Browsing by Issue Date, starting with "2020-04-09"

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Lipoplex-based targeted gene therapy for the suppression of tumours with VEGFR expression by producing anti-angiogenic molecules
(2020-04-09)
Ho, Shu-Yi
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Chen, Pin-Rong
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Chen, Chia-Hung
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Tsai, Nu-Man
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Lin, Yu-Hsin
Background The anti-angiogenic fusion protein RBDV-IgG1 Fc (RBDV), which comprises the receptor-binding domain of vascular endothelial growth factor-A (VEGF-A), has shown antitumour effects by reducing angiogenesis in vivo. This study used the cationic lipoplex lipo-PEG-PEI-complex (LPPC) to simultaneously encapsulate both the RBDV targeting protein and the RBDV plasmid (pRBDV) without covalent bonds to assess VEGFR targeting gene therapy in mice with melanoma in vivo. Results LPPC protected the therapeutic transgene from degradation by DNase, and the LPPC/RBDV complexes could specifically target VEGFR-positive B16-F10 cells both in vitro and in vivo. With or without RBDV protein-targeting direction, the pRBDV-expressing RBDV proteins were expressed and reached a maximal concentration on the 7th day in the sera after transfection in vivo and significantly elicited growth suppression against B16-F10 melanoma but not IgG1 control proteins. In particular, LPPC/pRBDV/RBDV treatment with the targeting molecules dramatically inhibited B16-F10 tumour growth in vivo to provide better therapeutic efficacy than the treatments with gene therapy with IgG1 protein targeting or administration of a protein drug with RBDV. Conclusions The simultaneous combination of the LPPC complex with pRBDV gene therapy and RBDV protein targeting might be a potential tool to conveniently administer targeted gene therapy for cancer therapy.
Neutral oxygen irradiation enhanced forming-less ZnO-based transparent analog memristor devices for neuromorphic computing applications
(2020-04-09)
Simanjuntak, Firman Mangasa
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Ohno, Takeo
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Chandrasekaran, Sridhar
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Tseng, Tseung-Yuen
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Samukawa, Seiji
Surface oxidation employing neutral oxygen irradiation significantly improves the switching and synaptic performance of ZnO-based transparent memristor devices. The endurance of the as-irradiated device is increased by 100 times, and the operating current can be lowered by 10 times as compared with the as-deposited device. Moreover, the performance-enhanced device has an excellent analog behavior that can exhibit 3 bits per cell nonvolatile multistate characteristics and perform 15 stable epochs of synaptic operations with highly linear weight updates. A simulated artificial neural network comprising 1600 synapses confirms the superiority of the enhanced device in processing a 40 x 40 pixels grayscale image. The irradiation effectively decreases the concentration of oxygen vacancy donor defects and promotes oxygen interstitial acceptor defects on the surface of the ZnO films, which consequently modulate the redox process during rupture and rejuvenation of the filament. This work not only proposes the potential of ZnO-based memristor devices for high-density invisible data storage and in-memory computing application but also offers valuable insight in designing high-performance memristor devices, regardless of the oxide system used, by taking advantage of our neutral oxygen irradiation technique.
Impact of Cumulative Unhealthy Sleep Practices in Adolescence on Substance Use in Young Adulthood Estimated Using Marginal Structural Modeling
(2020-04-09)
Ho, Chia-Yi
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Lin, Sheng-Hsuan
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Tsai, Meng-Che
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Yu, Tsung
;
Strong, Carol
Objectives The purpose of this study was to identify the impact of chronic, unhealthy sleep practices in adolescence on substance use in young adulthood. Unhealthy sleep practices in adolescent samples exhibit a bidirectional relationship with substance use. The relationship is further complicated if we consider that confounders such as depression vary over time and are often in response to adolescents' prior poor sleep practice, which can be addressed by a counterfactual approach using a marginal structural model. Methods Data in this study are from the Taiwan Youth Project, a longitudinal study that started in 2000 and surveyed 2,690 7th grade students at age 13. Outcomes include frequency of cigarette smoking and alcohol drinking at age 21. Three unhealthy sleep practices were included in this study: short sleep, social jetlag, and sleep disturbance. We used a marginal structural model with stabilized inverse probability-of-treatment weights to address time-varying confounders in each wave and a total sample of 1,678 adolescents with complete information for this study. Results Accumulated waves of sleep disturbance and social jetlag in adolescence were significantly associated with cigarette use in young adulthood. Accumulated social jetlag but not sleep disturbance was also associated with alcohol use in adulthood. Accumulated waves of short sleep were not associated with later alcohol use, but were negatively correlated with cigarette use. Conclusion Interventions that aim to reduce the likelihood of substance use in young adulthood should consider confronting unhealthy sleep practices, in particular the discrepancy between bedtimes on school days and weekends and sleep disturbance.
Adjustable panoramic inspection system for submillimeter fasteners
(2020-04-10)
Yan, Yung-Jhe
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Tsai, Ming-Shiou
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Chen, Wen-Bin
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Chen, You-Bo
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Sun, Ching-Cherng
Fasteners are critical and indispensable locking components in mechanical assembly. Submillimeter fasteners are massively and widely used in electronic devices. This study proposed an adjustable panoramic inspection system for M2 to M0.8 submillimeter fasteners. The system mainly consists of a panoramic imaging module, a back-light module, and an image grabbing and computing module. The panoramic imaging module would form four equal optical path lengths to keep the same imaging amplification between the different directions of the field of view. The back-light module was designed to provide uniform illumination and enhance the contrast of the pitch edge between the fasteners and the background. The image grabbing and computing module with a high-speed camera was designed to be adjustable for different sizes of submillimeter fasteners. The realized system can offer the function of four images in one shot to make a panoramic scene, independent illumination for recognizing, inspect screws from M0.8 to M2.0 screws, and short time consumption of image processing, such as 3.284 ms for M0.8 screws and 2.384 ms for M2.0 screws, to achieve examination of 6000 pieces in 1 min. (C) 2020 Optical Society of America.
Rotational spectroscopy and astronomical search for glutaronitrile
(2020-04-10)
Cabezas, C.
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Bermudez, C.
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Endo, Y.
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Tercero, B.
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Cernicharo, J.
Context. Nitriles constitute almost 15% of the molecules observed in the interstellar medium (ISM), surprisingly only two dinitriles have been detected in the ISM so far. The lack of astronomical detections for dinitriles may be partly explained by the absence of laboratory rotational spectroscopic data.Aims. Our goal is to investigate the rotational spectrum of glutaronitrile, N equivalent to C-CH2-CH2-CH2-C equivalent to N, in order to allow its possible detection in the ISM.Methods. The rotational spectrum of glutaronitrile was measured using two different experimental setups. A Fourier transform microwave spectrometer was employed to observe the supersonic jet rotational spectrum of glutaronitrile between 6 and 20 GHz. In addition, the mmW spectrum was observed in the frequency range 72-116.5 GHz using a broadband millimetre-wave spectrometer based on radio astronomy receivers with fast Fourier transform backends. The spectral searches were supported by high-level ab initio calculations.Results. A total of 111 rotational transitions with maximum values of J and K-a quantum numbers 54 and 18, respectively, were measured for the gg conformer of glutaronitrile. The analysis allowed us to accurately determine the rotational, nuclear quadrupole coupling, quartic and sextic centrifugal distortion constants. These rotational parameters were employed to search for glutaronitrile in the cold and warm molecular clouds Orion KL, Sgr B2(N), B1-b and TMC-1, using the spectral surveys captured by IRAM 30 m at 3 mm. Glutaronitrile was not detected, and the upper limits' column densities were derived. Those are a factor of 1.5 and 5 lower than those obtained for the total column densities of the analogous succinonitrile in Orion KL and Sgr B2, respectively.
連假趴趴走　惹議也惹「疫」
(2020-04-12)
張筠婕
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Department of Communication and Technology
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傳播與科技學系
新型冠狀病毒（COVID-19）在全球蔓延，根據中央流行疫情指揮中心統計，國內截至目前有385人確診（境外移入331例、本土感染54例）、6人死亡。相較許多疫情爆發的國家，台灣的防疫受到各國的讚賞及效仿，成為全球熱議焦點。不過，在經過四天的清明連假，不少人擔心台灣各景點的人潮已成為防疫破口，引發許多爭議。
想像與恐懼　怪物對你的心理戰
(2020-04-12)
邱于非
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Department of Communication and Technology
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傳播與科技學系
兒童文學中的怪物其實是有演變規則的，面對不同年齡層擁有的想像力與心態成熟度，如何會是「成功的」怪物，其中需要依循的是許多層面的心理學。
「圓」來沒自信　但要很努力
(2020-04-12)
詹庭瑄
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Department of Communication and Technology
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傳播與科技學系
她，沒有浪費任何舞台下的日常累積，那些在咖啡廳自我懷疑、在電視台焦頭爛額、在韓國冒險的日子，成為了最好的養分，造就如今54萬訂閱的Youtuber。她是阿圓，本名王莉茵，一個沒有自信，但很努力的女孩。
芝麻開門　走進平等的藝術世界
(2020-04-12)
何雨潮
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Department of Communication and Technology
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傳播與科技學系
林滿足自稱「小小米」，也就是芝麻開門（Sesame）的音譯。她希望能成為人與藝術之間的橋梁，帶領人們走入藝術大門。
用玩具紀錄人生的大男孩
(2020-04-12)
李詠濠
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Department of Communication and Technology
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傳播與科技學系
紀錄回憶有千種方法，你有沒有想過用玩具記下自己曾經發生過的事？
李榮峰　尊重生命的行動教育家
(2020-04-12)
梁子敬
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Department of Communication and Technology
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傳播與科技學系
「要先懂得尊重動物，才有辦法去愛人，我要用教育改變這個世界。」
「憾」你再次活著，第二個人生
(2020-04-12)
黃博暄
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Department of Communication and Technology
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傳播與科技學系
如果某一天妳死而復生，你最想做的是什麼？韓國熱播連續劇《哈囉掰掰，我是鬼媽媽》，透過深刻描寫鬼媽媽死後和復生的心境，來探討死亡的議題。
大自然的女兒　張碧員
(2020-04-12)
李而
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Department of Communication and Technology
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傳播與科技學系
一本書是如何誕生的？大樹文化主編張碧員從她熱愛的大自然裡獲取創作養分，真實地記錄她眼中的一草一木。對她來說，大自然不僅僅是工作的場域，更是養育她，使她不斷成長的溫暖母親。
Kumu Walis　台灣與大溪地間的橋樑
(2020-04-12)
王冠云
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Department of Communication and Technology
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傳播與科技學系
賽德克原住民與大溪地，透過舞蹈連結了南島民族，建立文化之間的交流。
那些年，我們誤會的「八卦」
(2020-04-12)
廖玥茹
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Department of Communication and Technology
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傳播與科技學系
你有沒有想過，為什麼多數人不願自己被貼上「愛說八卦」的標籤，但還是喜歡談論他人的事？一個德國研究在調查人們八卦的動機時，也分析了「黑暗」的人是否更容易跟別人咬耳根子。然而種種結果都與我們認知不同，八卦的壞名聲似乎看起來不太合理。
需要正能量？開啟「手癢計劃」
(2020-04-12)
黃順愉
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Department of Communication and Technology
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傳播與科技學系
《教你10分鐘變成台灣人》或是《在台灣挑戰馬來西亞腔》的影片你看過嗎？浮誇的表情、明亮的配色，加上顯眼的標題，是她影片縮圖的標誌。一句「哈囉大家好，我是Soya～」便開啟了她的搞笑日常。
總編輯的話
(2020-04-12)
謝孟如
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Department of Communication and Technology
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傳播與科技學系
本期為喀報333期，此次上架的文章共13篇，包含8篇人物專訪、2篇科技新知、2篇藝文評論以及1篇社會議題。本次頭題為邱于非的《想像與恐懼　怪物對你的心理戰》，為何我們兒時聽過的怪物大野狼、天狗，如今已不再可怕；我們害怕怪物的潛在原因是什麼，都可以在本篇報導找到答案。
那些關於《她們》與我們的故事
(2020-04-12)
高儷玲
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Department of Communication and Technology
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傳播與科技學系
《她們》一部探討女性如何探索自我、突破傳統框架的電影，同時帶領觀眾以現代的角度看經典名著《小婦人》。
只要有人，就有社群：陳思傑
(2020-04-12)
李育陞
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Department of Communication and Technology
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傳播與科技學系
一位優秀的社群行銷人，如何從外商離開後自己創立社群顧問公司？如何從經營自媒體到創立全台知名的社團「社群丼」？讓我們來看看屬於陳思傑的故事。
Polarization aberrations of electrically tunable liquid crystal mirrors
(2020-04-13)
Wang, Yu-Jen
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Lin, Yi-Hsin
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Cakmakci, Ozan
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Reshetnyak, Victor
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光電工程學系
Curved mirrors are able to fold optical paths and play important roles in compact optical systems in general. In this paper, we investigate the polarization aberrations of electrically tunable liquid crystal (LC) mirrors with two kinds of configurations (flat and curved ones). The LC mirrors exhibit spatially-continuous tunable wavefronts. The detailed wavefronts of two LC mirrors are related to angles of incidence, polarization of light, and the alignment direction of LC molecules. The key contribution of this paper is the development and characterization of a tunable liquid crystal mirror. The tunability of polarization aberration of LC mirrors should be able to provide extra parameters for optical engineers to design versatile optical systems. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement