Browsing by Issue Date, starting with "2020-04-02"

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Development of Novel Mixed Halide/Superhalide Tin-Based Perovskites for Mesoscopic Carbon-Based Solar Cells
(2020-04-02)
Rameez, Mohammad
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Shahbazi, Saeed
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Raghunath, Putikam
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Lin, Ming Chang
;
Hung, Chen Hsiung
Tin perovskites suffer from poor stability and a self-doping effect. To solve this problem, we synthesized novel tin perovskites based on superhalide with varied ratios of tetrafluoroborate to iodide and implemented them into solar cells based on a mesoscopic carbon-electrode architecture because film formation was an issue in applying this material for a planar heterojunction device structure. We undertook quantum-chemical calculations based on plane-wave density functional theory (DFT) methods and explored the structural and electronic properties of tin perovskites FASnI(3-x)(BF4)(x) in the series x = 0, 1, 2, and 3. We found that only the x = 2 case, FASnI(BF4)(2), was successfully produced, beyond the standard FASnI(3). The electrochemical impedance and X-ray photoelectron spectra indicate that the addition of tin tetrafluoroborate instead of SnI2 suppressed trap-assisted recombination by decreasing the Sn4+ content. The power conversion efficiency of the FASnI(BF4)(2) device with FAI and Sn(BF4)(2) in an equimolar ratio improved 72% relative to that of a standard FASnI(3) solar cell, with satisfactory photostability under ambient air conditions.
Target Identification Using Homopharma and Network-Based Methods for Predicting Compounds Against Dengue Virus-Infected Cells
(2020-04-02)
Hengphasatporn, Kowit
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Plaimas, Kitiporn
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Suratanee, Apichat
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Wongsriphisant, Peemapat
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Yang, Jinn-Moon
Drug target prediction is an important method for drug discovery and design, can disclose the potential inhibitory effect of active compounds, and is particularly relevant to many diseases that have the potential to kill, such as dengue, but lack any healing agent. An antiviral drug is urgently required for dengue treatment. Some potential antiviral agents are still in the process of drug discovery, but the development of more effective active molecules is in critical demand. Herein, we aimed to provide an efficient technique for target prediction using homopharma and network-based methods, which is reliable and expeditious to hunt for the possible human targets of three phenolic lipids (anarcardic acid, cardol, and cardanol) related to dengue viral (DENV) infection as a case study. Using several databases, the similarity search and network-based analyses were applied on the three phenolic lipids resulting in the identification of seven possible targets as follows. Based on protein annotation, three phenolic lipids may interrupt or disturb the human proteins, namely KAT5, GAPDH, ACTB, and HSP90AA1, whose biological functions have been previously reported to be involved with viruses in the family Flaviviridae. In addition, these phenolic lipids might inhibit the mechanism of the viral proteins: NS3, NS5, and E proteins. The DENV and human proteins obtained from this study could be potential targets for further molecular optimization on compounds with a phenolic lipid core structure in anti-dengue drug discovery. As such, this pipeline could be a valuable tool to identify possible targets of active compounds.
窺探南洋之美的冒險　彼岸之嫁
(2020-04-05)
黃順愉
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Department of Communication and Technology
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傳播與科技學系
一場以「冥婚」開啟的奇幻冒險，歷經險境只為揭開死亡謎團。《彼岸之嫁》作為Netflix第三部華語影集，這次選定了在南洋展開華麗舞台！
藍光背黑鍋　黃光才是狠角色！
(2020-04-05)
高儷玲
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Department of Communication and Technology
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傳播與科技學系
聽到「藍光」人們都避之唯恐不及，市面上更是出現各式各樣防藍光的商品。本篇報導帶你解開長久以來對藍光的誤解。
人生就是要《活個精彩》
(2020-04-05)
許峰睿
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Department of Communication and Technology
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傳播與科技學系
《活個精彩》是一部2011年法國電影《逆轉人生》的翻拍電影。由凱文哈特（Kevin Hart）、布萊恩克萊斯頓（Bryan Lee Cranston）等重量級演員主演。講述兩個天差地遠的人因緣際會成為了好朋友，也因此互相改變了對方的人生。
陽光普照　家庭何時開始瓦解？
(2020-04-05)
楊詠嵐
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Department of Communication and Technology
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傳播與科技學系
導演鍾孟宏所執導的第五部劇情長片《陽光普照》，故事聚焦在一個庶民的家庭成員之間，那些微小的事情仿若台灣社會的縮影。此片一舉得到第56屆金馬獎六項大獎，包含最佳劇情長片。
什麼樣的人愛放閃？
(2020-04-05)
張筠婕
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Department of Communication and Technology
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傳播與科技學系
相信當你在滑社群軟體時，多少有看過朋友將大頭照換成他和伴侶的合照，這時候你可能會想「也太高調了吧～」「好羨慕！」那你是否有想過，他們為什麼會這樣做？單純覺得照片好看？想炫耀？還是因為缺乏安全感呢？
又睡不著？益生元改善失眠問題
(2020-04-05)
王乃安
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Department of Communication and Technology
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傳播與科技學系
人家都說益生菌可以幫助消化、增強免疫力，現在還能改善失眠嗎？別把「益生菌」和「益生元」搞混啦！雖然中文跟英文都只差一個字，但是功能可是不一樣。想知道「益生元」不一樣在哪嗎？讓我們繼續看下去。
大麻跟台灣到底「合」不合？
(2020-04-05)
李育陞
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Department of Communication and Technology
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傳播與科技學系
大麻在台灣一直以來都是個禁忌般的植物，就如同哈利波特中那位不能說出名字的人，許多民眾對於談論大麻是避之唯恐不及。然而大麻合法化近年來逐漸在國際間興起風潮，台灣到底是否該跟上呢？
註定不賣座的影史經典　刺激1995
(2020-04-05)
詹庭瑄
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Department of Communication and Technology
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傳播與科技學系
由《陰屍路》導演弗蘭克達拉邦特（Frank Darabont）改編史蒂芬金（Stephen King）小說、《1917》攝影師羅傑狄金斯（Roger Deakins）親自操刀、「上帝之聲」的摩根費里曼（Morgan Freeman）與影帝提姆羅賓斯（Tim Robbins）主演，卻是一部「票房爛」片。這部25週年的影史經典，在今年三月強勢回歸大螢幕，卻因武漢肺炎再次與票房無緣。
台灣的垃圾處理，關鍵在你？
(2020-04-05)
黃博暄
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Department of Communication and Technology
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傳播與科技學系
巷口熟悉的音樂響起，大家一窩蜂的拿著垃圾丟進垃圾車裡。但每個人一天產生的垃圾，進了垃圾焚化廠之後，成本是要全體人民承擔。台灣的垃圾問題需要所有人的關切。
勞方對抗資方最終寶劍——罷工
(2020-04-05)
梁子敬
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Department of Communication and Technology
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傳播與科技學系
在民主以及資本主義社會中，罷工權是勞工在對抗資方的一大武器，經過了長時間的抗爭及改革，罷工這項議題也逐漸地受到大眾重視。
我可能不懂你——同理心的秘密
(2020-04-05)
謝孟如
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Department of Communication and Technology
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傳播與科技學系
自我們從農業社會邁向工業社會，甚至是科技社會，「合作」在人類社會中就佔有越來越重的比例。在這個注重人際關係的世代裡，很多能力被標上了「必備」的標籤，而「同理心」就是其中之一。
帶你置身遊戲　野蠻遊戲新續集
(2020-04-05)
吳政陽
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Department of Communication and Technology
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傳播與科技學系
近年來科技不斷突破，也帶動了電影題材的進化。從1995的第一集《野蠻遊戲》，到2019的《野蠻遊戲：全面晉級》，電影帶著我們走過桌遊盛行到電玩為主流的時代，只為帶來最「真實」的遊戲體驗。
來自大紐約的情書《摩登情愛》
(2020-04-05)
邱欣誼
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Department of Communication and Technology
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傳播與科技學系
亞馬遜影音平台推出原創影集《摩登情愛》，囊括愛情、親情、友情、還有更多難易名狀的都市情感，改編自《紐約時報》專欄八篇真人真事，展現社會的多元性。
再見童星　「再」見楊小黎
(2020-04-05)
周容萱
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Department of Communication and Technology
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傳播與科技學系
你或許記得，電影《狗蛋大兵》中郝紹文身旁的小女孩；或許你腦海裡是布丁廣告裡，因一個布丁而開心滿足的女孩；又或者是客家電視台《台北歌手》中壓抑卻又堅強的林雪絨⋯⋯不論你印象中是哪一個畫面，她都是在演藝圈長大的楊小黎。
無法置身事外的《不眠之夜》
(2020-04-05)
李而
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Department of Communication and Technology
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傳播與科技學系
《不眠之夜》不同於以往劇院的表演形式，演員沒有固定舞臺、觀眾沒有固定座位。在三個小時內，帶你穿越時空，回到1920年代，一探權力、忌妒與慾望所交織成的悲劇。
總編輯的話
(2020-04-05)
廖玥茹
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Department of Communication and Technology
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傳播與科技學系
本期為喀報332期，15篇稿。近一半為藝文評論，其他類目皆有一些。頭題為梁子敬的《勞方對抗資方最終寶劍——罷工》，點出現在臺灣勞工爭取權益面臨的問題。期望讀者們看到罷工事件時，除了不要僅是跟隨媒體輿論的批評外，能反思臺灣勞工的困境。
Linker and N-Terminal Domain Engineering of Pyrrolysyl-tRNA Synthetase for Substrate Range Shifting and Activity Enhancement
(2020-04-07)
Jiang, Han-Kai
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Lee, Man-Nee
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Tsou, Jo-Chu
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Chang, Kuan-Wen
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Tseng, Hsueh-Wei
The Methanosarcina mazei pyrrolysyl-tRNA synthetase (PylRS).tRNA(Pyl) pair can be used to incorporate non-canonical amino acids (ncAAs) into proteins at installed amber stop codons. Although engineering of the PylRS active site generates diverse binding pockets, the substrate ranges are found similar in charging lysine and phenylalanine analogs. To expand the diversity of the ncAA side chains that can be incorporated via the PylRS.tRNA(Pyl) pair, exploring remote interactions beyond the active site is an emerging approach in expanding the genetic code research. In this work, remote interactions between tRNA(Pyl), the tRNA binding domain of PylRS, and/or an introduced non-structured linker between the N- and C-terminus of PylRS were studied. The substrate range of the PylRS.tRNA(Pyl) pair was visualized by producing sfGFP-UAG gene products, which also indicated amber suppression efficiencies and substrate specificity. The unstructured loop linking the N-terminal and C-terminal domains (CTDs) of PylRS has been suggested to regulate the interaction between PylRS and tRNA(Pyl). In exploring the detailed role of the loop region, different lengths of the linker were inserted into the junction between the N-terminal and the C-terminal domains of PylRS to unearth the impact on remote effects. Our findings suggest that the insertion of a moderate-length linker tunes the interface between PylRS and tRNA(Pyl) and subsequently leads to improved suppression efficiencies. The suppression activity and the substrate specificity of PylRS were altered by introducing three mutations at or near the N-terminal domain of PylRS (N-PylRS). Using a N-PylRS.tRNA(Pyl) pair, three ncAA substrates, two S-benzyl cysteine and a histidine analog, were incorporated into the protein site specifically.
Solution-processed organometallic quasi-two-dimensional nanosheets as a hole buffer layer for organic light-emitting devices
(2020-04-07)
Liu, Shihao
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Wang, Ying-Chiao
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Chang, Chi-Ming
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Yasuda, Takeshi
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Fukui, Naoya
Two-dimensional (2D) vdW materials have been integrated into optoelectronic devices to achieve exceptional functionality. However, the integration of large-area 2D thin films into organic light-emitting devices (OLEDs) remains challenging because of the finite number of inorganic 2D materials and the high-temperature requirements of their deposition process. The construction of 2D organometallic materials holds immense potential because of their solution synthesis and unlimited structural and functional diversity. Here, we report a facile route using an oil-water interfacial coordination reaction between organic ligands and divalent metal ions to synthesize crystalline quasi-2D organometallic bis(dithiolato)nickel (NiDT) nanosheets with a centimeter scale and a tunable thickness. The NiDT nanosheets can be directly integrated into OLEDs for use as a hole buffer layer and a fluorescent mounting medium without the aid of a transfer process. Moreover, OLEDs with NiDT nanosheets show not only comparable efficiency to conventional OLEDs but also prolonged device lifetime by nearly 2 times. These results open up a new dimension to use quasi-2D organometallic nanosheets as functional layers in large-area organic devices.