Browsing by Issue Date, starting with "2020-04-14"

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Suppressed humoral immunity is associated with dengue nonstructural protein NS1-elicited anti-death receptor antibody fractions in mice
(2020-04-14)
Tsai, Chung-Lin
;
Sun, Der-Shan
;
Su, Mei-Tzu
;
Lien, Te-Sheng
;
Chen, Yen-Hsu
Dengue virus (DENV) infections may cause life-threatening dengue hemorrhagic fever (DHF). Suppressed protective immunity was shown in these patients. Although several hypotheses have been formulated, the mechanism of DENV-induced immunosuppression remains unclear. Previously, we found that cross-reactive antibodies against tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor 1 (death receptor 4 [DR4]) were elicited in DHF patients, and that anti-DR4 autoantibody fractions were elicited by nonstructural protein 1 (NS1) immunizations in experimental mice. In this study, we found that anti-DR4 antibodies could suppress B lymphocyte function in vitro and in vivo. Treatment with the anti-DR4 immunoglobulin (Ig) induced caspase-dependent cell death in immortalized B lymphocyte Raji cells in vitro. Anti-DR4 Igs elicited by NS1 and DR4 immunizations markedly suppressed mouse spleen transitional T2 B (IgM(+)IgD(+)), bone marrow pre-pro-B (B220(+)CD43(+)), pre-B (B220(+)CD43(-)), and mature B cell (B220(+)IgD(+)) subsets in mice. Furthermore, functional analysis revealed that the pre-elicitation of anti-NS1 and anti-DR4 Ig titers suppressed subsequently neutralizing antibody production by immunization with DENV envelop protein. Our data suggest that the elicitation of anti-DR4 titers through DENV NS1 immunization plays a suppressive role in humoral immunity in mice.
Functionalization and antioxidant activity of polyaniline-fullerene hybrid nanomaterials: a theoretical investigation
(2020-04-15)
Nguyen Minh Thong
;
Vo, Quan V.
;
Trinh Le Huyen
;
Mai Van Bay
;
Nguyen Nho Dung
Functionalized fullerene is one of the most advantageous nanotechnologies to develop novel materials for potential biomedical applications. In this study, we applied the ONIOM-GD3 approach to explore the nucleophilic addition reaction mechanism between polyaniline (emeraldine and leucoemeraldine forms) and fullerene. Potential energy surfaces were also analyzed to predict the predominantly formed products of the functionalized reaction. The themoparameters, such as bond dissociation enthalpy (BDE), ionization energy (IE), and electron affinity (EA), characterized by two mechanisms HAT and SET, were used to evaluate the antioxidant activities of the selected compounds. Moreover, the calculated HOMO, LUMO, and DOS results indicate that the electronic structures of polyaniline-fullerene were significantly affected by the presence of fullerene. The computational results show that C60-L1 seems to be the best antioxidant following the SET mechanism.
Electrically Injected GaN-Based Vertical-Cavity Surface-Emitting Lasers with TiO2 High-Index-Contrast Grating Reflectors
(2020-04-15)
Chang, Tsu-Chi
;
Hashemi, Ehsan
;
Hong, Kuo-Bin
;
Bengtsson, Jorgen
;
Gustaysson, Johan
We demonstrate the first electrically injected GaNbased vertical-cavity surface-emitting lasers (VCSELs) with a TiO2 high-index-contrast grating (HCG) as the top mirror. Replacing the top distributed Bragg reflector (DBR) with an HCG offers substantial thickness reduction, polarization-pinning, and setting of the resonance wavelength by the grating parameters. Conventional HCGs are usually suspended in the low refractive index material, such as air, in order to create the largest refractive index contrast. However, the mechanical stability of such structures can be questioned and creating free-hanging GaN-membrane on top of GaN is problematic. We have therefore fabricated TiO2-HCGs resting directly on GaN without an air-gap. No DBR layers are used below the HCG to boost the reflectivity. A VCSEL with an aperture diameter of 10 mu m shows a threshold current of 25 mA under pulsed operation at room temperature. The lasing modes locate around 400 nm and are transversely electrically -polarized with a line width of 0.5 nm. The full-width half-maximum beam divergence is 10 degrees. This demonstration of a TiO2-HCG VCSEL offers a new route to achieve polarization pinning and could also allow additional benefits such as postgrowth setting of the resonance wavelength.
【生活中的公衛系列專題演講】～看見自己的家鄉
(國立陽明大學, 2020-04-15)
陽明電子報編輯小組
陽大附醫攜手宜縣府打造P2實驗室，提高新冠肺炎篩檢效率
(國立陽明大學, 2020-04-15)
陽明電子報編輯小組
新冠肺炎（COVID-19）疫情持續延燒，宜蘭縣政府特別編列250萬經費，於縣內指定應變醫院──本校附醫，成立P2等級實驗室，4月13日...
【完美求職系列講座】跨領域－護理X保險職涯分享
(國立陽明大學, 2020-04-15)
陽明電子報編輯小組
High Sensitivity and Wide Dynamic Range Thermoresistive Micro Calorimetric Flow Sensor With CMOS MEMS Technology
(2020-04-15)
Xu, Wei
;
Wang, Xiaoyi
;
Chiu, Yi
;
Lee, Yi-Kuen
;
電機工程學系
In this paper, a thin film based Thermoresistive Micro Calorimetric Flow (TMCF) sensor by using a 0.35 mu m 2P4M CMOS MEMS technology is designed, fabricated and tested. The developed 1.6 mu m thick thin film CMOS TMCF sensor shows a maximum normalized sensitivity of 103 mV/(m/s)/mW with respect to the input heating power and a wide dynamic flow range of 0 similar to 19.4 m/s. The high sensitivity and wide dynamic range achieved by our CMOS MEMS flow sensor enable its deployment as a promising sensing node for HVAC application in the smart energy-efficient building (EeB). Moreover, a new one-dimensional (1D) analytical sensor model that considers the three-dimensional (3D) heat loss via the end of the thin film is proposed. The new 1D model can successfully capture the thin film based TMCF sensor's response, and its prediction results show a good agreement with the experimental study. Therefore, this new 1D model will be a useful design tool for the development of a high-performance TMCF sensor with a greatly reduced footprint.
【停課不停學～儀器資源中心線上學習網】
(國立陽明大學, 2020-04-15)
陽明電子報編輯小組
【德國「圍牆倒下實驗室」創新挑戰賽】臺灣區徵選活動
(國立陽明大學, 2020-04-15)
陽明電子報編輯小組
書寫一紙日常的美好～英文書法工作坊
(國立陽明大學, 2020-04-15)
鍾庭宜
;
陽明電子報編輯小組
這學期藝文中心舉辦的工作坊，邀請到本校醫學系二年級的薛承明同學擔任講師，來教大家寫英文書法。在三個小時的課程中，從簡約優雅的單線體出發，以麥克筆為主要書寫工具，薛同學為學員們介紹了英文書法的使用工具、基本用語與字體特色、各字母書寫方式與細節，最後並帶領學員們實際練習書寫。
Efficient methods of computing interior transmission eigenvalues for the elastic waves
(2020-04-15)
Chang, Wei-Chen
;
Lin, Wen-Wei
;
Wang, Jenn-Nan
;
應用數學系
;
Department of Applied Mathematics
We study the interior transmission eigenvalue problem for the elastic wave scattering in this paper. We aim to show the distribution of positive eigenvalues by efficient numerical algorithms. Here the elastic waves are scattered by the perturbations of medium parameters, which include the elasticity tensor C and the density rho. Let us denote (C-0, rho(0)) and (C-1, rho(1)) the background and the perturbed medium parameters, respectively. We consider two cases of perturbations, C-0 = C-1, rho 1 not equal rho(0) (case 1) and C-0 not equal C-1, rho(1) = rho(0) (case 2). After discretizing the associated PDEs by FEM, we are facing the computation of generalized eigenvalues problems (GEP) with matrices of large size. These GEPs contain huge number of nonphysical zeros (for case 1) or nonphysical infinities (for case 2). In order to locate several hundred positive eigenvalues effectively, we then convert GEPs to suitable quadratic eigenvalues problems (QEP). We then implement a quadratic JacobiDavidson method combining with partial locking or partial deflation techniques to compute 500 positive eigenvalues. (C) 2020 Elsevier Inc. All rights reserved.
《我們的青春在台灣》（Our Youth in Taiwan）
(國立陽明大學, 2020-04-15)
黃柏威
;
陽明電子報編輯小組
防疫再升級，密閉空間須全程戴口罩
(國立陽明大學, 2020-04-15)
陽明電子報編輯小組
因應清明連假後防疫，本校防疫小組4月7日決議，嚴格要求全校師生於上課、會議等密閉空間全程佩戴口罩；並啟動健康關懷問卷調查，...
【2020生醫科技就業徵才活動】～徵的就是你
(國立陽明大學, 2020-04-15)
陽明電子報編輯小組
The antioxidant activity of natural diterpenes: theoretical insights
(2020-04-15)
Vo, Quan V.
;
Nguyen Minh Tam
;
Le Trung Hieu
;
Mai Van Bay
;
Nguyen Minh Thong
Diterpenes that were isolated from Crossopetalum gaumeri (Loes.) Lundell (Celastraceae) plants are reported to exhibit a range of biological activities, in particular as radical scavengers. Thus further insight into the antioxidant activity of diterpenes in physiological environments is much needed but not studied yet. In this study, the antioxidant activity of nine natural diterpenes was evaluated using kinetic and thermodynamic calculations. It was found that the sequential proton loss electron transfer (SPLET) mechanism is favored in polar environments, whereas formal hydrogen transfer (FHT) is the main pathway for the radical scavenging of these diterpenes in the gas phase as well as in lipid media. The rate constants for the HOO & x2d9; radical scavenging of these compounds in the gas phase, polar and nonpolar solvents are in the range of 2.29 x 10(-2) to 4.58 x 10(7), 9.74 x 10(-3) to 1.67 x 10(8) and 3.54 x 10(-5) to 1.31 x 10(5) M-1 s(-1), respectively. 7-Deoxynimbidiol (6), exhibits the highest HOO & x2d9; radical scavenging with k(overall) = 1.69 x 10(8) M-1 s(-1) and 9.10 x 10(4) M-1 s(-1) in water and pentyl ethanoate solvents, respectively, that is about 1300 times higher than that of Trolox in polar environments. It is thus a promising natural antioxidant in physiological environments.
「科技部傑出研究獎」系列報導1：科社所王文基教授
(國立陽明大學, 2020-04-15)
陽明電子報編輯小組
人社院「科技與社會研究所」王文基教授，此次以歷史領域研究榮獲科技部「108年度傑出研究獎」。王文基教授畢業於劍橋大學，訓...
【生醫統計SPSS軟體應用】推廣教育課程
(國立陽明大學, 2020-04-15)
陽明電子報編輯小組
【藝文中心講座】～罹癌後，我更了解UX
(國立陽明大學, 2020-04-15)
陽明電子報編輯小組
「科技部傑出研究獎」系列報導4：醫學系與臨醫所陳志強助理教授
(國立陽明大學, 2020-04-15)
陽明電子報編輯小組
醫學系與臨醫所陳志強助理教授，以皮膚科領域的研究榮獲科技部「108年度傑出研究獎」。陳志強老師目前擔任臺北榮總皮膚部科主任，...
「科技部傑出研究獎」系列報導3：生理所唐德成教授
(國立陽明大學, 2020-04-15)
陽明電子報編輯小組
生理學研究所唐德成教授，此次是以腎臟領域研究榮獲科技部「108年度傑出研究獎」。唐德成教授二十多年來致力於以紅血球生成素輔以...