Browsing by Issue Date, starting with "2019-05-29"

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High-Uniformity Planar Mini-Chip-Scale Packaged LEDs with Quantum Dot Converter for White Light Source
(2019-05-29)
Chen, Lung-Chien
;
Tien, Ching-Ho
;
Chen, De-Fu
;
Ye, Zhi-Ting
;
Kuo, Hao-Chung
This study proposes a novel direct-lit mini-chip-scale packaged light-emitting diode (mini-CSPLED) backlight unit (BLU) that used quantum dot (QD) film, diffusion plate, and two prism films to improve brightness uniformity. Three different luminous intensity units, 120 degrees mini-CSPLED, 150 degrees mini-CSPLED, and 180 degrees mini-CSPLED with different emission angle structures were fabricated using a CSP process. In terms of component characteristics, although the 180 degrees mini-CSPLED light output power is about loss 4% (at 10mA) compared with 150 degrees mini-CSPLED, it has a large emission angle that forms a planar light source that contributes to improving the BLU brightness uniformity and reduced quantity of LEDs at the same area. In terms of BLU analysis, the blue mini-CSPLEDs with different emission angles excite the different QD film thicknesses; the chromaticity coordinates conversion to the white light region. The BLU brightness increases as the QD film thickness increases from 60, 90, and 150m. This result can achieve a brightness uniformity of 86% in a 180 degrees mini-CSPLED BLU + 150-m-thick QD films as compared to the 120 degrees mini-CSPLED BLU and 150 degrees mini-CSPLED BLU.
Bio-Inspired Flexible Fluoropolymer Film for All-Mode Light Extraction Enhancement
(2019-05-29)
Liang, Renli
;
Hu, Run
;
Long, Hanling
;
Huang, Xinyu
;
Dai, Jiangnan
Enhancing the light extraction efficiency is a prevalent but vital challenge for most solid-state lighting technologies, especially for deep ultraviolet light-emitting diodes (DUV-LEDs). In this paper, inspired by the micro-structure of the butterfly's eye, we propose and fabricate a flexible fluoropolymer film (FFP film) to tackle this issue for all-mode, full-wavelength light extraction enhancement for most solid-state lighting technologies compatibly. The experimental results demonstrate that compared with one mounted with a smooth FFP film, the light output power of DUV-LED is enhanced up to 26.7% by mounting the FFP film with 325 nm radius nanocones at a driving current of 200 mA. Importantly, thanks to the super-flexible feature of the FFP film, it can both cover the top surface and sidewalls of the DUV-LED chip, leading to the improvement of transverse electric and transverse magnetic mode light extraction by 20.5 and 21.8%, respectively. Finite element analysis (FEA) simulations of the electric field distribution of DUV-LEDs with the FFP film reveal the underlying physics. The present strategy is proposed from the view of the packaging level, which is cost-effective, able to be manufactured at a large scale, and compatible with the solid-state lighting technologies.
戰況激烈精彩，水運會展現青春活力
(國立陽明大學, 2019-05-31)
陽明電子報編輯小組
每年校慶的重頭戲──水上運動大會，5月17日熱鬧登場。從一早8:30開始，連續將近10小時，32項比賽接連上陣，讓游泳健身館水花四濺...
【補充工作新動力】愛與慾的糾葛～音樂劇《鐘樓怪人》賞析
(國立陽明大學, 2019-05-31)
陽明電子報編輯小組
【生技咖啡館】6月份～微流體晶片之商品化與其體外檢測應用
(國立陽明大學, 2019-05-31)
陽明電子報編輯小組
【藥物科學院職涯講座III】TCRA臨床試驗領域相關工作職涯分享
(國立陽明大學, 2019-05-31)
陽明電子報編輯小組
神農坡與陽明2.0的距離──107學年第2學期【早安，神農坡】
(國立陽明大學, 2019-05-31)
陽明電子報編輯小組
這學期的「早安神農坡」，5月22日上午在剛整修好的大禮堂舉行，主題是「神農坡與陽明2.0的距離」；延續歷年來知性與感性、公益與...
三社聯合舞展《永舞指境》
(國立陽明大學, 2019-05-31)
陳婕翎
;
陽明電子報編輯小組
準備已久的三社聯合舞展《永舞指境》，由民舞社、國標社與手語社帶來的「舞」光十色表演，結合現代潮流、舞者的熱情還有絕美的燈光氣氛，為觀眾帶來一場藝術盛宴。光看著精美的節目表，就讓人覺得這次的舞展不虛此行！
陽明、交大、中研院成立「數位醫學聯盟」，提升防治疾病精準度
(國立陽明大學, 2019-05-31)
陽明電子報編輯小組
陽明5月14日宣布成立「數位醫學聯盟」（Digital Medicine Alliance），結合交通大學數據科學與工程研究所、中央研究院資訊科學研...
【勞維俊老師電影《莫失莫忘》】公開首映
(國立陽明大學, 2019-05-31)
陽明電子報編輯小組
國際產學聯盟輔導補助計畫說明會，鼓勵研發成果商品化
(國立陽明大學, 2019-05-31)
陽明電子報編輯小組
為協助醫療機構將臨床研發成果商品化，本校國際產學聯盟透過科技部產學司委託執行的國際產學聯盟計畫，於4月10日在振興醫院國際會...
【合校事宜公聽會】(三)～(五)
(國立陽明大學, 2019-05-31)
陽明電子報編輯小組
【107學年度畢業周】系列活動
(國立陽明大學, 2019-05-31)
陽明電子報編輯小組
【107學年度畢業典禮】
(國立陽明大學, 2019-05-31)
陽明電子報編輯小組
陽明GLORIA引介醫療AI創新應用，串起數位醫學新機
(國立陽明大學, 2019-05-31)
陽明電子報編輯小組
陽明大學國際產學聯盟（GLORIA）以「Digital Medicine」為題，5月14日盛大舉辦國際級論壇暨產學媒合會，邀請科技部、衛福部、台中...
美麗新視界～視覺障礙學生特徵及輔具運用
(國立陽明大學, 2019-05-31)
劉容孜
;
陽明電子報編輯小組
【生醫資訊所演講】～人工智慧對醫療影像診斷之衝擊
(國立陽明大學, 2019-05-31)
陽明電子報編輯小組
Simultaneous Colorimetric Detection of a Variety of Salmonella spp. in Food and Environmental Samples by Optical Biosensing Using Oligonucleotide-Gold Nanoparticles
(2019-05-31)
Quintela, Irwin A.
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de los Reyes, Benildo G.
;
Lin, Chih-Sheng
;
Wu, Vivian C. H.
;
生物科技學系
Optical biosensors for rapid detection of significant foodborne pathogens are steadily gaining popularity due to its simplicity and sensitivity. While nanomaterials such as gold nanoparticles (AuNPs) are commonly used as signal amplifiers for optical biosensors, AuNPs can also be utilized as a robust biosensing platform. Many reported optical biosensors were designed for individual pathogen detection in a single assay and have high detection limit (DL). Salmonella spp. is one of the major causative agents of foodborne sickness, hospitalization and deaths. Unfortunately, there are around 2,000 serotypes of Salmonella worldwide, and rapid and simultaneous detection of multiple strains in a single assay is lacking. In this study, a comprehensive and highly sensitive simultaneous colorimetric detection of nineteen (19) environmental and outbreak Salmonella spp. strains was achieved by a novel optical biosensing platform using oligonucleotide-functionalized AuNPs. A pair of newly designed single stranded oligonucleotides (30-mer) was displayed onto the surface of AuNPs (13 nm) as detection probes to hybridize with a conserved genomic region (192-bases) of ttrRSBCA found on a broad range of Salmonella spp. strains. The sandwich hybridization (30 min, 55 degrees C) resulted in a structural formation of highly stable oligonucleotide/AuNPs-DNA complexes which remained undisturbed even after subjecting to an increased salt concentration (2 M, final), thus allowing a direct discrimination via color change of target (red color) from non-target (purplish-blue color) reaction mixtures by direct observation using the naked eye. In food matrices (blueberries and chicken meat), nineteen different Salmonella spp. strains were concentrated using immunomagnetic separation and then simultaneously detected in a 96-well microplate by oligonucleotide-functionalized AuNPs after DNA preparation. Successful oligonucleotide/AuNPs-DNA hybridization was confirmed by gel electrophoresis while AuNPs aggregation in non-target and control reaction mixtures was verified by both spectrophotometric analysis and TEM images. Results showed that the optical AuNP biosensing platform can simultaneously screen nineteen (19) viable Salmonella spp. strains tested with 100% specificity and a superior detection limit of <10 CFU/mL or g for both pure culture and complex matrices setups. The highly sensitive colorimetric detection system can significantly improve the screening and detection of viable Salmonella spp. strains present in complex food and environmental matrices, therefore reducing the risks of contamination and incidence of foodborne diseases.
【生科院生物醫學講座】～人工智慧時代人類的心方向
(國立陽明大學, 2019-05-31)
陽明電子報編輯小組
Rapid and Safe Isolation of Human Peripheral Blood B and T Lymphocytes through Spiral Microfluidic Channels
(2019-05-31)
Chiu, Po-Lin
;
Chang, Chun-Hao
;
Lin, Yu-Ling
;
Tsou, Ping-Hsien
;
Li, Bor-Ran
Peripheral blood lymphocytes (PBLs) are mature lymphocytes that circulate in the blood rather than being localized to organs. A reliable label-free collection approach that can viably and appropriately isolate PBLs to establish in vitro culture systems is crucial for basic research and clinical requirements. However, isolation of PBLs from whole blood is difficult, and so the development of a rapid and safe method to perform this task is required. Microfluidic technology offers opportunities that challenge the performance of macroscale methods. In this study, we proposed a simple spiral microfluidic chip for efficient and high-throughput isolation of lymphocytes from a sample with prelysed RBCs. This spiral microfluidic platform does not rely on antibodies or biological markers for labeling cells of interest while isolating lymphocytes but rather enriches B and T lymphocytes through the different physical properties that are intrinsic to lymphocytes and other blood cells. The device was used to achieve high-throughput (similar to 1.3 x 10(5) cells/min) separation of lymphocytes with high viability (>95%). Compared with previous approaches, our device provided rapid, label-free, high-throughput, and safe lymphocyte separation.