-glucosamine moiety at the C-terminus and fluorinated benzyl group at the N-terminus. From a systematic study on chemical structures, we discovered that the glucosamine-based supramolecular hydrogel [pentafluorobenzyl (PFB)-F-Glu] self-assembled with one-dimensional nanotubular structures at physiological pH. The self-assembly of a newly discovered PFB-F-Glu motif is attributed to the synergistic effect of pi-pi stacking and extensive intermolecular hydrogen bonding network in aqueous medium. Notably, PFB-F-Glu nanotubes are proven to be nontoxic to human mesenchymal stem cells (hMSCs) and have been shown to enhance hMSC proliferation while maintaining their pluripotency. Retaining of pluripotency capabilities provides potentially unlimited source of undifferentiated cells for the treatment of future cell therapies. Furthermore, hMSCs cultured on PFB-F-Glu are able to secrete paracrine factors that downregulate profibrotic gene expression in lipopolysaccharide-treated human skin fibroblasts, which demonstrates that PFB-F-Glu nanotubes have the potential to be used for wound healing applications. Overall, this article addresses the importance of chemical design to generate supramolecular biomaterials for stem cell therapy.
Single-Crystal Antimonene Films Prepared by Molecular Beam Epitaxy: Selective Growth and Contact Resistance Reduction of the 2D Material Heterostructure
(2018-05-02)
Chen, Hsuan-An
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Sun, Hsu
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Wu, Chong-Rong
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Wang, Yu-Xuan
;
Lee, Po-Hsiang
Single-crystal antimonene flakes are observed on sapphire substrates after the postgrowth annealing procedure of amorphous antimony (Sb) droplets prepared by using molecular beam epitaxy at room temperature. The large wetting angles of the antimonene flakes to the sapphire substrate suggest that an alternate substrate should be adopted to obtain a continuous antimonene film. By using a bilayer MoS2/sapphire sample as the new substrate, a continuous and single-crystal antimonene film is obtained at a low growth temperature of 200 degrees C. The results are consistent with the theoretical prediction of the lower interface energy between antimonene and MoS2. The different interface energies of antimonene between sapphire and MoS2 surfaces lead to the selective growth of antimonene only atop MoS2 surfaces on a prepatterned MoS2/sapphire substrate. With similar sheet resistance to graphene, it is possible to use antimonene as the contact metal of 2D material devices. Compared with Au/Ti electrodes, a specific contact resistance reduction up to 3 orders of magnitude is observed by using the multilayer antimonene as the contact metal to MoS2. The lower contact resistance, the lower growth temperature, and the preferential growth to other 2D materials have made antimonene a promising candidate as the contact metal for 2D material devices.
Interaction of a pair of ferrofluid drops in a rotating magnetic field
(2018-05-03)
Qiu, Mingfeng
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Afkhami, Shahriar
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Chen, Ching-Yao
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Feng, James J.
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機械工程學系
We use two-dimensional numerical simulation to study the interaction between a pair of ferrofluid drops suspended in a rotating uniform magnetic field. Numerical results show four distinct regimes over the range of parameters tested: independent spin, planetary motion, drop locking and direct coalescence. These are in qualitative agreement with experiments, and the transition between them can be understood from the competition between magnetophoretic forces and viscous drag. We further analyse in detail the planetary motion, i.e. the revolution of the drops around each other while each spins in phase with the external magnetic field. For drops, as opposed to solid microspheres, the interaction is dominated by viscous sweeping, a form of hydrodynamic interaction. Magnetic dipole-dipole interaction via mutual induction only plays a secondary role. This insight helps us explain novel features of the planetary revolution of the ferrofluid drops that cannot be explained by a dipole model, including the increase of the angular velocity of planetary motion with the rotational rate of the external field, and the attainment of a limit separation between the drops that is independent of the initial separation.
Fe Doped Magnetic Nanodiamonds Made by Ion Implantation as Contrast Agent for MRI
(2018-05-04)
Lin, Bo-Rong
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Chen, Chien-Hsu
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Kunuku, Srinivasu
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Chen, Tzung-Yuang
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Hsiao, Tung-Yuan
We report in this paper a new MRI contrast agent based on magnetic nanodiamonds fabricated by Fe ion implantation. The Fe atoms that are implanted into the nanodiamonds are not in direct contact with the outside world, enabling this new contrast agent to be free from cell toxicity. The image enhancement was shown clearly through T2 weighted images. The concentration dependence of the T2 relaxation time gives a relaxivity value that is about seven times that of the regular non-magnetic nanodiamonds. Cell viability study has also been performed. It was shown that they were nearly free from cytotoxicity independent of the particle concentration used. The imaging capability demonstrated here adds a new dimension to the medical application of nanodiamonds. In the future one will be able to combine this capability of magnetic nanodiamonds with other functions through surface modifications to perform drug delivery, targeted therapy, localized thermal treatment and diagnostic imaging at the same time.
UV absorption spectrum of allene radical cations in solid argon
(2018-05-05)
Chin, Chih-Hao
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Lin, Meng-Yeh
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Huang, Tzu-Ping
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Wu, Yu-Jong
;
應用化學系
Electron bombardment during deposition of an Ar matrix containing a small proportion of allene generated allene cations. Further irradiation of the matrix sample at 385 nm destroyed the allene cations and formed propyne cations in solid Ar. Both cations were identified according to previously reported IR absorption bands. Using a similar technique, we recorded the ultraviolet absorption spectrum of allene cations in solid Ar. The vibrationally resolved progression recorded in the range of 266-237 nm with intervals of about 800 cm(-1) was assigned to the A E-2 <- X E-2 transition of allene cations, and the broad continuum absorption recorded in the region of 229-214 nm was assigned to their B (2)A(1) <- X E-2 transition. These assignments were made based on the observed photolytic behavior of the progressions and the vertical excitation energies and oscillator strengths calculated using time-dependent density functional theory. (C) 2018 Elsevier B.V. All rights reserved.
向毛孩說再見　寵物殯葬
(2018-05-06)
顏維萱
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林明慧
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Department of Communication and Technology
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傳播與科技學系
【「寵」愛】專題

當寵物離開時該如何是好？寵物殯葬化身毛孩送行者，辦理相關後事之餘也撫慰飼主喪失寵物之痛。
默默耕耘　舞台監督徐仲驊
(2018-05-06)
朱珈漪
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Department of Communication and Technology
;
傳播與科技學系
【劇場到底在幹什麼？】專題

專訪交大演藝廳場館舞監徐仲驊，帶您一窺舞台監製的真實樣貌。
毛寶貝怎麼保　寵物保險知多少
(2018-05-06)
陳咨諭
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Department of Communication and Technology
;
傳播與科技學系
【「寵」愛】專題

寵物產業蓬勃發展，也帶動了寵物保險這個新興產業。
當紅自助烘焙你了解了沒？
(2018-05-06)
洪儷娟
;
Department of Communication and Technology
;
傳播與科技學系
【自助烘焙】專題

用簡易圖文帶你了解自助烘焙的差異、流程和手作趨勢。
展翅吧！終止兒少性剝削
(2018-05-06)
蔡亞融
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Department of Communication and Technology
;
傳播與科技學系
【色世未深　未成年網路時代】專題

2015年《兒少性交防治條例》更改為《兒少性剝削防治條例》，並於2017年正式上路。本篇透過台灣展翅協會秘書長陳逸玲，來帶您了解何謂兒少性剝削？以及網路時代對於兒少性剝削，所帶來的犯罪型態的改變與影響。
復仇者集結！前進無限之戰
(2018-05-06)
游允彤
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Department of Communication and Technology
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傳播與科技學系
【Marvel　讓我們驚嘆的英雄電影】專題

希望這篇影評可以為已經看過電影的人提供不同的想法；也為還沒看過電影的人在觀賞前提供不同的觀點。
追星旅行發燒　韓流粉絲玩什麼
(2018-05-06)
馮瑜庭
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Department of Communication and Technology
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傳播與科技學系
【韓流粉絲新現象】專題

介紹最近風靡韓流粉絲間的追星旅行，最「夯」的行程「報乎你知」！
宅男打籃球　平凡中的不平凡
(2018-05-06)
鄭仰珉
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Department of Communication and Technology
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傳播與科技學系
【褪下球衣的籃球夢】專題

透過《宅男打籃球》這部生活化的漫畫，讓讀者重新回憶年輕時熱血的籃球回憶。
無限商機　寵物新興產業
(2018-05-06)
葉宜瑩
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Department of Communication and Technology
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傳播與科技學系
【「寵」愛】專題

飼養寵物的人越來越多，寵物新興產業蓬勃發展，一起認識寵物產業的發展歷程。
共享經濟重新思考
(2018-05-06)
嚴銘浩
;
Department of Communication and Technology
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傳播與科技學系
【公共自行車議題】專題

無樁式公共自行車，又名共享單車，被認為是「共享經濟」的一種，那「共享經濟」的發展脈絡又是如何？這種方式又如何成為近年的經濟新浪潮？本文將為大家一一介紹。
愛屋及烏？　寵物吃素行不行
(2018-05-06)
李哲君
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Department of Communication and Technology
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傳播與科技學系
【「寵」愛】專題

隨著吃素的人越來越多，身為素食者卻餵毛寶貝吃肉顯得違反了自己的原則，但這樣對貓、狗身、心理健康是有益的嗎？
誰拼誰寫　注音符號V.S.羅馬拼音
(2018-05-06)
謝宛蓁
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Department of Communication and Technology
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傳播與科技學系
【注音符號：中文巴別塔】專題

實際上，注音符號或拼音都與外語學習沒有直接關係，拼音系統的本位在於拼寫中文，這才是我們學習注音符號和拼音的主因。
城市裡的迷走之音　二本貓樂團
(2018-05-06)
凃易暄
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Department of Communication and Technology
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傳播與科技學系
【客家音樂　從傳統到現代】專題

於2017年拿下客家金曲歌手的二本貓樂團，以他們獨有的民謠爵士曲風，帶來一首又一首撫慰人心的客家音樂。
只給你寵愛　不可小覷的毛經濟
(2018-05-06)
蕭巧昱
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Department of Communication and Technology
;
傳播與科技學系
陪伴、忠心、依賴讓毛寶貝們在現代人的生活中越來越不可或缺，也隨之帶動了商機無限的毛經濟，成為新興服務業的領頭羊，趕緊透過互動圖表來認識這股新趨勢吧！