Browsing by Issue Date, starting with "2020-02-13"

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SLIM: Simultaneous Logic-in-Memory Computing Exploiting Bilayer Analog OxRAM Devices
(2020-02-13)
Kingra, Sandeep Kaur
;
Parmar, Vivek
;
Chang, Che-Chia
;
Hudec, Boris
;
Hou, Tuo-Hung
von Neumann architecture based computers isolate computation and storage (i.e. data is shuttled between computation blocks (processor) and memory blocks). The to-and-fro movement of data leads to a fundamental limitation of modern computers, known as the Memory wall. Logic in-Memory (LIM)/In-Memory Computing (IMC) approaches aim to address this bottleneck by directly computing inside memory units thereby eliminating energy-intensive and time-consuming data movement. Several recent works in literature, propose realization of logic function(s) directly using arrays of emerging resistive memory devices (example- memristors, RRAM/ReRAM, PCM, CBRAM, OxRAM, STT-MRAM etc.), rather than using conventional transistors for computing. The logic/embedded-side of digital systems (like processors, micro-controllers) can greatly benefit from such LIM realizations. However, the pure storage-side of digital systems (example SSDs, enterprise storage etc.) will not benefit much from such LIM approaches as when memory arrays are used for logic they lose their core functionality of storage. Thus, there is the need for an approach complementary to existing LIM techniques, that's more beneficial for the storage-side of digital systems; one that gives compute capability to memory arrays not at the cost of their existing stored states. Fundamentally, this would require memory nanodevice arrays that are capable of storing and computing simultaneously. In this paper, we propose a novel 'Simultaneous Logic in-Memory' (SLIM) methodology which is complementary to existing LIM approaches in literature. Through extensive experiments we demonstrate novel SLIM bitcells (1T-1R/2T-1R) comprising non-filamentary bilayer analog OxRAM devices with NMOS transistors. Proposed bitcells are capable of implementing both Memory and Logic operations simultaneously. Detailed programming scheme, array level implementation, and controller architecture are also proposed. Furthermore, to study the impact of proposed SLIM approach for real-world implementations, we performed analysis for two applications: (i) Sobel Edge Detection, and (ii) Binary Neural Network- Multi layer Perceptron (BNN-MLP). By performing all computations in SLIM bitcell array, huge Energy Delay Product (EDP) savings of approximate to 75x for 1T-1R (approximate to 40x for 2T-1R) SLIM bitcell were observed for edge-detection application while EDP savings of approximate to 3.5x for 1T-1R (approximate to 1.6x for 2T-1R) SLIM bitcell were observed for BNN-MLP application respectively, in comparison to conventional computing. EDP savings owing to reduction in data transfer between CPU <-> memory is observed to be approximate to 780x (for both SLIM bitcells).
Two new, near-infrared, fluorescent probes as potential tools for imaging bone repair
(2020-02-13)
Lin, Chien-Chou
;
Chang, Walter Hong-Shong
;
Cheng, Tsai-Mu
;
Chiu, Li-Hsuan
;
Wang, Yen-Hsun
A precise imaging technique to evaluate osteogenesis, osteodifferentiation, and osseointegration following peri-implant surgery is in high clinical demand. Herein, we report the generation of two new, near-infrared (NIR) fluorescent probes for use in the molecular imaging of bone repair. The first probe aims to monitor the in vitro differentiation of human mesenchymal stem cells (MSCs) into osteoblasts. A NIR fluorochrome was conjugated to a cyclic peptide that binds to integrin alpha 5 beta 1, a factor that promotes osteogenesis in MSCs and therefore functioned as an osteoblast-specific marker. The second probe aims to monitor osteogenesis, and was generated by conjugating the drug pamidronate to a NIR fluorescent gold nanocluster. Pamidronate specifically binds to hydroxyapatite (HA), a mineral present in bone that is produced by osteoblasts, and therefore provides a functional marker for new bone formation. Our results show that both probes bind to their specific targets in vitro-differentiated osteoblasts, and not to undifferentiated MSCs, and emit NIR fluorescence for functional detection. This in vitro work demonstrates the ability of these probes to bind to active osteoblasts and their mineral deposits and highlight their potential utility as clinical tools for the imaging of the osseointegration process at the molecular level.
Superhelices with tunable twisting power directed from supramolecular pairing of focal asymmetry in achiral dendron-jacketed block copolymers
(2020-02-14)
Lin, I-Ming
;
Chou, Che-Min
;
Li, Ming-Chia
;
Guo, Rong-Hao
;
Lee, Cheng-Kuang
The formation of helical assemblies from achiral supramacromolecules has been a highly mysterious process, but is of interest for the generation of a variety of structures and properties. Herein, novel hierarchical superhelices are developed from self-assembly of achiral dendron-jacketed block copolymers (DJBCPs). The presence of focal asymmetry in both the stereochemistry of the dendrons (donors) and interactive binding sites of the copolymer chains (acceptors) plays a pivotal role in generating a spontaneous symmetry breaking through tailored donor-acceptor matching via hydrogen bonding. The focal asymmetry, on a scale of several nanometers, propagates to helical twists of the achiral DJBCP hierarchical assemblies over hundreds of nanometers, such that the primary molecular asymmetry sequentially triggers a secondary helical conformation of the dendron-jacketed blocks, then tertiary supramolecular helical assemblies and eventually quaternary superhelices. The helical twisting power of the superhelices is tunable using the dendron grafting ratio, indicating that the magnitude of helical twisting can be quantitatively adjusted from local to entire structures.
Fabrication of TiO2-coated nanostructured Ni foams for improved mechanical properties
(2020-02-15)
Hung, Pei-Sung
;
Chou, Yu-Szu
;
Wang, Guang-Ren
;
Chung, Wei-An
;
Wu, Pu-Wei
We demonstrate a composite approach to improve the mechanical strength of nanostructured Ni foams by producing a conformal coating of TiO2 on the skeletons of the Ni foam. The nanostructured Ni foam is fabricated by a template approach in which colloidal crystals of polystyrene microspheres in 720 nm diameter are constructed by a vertical electrophoresis process, followed by electroplating of Ni to fill the interstitial voids among the closely-packed microspheres and removal of the colloidal template afterward. The formation of TiO2 overcoat is achieved by optimization of sol-gel synthesis to prepare desirable TiO2 sols and their subsequent electrophoresis toward the nanostructured Ni foam in a square wave pulsing mode. The thickness of the TiO2 deposit is proportional to the duration of pulsing electrophoresis. From nano-indentation, the TiO2 -coated nanostructured Ni foams exhibit notable improvements in hardness (53-68%) and reduced elastic modulus (26-37%) over those of pristine nanostructured Ni foams. This strategy of implementing a thin ceramic overcoat provides an effective mean to improve the mechanical properties of nanostructured metals.
《聲之形》（A Silent Voice）
(國立陽明大學, 2020-02-15)
黃柏威
;
陽明電子報編輯小組
榮陽交成立「新型冠狀病毒研發聯盟」，投入快篩試劑與藥物研發
(國立陽明大學, 2020-02-15)
陽明電子報編輯小組
為支援全球面對2019新型冠狀病毒（2019-nCoV）防疫需求，陽明與交通大學、臺北榮民總醫院2月6 日成立研發聯盟，將結合產業，首先...
牙醫學院院長交接，張國威教授出任新院長
(國立陽明大學, 2020-02-15)
陽明電子報編輯小組
牙醫學院2月3日舉行交接典禮，原任的許明倫院長功成身退，由牙醫系張國威特聘教授接任第七任院長。新任的張國威院長表示，43年前...
【2020春季智齡講堂】
(國立陽明大學, 2020-02-15)
陽明電子報編輯小組
【腦科所學術演講系列】
(國立陽明大學, 2020-02-15)
陽明電子報編輯小組
【愛心口罩運動】～讓我們把「口罩」捐給需要的人
(國立陽明大學, 2020-02-15)
陽明電子報編輯小組
Simultaneous detection of two growth factors from human single-embryo culture medium by a bead-based digital microfluidic chip
(2020-02-15)
Lee, Meng-Shiue
;
Hsu, Wensyang
;
Huang, Hong-Yuan
;
Tseng, Hsueh-Yang
;
Lee, Chia-Tung
The measurement of growth factors released in a culture medium is considered to be an attractive non-invasive approach, apart from the embryo morphology, to identify the condition of an embryo development after fertilization in vitro (IVF), but the available embryo culture medium in the current method is only a few microlitres. This small sample volume, also of small concentration, makes difficult the application of a conventional detection method, such as an enzyme-linked immunosorbent assay (ELISA). A reliable detection of the growth factor from each embryo culture medium of such a small concentration hence remains a challenge. Here for the first time we report the results of measurement of not just one, but two, growth factors, human IL-1 beta and human TNF-alpha, from an individual droplet of embryo culture medium with a bead-based digital microfluidic chip. The required sample volume for a single measurement is only 520 nL; the total duration of the on-chip process is less than 40 min. Using the culture media of human embryos with normal morphologic features, we found that the concentrations of TNF-alpha change little from day 3 to day 5-6, but the concentrations of IL-1 beta for some embryos might double from day 3 to day 5-6. For other embryos even with similar normal morphologic features, some growth factors, such as IL-1 beta, might exhibit different expressions during the culture period. Those growth factors could serve to distinguish the development conditions of each embryo, not merely from an observation of embryo morphology.
【校外講座】人工智慧運用於心臟血管疾病之最新發展
(國立陽明大學, 2020-02-15)
陽明電子報編輯小組
Diatom-assisted biomicroreactor targeting the complete removal of perfluorinated compounds
(2020-02-15)
Albert, Karunya
;
Hsieh, Pei-Ying
;
Chen, Tsai-Hsuan
;
Hou, Chia-Hung
;
Hsu, Hsin-Yun
Persistent perfluorinated compounds (PFCs) have been recognized as a global environmental issue. Developing methods without leading to additional burden in nature will be essential for PFCs removal. Herein, we functionalized iron nanoparticles on living diatom (Dt) to efficiently enable the Fenton reaction and reactive oxygen species (ROS) production. Iron nanoparticles at the surface of living diatom act as promising catalytic agents to trigger (OH)-H-center dot radical generation from H2O2. Dt plays dual roles: i) as solid support for effective adsorption, and ii) it supplies oxygen and inherently produces ROS under stress conditions, which improves removal efficiency of PFCs. We also demonstrated its reusability by simple magnetic separation and 85% of decomposition efficiency could still be achieved. This newly developed diatom-assisted bioremediation strategy enables green and efficient PFC decomposition and shall be readily applicable to other persistent pollutants.
陽明X桂冠產學合作，推出美味湯品與逆齡食譜
(國立陽明大學, 2020-02-15)
陽明電子報編輯小組
冷凍食品界的龍頭「桂冠實業」，自2018年加入「陽明大學國際產學聯盟」國際級會員後，便與陽明展開2000萬的高值化產學合作，成立...
Reliability analysis of composite wind turbine blades considering material degradation of blades
(2020-02-15)
Su, H. M.
;
Kam, T. Y.
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交大名義發表
;
National Chiao Tung University
In this study, a set of analytical methods was proposed to evaluate the reliability of composite wind turbine blades after material aging, and to improve the blade structure strength to enhance its reliability. Because, the material aging will occur when the blade is affected by the external environment for a long time, consequently, time is an extremely important factor in reliability. Therefore, it is necessary to simulate the effect of environment on materials by aging experiments, so as to obtain the relationship between time, material strength and material constant. The reliability evaluation method used in this study is the direct integration method, which can quickly evaluate the reliability of blades degraded by materials. Because the reliability of the unmodified blade impossible be more than 98% after 20 years, it is necessary to improve the blade and then evaluate the reliability. The weight of the improved blade increased by only 8.57%, but the wind speed of buckling could be delayed by 32.47%, and the reliability could be more than 99% after 20 years, so the improved method meets the demand.
【實驗動物基本技術操作技能】3/12大鼠班
(國立陽明大學, 2020-02-15)
陽明電子報編輯小組
陽明GLORIA 2020首場企業講座：當新創遇見創投
(國立陽明大學, 2020-02-15)
陽明電子報編輯小組
陽明國際產學聯盟2020年首場「生醫領航方舟企業講座」，特別邀請到對於企業策略規劃、併購有豐富經驗的橡子園創投合夥人、永加利...
因應新型冠狀病毒疫情，陽明延至3/2開學
(國立陽明大學, 2020-02-15)
陽明電子報編輯小組
因應新型冠狀病毒（2019-nCoV，武漢肺炎）疫情，陽明配合教育部防疫政策，本學期開學日將延後至3月2日，相關課務、學務等配套措施...
【生醫領航方舟～企業講座】謝仁俊教授：禪與腦
(國立陽明大學, 2020-02-15)
陽明電子報編輯小組
「基因丶進化丶革命：生物藝術展」～藝文中心三月份展覽預告
(國立陽明大學, 2020-02-15)
陽明電子報編輯小組
今年三月，藝文中心將舉辦生物藝術展，由視覺文化所勞維俊老師擔任策展人，𨘋請多位國內外知名的年輕藝術家及團體，展出他們精選的生物藝術作品；透過這些作品，呈現並強調生命科學丶生醫工程丶科技丶哲學等各學科與藝術間互相拉鋸又融合的關係。