Browsing by Issue Date, starting with "2019-01-03"

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BIOSENSOR DEVICE AND METHOD FOR MANUFACTURING THEREOF AND METHOD FOR DETECTING BIOLOGICAL MOLECULES
(2019-01-03)
Chiun-Jye YUAN
;
Chun-Lung LIEN
;
Paul C.-P. CHAO
A biosensor device includes a substrate plate, a metal conductive layer, a plurality of working electrodes and an insulating layer. The metal conductive layer is disposed over the substrate plate and has an upper surface. The working electrodes are disposed over the upper surface of the metal conductive layer, wherein each of the working electrodes has a top surface and each of the top surfaces is higher than the upper surface of the metal conductive layer. The insulating layer covers the metal conductive layer and surrounds the working electrodes, wherein an upper surface of the insulating layer is located between the top surfaces and the upper surface of the metal conductive layer such that the working electrodes protrude beyond the upper surface of the insulating layer. A method for manufacturing the biosensor device and a method for detecting biological molecules by using the biosensor device are also provided herein.
CHEMICAL VAPOR PHASE GROWTH APPARATUS
(2019-01-03)
Wei-Kuo CHEN
;
Chun-Hung CHENG
A chemical vapor phase growth apparatus for growing films on substrates comprises of a thermostated lower heating element, including a plurality of carrier disks thereon, wherein each carrier disk further includes a plurality of substrates thereon for film deposition; a plurality of partitions, disposed above the lower heating element to define a plurality of sub-reaction chambers; a plurality of upper heating elements made of a plurality of thermostated upper heating units, disposed over the lower heating element by a gap to form reaction zones in each sub-reaction chamber; a gas inlet installed in each sub-reaction chamber to provide at least one precursor into the sub-reaction chamber; and a gas outlet installed in the chemical vapor phase growth apparatus to exhaust the gases.
SUNLIGHT MODULATION DEVICE FOR SOLAR ENERGY UTILIZATION ON ILLUMINATION AND ENERGY GENERATION
(2019-01-03)
Cheng-Huan CHEN
A sunlight modulation device includes a light focusing module and a light deflection module. The light focusing module is configured to let incident sunlight pass through and to converge direct sunlight of the incident sunlight. The light deflection module is configured to separate the converged direct sunlight from diffusion sunlight of the incident sunlight by reflecting the converged direct sunlight. The above-mentioned sunlight modulation device allows more diverse configurations for solar panels, heating devices or the like means, as well as illumination purpose.
Epitaxies of a Chemical Compound Semiconductor
(2019-01-03)
Hung-Wei Yu
;
Yi Chang
;
Tsun-Ming Wang
Methods and structures includes providing a substrate, forming a prelayer over a substrate, forming a barrier layer over the prelayer, and forming a channel layer over the barrier layer. Forming the prelayer may include growing the prelayer at a graded temperature. Forming the barrier layer is such that the barrier layer may include GaAs or InGaAs. Forming the channel layer is such that the channel layer may include InAs or an Sb-based heterostructure. Thereby structures are formed.
High-temperature ratchets driven by deterministic and stochastic fluctuations
(2019-01-03)
Rozenbaum, V. M.
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Shapochkina, I. V.
;
Teranishi, Y.
;
Trakhtenberg, L. I.
;
物理研究所
We consider the overdamped dynamics of a Brownian particle in an arbitrary spatial periodic and time-dependent potential on the basis of an exact solution for the probability density in the form of a power series in the inverse friction coefficient. The expression for the average velocity of a Brownian ratchet is simplified in the high-temperature consideration when only the first terms of the series can be used. For the potential of an additive-multiplicative form (a sum of a time-independent contribution and a time-dependent multiplicative perturbation), general explicit expressions are obtained which allow comparative analysis of frequency dependencies of the average velocity, implying deterministic and stochastic potential energy fluctuations. For qualitative and quantitative analysis of these dependences, we choose illustrative examples for spatial harmonic fluctuations: with deterministic time dependences of a relaxation type and stochastic time dependences describing Markovian dichotomous and harmonic noise processes. We explore the influence of fluctuation types on the ratchet effect and demonstrate its enhancement in the case of harmonic noise.
Investigation of hydrogen-bonding mediated molecular packing of diketopyrrolopyrrole based donor-acceptor oligomers in the solid state
(2019-01-03)
Yang, Kun
;
Li, Xiang
;
Huang, Yi-Fan
;
Bhatta, Ram S.
;
Liu, Jiawei
Two diketopyrrolopyrrole (DPP)-based donor-acceptor oligomers with thermal labile 2-methylhexyl-2-oxylcarbonyl (mHoc) groups, mHocPBT and mHocTBT, were synthesized and characterized to study the hydrogenbonding mediated molecular packing in solid state. The soluble oligomers can be converted to strong intermolecular hydrogen-bonded and pigment-like materials HPBT and HTBT by annealing the casted solid film at a temperature between 180 and 200 degrees C. The formation of intermolecular hydrogen bonding significantly altered the conformation of the molecules, molecular packing structure and related optical properties of the oligomers, with HPBT molecule exhibiting bathochromic shift and HTBT molecule exhibiting hypsochromic shift on UV/Vis spectra. Spin-casted mHocTBT and HTBT films also exhibited interesting morphology and charge transport properties. Even though the single mHocTBT oligomer molecule has a better coplanar molecular conformation as compared with that of HTBT, an enhanced pi-pi stacking structure and larger crystal grain size rendered HTBT film better charge transport performance.
Miscible density-driven flows in heterogeneous porous media: Influences of correlation length and distribution of permeability
(2019-01-04)
Li, Qian
;
Cai, Weihua
;
Li, Feng-Chen
;
Li, Bingxi
;
Chen, Ching-Yao
A random process and highly accurate pseudospectral method associated with compact finite differences are incorporated to evaluate effects of permeability heterogeneity to gravity-driven miscible porous media flows. Flows in heterogeneous permeability fields, based on multiple sets of random realizations with identical statistical characteristics, are simulated to elucidate the global trend of mean quantities and local variations. The presence of heterogeneity provokes more prominent fingering competition and greater variation of fingers' widths, hence the mean values of interested quantitative measures, i.e., breakthrough time, amount of fluid volumes transported, and normalized mixing effectiveness, are generally reduced. Resonant effects, whose influences on the flow fields are the most significant, are verified to occur in an intermediate correlation length, in which the widths of fingers are slightly less than the correspondent correlation length. Nevertheless, under the resonant conditions these measures are the most widely scattered between different random realizations associated with the same control parameters. The widest scatterings are mainly because of the enhancing sensitivity of flow path selections under such resonant conditions, especially in a few realizations whose high or low permeability regions align along with or transverse to the main flow direction. The significant scatterings of these quantitative measures, which had drawn little attention previously, suggest more cautious treatments for practical implementations in the regime of resonant effects.
看見土地的關懷－賴唐鴉與高沁余
(國立交通大學傳播與科技學系, 2019-01-04)
黃昱晉
賴唐鴉與高沁余（簡稱唐鴉與唐婆）兩人所經營的家庭美術館，有別於一般美術館的莊嚴，在這裡更多了些樸實的親切感。除了能欣賞到賴唐鴉的藝術創作外，也能在漫步在果園內享受天然的薰陶，另外還許多排列劃一的陶缸，裡頭正在釀製遠近馳名的唐婆醋，夫妻倆希望能分別靠著身為藝術家與科學家的專業，在各自截然不同的領域喚起人們對土地關懷的認知。
Emerging Organic and Organic/Inorganic Hybrid Photovoltaic Devices for Specialty Applications: Low-Level-Lighting Energy Conversion and Biomedical Treatment
(2019-01-04)
Chen, Fang-Chung
;
交大名義發表
;
光電工程學系
;
National Chiao Tung University
;
Department of Photonics
This article reviews the progress made in emerging photovoltaic devices, including dye-sensitized solar cells, organic solar cells, and perovskite solar cells, for specialty applications. Because they all feature tunable band structures, which can be modified through molecular design and/or altered compositions, the properties of emerging photovoltaic devices can be tailored to fit the special requirements of a particular application. For instance, they can be designed according to the emission spectrum of an artificial light source (e.g., fluorescence lamp and white light-emitting diode), thereby efficiently converting the indoor lighting to electricity. Furthermore, because there exists a near-infrared windowranging from 650 to 1350 nmin which photons can penetrate deeply into tissues, the absorption bands of these photovoltaic devices can be tailored specially to this therapeutic window to harvest tissue-penetrating light, thereby wirelessly providing power to biomedical devices positioned beneath the skin. The rapid progress made in these two representative areas suggests further promising applications of such emerging photovoltaic devices.
當食農碰到教育──內城生態學校
(國立交通大學傳播與科技學系, 2019-01-05)
楊巧柔
兩位宜蘭人賴志政與黃勝宏創立了「內城生態學校」。將社區跟周邊區域的配合，把社區的文化、歷史、人文帶進來。配合內城社區鐵牛車，先繞完認識社區以及阿公阿嬤輩以前在內城的記憶，認識完整個內城區域之後，再去生態學校，做農村實在的體驗。
讓產地與消費者更近的橋樑
(國立交通大學傳播與科技學系, 2019-01-05)
洪儷娟
曹育銓與自己的團隊搭建了一個生產者與消費者之間的橋梁－－bigreeny 料理．家，讓那些被用心生產的食材可以呈現在你眼前的杯盤茶具中，連結產地與消費者的菜單應運而生。
阿爸的米：田埂間的堅持與熱忱
(國立交通大學傳播與科技學系, 2019-01-05)
郭庭芸
宜蘭縣員山鄉內城，一個令人心曠神怡的鄉間社區。通稱螞蟻大哥，於2017受農委會獲選為第四屆百大青農的曾繁宜先生，分享一個在台北長大的青年怎麼投身友善農業，以及他至今六年多的務農故事中的酸甜苦辣。
博幼基金會　讓知識帶希望回家
(國立交通大學傳播與科技學系, 2019-01-05)
呂靜沅
博幼基金會成立於2002年，至今在台灣已經有18個課輔中心。成立的目的是希望可以用因材施教的方式，幫助弱勢家庭的孩童學習。
歐怡伶　不麻煩別人的環保推廣者
(國立交通大學傳播與科技學系, 2019-01-06)
陳子與
新村小商號誕生在新竹，它主打購物無包裝的理念，邀請前來的客人自備容器，如此一來便能減少塑膠袋垃圾。新村小商號並沒有非要賣什麼東西不可，因為打從一開始，歐怡伶就只是想示範一個天然的生活方式。
Exploring the ultrafast dynamics of a diarylethene derivative using sub-10 fs laser pulses
(2019-01-07)
Jarota, Arkadiusz
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Pastorczak, Ewa
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Tawfik, Walid
;
Xue, Bing
;
Kania, Rafal
A diarylethene derivative, 1,2-bis(2,4-dimethyl-5-phenyl-3-thienyl)perfluorocyclopentene (DMP), is a photoswitch molecule utilizing a reversible aromatic ring-opening reaction. The quantum yield of the ring-opening reaction is however remarkably low. We investigate the origin of this behaviour by means of ultrafast transient absorption spectroscopy utilizing sub-10 fs pulses, which is an invaluable tool for simultaneously studying both the electronic and the vibrational molecular dynamics. Namely, a noncollinear optical parametric amplifier (NOPA) generating sub-10 fs pulses in the spectral range 605-750 nm is employed. The transient absorption signal is modulated by several vibrational modes, which are compared with experimental and computational Raman spectra and then assigned to the ground or excited electronic state. We observe that the most pronounced vibrational mode - the ethylenic stretching mode at a frequency of 1501 cm(-1) - exhibits instantaneous frequency and amplitude modulation. The observed modulations occur due to weak coupling with another 1431 cm(-1) stretching mode mediated by a vibrational mode of low frequency, i.e. around 60 cm(-1). Fast internal conversion S-1 S-0 originates in a relaxation through a conical intersection (found by density-functional theory computations), facilitated by the two aforementioned stretching modes.
Molecular design of near-infrared fluorescent Pdots for tumor targeting: aggregation-induced emission versus anti-aggregation-caused quenching
(2019-01-07)
Tsai, Wei-Kai
;
Wang, Chun-I.
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Liao, Chia-Hsien
;
Yao, Chun-Nien
;
Kuo, Tsai-Jhen
Semiconducting polymer dots (Pdots) have recently emerged as a new type of ultrabright fluorescent probe that has been proved to be very useful for biomedical imaging. However, Pdots often suffer from serious fluorescence aggregation-caused quenching (ACQ) especially for near-infrared (NIR) fluorescent Pdots. This article compared two strategies to overcome the ACQ effect in near-infrared emissive Pdot systems: aggregation-induced emission (AIE) and anti-aggregation-caused quenching (anti-ACQ). The results show that the anti-ACQ platform outperforms the AIE system. The fluorescence quantum yield of anti-ACQ-based Pdots can be over 50% and the average per-particle brightness of the Pdots is about 5 times higher than that of the commercially available quantum dots. To help understand why the monomer conformations could greatly affect the optical properties of Pdots, molecular dynamics simulations were performed for the first time in such complicated Pdot systems. To demonstrate applications for in vivo fluorescence imaging, both microangiography imaging on living zebrafish embryos and specific tumor targeting on mice were performed. We anticipate that these studies will pave the way for the design of new highly fluorescent Pdot systems.
Stereoselective synthesis of a 9-O-sulfo Neu5Gc-capped O-linked oligosaccharide found on the sea urchin egg receptor
(2019-01-07)
Das, Anindya
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Li, Pei-Jhen
;
Adak, Avijit K.
;
Wu, Hsin-Ru
;
Anwar, Mohammad Tarique
A straightforward synthesis of the (25)-linked 9-O-sulfated Neu5Gc-capped O-linked tetrasaccharide (1) identified in the egg cell surface glycoproteins of the sea urchin Strongylocentrotus purpuratus receptor for sperm is reported. The construction of the (25)Neu5Gc trimer by the formation of an amide linkage rather than a glycosidic bond avoids the requirement for -stereoselective glycosylation. To highlight this amide bond formation strategy as a relatively facile method for synthesizing oligo-Neu5Gc containing O-linked glycans, its versatility is demonstrated by application to the coupling of SO3H-9Neu5Gc(25)Neu5Gc glycolic acid and a sialyl-Tn-derived amine for achieving the target tetrasaccharide. This synthetic strategy may be implemented in the generation of other structurally similar O-sulfo Neu5Gc-capped 25-O-glycolyl-linked oligo-Neu5Gc chains, enabling additional biological and chemical investigations.
交大e-News第270期-國際無人駕駛船挑戰賽交通大學首度出賽獲佳績
(2019-01-07)
國立交通大學秘書室
;
Secretariat
Liver X Receptor/Retinoid X Receptor Pathway Plays a Regulatory Role in Pacing-Induced Cardiomyopathy
(2019-01-08)
Lin, Yu-Sheng
;
Chang, Tzu-Hao
;
Shi, Chung-Sheng
;
Wang, Yi-Zhen
;
Ho, Wan-Chun
Background-The molecular mechanisms through which high-demand pacing induce myocardial dysfunction remain unclear. Methods and Results-We created atrioventricular block in pigs using dependent right ventricular septal pacing for 6 months. Echocardiography was performed to evaluate dyssynchrony between pacing (n=6) and sham control (n=6) groups. Microarray and enrichment analyses were used to identify differentially expressed genes (DEGs) in the left ventricular (LV) myocardium between pacing and sham control groups. Histopathological and protein changes were also analyzed and an A cell pacing model was also performed. Pacing significantly increased mechanical dyssynchrony. Enrichment analysis using Ingenuity Pathway Analysis and the activation z-score analysis method demonstrated that there were 5 DEGs (ABCA1, APOD, CLU, LY96, and SERPINF1) in the LV septum (z-score=- 0.447) and 5 DEGs (APOD, CLU, LY96, MSR1, and SERPINF1) in the LV free wall (z-score=- 1.000) inhibited the liver X receptor/retinoid X receptor (LXR/RXR) pathway, and 4 DEGs (ACTA2, MYL1, PPP2R3A, and SNAI2) activated the integrin-linked kinase (ILK) pathway in the LV septum (z-score=1.000). The pacing group had a larger cell size, higher degree of myolysis and fibrosis, and increased expression of intracellular lipid, inflammatory cytokines, and apoptotic markers than the sham control group. The causal relationships between pacing and DEGs related to LXR/RXR and ILK pathways, apoptosis, fibrosis, and lipid expression after pacing were confirmed in the cell pacing model. Luciferase reporter assay in the cell pacing model also supported inhibition of the LXR pathway by pacing. Conclusions-Right ventricular septal-dependent pacing was associated with persistent LV dyssynchrony-induced cardiomyopathy through inhibition of the LXR/RXR pathway.
教育從小地方做起筆耕小書店
(國立交通大學傳播與科技學系, 2019-01-08)
蔡翔宇
筆耕小書店的成立與創辦人蔡文力現在的工作有關，他本身是友善書業合作社的成員，而筆耕小書店目前為友善書業合作社底下的獨立書店之一。筆耕小書店的二樓為筆耕寫作坊，主要提供給附近中小學生寫作課程，由蔡文力的太太擔任指導老師。