Browsing by Issue Date, starting with "2019-08-28"

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Bone marrow concentrate-induced mesenchymal stem cell conditioned medium facilitates wound healing and prevents hypertrophic scar formation in a rabbit ear model
(2019-08-28)
Hu, Ching-Hsuan
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Tseng, Yi-Wen
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Chiou, Chih-Yung
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Lan, Kuan-Chun
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Chou, Chih-Hung
Background Hypertrophic scars (HSs) are formed via an aberrant response to the wound healing process. HSs can be cosmetic or can result in functional problems. Prolonged proliferation and remodeling phases disrupt wound healing, leading to excessive collagen production and HS formation. However, there are currently no satisfactory drugs to prevent HS formation. Mesenchymal stem cell (MSC) conditioned medium (CM) has therapeutic effects on wound healing and preventing HS formation. Bone marrow concentrate (BMC) contains various growth factors and cytokines that are crucial for regeneration and has been applied in the clinical setting. In this study, we evaluated the effects of BMC-induced MSC CM on HS formation in a rabbit ear model. Methods We established a rabbit ear wound model by generating full-thickness wounds in the ears of rabbits (n = 12) and treated wounds with MSC CM, BMC CM, or BMC-induced MSC CM. Dermal fibroblasts from human hypertrophic scar were stimulated with transforming growth factor beta 1 (TGF-beta 1) for 24 h and cultured in each culture medium for 72 h. We measured the hypertrophic scar (HS) formation during the skin regeneration by measuring the expression of several remodeling molecules and the effect of these conditioned media on active human HS fibroblasts. Results Our results showed that BMC-induced MSC CM had greater antifibrotic effects than MSC CM and BMC CM significantly attenuated HS formation in rabbits. BMC-induced MSC CM accelerated wound re-epithelization by increasing cell proliferation. Additionally, BMC-induced MSC CM also inhibited fibrosis by decreasing profibrotic gene and protein expression, promoting extracellular matrix turnover, inhibiting fibroblast contraction, and reversing myofibroblast activation. Conclusions BMC-induced MSC CM modulated the proliferation and remodeling phases of wound healing, representing a potential wound healing agent and approach for preventing HS formation.
Rate coefficient of the reaction CH2OO + NO2 probed with a quantum-cascade laser near 11 mu m
(2019-08-28)
Luo, Pei-Ling
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Chung, Chen-An
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Lee, Yuan-Pern
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交大名義發表
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應用化學系
The reaction of the simplest Criegee intermediate CH2OO with NO2 is considered to be important in atmospheric chemistry because of its prospective contribution to the decay of CH2OO and the additional source of NO3, hence its effects on the NOx and HOx cycles. The reported rate coefficients of this reaction varied by a factor of 5. Employing a cw quantum-cascade laser with wavelength near 11 mu m coupled with Herriott mirrors to probe CH2OO sensitively, we investigated in detail the reaction CH2OO + NO2 under total pressure 5.9-9.7 Torr at 298 K and reported a rate coefficient k(NO2) = (1.0 +/- 0.2) x 10(-12) cm(3) molecule(-1) s(-1), about one-seventh the value determined with direct measurements of CH2OO by Weltz et al. This smaller rate coefficient implies that the title reaction contributes to the atmospheric source of NO3 and the decay of CH2OO much less than previously conceived.
Li-Ion Capacitor Integrated with Nano-network-Structured Ni/NiO/C Anode and Nitrogen-Doped Carbonized Metal-Organic Framework Cathode with High Power and Long Cyclability
(2019-08-28)
Cheng, Chung-Fu
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Chen, Yu-Ming
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Zou, Feng
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Liu, Kewei
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Xia, Yanfeng
Lithium-ion capacitors (LICs) represent a new type of energy-storage devices, which have combined merits of high energy density Li-ion battery and high power density supercapacitor. Nevertheless, one significant challenge for LICs is the imbalanced kinetics between the fast capacitive cathode and relatively slow intercalation anode that limit the energy-storage performance. Here, the asymmetric LIC devices were developed based on a nitrogen-doped, carbonized zeolitic imidazolate framework (ZIF-8) cathode and a three-dimensional, nano-network-structured, conversion reaction-based Ni/NiO/C anode. These nanostructures associated with both the cathode and anode enable rapid electron and ions transport in the LIC devices, which allows the asymmetric LICs to be operated on either high energy mode (energy density of 114.7 Wh/kg at power density of 98.0 W/kg) or high power mode (power density of 60.1 kW/kg at energy density of 17.6 Wh/kg). The device also exhibited long-term cycle stability with 87% capacitance retention after 12 000 cycles. These results demonstrate that the rational design of nanoporous electrode structures can deliver a balanced, high-performance-activated cZIF-8 vertical bar Ni/NiO/C-based lithium-ion capacitor.
Interface Engineering Strategy Utilizing Electrochemical ALD of Cu-Zn for Enabling Metallization of Sub-10 nm Semiconductor Device Nodes
(2019-08-28)
Joi, Aniruddha
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Venkatraman, Kailash
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Tso, Kuang-Chih
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Dictus, Dries
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Dordi, Yezdi
A novel interface engineering approach, utilizing electrochemical atomic layer deposition (e-ALD) of Cu(Zn) on a Ru liner, is presented for enabling the metallization of sub-10 nm interconnects in future semiconductor devices. Upon thermal treatment, Zn present in the e-ALD Cu layer at similar to 0.8 at.% is shown to diffuse through the Ru liner and react with the SiO2 to form a Zn-silicate layer at the Ru-SiO2 interface. This 'self-forming' interfacial layer provides adhesion enhancement to the Ru-SiO2 interface and serves as a diffusion barrier retarding Cu diffusion into the SiO2 layer while enabling void-free gap-filling of high aspect ratio trench structures. Absorption Near-Edge Spectroscopy and Extended X-ray Absorption Fine Structure analyses confirm that the self-formed barrier layer is composed primarily of Zn2SiO4. The interface engineering approach utilizing Cu(Zn) presented herein offers several potential advantages over traditional Mn-based self-forming barrier approaches, i.e., scalability to narrower dimensions and minimal impact to interconnect resistance. (C) The Author(s) 2019. Published by ECS.
GdFe0.8Ni0.2O3: A Multiferroic Material for Low-Power Spintronic Devices with High Storage Capacity
(2019-08-28)
Chang, Shu-Jui
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Chung, Ming-Han
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Kao, Ming-Yi
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Lee, Shang-Fan
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Yu, Yi-Hsing
Multiferroic materials are strong candidates for reducing the energy consumption of voltage-controlled spintronic devices because of the coexistence of ferroelectric (FE) and magnetic orders in a single phase. In this article, we present a new multiferroic perovskite, GdNixFe1-xO3 (GFNO), produced via sputtering on a SrTiO3 substrate. The proposed GFNO is FE and canted antiferromagnetic (AFM) within a monoclinic framework at room temperature. The FE polarization of the GFNO is up to 37 mu C/cm(2). When capped with a Co layer, the resulting heterostructure exhibits voltage-controlled magnetism (VCM). The heterostructured device exhibits two distinct features. First, its VCM depends on the magnitude as well as the polarity of the applied bias, thereby doubling the number of available magnetic readout states under a fixed voltage. Furthermore, the magnetic order of the device can be controlled very effectively within +/- 1 V. These two characteristics satisfy the requirements for low-power and high-storage technology. Theoretical analysis and experimental results indicate the importance of Ni dopant in regulating the polarity-dependent multiferroicity of this gadolinium ferrite system.
Single-Junction Organic Solar Cell Containing a Fluorinated Heptacyclic Carbazole-Based Ladder-Type Acceptor Affords over 13% Efficiency with Solution-Processed Cross-Linkable Fullerene as an Interfacial Layer
(2019-08-28)
Chen, Tsung-Wei
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Chang, Chia-Chih
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Hsiao, Yu-Tang
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Chan, ChoonKee
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Hong, Ling
In this article, a fluorinated heptacyclic dithienocyclopentacarbazole (DTC)-based non-fullerene acceptor (NFA), DTC(4Ph)-4FIC, is synthesized and blended with J71, PBDB-T, and PBDB-TF, featuring complementary absorption and well-matched energy levels. The DTC(4Ph)-4FIC neat film exhibits face-on preference, whereas the nonfluorinated counterpart, DTC(4Ph)-IC, exhibits edge-on preference; this unique feature owing to fluorination in DTC-based NFAs is observed for the first time. More importantly, DTC(4Ph)-4FIC exhibits improved power conversion efficiencies (PCEs) of 10.92 and 10.41% in J71- and PBDB-T-containing devices, while the devices that employed DTC(4Ph)-IC afford PCEs of 7.76 and 9.48%, respectively. Because PBDB-TF is known to exhibit lower energy levels than J71 and PBDB-T, the corresponding device affords a V-OC of 0.95 V, a J(SC) of 18.29 mA cm(-2), a FF of 75.70%, and a PCE of 13.15%, which is 20 and 26% higher than J71- and PBDB-T-containing devices. Furthermore, the inverted device containing the PBDB-TF:DTC(4Ph)-4FIC blend is fabricated using cross-linkable fullerene (C-PCBSD) as the cathode interlayer, affording a decent PCE of 13.36%, with a V-OC of 0.94 V, a J(SC) of 20.20 mA cm(-2), and a FF of 70.42%.
【第十一屆陽明－海德堡雙邊研討會】
(國立陽明大學, 2019-08-29)
陽明電子報編輯小組
陽明成立數位醫學中心，首波助偏鄉建立遠距加護病房
(國立陽明大學, 2019-08-29)
陽明電子報編輯小組
陽明成立「數位醫學中心」（Digital Medicine Center, DMC），將與陽明大學附設醫院（簡稱陽大附醫）及宜蘭縣策略結盟，透過「遠...
【108學年度新生入學典禮】偉大航道啟程
(國立陽明大學, 2019-08-29)
陽明電子報編輯小組
【生醫研發數據的Excel VBA分析】推廣教育課程
(國立陽明大學, 2019-08-29)
陽明電子報編輯小組
【危害性化學品通識安全衛生教育訓練】
(國立陽明大學, 2019-08-29)
陽明電子報編輯小組
懷生社：十年軌跡
(國立陽明大學, 2019-08-29)
懷生社
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陽明電子報編輯小組
今年的懷生社，即將邁向第十個年頭！從學長姐救援的小黃開始，一路篳路藍縷走來，經歷小狗送養安置、師生與狗狗問題處理、學校一開始不支持……種種狀況，至今終於有了穩定的狗況，學校也漸漸軟化了對狗狗的拒絕態度，給予經費及支持。
榮陽團隊領先全球幹細胞療法，「菜瓜布肺」有救了
(國立陽明大學, 2019-08-29)
陽明電子報編輯小組
由醫學系解剖學科傅毓秀教授率領的榮陽團隊發現，將人類臍帶間質幹細胞移植至肺臟纖維化的大白鼠中，不僅能長時間存活於大白鼠肺...
永劫
(國立陽明大學, 2019-08-29)
蜜蜜
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陽明電子報編輯小組
【緊急救護教育訓練】
(國立陽明大學, 2019-08-29)
陽明電子報編輯小組
【圖資遠距教室環控及設備操作教育訓練】
(國立陽明大學, 2019-08-29)
陽明電子報編輯小組
暑期生醫科技挑戰營，體驗醫學與科學的奧妙
(國立陽明大學, 2019-08-29)
陽明電子報編輯小組
由陽明生醫暨工程學院舉辦的「2019生醫科技挑戰營」，帶領學員實際體驗超音波、正子電腦斷層、3D列印、X光及血型鑑定等先進醫學技...
陽明－海德堡雙聯學位計畫，首批學生赴德
(國立陽明大學, 2019-08-29)
陽明電子報編輯小組
本校去年九月與德國海德堡大學（Heidelberg University）簽訂雙聯學位計畫，今年已有兩位生醫光電研究所的同學通過申請，將從九月...
陽大附醫國際研討會，探討新藥對乳癌復發治療的影響
(國立陽明大學, 2019-08-29)
陽明電子報編輯小組
由本校附設醫院舉辦的「第11屆國際醫療研討會」，8月24日以「新藥對於乳癌復發治療的影響」為主題，邀請國內外醫學專家，包括：日...
【生醫領航方舟外一章】神經美學：從腦科學看藝術美學
(國立陽明大學, 2019-08-29)
陽明電子報編輯小組