Browsing by Issue Date, starting with "2020-03-13"

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【動物飼養管理課程】
(國立陽明大學, 2020-03-13)
陽明電子報編輯小組
陽明攜手遠雄，打造自貿區國際醫療中心
(國立陽明大學, 2020-03-13)
陽明電子報編輯小組
陽明與遠雄自由貿易港區股份有限公司2月27日簽署「國際醫療暨生技產業發展合作備忘錄」，將以遠雄自由貿易港區為基地，共同打造自...
Cholesteryl alpha-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium
(2020-03-13)
Jan, Hau-Ming
;
Chen, Yi-Chi
;
Yang, Tsai-Chen
;
Ong, Lih-Lih
;
Chang, Chia-Chen
Helicobacter pylori, the most common etiologic agent of gastric diseases including gastric cancer, is auxotrophic for cholesterol and has to hijack it from gastric epithelia. Upon uptake, the bacteria convert cholesterol to cholesteryl 6 '-O-acyl-alpha-D-glucopyranoside (CAG) to promote lipid raft clustering in the host cell membranes. However, how CAG appears in the host to exert the pathogenesis still remains ambiguous. Herein we identified hp0499 to be the gene of cholesteryl alpha-D-glucopyranoside acyltransferase (CGAT). Together with cholesteryl glucosyltransferase (catalyzing the prior step), CGAT is secreted via outer membrane vesicles to the host cells for direct synthesis of CAG. This significantly enhances lipid rafts clustering, gathers adhesion molecules (including Lewis antigens and integrins alpha 5, beta 1), and promotes more bacterial adhesion. Furthermore, the clinically used drug amiodarone was shown as a potent inhibitor of CGAT to effectively reduce the bacterial adhesion, indicating that CGAT is a potential target of therapeutic intervention. Jan et al. identify cholesteryl alpha-D- glucopyranoside acyltransferase as a key enzyme in Helicobacter pylori's synthesis of cholesteryl 6'-O-acyl-alpha-D-glucopyranoside, which promotes bacterial adhesion. This study provides insights into the H. pylori-induced pathogenesis and therapeutic strategies against it.
【陽明九景文學與攝影獎】
(國立陽明大學, 2020-03-13)
陽明電子報編輯小組
加強校園防疫，將採體溫量測與線上授課
(國立陽明大學, 2020-03-13)
陽明電子報編輯小組
因應武漢新型冠狀病毒疫情升溫，本校防疫小組3月9日決議，在人潮眾多的學餐一樓，將採用紅外線熱像儀全面量測體溫。同時，若校園...
【內在力量工作坊】～身體感知與生命敘說
(國立陽明大學, 2020-03-13)
陽明電子報編輯小組
本校第17屆傑出校友當選名單出爐
(國立陽明大學, 2020-03-13)
陽明電子報編輯小組
恭賀蔡錦華校友、顏鴻順校友、賈淑麗校友、林故廷校友、劉瑞玲校友、劉靜怡校友和謝景祥校友，榮獲本(17)屆「國立陽明大學傑出校...
Functional analysis of Clostridium difficile sortase B reveals key residues for catalytic activity and substrate specificity
(2020-03-13)
Kang, Chia-Yu
;
Huang, I-Hsiu
;
Chou, Chi-Chi
;
Wu, Tsai-Yu
;
Chang, Jyun-Cyuan
Most of Gram-positive bacteria anchor surface proteins to the peptidoglycan cell wall by sortase, a cysteine transpeptidase that targets proteins displaying a cell wall sorting signal. Unlike other bacteria, Clostridium difficile, the major human pathogen responsible for antibiotic-associated diarrhea, has only a single functional sortase (SrtB). Sortase's vital importance in bacterial virulence has been long recognized, and C. difficile sortase B (Cd-SrtB) has become an attractive therapeutic target for managing C. difficile infection. A better understanding of the molecular activity of Cd-SrtB may help spur the development of effective agents against C. difficile infection. In this study, using site-directed mutagenesis, biochemical and biophysical tools, LC-MS/MS, and crystallographic analyses, we identified key residues essential for Cd-SrtB catalysis and substrate recognition. To the best of our knowledge, we report the first evidence that a conserved serine residue near the active site participates in the catalytic activity of Cd-SrtB and also SrtB from Staphylococcus aureus. The serine residue indispensable for SrtB activity may be involved in stabilizing a thioacyl-enzyme intermediate because it is neither a nucleophilic residue nor a substrate-interacting residue, based on the LC-MS/MS data and available structural models of SrtB?substrate complexes. Furthermore, we also demonstrated that residues 163?168 located on the ?6/?7 loop of Cd-SrtB dominate specific recognition of the peptide substrate PPKTG. The results of this work reveal key residues with roles in catalysis and substrate specificity of Cd-SrtB.
【安全是回家唯一的路】~交通安全教育宣導講座
(國立陽明大學, 2020-03-13)
陽明電子報編輯小組
Comparison of alternative approaches for difference, noninferiority, and equivalence testing of normal percentiles
(2020-03-13)
Shieh, Gwowen
;
管理科學系
;
Department of Management Science
Background Percentiles are widely used in scientific research for determining the comparative magnitude and reference limit of quantitative measurements. The investigations for point and interval estimation of normal percentiles are well documented in the literature. However, the corresponding statistical tests of hypothesis have received relatively little attention. Methods To facilitate data analysis and design planning of percentile study, this paper aims to present hypothesis testing procedures and associated power functions for assessing the difference, noninferiority, and equivalence of normal percentiles. Results Numerical illustrations about drug dissolution are provided to demonstrate the usefulness of the suggested exact approaches and the deficiency of approximate methods. Conclusions The exact approaches are superior to the approximate methods on the basis of control of Type I errors. Computer algorithms are constructed to implement the recommended test procedures and sample size calculations for percentile analysis.
衣櫥醫生，帶你走入對的人生
(國立陽明大學, 2020-03-13)
陽明電子報編輯小組
新學期伊始，為了要讓大家有新氣象並且更了解自己，藝文中心邀請到曾登上TED演講的衣櫥醫生賴庭荷，來幫大家整治服裝。衣櫥醫生首先讓同學們兩兩一組，互相量彼此的頭長、臉長，用來計算頭身比以及五官比例等等，試圖用科學的方式幫大家分類自己所屬的類型。衣櫥醫生設計了角色三原型，讓同學們測量自己從眼窩到唇心間的距離，再以此除以頭長，得出來的數字可以被分類為夢想家、照顧者、領導者三種型式。
劉興成校友熱心捐助，心肺功能室重新開幕
(國立陽明大學, 2020-03-13)
陽明電子報編輯小組
廣受許多人喜愛的心肺功能室，在牙醫系劉興成校友熱心捐助下，利用寒假期間重新裝潢並增添器材，3月3日於活動中心三樓重新開幕，...
【完美求職系列講座】量身訂做～打造我的專屬履歷
(國立陽明大學, 2020-03-13)
陽明電子報編輯小組
【職業興趣探索～職涯適性測驗&解測】
(國立陽明大學, 2020-03-13)
陽明電子報編輯小組
《我們》（Us）
(國立陽明大學, 2020-03-13)
黃柏威
;
陽明電子報編輯小組
【生科院3月份生物醫學講座】
(國立陽明大學, 2020-03-13)
陽明電子報編輯小組
陽明醫學系首創「醫師工程師」，培育台灣數位醫療人才
(國立陽明大學, 2020-03-13)
陽明電子報編輯小組
醫療與電資是台灣經濟發展命脈，為了培育兼具兩者的跨領域人才，陽明醫學系今年首創「醫師工程師組」，替台灣培育未來數位醫療產...
【輔導股長專屬活動】～輔導股長大團圓
(國立陽明大學, 2020-03-13)
陽明電子報編輯小組
Maximizing accuracy in multi-scanner malware detection systems
(2020-03-14)
Sakib, Muhammad N.
;
Huang, Chin-Tser
;
Lin, Ying-Dar
;
資訊工程學系
;
Department of Computer Science
A variety of anti-malware scanners have been developed for malware detection. Previous research has indicated that combining multiple different scanners can achieve better result compared to any single scanner. However, given the diversity in detection rates and accuracy of different anti-malware scanners, how to determine the best possible outcome of multi-scanner systems in terms of accuracy and how to achieve this best outcome remain formidable tasks. In this paper, we propose three models to capture the combined output of different combinations of anti-malware scanners based on the limited amount of historical information available. These models enable us to predict the accuracy level of each combination, which helps us to determine the optimal configuration of the multi-scanner detection system to achieve maximum accuracy. We also introduce two methods to identify a near-optimal subset of scanners that can help reduce scanning cost while under time constraint. From simulations over randomly generated hypothetical datasets and experiments conducted with real world malware and goodware datasets and anti-virus scanners, we found that our models perform well in predicting the optimal configuration and can achieve an accuracy as high as within 1% of true maximum. (C) 2019 Elsevier B.V. All rights reserved.
Extremely solvent-enhanced absorbance and fluorescence of carbazole interpreted using a damped Franck-Condon simulation
(2020-03-14)
Wang, Chen-Wen
;
Zhu, Chaoyuan
;
Lin, Sheng Hsien
;
交大名義發表
;
應用化學系
Extremely solvent-enhanced absorption and fluorescence spectra of carbazole were investigated by performing a generalized multi-set damped Franck-Condon spectral simulation. Experimental absorption and fluorescence spectra of carbazole in the gas phase were first well reproduced by performing an un-damped Franck-Condon simulation, but a one-set scaling damped Franck-Condon simulation severely underestimated the intensities of the peaks of experimental absorption and fluorescence spectra of carbazole in n-hexane. Then, a multi-set scaling damped Franck-Condon simulation was proposed and carried out for simulating the extremely solvent-enhanced absorbance and fluorescence, and here, the simulated spectra agreed well with the experimental ones. Five (four) representative solvent-enhanced normal modes corresponding to the combination of ring stretching and ring breathing vibrational motions were determined to be responsible for enhanced absorbance (fluorescence) in n-hexane solution. Furthermore, different scalings were applied to the ground and first-excited states, resulting in different enhancement of absorbance and fluorescence, and this analysis revealed atoms in the carbazole interacting with n-hexane solvent molecules and, hence, leading to different normal-mode vibrational vector patterns in the ground and first-excited states, respectively. Basically, the same conclusion was drawn from a simulation with HF-CIS and the three functionals (TD)B3LYP, (TD)B3LYP-35, and (TD)BHandHLYP. The present multi-set scaling damped Franck-Condon simulation scheme was demonstrated to successfully interpret extremely solvent-enhanced absorbance and fluorescence of carbazole in n-hexane-solvent.